F. Latif

Publication List Details

Period

1989 - 2009

Number

224

Co-Authors

RAN GTPase is a RASSF1A effector involved in controlling microtubule organization (2009)

Dallol, A., Hesson, L.B., Matallanas, D., Cooper, W.N., O'Neill, E., Maher, E.R., ...

Summary RASSF1A is a tumor suppressor gene that is inactivated by hypermethylation of its promoter region in most types of human cancers [1], [2] and [3]. The incidence of spontaneous or induced...

RASSF2 associates with and stabilizes the proapoptotic kinase MST2 (2009)

Cooper, W.N., Hesson, L.B., Matallanas, D., Dallol, A., Von Kriegsheim, A., Ward, R., ...

RASSF2 is a tumour suppressor that in common with the rest of the RASSF family contains Ras association and SARAH domains. We identified the proapoptotic kinases, MST1 and MST2, as the most...

The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias (2009)

Hesson, L. B., Dunwell, T. L., Cooper, W. N., Catchpoole, D., Brini, A. T., Chiaramonte, R., ...

Background: The Ras-assocation family (RASSF) of tumour suppressor genes (TSGs) contains 10 members that encode proteins containing Ras-assocation (RA) domains. Several members of the RASSF family...

XRD and Surface Morphology Studies on Chitosan-Based Film Electrolytes (2006)

M.K. Harun, M.F. Mohammat, S.C. Ibrahim, ...

Chitosan was used as the host polymer with lithium acetate (LiOAc) as the doping salt and Palmitic Acid (PA) and Oleic Acid (OA) as plasticizers. The highest conductivity value was obtained for film...

XRD and Surface Morphology Studies on Chitosan-Based Film Electrolytes (2006)

M.K. Harun, M.F. Mohammat, S.C. Ibrahim, ...

Chitosan was used as the host polymer with lithium acetate (LiOAc) as the doping salt and Palmitic Acid (PA) and Oleic Acid (OA) as plasticizers. The highest conductivity value was obtained for film...

These include: (2002)

Email Alerting, M Zatyka, C Morrissey, I Kuzmin, M I Lerman, F Latif, ...

Genetic and functional analysis of the von

Genetic linkage between Von Hippel--Lindau disease and three microsatellite polymorphisms refines the localisation of the VHL locus (1993)

Crossey, P.A., Maher, E.R., Jones, M.H., Richards, F.M., Latif, F., Phipps, M.E., ...

Von Hippel—Lindau (VHL) disease is a dominantly inherited familial cancer syndrome characterised by the development of retinal and central nervous system haemangioblastomas, renal cell carcinoma...

Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns.

Sekido, Y, Bader, S, Latif, F, Chen, J Y, Duh, F M, Wei, M H, ...

Semaphorins and collapsins make up a family of conserved genes that encode nerve growth cone guidance signals. We have identified two additional members of the human semaphorin family [human...

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

Herman, J G, Latif, F, Weng, Y, Lerman, M I, Zbar, B, Liu, S, ...

Mutational inactivation and allelic loss of the von Hippel-Lindau (VHL) gene appear to be causal events for the majority of spontaneous clear-cell renal carcinomas. We now show that hypermethylation...

Distinct hypermethylation patterns occur at altered chromosome loci in human lung and colon cancer.

Makos, M, Nelkin, B D, Lerman, M I, Latif, F, Zbar, B, Baylin, S B

Regional increases in DNA methylation occur in normally unmethylated cytosine-rich areas in neoplastic cells. These changes could potentially alter chromatin structure to inactivate gene...

3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region.

Sithanandam, G, Latif, F, Duh, F M, Bernal, R, Smola, U, Li, H, ...

NotI linking clones, localized to the human chromosome 3p21.3 region and homozygously deleted in small cell lung cancer cell lines NCI-H740 and NCI-H1450, were used to search for a putative tumor...

