F. Govers

Publication List Details

Period

1983 - 2009

Number

327

Co-Authors

Unraveling the senses of Phytophthora; leads to novel control strategies? (2009)

Govers, F., Meijer, H.J.G., Tran, H., Wagemakers, L., Raaijmakers, J.M.

Oomycetes cause devastating diseases on plants and animals. They cause major yield losses in many crop plants and their control heavily depends on agrochemicals. This is certainly true for the potato...

Functional Genomics of G-protein coupled receptors (GPCR) in Phytophthora sojae (2009)

Wei, Z., Wang, Y., Wang, X., Wu, H., Dou, D., ...

G protein coupled receptors (GPCRs) present a large family of receptors involved in a broad spectrum of cell signaling, which are responsive for transmitting the extracellular signals to...

Cellular Responses of the Late Blight Pathogen Phytophthora infestans to Cyclic Lipopeptide Surfactants and Their Dependence on G Proteins (2009)

Tran, H., Govers, F., Raaijmakers, J.M.

Oomycete pathogens cause major yield losses for many crop plants, and their control depends heavily on agrochemicals. Cyclic lipopeptides (CLPs) were recently discovered as a new class of natural...

Recognition of Phytophthora infestans Avr4 by potato R4 is triggered by C-terminal domains comprising W motifs (2009)

Jiang, R.H.Y., Sliwka, J., Govers, F.

Oomycete RXLR-dEER effector proteins are rapidly evolving proteins with the selective pressure targeted predominantly at their C-terminal ends. The majority of RXLR-dEER proteins have recognizable...

A novel method for efficient and abundant production of Phytophthora brassicae zoospores on Brussels sprout leaf discs (2009)

Bouwmeester, K., Govers, F.

Background - Phytophthora species are notorious oomycete pathogens that cause diseases on a wide range of plants. Our understanding how these pathogens are able to infect their host plants will...

Differential recognition of Phytophthora infestans races in potato R4 breeding lines (2009)

Huigen, D.J., Govers, F.

Introgression breeding has resulted in several potato lines that are resistant to late blight, a devastating plant disease caused by the oomycete Phytophthora infestans. The traditional differential...

Arabidopsis L-type lectin receptor kinases: phylogeny, classification, and expression profiles (2009)

Bouwmeester, K., Govers, F.

In plants, lectin receptor kinases are considered to play crucial roles during development and in the adaptive response to various stimuli. Arabidopsis lectin receptor kinases can be divided into...

Phytophthora heeft 'junk DNA' als geheim wapen (interview met F. Govers) (2009)

Govers, F.

Het genoom van de veroorzaker van de gevreesde aardappelziekte Phytophthora infestans heeft een aantal intrigerende kenmerken. Zo gebruikt deze oömyceet het repetitieve DNA om zich in hoog tempo...

Phytophthora vindt altijd wel een weg om resistentie te omzeilen (interview met F. Govers) (2009)

Hanse, L., Govers, F.

Zeven vragen aan de Professor Govers over de meest gevreesde oömyceet in aardappelland

Avirulentiegenen in Phytophthora infestans, de veroorzaker van de aardappelziekte (2009)

Govers, F.

Een proefschrift van Wageningen Universiteit beschrijft het karteren en kloneren van Avr-genen in Phytophthora infestans. Ook is de fenotypische en genotypische diversiteit in P....

Gene expression profiling during asexual development of the late blight pathogen Phytophthora infestans reveals a highly dynamic transcriptome (2008)

Judelson, H.S., Aux, G., Avrova, A.O., Bruce, C., Cakir, C., ...

Much of the pathogenic success of Phytophthora infestans, the potato and tomato late blight agent, relies on its ability to generate from mycelia large amounts of sporangia, which release zoospores...

RXLR effector reservoir in two Phytophthora species is dominated by a single rapidly evolving superfamily with more than 700 members (2008)

Jiang, R.H.Y., Tripathy, S., Govers, F., Tyler, B.M.

Pathogens secrete effector molecules that facilitate the infection of their hosts. A number of effectors identified in plant pathogenic Phytophthora species possess N-terminal motifs (RXLR-dEER)...

