F. J. Schoen

Toward a cardiovascular pathology training - Report on the forum held in Vancouver, March 6, 2004, Society for Cardiovascular Pathology (2005)

Thiene, G., Becker, A.E., Buja, L.M., Fallon, P., McManus, B.M., Schoen, F.J., ...

Site-specific delivery of ethanehydroxy diphosphonate from refillable polyurethane reservoirs to inhibit bioprosthetic tissue calcification (1993)

Johnston, Thomas P., Webb, C. L., Schoen, F. J., Levy, Robert J.

Calcification (CALC) is the most frequent cause for the failure of bioprosthetic heart valves fabricated from glutaraldehyde-pretreated porcine aortic valve, and contributes to the failure of...

Bioprosthetic heart valve calcification: membrane-mediated events and alkaline phosphatase (1992)

Schoen, F. J., Levy, Robert J.

Peer Reviewed

Transient cardiac expression of constitutively active Gαq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways

Mende, U., Kagen, A., Cohen, A., Aramburu, J., Schoen, F. J., Neer, E. J.

Cardiac hypertrophy and dilatation can result from stimulation of signal transduction pathways mediated by heterotrimeric G proteins, especially Gq, whose α subunit activates phospholipase Cβ...

Derivation and characterization of an efficiently myocarditic reovirus variant.

Sherry, B, Schoen, F J, Wenske, E, Fields, B N

A reovirus variant, 8B, was isolated from a neonatal mouse which had been inoculated with a mixture of two reovirus strains: type 1 Lang (T1L) and type 3 Dearing (T3D) (E. A. Wenske, S.J. Chanock, L....

Diastolic dysfunction in hypertrophic cardiomyopathy. Effect on active force generation during systole.

Gwathmey, J K, Warren, S E, Briggs, G M, Copelas, L, Feldman, M D, Phillips, P J, ...

We tested the hypothesis that intracellular Ca++ [( Ca++]i) overload underlies the diastolic dysfunction of patients with hypertrophic cardiomyopathy. Myocardial tissue was obtained at the time of...

Expression of dihydropyridine receptor (Ca2+ channel) and calsequestrin genes in the myocardium of patients with end-stage heart failure.

Takahashi, T, Allen, P D, Lacro, R V, Marks, A R, Dennis, A R, Schoen, F J, ...

Cytoplasmic free calcium ions (Ca2+) play a central role in excitation-contraction coupling of cardiac muscle. Abnormal Ca2+ handling has been implicated in systolic and diastolic dysfunction in...

Responses of coronary arteries of cardiac transplant patients to acetylcholine.

Fish, R D, Nabel, E G, Selwyn, A P, Ludmer, P L, Mudge, G H, Kirshenbaum, J M, ...

Accelerated coronary atherosclerosis is a major cause of graft failure after heart transplantation. Graft atherosclerosis is typically diffuse and difficult to detect even with coronary...

Transient cardiac expression of constitutively active Gαq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways

Mende, U., Kagen, A., Cohen, A., Aramburu, J., Schoen, F. J., Neer, E. J.

Cardiac hypertrophy and dilatation can result from stimulation of signal transduction pathways mediated by heterotrimeric G proteins, especially Gq, whose α subunit activates phospholipase Cβ...

Derivation and characterization of an efficiently myocarditic reovirus variant.

Sherry, B, Schoen, F J, Wenske, E, Fields, B N

A reovirus variant, 8B, was isolated from a neonatal mouse which had been inoculated with a mixture of two reovirus strains: type 1 Lang (T1L) and type 3 Dearing (T3D) (E. A. Wenske, S.J. Chanock, L....

Diastolic dysfunction in hypertrophic cardiomyopathy. Effect on active force generation during systole.

Gwathmey, J K, Warren, S E, Briggs, G M, Copelas, L, Feldman, M D, Phillips, P J, ...

We tested the hypothesis that intracellular Ca++ [( Ca++]i) overload underlies the diastolic dysfunction of patients with hypertrophic cardiomyopathy. Myocardial tissue was obtained at the time of...

Expression of dihydropyridine receptor (Ca2+ channel) and calsequestrin genes in the myocardium of patients with end-stage heart failure.

Takahashi, T, Allen, P D, Lacro, R V, Marks, A R, Dennis, A R, Schoen, F J, ...

Cytoplasmic free calcium ions (Ca2+) play a central role in excitation-contraction coupling of cardiac muscle. Abnormal Ca2+ handling has been implicated in systolic and diastolic dysfunction in...

