Aerosol and parenteral pneumocandins are effective in a rat model of pulmonary aspergillosis.
Kurtz, M B, Bernard, E M, Edwards, F F, Marrinan, J A, Dropinski, J, Douglas, C M, ...
The pneumocandins are semisynthetic analogs of echinocandin-like compounds that have shown efficacy in animal models of systemic candidiasis, disseminated aspergillosis, and pneumocystis pneumonia....
Pharmacokinetics of aerosol amphotericin B in rats.
Niki, Y, Bernard, E M, Schmitt, H J, Tong, W P, Edwards, F F, Armstrong, D
The distributions of amphotericin B (AmB) in tissue were compared after intraperitoneal or aerosol administration. Rats were sacrificed 24 h after receiving single or repeated daily doses; AmB...
Brown, S T, Edwards, F F, Bernard, E M, Tong, W, Armstrong, D
Azithromycin, rifabutin, and rifapentine were used to treat or prevent disseminated Mycobacterium avium complex (MAC) infections produced in rats immunosuppressed with cyclosporine. Animals with...
Activities of antimicrobial agents against clinical isolates of Mycobacterium haemophilum.
Bernard, E M, Edwards, F F, Kiehn, T E, Brown, S T, Armstrong, D
Mycobacterium haemophilum, first described in 1978, can cause severe infections of skin, respiratory tract, bone, and other organs of immunocompromised patients. There is no standardized...
Evaluation of the Quantum II yeast identification system.
Kiehn, T E, Edwards, F F, Tom, D, Lieberman, G, Bernard, E M, Armstrong, D
We compared three methods for identifying clinical yeast isolates: Abbott Quantum II, API 20C, and a modified BBL Minitek system. The API 20C and modified Minitek systems agreed on the identification...
Specific DNA probes (Gen-Probe Corp., San Diego, Calif.) for Mycobacterium avium, Mycobacterium intracellulare, and Mycobacterium tuberculosis were compared with conventional methods for the...
Liver infection caused by Coniothyrium fuckelii in a patient with acute myelogenous leukemia.
Kiehn, T E, Polsky, B, Punithalingam, E, Edwards, F F, Brown, A E, Armstrong, D
A case of liver infection caused by Coniothyrium fuckelii is described in a patient with acute myelogenous leukemia. This fungus is found in the soil and can be a pathogen of plants. Coniothyrium...
Model of recurrent pulmonary aspergillosis in rats.
Niki, Y, Bernard, E M, Edwards, F F, Schmitt, H J, Yu, B, Armstrong, D
Male Sprague-Dawley rats were treated with cortisone acetate and fed a low-protein diet for 3 weeks. At the end of week 2, animals were infected intratracheally with 10(5) conidia of Aspergillus...
Kiehn, T E, Wong, B, Edwards, F F, Armstrong, D
Blood cultures obtained with a lysis-centrifugation (L-C) system and a conventional two-bottle broth system were compared for the recovery of bacteria and yeasts from 7,000 cultures. The L-C system...
Routine aerobic terminal subculturing of blood cultures in a cancer hospital.
Kiehn, T E, Wong, B, Edwards, F F, Armstrong, D
Routine terminal aerobic subcultures of macroscopically negative blood culture bottles were evaluated during a 15-month period when 30,000 blood cultures were processed. Each blood culture set...
Kiehn, T E, Edwards, F F, Brannon, P, Tsang, A Y, Maio, M, Gold, J W, ...
The Mycobacterium avium complex, only rarely described as an invasive pathogen in humans, has recently been reported to frequently cause disseminated disease in patients with the acquired immune...
Kiehn, T E, Nelson, P E, Bernard, E M, Edwards, F F, Koziner, B, Armstrong, D
A case of catheter-associated fungemia caused by Fusarium chlamydosporum is described in a patient with lymphocytic lymphoma. The fungus, which has been isolated from soil but not reported to cause...