Internuclear gene silencing in Phytophthora infestans is established through chromatin remodelling (2008)

Shepherd, S.J., Walker, C.A., Li, S., Appiah, A.A., Grenville-Briggs, L., ...

In the plant pathogen Phytophthora infestans, nuclear integration of inf1 transgenic DNA sequences results in internuclear gene silencing of inf1. Although silencing is regulated at the...

Biologically active Phytophthora mating hormone prepared by catalytic asymmetric total synthesis (2008)

Harutyunyan, S.R., Zhao, Z., Bouwmeester, K., Minnaard, A.J., Feringa, B.L., ...

A Phytophthora mating hormone with an array of 1,5-stereogenic centers has been synthesized by using our recently developed methodology of catalytic enantioselective conjugate addition of Grignard...

Effector genomics accelerates discovery and functional profiling of potato disease resistance and Phytophthora infestans avirulence genes (2008)

Rietman, H., Krenek, P., Champouret, N., Young, C., Oh, S-K., ...

Potato is the world's fourth largest food crop yet it continues to endure late blight, a devastating disease caused by the Irish famine pathogen Phytophthora infestans. Breeding broad-spectrum...

Effector trafficking: RXLR-dEER as extra gear for delivery into plant cells (2008)

Govers, F., Bouwmeester, K.

When driving a car with automatic transmission, one hardly notices that extra gears give more power to the car. But in a car with manual transmission, one is constantly aware that even one gear shift...

The Phytophthora infestans avirulence gene Avr4 encodes an RXLR-dEER effector (2008)

Jung, M.W.M., Birch, P.R.J., Whisson, S.C., ...

Resistance in potato against the oomycete Phytophthora infestans is conditioned by resistance (R) genes that are introgressed from wild Solanum spp. into cultivated potato. According to the...

A Phytophthora sojae G protein ¿ subunit is involved in chemotaxis to soybean isoflavones (2008)

Hua, C., Wang, Y., Zheng, X., Dou, D., Zhang, Z., Govers, F., ...

For the soybean pathogen Phytophthora sojae, chemotaxis of zoospores to isoflavones is believed to be critical for recognition of the host and for initiating infection. However, the molecular...

Phytophthora infestans isolates from Northern China show high virulence diversity but low genotypic diversity (2008)

Guo, J., Yao, Y.Q., Gong, X.F., Liang, D.L., ...

Phenotypic and genotypic characteristics of 48 Phytophthora infestans isolates, collected in five provinces in Northern China between 1997 and 2003, were determined and compared with reference...

The Phytophthora infestans avirulence gene PiAvr4 encodes an RxLR-dEER effector protein (2007)

Govers, F.

The oomycete pathogen Phytophthora infestans causes late blight, an important disease in potato world wide. P. infestans secretes numerous effector molecules, some of which are recognized by host...

Ancient origin of elicitin gene clusters in Phytophthora genomes (2006)

Jiang, R.H.Y., Tyler, B..M., Whisson, S.C., Hardham, A.R., Govers, F.

The genus Phytophthora belongs to the oomycetes in the eukaryotic stramenopile lineage and is comprised of over 65 species that are all destructive plant pathogens on a wide range of dicotyledons....

A cDNA-AFLP based strategy to identify transcripts associated with avirulence in Phytophthora infestans (2006)

Jiang, R.H.Y., Kamphuis, L.G., Govers, F.

Expression profiling using cDNA-AFLP is commonly used to display the transcriptome of a specific tissue or developmental stage. Here, cDNA-AFLP was used to identify transcripts in a segregating F1...

Lectin receptor kinases participate in protein-protein interactions to mediate plasma membrane-cell wall adhesions in Arabidopsis (2006)

Gouget, A., Senchou, V., Govers, F., Sanson, A., Barre, A., Rougé, P., ...

Interactions between plant cell walls and plasma membranes are essential for cells to function properly, but the molecules that mediate the structural continuity between wall and membrane are...

Amplification generates modular diversity at an avirulence locus in the pathogen Phytophthora (2006)

Jiang, R.H.Y., Weide, R., Govers, F.

The destructive late blight pathogen Phytophthora infestans is notorious for its rapid adaptation to circumvent detection mediated by plant resistance (R) genes. We performed comparative genomic...

