Douglas, C M, Foor, F, Marrinan, J A, Morin, N, Nielsen, J B, Dahl, A M, ...
In Saccharomyces cerevisiae, mutations in FKS1 confer hypersensitivity to the immunosuppressants FK506 and cyclosporin A, while mutations in ETG1 confer resistance to the cell-wall-active...
Yeast FKBP-13 is a membrane-associated FK506-binding protein encoded by the nonessential gene FKB2.
Nielsen, J B, Foor, F, Siekierka, J J, Hsu, M J, Ramadan, N, Morin, N, ...
The immunosuppressants FK506 and rapamycin prevent T-cell activation and also inhibit the growth of certain strains of the yeast Saccharomyces cerevisiae. It has previously been shown that yeast...
Foor, F, Morin, N, Bostian, K A
The gene (tutA) encoding tyrosine phenol-lyase from Erwinia herbicola was cloned into Escherichia coli, and fusions to the lac and tac promoters were constructed. The enzyme was expressed at high...
Xiao, X, Hintermann, G, Häusler, A, Barker, P J, Foor, F, Demain, A L, ...
A 26-mer DNA probe was designed from N-terminal sequence data for the cephalosporin 7 alpha-hydroxylase (CH) of Streptomyces clavuligerus NRRL 3585 and used to screen a DNA library from this...
Reuveny, Z, Foor, F, Magasanik, B
A mutation of Klebsiella aerogenes causing production of an altered PII regulatory protein which stimulates overadenylylation of glutamine synthetase and also prevents its derepression was combined...
Rothman, N, Rothstein, D, Foor, F, Magasanik, B
We isolated mutants of Klebsiella aerogenes with insertions of transposon Tn5 linked to the structural gene for glutamine synthetase, glnA. We found that K. aerogenes, like Escherichia coli and...
Foor, F, Cedergren, R J, Streicher, S L, Rhee, S G, Magasanik, B
The glnD mutation of Klebsiella aerogenes is cotransducible by phage P1 with pan (requirement for pantothenate) and leads to a loss of uridylytransferase and uridylyl-removing enzyme, components of...
Bloom, F R, Levin, M S, Foor, F, Tyler, B
A lambda phage (lambdaNK55) carrying the translocatable element Tn10, conferring tetracycline resistance (Tetr), has been utilized to isolate glutamine auxotrophs of Escherichia coli K-12. Such...
Differential expression and function of two homologous subunits of yeast 1,3-beta-D-glucan synthase.
Mazur, P, Morin, N, Baginsky, W, El-Sherbeini, M, Clemas, J A, Nielsen, J B, ...
1,3-beta-D-Glucan is a major structural polymer of yeast and fungal cell walls and is synthesized from UDP-glucose by the multisubunit enzyme 1,3-beta-D-glucan synthase. Previous work has shown that...
Biochemical parameters of glutamine synthetase from Klebsiella aerogenes.
Bender, R A, Janssen, K A, Resnick, A D, Blumenberg, M, Foor, F, Magasanik, B
The glutamine synthetase (GS) from Klebsiella aerogenes is similar to that from Escherichia coli in several respects: (i) it is repressed by high levels of ammonia in the growth medium; (ii) its...
Regulation of the synthesis of glutamine synthetase by the PII protein in Klebsiella aerogenes.
Foor, F, Reuveny, Z, Magasanik, B
Certain mutations at the glaB locus result in the failure to fully derepress glutamine synthetase [L-glutamate:ammonia ligase (ADP-forming), EC 6.3.1.2] and to convert it to the active...
Regulation of synthesis of glutamine synthetase by adenylylated glutamine synthetase.
Foor, F, Janssen, K A, Magasanik, B
We have examined three mutants of Klebsiella aerogenes whose genetic lesions (glnB, glnD, and glnE) are in loci unlinked to the structural gene for glutamine sythetase (glnA) and in which the control...
