F. J. Dommerholt

Diastereoselective synthesis of (2S,5R)-5-hydroxypipecolic acid and 6-substituted derivatives (2004)

Botman, P.N.M., Dommerholt, F.J., Broxterman, Q.B., Schoemaker, H.E., Blaauw, R.H.

Herein, we report a diastereoselective synthesis of the natural product (2S,5R)-5-hydroxypipecolic acid and 6-substituted derivatives thereof. The key step in the synthetic sequence is a novel highly...

Complexants for the clathration mediated synthesis of the antibiotic cephradine (2001)

Kemperman, G.J., Dommerholt, F.J., Bosma, R., Zwanenburg, B.

Enzymatic synthesis of cephalosporins is hampered by secondary hydrolysis and by complicated down-stream processing. Instantaneous removal of cephalosporin product by clathration, using an efficient...

Asymmetric Ketone Reduction Using Oxazaborolidines Derived from Aziridine Carbinols (1995)

Zwanenburg, B., Thijs, L., Vaarhorst, A.M., Hammink, J.B., Dommerholt, F.J., Willems, J.G.H.

Asymmetric Ketone Reduction Using Chiral Oxazaborolidines Derived from Aziridine Carbinols (1995)

Zwanenburg, B., Thijs, L., Vaarhorst, A.M., Hammink, J.B., Dommerholt, F.J., Willems, J.G.H.