Novel phosphatidylinositol phosphate kinases with a G-protein coupled receptor signature are shared by Dictyostelium and Phytophthora (2006)

Bakthavatsalam, D., Meijer, H.J.G., Noegel, A.A., Govers, F.

G-protein coupled receptors (GPCR) and phosphatidylinositol phosphate kinases (PIPK) are important key switches in signal transduction pathways. A novel class of proteins was identified in the...

Phytophthora genome sequences uncover evolutionary origins and mechanisms of pathogenesis (2006)

Tyler, B..M., Tripathy, S., Zhang, X., Dehal, P., Jiang, R.H.Y., Aerts, A., ...

Draft genome sequences have been determined for the soybean pathogen Phytophthora sojae and the sudden oak death pathogen Phytophthora ramorum. Oömycetes such as these Phytophthora species share the...

Agroinfection-based high throughput screening reveals specific recognition of INF elicitins in Solanum (2006)

Driesprong, J.D., Kamphuis, L., Torto-Alalibo, T., Govers, F., ...

We adapted and optimized the use of the Agrobacterium tumefaciens binary PVX expression system (PVX agroinfection) to screen Solanum plants for response to pathogen elicitors and applied the assay to...

Nonneutral GC3 and retroelement codon mimicry in Phytophthora (2006)

Jiang, R.H.Y., Govers, F.

Phytophthora is a genus entirely comprised of destructive plant pathogens. It belongs to the Stramenopila, a unique branch of eukaryotes, phylogenetically distinct from plants, animals, or fungi....

Phytophthora genomics: the plant destroyers' genome decoded (2006)

Govers, F., Gijzen, M.

The year 2004 was an exciting one for the Phytophthora research community. The United States Department of Energy Joint Genome Institute (JGI) completed the draft genome sequence of two Phytophthora...

Elicitin genes in Phytophthora infestans are clustered and interspersed with various transposon-like elements (2005)

Jiang, R.H.Y., Dawe, A.L., Weide, R., Peters, S., Nuss, D.L., ...

Sequencing and annotation of a contiguous stretch of genomic DNA (112.3 kb) from the oomycete plant pathogen Phytophthora infestans revealed the order, spacing and genomic context of four members of...

Differences in intensity and specificity of hypersensitive response induction in Nicotiana spp. by INF1, INF2A, and INF2B of Phytophthora infestans (2005)

Huitema, E., Cakir, C., Kamoun, S., Govers, F.

Elicitins form a family of structurally related proteins that induce the hypersensitive response (HR) in plants, particularly Nicotiana spp. The elicitin family is composed of several classes. Most...

A transmembrane phospholipase D in Phytophthora; a novel PLD subfamily (2005)

Meijer, H.J.G., Latijnhouwers, M., Ligterink, W., Govers, F.

Phospholipase D (PLD) is a ubiquitous enzyme in eukaryotes that participates in various cellular processes. Its catalytic domain is characterized by two HKD motifs in the C-terminal part. Until now,...

Generation of a large set of microsatellites markers for Phytophthora infestans by mining sequence data (2005)

Mendes, O., Ruyter, C.P., Govers, F., ...

Microsatellite or simple-sequence repeat (SSR) markers are extremely useful in population studies particularly in diploid species. So far, however, only a limited number of informative microsatellite...

Generation of a large set of microsatellite-markers for Phytophthora infestans by mining sequence data (2005)

Mendes, O., Ruyter, C.P., Govers, F., ...

Microsatellite or simple-sequence repeat (SSR) markers are extremely useful in population studies particularly in diploid species. So far, however, only a limited number of informative microsatellite...

Large-scale gene discovery in the oomycete Phytophthora infestans reveals likely components of phytopathogenicity shared with true fungi (2005)

Randall, T.A., Dwyer, R.A., Huitema, E., Beyer, K., Cvitanich, C., Kelkar, H., ...

o overview the gene content of the important pathogen Phytophthora infestans, large-scale cDNA and genomic sequencing was performed. A set of 75,757 high-quality expressed sequence tags (ESTs) from...