Role of chromosome 3p12–p21 tumour suppressor genes in clear cell renal cell carcinoma: analysis of VHL dependent and VHL independent pathways of tumorigenesis

Martinez, A, Fullwood, P, Kondo, K, Kishida, T, Yao, M, Maher, E R, ...

Aims—Chromosome 3p deletions and loss of heterozygosity (LOH) for 3p markers are features of clear cell renal cell carcinoma but are rare in non-clear cell renal cell carcinoma. The VHL tumour...

Microsatellite instability and mutational analysis of transforming growth factor β receptor type II gene (TGFBR2) in sporadic ovarian cancer

Alvi, A J, Rader, J S, Broggini, M, Latif, F, Maher, E R

Aims—To investigate the possible role of mutations in the transforming growth factor β receptor type II gene (TGFBRII) in ovarian cancer and its relation to microsatellite instability (MSI), 43...

Chromosome 3p allele loss in early invasive breast cancer: detailed mapping and association with clinicopathological features

Martinez, A, Walker, R A, Shaw, J A, Dearing, S J, Maher, E R, Latif, F

Aims—Chromosome 3p allele loss is a frequent event in many common sporadic cancers including lung, breast, kidney, ovarian, and head and neck cancer. To analyse the extent and frequency of 3p...

Mutation screening analysis of the retinoblastoma related gene RB2/p130 in sporadic ovarian cancer and head and neck squamous cell cancer

Alvi, A J, Hogg, R, Rader, J S, Kuo, M J, Maher, E R, Latif, F

Aims: To investigate the involvement of the RB2/p130 gene in the pathogenesis of sporadic ovarian cancer in addition to head and neck squamous cell carcinoma (HNSCC).

Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns.

Sekido, Y, Bader, S, Latif, F, Chen, J Y, Duh, F M, Wei, M H, ...

Semaphorins and collapsins make up a family of conserved genes that encode nerve growth cone guidance signals. We have identified two additional members of the human semaphorin family [human...

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

Herman, J G, Latif, F, Weng, Y, Lerman, M I, Zbar, B, Liu, S, ...

Mutational inactivation and allelic loss of the von Hippel-Lindau (VHL) gene appear to be causal events for the majority of spontaneous clear-cell renal carcinomas. We now show that hypermethylation...

Distinct hypermethylation patterns occur at altered chromosome loci in human lung and colon cancer.

Makos, M, Nelkin, B D, Lerman, M I, Latif, F, Zbar, B, Baylin, S B

Regional increases in DNA methylation occur in normally unmethylated cytosine-rich areas in neoplastic cells. These changes could potentially alter chromatin structure to inactivate gene...

3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region.

Sithanandam, G, Latif, F, Duh, F M, Bernal, R, Smola, U, Li, H, ...

NotI linking clones, localized to the human chromosome 3p21.3 region and homozygously deleted in small cell lung cancer cell lines NCI-H740 and NCI-H1450, were used to search for a putative tumor...

Role of chromosome 3p12–p21 tumour suppressor genes in clear cell renal cell carcinoma: analysis of VHL dependent and VHL independent pathways of tumorigenesis

Martinez, A, Fullwood, P, Kondo, K, Kishida, T, Yao, M, Maher, E R, ...

Aims—Chromosome 3p deletions and loss of heterozygosity (LOH) for 3p markers are features of clear cell renal cell carcinoma but are rare in non-clear cell renal cell carcinoma. The VHL tumour...

Microsatellite instability and mutational analysis of transforming growth factor β receptor type II gene (TGFBR2) in sporadic ovarian cancer

Alvi, A J, Rader, J S, Broggini, M, Latif, F, Maher, E R

Aims—To investigate the possible role of mutations in the transforming growth factor β receptor type II gene (TGFBRII) in ovarian cancer and its relation to microsatellite instability (MSI), 43...

Chromosome 3p allele loss in early invasive breast cancer: detailed mapping and association with clinicopathological features

Martinez, A, Walker, R A, Shaw, J A, Dearing, S J, Maher, E R, Latif, F

Aims—Chromosome 3p allele loss is a frequent event in many common sporadic cancers including lung, breast, kidney, ovarian, and head and neck cancer. To analyse the extent and frequency of 3p...

