Hawkins, M E, Mitsuya, H, McCully, C M, Godwin, K S, Murakami, K, Poplack, D G, ...
The pharmacokinetics of 2',3'-dideoxyadenosine (ddA), didanosine, 2',3'-dideoxyguanosine (ddG), and 6-halogenated prodrugs of ddG, 6-chloro-ddG and 6-iodo-ddG, in plasma and cerebrospinal fluid (CSF)...
Pharmacokinetics of lamivudine and BCH-189 in plasma and cerebrospinal fluid of nonhuman primates.
Blaney, S M, Daniel, M J, Harker, A J, Godwin, K, Balis, F M
2'-Deoxy-3'-thiacytidine is a dideoxycytidine analog with a sulfur in place of the 3' carbon of the ribose. There are two enantiomeric forms of the compound, both of which inhibit human...
Penetration of SCH-39304, a new antifungal triazole, into cerebrospinal fluid of primates.
Walsh, T J, Lester-McCully, C, Rinaldi, M G, Wallace, J E, Balis, F M, Lee, J W, ...
We characterized the cerebrospinal fluid (CSF) penetration and pharmacokinetics of SCH-39304 in adult rhesus monkeys receiving a single oral dose of SCH-39304 (2.0 mg/kg of body weight). The mean...
Bioavailability of oral trimetrexate in patients with acquired immunodeficiency syndrome.
Rogers, P, Allegra, C J, Murphy, R F, Drake, J C, Masur, H, Poplack, D G, ...
The combination of the lipophilic antifolate trimetrexate and the rescue agent leucovorin has shown promise in the treatment of Pneumocystis carinii pneumonia in patients with acquired...
Pharmacokinetics of subcutaneous azidothymidine in rhesus monkeys.
Balis, F M, McCully, C, Gough, L, Pizzo, P A, Poplack, D G
The pharmacokinetics of subcutaneous bolus and continuous infusion azidothymidine (AZT) was studied in rhesus monkeys. Three animals received 100 mg/m2 as a bolus injection both intravenously and...
Quantitative relationships between zidovudine exposure and efficacy and toxicity.
Drusano, G L, Balis, F M, Gitterman, S R, Pizzo, P A
We examined the relationship between the concentrations of zidovudine in plasma given by continuous intravenous infusion to human immunodeficiency virus-positive pediatric patients and a surrogate...
Hawkins, M E, Pfleiderer, W, Mazumder, A, Pommier, Y G, Balis, F M
We have synthesized a highly fluorescent (quantum yield 0.88) guanosine analog, (3-methyl-8-(2-deoxy-beta-D-ribofuranosyl) isoxanthopterin (3-Mi) in a dimethoxytrityl, phosphoramidite protected form,...
Fluorescence properties of a new guanosine analog incorporated into small oligonucleotides.
Driscoll, S L, Hawkins, M E, Balis, F M, Pfleiderer, W, Laws, W R
The fluorescence properties of 3-methyl-isoxanthopterin (3-MI) incorporated into different oligonucleotides have been determined. This highly fluorescent guanosine analog has its absorption and...
Hawkins, M E, Mitsuya, H, McCully, C M, Godwin, K S, Murakami, K, Poplack, D G, ...
The pharmacokinetics of 2',3'-dideoxyadenosine (ddA), didanosine, 2',3'-dideoxyguanosine (ddG), and 6-halogenated prodrugs of ddG, 6-chloro-ddG and 6-iodo-ddG, in plasma and cerebrospinal fluid (CSF)...
Pharmacokinetics of lamivudine and BCH-189 in plasma and cerebrospinal fluid of nonhuman primates.
Blaney, S M, Daniel, M J, Harker, A J, Godwin, K, Balis, F M
2'-Deoxy-3'-thiacytidine is a dideoxycytidine analog with a sulfur in place of the 3' carbon of the ribose. There are two enantiomeric forms of the compound, both of which inhibit human...
Penetration of SCH-39304, a new antifungal triazole, into cerebrospinal fluid of primates.
Walsh, T J, Lester-McCully, C, Rinaldi, M G, Wallace, J E, Balis, F M, Lee, J W, ...
We characterized the cerebrospinal fluid (CSF) penetration and pharmacokinetics of SCH-39304 in adult rhesus monkeys receiving a single oral dose of SCH-39304 (2.0 mg/kg of body weight). The mean...
Bioavailability of oral trimetrexate in patients with acquired immunodeficiency syndrome.
Rogers, P, Allegra, C J, Murphy, R F, Drake, J C, Masur, H, Poplack, D G, ...
The combination of the lipophilic antifolate trimetrexate and the rescue agent leucovorin has shown promise in the treatment of Pneumocystis carinii pneumonia in patients with acquired...
Pharmacokinetics of subcutaneous azidothymidine in rhesus monkeys.
Balis, F M, McCully, C, Gough, L, Pizzo, P A, Poplack, D G
The pharmacokinetics of subcutaneous bolus and continuous infusion azidothymidine (AZT) was studied in rhesus monkeys. Three animals received 100 mg/m2 as a bolus injection both intravenously and...
Quantitative relationships between zidovudine exposure and efficacy and toxicity.
Drusano, G L, Balis, F M, Gitterman, S R, Pizzo, P A
We examined the relationship between the concentrations of zidovudine in plasma given by continuous intravenous infusion to human immunodeficiency virus-positive pediatric patients and a surrogate...
Hawkins, M E, Pfleiderer, W, Mazumder, A, Pommier, Y G, Balis, F M
We have synthesized a highly fluorescent (quantum yield 0.88) guanosine analog, (3-methyl-8-(2-deoxy-beta-D-ribofuranosyl) isoxanthopterin (3-Mi) in a dimethoxytrityl, phosphoramidite protected form,...
Fluorescence properties of a new guanosine analog incorporated into small oligonucleotides.
Driscoll, S L, Hawkins, M E, Balis, F M, Pfleiderer, W, Laws, W R
The fluorescence properties of 3-methyl-isoxanthopterin (3-MI) incorporated into different oligonucleotides have been determined. This highly fluorescent guanosine analog has its absorption and...