High affinity recognition of a Phytophthora protein by Arabidopsis via an RGD motif (2004)

Senchou, V., Weide, R.L., Carrasco, A., Bouyssou, H., Pont-Lezica, R., Govers, F., ...

The RGD tripeptide sequence, a cell adhesion motif present in several extracellular matrix proteins of mammalians, is involved in numerous plant processes. In plant-pathogen interactions, the RGD...

A G alpha subunit controls zoospore motility and virulence in the potato late blight pathogen Phytophthora infestans (2004)

Latijnhouwers, M., Ligterink, J.W., Govers, F.

The heterotrimeric G-protein pathway is a ubiquitous eukaryotic signalling module that is known to regulate growth and differentiation in many plant pathogens. We previously identified Pigpa1, a gene...

High-density genetic linkage maps of Phytophthora infestans reveal trisomic progeny and chromosomal rearrangements (2004)

Testa, A., Robold, A., Govers, F.

Detailed analysis of the inheritance of molecular markers was performed in the oomycete plant pathogen Phytophthora infestans. Linkage analysis in the sexual progeny of two Dutch field isolates...

Downstream targets of the Phytophthora infestans G alpha subunit PiGPA1 revealed by cDNA-AFLP (2004)

Dong, W., Latijnhouwers, M., Jiang, R.H.Y., Meijer, H.J.G., Govers, F.

In many plant pathogens heterotrimeric G-proteins are essential signalling components involved in development and pathogenicity. In the late blight oomycete pathogen Phytophthora infestans the...

Sequencing the Phytophthora infestans Genome: Preliminary Studies (2004)

O'Neill, K., Zody, M.C., Karlsson, E., Govers, F., Weide, R.L., ...

Phytophthora infestans, the causal agent of Late Blight of potato, is arguably the most significant biotic threat to global food security. An annotated P. infestans genome sequence is a critically...

High affinity recognition of a Phytophthora protein by Arabidopsis via an RGD motif. (2004)

Senchou, V., Weide, R., Carrasco, A., Bouyssou, H., Pont-Lezica, R., Govers, F., ...

The RGD tripeptide sequence, a cell adhesion motif present in several extracellular matrix proteins of mammalians, is involved in numerous plant processes. In plant-pathogen interactions, the RGD...

High affinity recognition of a Phytophthora protein by Arabidopsis via an RGD motif. (2004)

Senchou, V., Weide, R., Carrasco, A., Bouyssou, H., Pont-Lezica, R., Govers, F., ...

The RGD tripeptide sequence, a cell adhesion motif present in several extracellular matrix proteins of mammalians, is involved in numerous plant processes. In plant-pathogen interactions, the RGD...

Identification of race-specific avirulence genes in Phytophthora infestans by transciptional profiling (2003)

Jiang, R.H.Y., Govers, F.

Phytophthora infestans is a destructive oomycete pathogen causing potato late blight worldwide. Genetic analyses of potato and P. infestans have demonstrated that in this pathosystem, monogenic...

A Phytophthora infestans G-protein beta subunit is involved in sporangium formation (2003)

Latijnhouwers, M., Govers, F.

The heterotrimeric G-protein pathway regulates cellular responses to a wide range of extracellular signals in virtually all eukaryotes. It also controls various developmental processes in the...

Oomycetes and fungi: similar weaponry to attack plants (2003)

Latijnhouwers, M., Govers, F.

Fungi and Oomycetes are the two most important groups of eukaryotic plant pathogens. Fungi form a separate kingdom and are evolutionarily related to animals. Oomycetes are classified in the kingdom...

Durability of resistance (2002)

Govers, F., Niks, R.E.

In evolutionary sense no resistance lasts forever. The durability of a resistance can be seen as a quantitative trait; resistances may range from not durable at all (ephemeral, or transient) to...

Differential expression of G protein alpha and ß subunit genes during development of Phytophthora infestans (2002)

Laxalt, A.M., Latijnhouwers, M., Govers, F.

A G protein subunit gene (pigpa1) and a G protein subunit gene (pigpb1) were isolated from the oomycete Phytophthora infestans, the causal agent of potato late blight. Heterotrimeric G proteins are...

