F. Lafeber

INTERMITTENT HYDROSTATIC COMPRESSIVE FORCE STIMULATES EXCLUSIVELY THE PROTEOGLYCAN SYNTHESIS OF OSTEOARTHRITIC HUMAN CARTILAGE (1992)

LAFEBER, F., VELDHUIJZEN, J. P., HUBER-BRUNING, O., BIJLSMA, J. W. J.

In paired observations the in vitro proteoglycan turnover was studied of human normal and osteoarthritic cartilage in the absence and presence of intermittent hydrostatic compressive force. Shortly...

Decrease in peripheral type 1 over type 2 T cell cytokine production in patients with rheumatoid arthritis correlates with an increase in severity of disease

Verhoef, C., Gmelig-Meyling, F., Huber-Bruning, O., Lafeber, F., ...

Objectives—To compare peripheral type 1 (T1) and type 2 (T2) T cell activities in rheumatoid arthritis (RA) patients with that found for osteoarthritic (OA) patients and healthy controls and to...

Mutual antagonism of rheumatoid arthritis and hay fever; a role for type 1/type 2 T cell balance

Verhoef, C., Vianen, M., Bruijnzeel-Koomen, C., Lafeber, F., Bijlsma, J.

OBJECTIVES—The balance between interferon γ(IFNγ) and interleukin 4 (IL4) producing T cells (T1 and T2 cells) seems to be of importance in many (auto)immune disorders. In general, T1 cell...

The immune suppressive effect of dexamethasone in rheumatoid arthritis is accompanied by upregulation of interleukin 10 and by differential changes in interferon γ and interleukin 4 production

Verhoef, C., Vianen, M., Lafeber, F., Bijlsma, J.

OBJECTIVES—The influence of dexamethasone on interleukin 10 (IL10) production and the type 1 (T1)/type 2 (T2) T cell balance found in rheumatoid arthritis (RA) was...

Interleukin 7 stimulates tumour necrosis factor α and Th1 cytokine production in joints of patients with rheumatoid arthritis

Glaudemans, K, Bijlsma, J, Lafeber, F

Background: A large number of activated T cells are found in the joints of patients with rheumatoid arthritis (RA). Interleukin 7 (IL7), a T cell growth factor and a regulator of Th1 and Th2 cytokine...

Depletion of synovial macrophages in rheumatoid arthritis by an anti-FcγRI-calicheamicin immunoconjugate

Bijlsma, J, Lafeber, F

Background: Monocytes/macrophages have an important and versatile role in joint inflammation and destruction in rheumatoid arthritis (RA).

Salivary gland and peripheral blood T helper 1 and 2 cell activity in Sjögren's syndrome compared with non-Sjögren's sicca syndrome

Van Woerkom, J M, Kruize, A, Knol, E, Bihari, I, Jacobs, J, ...

Objectives: To investigate whether differences in T helper (Th) 1 and Th2 cell activity in salivary glands ("local") or ("peripheral") blood can discriminate between Sjögren's syndrome (SS) and...