Douglas, C M, Foor, F, Marrinan, J A, Morin, N, Nielsen, J B, Dahl, A M, ...
In Saccharomyces cerevisiae, mutations in FKS1 confer hypersensitivity to the immunosuppressants FK506 and cyclosporin A, while mutations in ETG1 confer resistance to the cell-wall-active...
Yeast FKBP-13 is a membrane-associated FK506-binding protein encoded by the nonessential gene FKB2.
Nielsen, J B, Foor, F, Siekierka, J J, Hsu, M J, Ramadan, N, Morin, N, ...
The immunosuppressants FK506 and rapamycin prevent T-cell activation and also inhibit the growth of certain strains of the yeast Saccharomyces cerevisiae. It has previously been shown that yeast...
Foor, F, Morin, N, Bostian, K A
The gene (tutA) encoding tyrosine phenol-lyase from Erwinia herbicola was cloned into Escherichia coli, and fusions to the lac and tac promoters were constructed. The enzyme was expressed at high...
Xiao, X, Hintermann, G, Häusler, A, Barker, P J, Foor, F, Demain, A L, ...
A 26-mer DNA probe was designed from N-terminal sequence data for the cephalosporin 7 alpha-hydroxylase (CH) of Streptomyces clavuligerus NRRL 3585 and used to screen a DNA library from this...
Reuveny, Z, Foor, F, Magasanik, B
A mutation of Klebsiella aerogenes causing production of an altered PII regulatory protein which stimulates overadenylylation of glutamine synthetase and also prevents its derepression was combined...
Rothman, N, Rothstein, D, Foor, F, Magasanik, B
We isolated mutants of Klebsiella aerogenes with insertions of transposon Tn5 linked to the structural gene for glutamine synthetase, glnA. We found that K. aerogenes, like Escherichia coli and...
Foor, F, Cedergren, R J, Streicher, S L, Rhee, S G, Magasanik, B
The glnD mutation of Klebsiella aerogenes is cotransducible by phage P1 with pan (requirement for pantothenate) and leads to a loss of uridylytransferase and uridylyl-removing enzyme, components of...
Bloom, F R, Levin, M S, Foor, F, Tyler, B
A lambda phage (lambdaNK55) carrying the translocatable element Tn10, conferring tetracycline resistance (Tetr), has been utilized to isolate glutamine auxotrophs of Escherichia coli K-12. Such...
Differential expression and function of two homologous subunits of yeast 1,3-beta-D-glucan synthase.
Mazur, P, Morin, N, Baginsky, W, El-Sherbeini, M, Clemas, J A, Nielsen, J B, ...
1,3-beta-D-Glucan is a major structural polymer of yeast and fungal cell walls and is synthesized from UDP-glucose by the multisubunit enzyme 1,3-beta-D-glucan synthase. Previous work has shown that...
Biochemical parameters of glutamine synthetase from Klebsiella aerogenes.
Bender, R A, Janssen, K A, Resnick, A D, Blumenberg, M, Foor, F, Magasanik, B
The glutamine synthetase (GS) from Klebsiella aerogenes is similar to that from Escherichia coli in several respects: (i) it is repressed by high levels of ammonia in the growth medium; (ii) its...
Regulation of the synthesis of glutamine synthetase by the PII protein in Klebsiella aerogenes.
Foor, F, Reuveny, Z, Magasanik, B
Certain mutations at the glaB locus result in the failure to fully derepress glutamine synthetase [L-glutamate:ammonia ligase (ADP-forming), EC 6.3.1.2] and to convert it to the active...
Regulation of synthesis of glutamine synthetase by adenylylated glutamine synthetase.
Foor, F, Janssen, K A, Magasanik, B
We have examined three mutants of Klebsiella aerogenes whose genetic lesions (glnB, glnD, and glnE) are in loci unlinked to the structural gene for glutamine sythetase (glnA) and in which the control...