Responses of coronary arteries of cardiac transplant patients to acetylcholine.

Fish, R D, Nabel, E G, Selwyn, A P, Ludmer, P L, Mudge, G H, Kirshenbaum, J M, ...

Accelerated coronary atherosclerosis is a major cause of graft failure after heart transplantation. Graft atherosclerosis is typically diffuse and difficult to detect even with coronary...

Smooth muscle cells of the coronary arterial tunica media express tumor necrosis factor-alpha and proliferate during acute rejection of rabbit cardiac allografts.

Tanaka, H., Swanson, S. J., Sukhova, G., Schoen, F. J., Libby, P.

Graft coronary arteriosclerosis (GCA) frequently limits the long-term success of cardiac transplantation. The pathogenic mechanisms of and stimuli that provoke GCA remain uncertain. Whatever the...

Inhibition of mineralization of glutaraldehyde-pretreated bovine pericardium by AlCl3. Mechanisms and comparisons with FeCl3, LaCl3, and Ga(NO3)3 in rat subdermal model studies.

Webb, C. L., Schoen, F. J., Flowers, W. E., Alfrey, A. C., Horton, C., Levy, R. J.

In the present study, the authors investigated the mechanism by which Al3+ preincubations inhibited the pathologic calcification of glutaraldehyde-pretreated bovine pericardium (GPBP) implanted...

Human coronary transplantation-associated arteriosclerosis. Evidence for a chronic immune reaction to activated graft endothelial cells.

Salomon, R. N., Hughes, C. C., Schoen, F. J., Payne, D. D., Pober, J. S., Libby, P.

Occlusive disease of coronary arteries of engrafted hearts is the major obstacle to long-term survival of human cardiac allografts. The pathogenesis of this process remains uncertain. The identity...

Calcification of allograft aortic wall in a rat subdermal model. Pathophysiology and inhibition by Al3+ and aminodiphosphonate preincubations.

Webb, C. L., Nguyen, N. M., Schoen, F. J., Levy, R. J.

Aortic allograft conduits and valves frequently undergo calcific degeneration. To study this problem, a rat subdermal model of nonvalved aortic wall allograft calcification was characterized, and...

Endothelial and smooth muscle cells express leukocyte adhesion molecules heterogeneously during acute rejection of rabbit cardiac allografts.

Tanaka, H., Sukhova, G. K., Swanson, S. J., Cybulsky, M. I., Schoen, F. J., Libby, P.

Interactions of leukocytes with vascular wall cells figure prominently in acute rejection and development of vascular occlusive disease after cardiac transplantation. To investigate the time course...

Triphenyltetrazolium staining of irreversible ischemic injury following coronary artery occlusion in rats.

Vivaldi, M. T., Kloner, R. A., Schoen, F. J.

The objectives of this study of triphenyltetrazolium chloride (TTC) gross histochemical staining of myocardial infarcts were to determine the accuracy of sizing of established infarcts, to determine...

Calcification of subcutaneously implanted type I collagen sponges. Effects of formaldehyde and glutaraldehyde pretreatments.

Levy, R. J., Schoen, F. J., Sherman, F. S., Nichols, J., Hawley, M. A., Lund, S. A.

Although collagen-containing implants are widely used in various surgical applications, there has been relatively little attention paid to the possibility that this type of biomaterial may undergo...

Calcification of bovine pericardium used in cardiac valve bioprostheses. Implications for the mechanisms of bioprosthetic tissue mineralization.

Schoen, F. J., Tsao, J. W., Levy, R. J.

Calcification of bioprosthetic heart valves fabricated from glutaraldehyde-pretreated bovine pericardium has not been investigated. The objectives of this study were to characterize pericardium...

The role of glutaraldehyde-induced cross-links in calcification of bovine pericardium used in cardiac valve bioprostheses.

Golomb, G., Schoen, F. J., Smith, M. S., Linden, J., Dixon, M., Levy, R. J.

Calcification is the principal cause of failure of tissue-derived cardiac valve replacements pretreated with glutaraldehyde (GLUT). The objective of this study was to determine the role of...

Biologic determinants of dystrophic calcification and osteocalcin deposition in glutaraldehyde-preserved porcine aortic valve leaflets implanted subcutaneously in rats.

Levy, R. J., Schoen, F. J., Levy, J. T., Nelson, A. C., Howard, S. L., Oshry, L. J.

Bioprosthetic cardiac valve calcification is a frequent complication after long-term valve replacement. In this study the authors sought to examine the biologic determinants of this type of...