Mutation screening analysis of the retinoblastoma related gene RB2/p130 in sporadic ovarian cancer and head and neck squamous cell cancer

Alvi, A J, Hogg, R, Rader, J S, Kuo, M J, Maher, E R, Latif, F

Aims: To investigate the involvement of the RB2/p130 gene in the pathogenesis of sporadic ovarian cancer in addition to head and neck squamous cell carcinoma (HNSCC).

Molecular genetic analysis of FIH-1, FH, and SDHB candidate tumour suppressor genes in renal cell carcinoma

Morris, M R, Maina, E, Morgan, N V, Gentle, D, Astuti, D, Moch, H, ...

Background: Overexpression of the hypoxia inducible factor 1 (HIF-1) and HIF-2 transcription factors and the consequent upregulation of hypoxia inducible mRNAs is a feature of many human cancers and...

Expression of the Von Hippel-Lindau tumor suppressor gene, VHL, in human fetal kidney and during mouse embryogenesis.

Kessler, P. M., Vasavada, S. P., Rackley, R. R., Stackhouse, T., Duh, F. M., Latif, F., ...

BACKGROUND: Von Hippel-Lindau (VHL) disease is a familial cancer syndrome that has a dominant inherited pattern which predisposes affected individuals to a variety of tumours. The most frequent...

Presymptomatic diagnosis of von Hippel-Lindau disease with flanking DNA markers.

Maher, E R, Bentley, E, Payne, S J, Latif, F, Richards, F M, Chiano, M, ...

Von Hippel-Lindau (VHL) disease is a dominantly inherited cancer syndrome characterised by the development of retinal, cerebellar, and spinal haemangioblastomas, renal cell carcinoma, and...

Detailed genetic mapping of the von Hippel-Lindau disease tumour suppressor gene.

Richards, F M, Maher, E R, Latif, F, Phipps, M E, Tory, K, Lush, M, ...

Von Hippel-Lindau (VHL) disease is an autosomal dominant inherited familial cancer syndrome characterised by a predisposition to the development of retinal, cerebellar, and spinal haemangioblastomas,...

Detailed mapping of a congenital heart disease gene in chromosome 3p25

Green, E., Priestley, M., Waters, J., Maliszewska, C., Latif, F., Maher, E.

Distal deletion of chromosome 3p25-pter (3p− syndrome) produces a distinct clinical syndrome characterised by low birth weight, mental retardation, telecanthus, ptosis, and micrognathia. Congenital...

Genetic and functional analysis of the von Hippel-Lindau (VHL) tumour suppressor gene promoter

Zatyka, M, Morrissey, C, Kuzmin, I, Lerman, M, Latif, F, Richards, F, ...

The VHL gatekeeper tumour suppressor gene is inactivated in the familial cancer syndrome von Hippel-Lindau disease and in most sporadic clear cell renal cell carcinomas. Recently the VHL gene product...

Functional epigenomics approach to identify methylated candidate tumour suppressor genes in renal cell carcinoma

Morris, M R, Gentle, D, Abdulrahman, M, Clarke, N, Brown, M, Kishida, T, ...

Promoter region hypermethylation and transcriptional silencing is a frequent cause of tumour suppressor gene (TSG) inactivation in many human cancers. Previously, to identify candidate epigenetically...

Epigenetic alteration at the DLK1-GTL2 imprinted domain in human neoplasia: analysis of neuroblastoma, phaeochromocytoma and Wilms' tumour

Astuti, D, Latif, F, Wagner, K, Gentle, D, Cooper, W N, Catchpoole, D, ...

Epigenetic alterations in the 11p15.5 imprinted gene cluster are frequent in human cancers and are associated with disordered imprinting of insulin-like growth factor (IGF)2 and H19. Recently, an...