Mapping of avirulence genes in Phytophthora infestans with amplified fragment length polymorphism markers selected by bulked segregant analysis (2001)

Robold, A., Testa, A., Govers, F.

In this study we investigated the genetic control of avirulence in the diploid oomycete pathogen Phytophthora infestans, the causal agent of late blight on potato. The dominant avirulence (Avr) genes...

Ancient diversification of the Pto kinase family preceded speciation in Solanum (2001)

Martens, A., Colon, L.T., Govers, F., Kamoun, S.

Recent phylogenetic analyses of the nucleotide binding sites (NBS)-leucine-rich repeats (LRR) class of plant disease resistance (R) genes suggest that these genes are ancient and coexist next to...

Physical mapping across an avirulence locus of Phytophthora infestans using a highly representative, large-insert bacterial artificial chromosome library (2001)

Whisson, S.C., Bryan, G.J., Waugh, R., Govers, F., Birch, P.R.J.

The oomycete plant pathogen Phytophthora infestans is the causal agent of late blight, one of the most devastating diseases of potato worldwide. As part of efforts to clone avirulence (Avr) genes and...

Chromosomal deletion in isolates of Phytophthora infestans correlates with virulence on R3, R10, and R11 potato lines (2001)

Testa, A., Govers, F.

In Phytophthora infestans, a cluster of three dominant avirulence genes is located on the distal part of linkage group VIII. In a mapping population from a cross between two Dutch field isolates,...

Mapping of avirulence genes in Phytophthora infestans with amplified fragment length polymorphism markers selected by bulked segregant analysis (2001)

Robold, A., Testa, A., Govers, F.

In this study we investigated the genetic control of avirulence in the diploid oomycete pathogen Phytophthora infestans, the causal agent of late blight on potato. The dominant avirulence (Avr) genes...

Independent pathways leading to apoptotic cell death, oxidative burst and defence gene expression in response to elicitin in tobacco cell suspension culture (2000)

Sasabe, M., Takeuchi, K., Kamoun, S., Ichinose, Y., Govers, F., Toyoda, K., ...

We characterized pharmacologically the hypersensitive cell death of tobacco BY-2 cells that followed treatments with Escherichia coli preparations of INF1, the major secreted elicitin of the late...

tef1, a Phytophthora infestans gene encoding translation elongation factor 1-alpha (2000)

Govers, F.

From a set of Phytophthora infestans cDNA clones randomly selected from a potato-P. infestans interaction cDNA library, three out of 22 appeared to correspond to a gene encoding translation...

The hypersensitive response is associated with host and nonhost resistance to Phytophthora infestans (2000)

Govers, F., Kamoun, S., Colon, L.T.

The interaction between Phytophthora infestans (Mont.) de Bary and Solanum was examined cytologically using a diverse set of wild Solanum species and potato (S. tuberosum L.) cultivars with various...

Does basal PR gene expression in Solanum species contribute to non-specific resistance to Phytophthora infestans? (2000)

Govers, F., Kamoun, S., Colon, L.T.

Systemic acquired resistance (SAR) occurs in many plant species, including potato. SAR can be induced by various signals, but also basal levels of SAR may vary between plants. In Arabidopsis mutants,...

A laboratory assay for Phytophthora infestans resistance in various Solanum species reflects the field situation (1999)

Keizer, L.C.P., Sijpkes, L., Govers, F., Colon, L.T.

Physiological and molecular research on resistance responses of Solanum tuberosum cultivars and partially resistant Solanum species to Phytophthora infestans requires a reliable resistance test that...

A gene encoding a protein elicitor of Phytophthora infestans is down-regulated during infection of potato. (1997)

Kamoun, S., Govers, F.

Most species of the genus Phytophthora produce 10-kDa extracellular protein elicitors, collectively termed elicitins. Elicitins induce hypersensitive response in a restricted number of plants,...

NiaA, the structural nitrate reductase gene of Phytophthora infestans: isolation, characterization and expression analysis in Aspergillus nidulans (1995)

Pieterse, C.M.J., Klooster, J. Van 't, Govers, F.

The nitrate reductase (NR) gene niaA of the oomycete Phytophthora infestans was selected from a gene library by heterologous hybridization. NiaA occurs as a single-copy gene ant its expression is...