Aerosol and parenteral pneumocandins are effective in a rat model of pulmonary aspergillosis.
Kurtz, M B, Bernard, E M, Edwards, F F, Marrinan, J A, Dropinski, J, Douglas, C M, ...
The pneumocandins are semisynthetic analogs of echinocandin-like compounds that have shown efficacy in animal models of systemic candidiasis, disseminated aspergillosis, and pneumocystis pneumonia....
Pharmacokinetics of aerosol amphotericin B in rats.
Niki, Y, Bernard, E M, Schmitt, H J, Tong, W P, Edwards, F F, Armstrong, D
The distributions of amphotericin B (AmB) in tissue were compared after intraperitoneal or aerosol administration. Rats were sacrificed 24 h after receiving single or repeated daily doses; AmB...
Brown, S T, Edwards, F F, Bernard, E M, Tong, W, Armstrong, D
Azithromycin, rifabutin, and rifapentine were used to treat or prevent disseminated Mycobacterium avium complex (MAC) infections produced in rats immunosuppressed with cyclosporine. Animals with...
Activities of antimicrobial agents against clinical isolates of Mycobacterium haemophilum.
Bernard, E M, Edwards, F F, Kiehn, T E, Brown, S T, Armstrong, D
Mycobacterium haemophilum, first described in 1978, can cause severe infections of skin, respiratory tract, bone, and other organs of immunocompromised patients. There is no standardized...
Evaluation of the Quantum II yeast identification system.
Kiehn, T E, Edwards, F F, Tom, D, Lieberman, G, Bernard, E M, Armstrong, D
We compared three methods for identifying clinical yeast isolates: Abbott Quantum II, API 20C, and a modified BBL Minitek system. The API 20C and modified Minitek systems agreed on the identification...
Specific DNA probes (Gen-Probe Corp., San Diego, Calif.) for Mycobacterium avium, Mycobacterium intracellulare, and Mycobacterium tuberculosis were compared with conventional methods for the...
Liver infection caused by Coniothyrium fuckelii in a patient with acute myelogenous leukemia.
Kiehn, T E, Polsky, B, Punithalingam, E, Edwards, F F, Brown, A E, Armstrong, D
A case of liver infection caused by Coniothyrium fuckelii is described in a patient with acute myelogenous leukemia. This fungus is found in the soil and can be a pathogen of plants. Coniothyrium...
Model of recurrent pulmonary aspergillosis in rats.
Niki, Y, Bernard, E M, Edwards, F F, Schmitt, H J, Yu, B, Armstrong, D
Male Sprague-Dawley rats were treated with cortisone acetate and fed a low-protein diet for 3 weeks. At the end of week 2, animals were infected intratracheally with 10(5) conidia of Aspergillus...
Kiehn, T E, Wong, B, Edwards, F F, Armstrong, D
Blood cultures obtained with a lysis-centrifugation (L-C) system and a conventional two-bottle broth system were compared for the recovery of bacteria and yeasts from 7,000 cultures. The L-C system...
Routine aerobic terminal subculturing of blood cultures in a cancer hospital.
Kiehn, T E, Wong, B, Edwards, F F, Armstrong, D
Routine terminal aerobic subcultures of macroscopically negative blood culture bottles were evaluated during a 15-month period when 30,000 blood cultures were processed. Each blood culture set...
Kiehn, T E, Edwards, F F, Brannon, P, Tsang, A Y, Maio, M, Gold, J W, ...
The Mycobacterium avium complex, only rarely described as an invasive pathogen in humans, has recently been reported to frequently cause disseminated disease in patients with the acquired immune...
Kiehn, T E, Nelson, P E, Bernard, E M, Edwards, F F, Koziner, B, Armstrong, D
A case of catheter-associated fungemia caused by Fusarium chlamydosporum is described in a patient with lymphocytic lymphoma. The fungus, which has been isolated from soil but not reported to cause...