Expression of the Phytophthora infestans ipiB and ipiO genes in planta and in vitro (1994)

Pieterse, C.M.J., Folders, J., Govers, F.

The ipiB and ipiO genes of the potato late blight fungus Phytophthora infestans (Mont.) de Bary were isolated from a genomic library in a screen for genes induced in planta. Expression of these genes...

Structure and genomic organization of the ipiB and ipiO gene clusters of Phytophthora infestans (1994)

Pieterse, C.M.J., West, P. Van, Verbakel, H.M., Govers, F.

Two in planta-induced (ipi) genes, designated ipiB and ipiO, of the potato late blight fungus, Phytophthora infestans (Mont.) de Bary, were isolated from a genomic library by a differential...

Isolation of putative pathogenicity genes of the potato late blight fungus Phytophthora infestans by differential hybridization of a genomic library (1993)

Pieterse, C.M.J., Riach, M.B.R., Bleker, T., Govers, F.

Plant pathogens produce pathogenicity factors which enable them to parasitize and colonize their host. A strategy for identifying pathogenicity factors involves the isolation and characterization of...

Characterization of the pea ENOD12B gene and expression analyses of the two ENOD12 genes in nodule, stem and flower tissue. (1991)

Govers, F., Harmsen, H., Heidstra, R., Michielsen, P., Prins, M., ...

The ENOD12 gene family in pea consists of two different members. The cDNA clone, pPsENOD12, represents the PsENOD12A gene. The second ENOD12 gene, PsENOD12B, was selected from a genomic library using...

cDNA cloning and development expression of pea nodulin genes. (1987)

Govers, F., Nap, J.P., Moerman, M., Franssen, H.J., Bisseling, T.

A cDNA library prepared from pea nodule poly(A) RNA was screened by differential hybridization with cDNA probes synthesized from root and nodule RNA respectively. From the cDNA clones that hybridized...

Rhizobium nod genes are involved in the induction of two early nodulin genes in Vicia sativa root nodules. (1987)

Moerman, M., Nap, J.P., Govers, F., Schilperoort, R., Bisseling, T.

Nodulin gene expresison was studied in Vicia sativa (common vetch) root nodules induced by several Rhizobium and Agrobacterium strains. An Agrobacterium transconjugant containing a R. leguminosarum...

Microaerobiosis is not involved in the induction of pea nodulin-gene expression. (1986)

Govers, F., Moerman, M., Hooymans, J., Bisseling, T.

Gene expression in pea roots grown in a medium with a low oxygen concentration was compared with that in nitrogen-fixing pea root nodules induced by Rhizobium bacteria. The results show that during...

Resistance of nicotiana benthamiana to phytophthora infestans is mediated by the recognition of the elicitor protein INF1

Kamoun, S, Van West P, Vleeshouwers, VG, De Groot KE, Govers, F

Phytophthora infestans, the agent of potato and tomato late blight disease, produces a 10-kD extracellular protein, INF1 elicitin. INF1 induces a hypersensitive response in a restricted number of...

Mapping of avirulence genes in Phytophthora infestans with amplified fragment length polymorphism markers selected by bulked segregant analysis.

Robold, A, Testa, A, Van 't Klooster, J W, Govers, F

In this study we investigated the genetic control of avirulence in the diploid oomycete pathogen Phytophthora infestans, the causal agent of late blight on potato. The dominant avirulence (Avr) genes...

Resistance of nicotiana benthamiana to phytophthora infestans is mediated by the recognition of the elicitor protein INF1

Kamoun, S, Van West P, Vleeshouwers, VG, De Groot KE, Govers, F

Phytophthora infestans, the agent of potato and tomato late blight disease, produces a 10-kD extracellular protein, INF1 elicitin. INF1 induces a hypersensitive response in a restricted number of...

Mapping of avirulence genes in Phytophthora infestans with amplified fragment length polymorphism markers selected by bulked segregant analysis.

Robold, A, Testa, A, Van 't Klooster, J W, Govers, F

In this study we investigated the genetic control of avirulence in the diploid oomycete pathogen Phytophthora infestans, the causal agent of late blight on potato. The dominant avirulence (Avr) genes...