Permeability to {beta}-lactams in Bacteroides fragilis (1988)
Cuchural, G. J., Hurlbut, S., Malamy, M. H., Tally, F. P.
Bacteroides fragilis strains TAL2480 and TAL3636 were used to assess outer membrane permeability to various β-lactam compounds. These strains were chosen because they possess β-lactamases capable...
Davey, P. G., Jacobus, N. V, Tally, F. P.
Spriramycin, a macrolide antibiotic, has inferior in-vitro activity to erythromycin, but superior tissue penetration. Recent publications have suggested that the in-vivo activity of spiramycin should...
Activity of metronidazole against Escherichia coli in experimental infra-abdominal sepsis (1979)
Onderdonk, A. B., Louie, T. J., Tally, F. P., Bartlett, J. G.
Metronidazole treatment was found to reduce both mortality rates and the incidence of abscess formation in experimental animals challenged with an intraperitoneal implant of pooled caecal contents....
Once-Daily Dosing in Dogs Optimizes Daptomycin Safety
Oleson, F. B., Berman, C. L., Kirkpatrick, J. B., Regan, K. S., Tally, F. P.
Daptomycin is a novel lipopeptide antibiotic with potent bactericidal activity against most clinically important gram-positive bacteria, including resistant strains. Daptomycin has been shown to have...
Imipenem resistance in Bacteroides distasonis mediated by a novel beta-lactamase.
Hurlbut, S, Cuchural, G J, Tally, F P
Imipenem is a highly active drug against the Bacteroides fragilis group of organisms. On the basis of a nationwide survey of over 500 isolates, it was found that the frequency of imipenem resistance...
Cuchural, G J, Tally, F P, Jacobus, N V, Cleary, T, Finegold, S M, Hill, G, ...
A nationwide susceptibility survey of 557 isolates of the Bacteroides fragilis group was continued in 1986. The most active beta-lactam drugs were imipenem and ticarcillin-clavulanic acid, which had...
Cloning and sequencing of the class B beta-lactamase gene (ccrA) from Bacteroides fragilis TAL3636.
Rasmussen, B A, Gluzman, Y, Tally, F P
Bacteroides fragilis TAL3636 produces a class B, Zn2(+)-requiring beta-lactamase. The gene, ccrA, was cloned and expressed in Escherichia coli. The gene was sequenced and shown to share greater than...
Activity of trospectomycin against Bacteroides fragilis and other Bacteroides species.
The in vitro activity of trospectomycin (U-63366; 6'-n-propyl spectinomycin pentahydrate sulfate) was evaluated against 189 clinical isolates of the Bacteroides fragilis group and 65 Bacteroides...
Cuchural, G J, Tally, F P, Jacobus, N V, Aldridge, K, Cleary, T, Finegold, S M, ...
An ongoing survey of the susceptibility of the Bacteroides fragilis group of bacteria was continued at New England Medical Center in 1984 and 1985. A total of 1,229 strains were obtained from eight...
Park, B H, Hendricks, M, Malamy, M H, Tally, F P, Levy, S B
Escherichia coli bearing a cryptic tetracycline resistance determinant from Bacteroides fragilis expressed low-level constitutive resistance to tetracycline under aerobic, but not anaerobic, growth...
Nationwide study of the susceptibility of the Bacteroides fragilis group in the United States.
Tally, F P, Cuchural, G J, Jacobus, N V, Gorbach, S L, Aldridge, K, Cleary, T, ...
A nationwide susceptibility survey of the Bacteroides fragilis group was continued at New England Medical Center in 1983. A total of 555 strains were obtained from eight centers in the United States....
Tally, F P, Kellum, J M, Ho, J L, O'Donnell, T F, Barza, M, Gorbach, S L
The efficacy and toxicity of moxalactam were compared with the efficacy and toxicity of cefoxitin given with or without tobramycin to 109 patients with surgical infections. A total of 66 patients...
Beta-lactamase-mediated imipenem resistance in Bacteroides fragilis.
Cuchural, G J, Malamy, M H, Tally, F P
Imipenem has excellent antimicrobial activity owing in part to beta-lactamase stability. We found that only 2 of over 350 Bacteroides fragilis group clinical isolates were resistant to imipenem, with...
Antimicrobial spectrum of Win 49375.
Jacobus, N V, Tally, F P, Barza, M
Win 49375 had excellent activity against members of the family Enterobacteriaceae and staphylococcal species. Its activity against Pseudomonas aeruginosa was equal to that of gentamicin. Win 49375...
In vitro activity of cefbuperazone against Bacteroides spp.
Dias, M B, Jacobus, N V, Gorbach, S L, Tally, F P
The activity of cefbuperazone was tested in vitro against 287 clinical isolates of Bacteroides spp. Cefbuperazone showed good activity against B. fragilis, B. vulgatus, and other Bacteroides species,...
Susceptibility of the Bacteroides fragilis group in the United States in 1981.
Tally, F P, Cuchural, G J, Jacobus, N V, Gorbach, S L, Aldridge, K E, Cleary, T J, ...
The minimal inhibitory concentrations of nine antimicrobial agents was determined for over 750 clinical isolates of the Bacteroides fragilis group of anaerobic bacteria collected from nine centers in...
Sequence homology of clindamycin resistance determinants in clinical isolates of Bacteroides spp.
Marsh, P K, Malamy, M H, Shimell, M J, Tally, F P
The sequence homology of clindamycin resistance (Clnr) determinants was studied in 16 Clnr Bacteroides strains. The isolates were surveyed for plasmid content, homology with the Clnr determinant of...
Cefoxitin inactivation by Bacteroides fragilis.
Cuchural, G J, Tally, F P, Jacobus, N V, Marsh, P K, Mayhew, J W
We have surveyed the susceptibility of 1,575 clinical isolates of the Bacteroides fragilis group of organisms to cefoxitin and eight other antimicrobial agents. Eleven isolates, 0.7% of the total,...
Bacteroides fragilis resistance to clindamycin in vitro.
Sosa, A, Tally, F P, Jacobus, N V, Gorbach, S L
Clindamycin resistance in Bacteroides fragilis was examined in 507 strains isolated from 1973 to 1981. Three groups were recognized: highly susceptible (minimum inhibitory concentration [MIC] less...
Testa, R T, Petersen, P J, Jacobus, N V, Sum, P E, Lee, V J, Tally, F P
N,N-Dimethylglycylamido (DMG) derivatives of minocycline and 6-demethyl-6-deoxytetracycline are new semisynthetic tetracyclines referred to as the glycylcyclines. The in vitro activities of the...
Tn4400, a compound transposon isolated from Bacteroides fragilis, functions in Escherichia coli.
Robillard, N J, Tally, F P, Malamy, M H
Transfer factor pBFTM10, isolated from the obligate anaerobic bacterium Bacteroides fragilis, carries a clindamycin resistance determinant which we have suggested is part of a transposable element....
Tally, F P, Snydman, D R, Shimell, M J, Malamy, M H
Bacteroides fragilis TMP10, which is clindamycin-erythromycin resistant (Clnr) and tetracycline resistant (Tetr), contains several plasmids and is capable of transferring drug resistance markers to...
Shimell, M J, Smith, C J, Tally, F P, Macrina, F L, Malamy, M H
Two clindamycin-erythromycin resistance transfer factors of Bacteroides fragilis, pBF4 and pBFTM10, were analyzed for regions of DNA homology. Although the plasmids were derived from different...
Rasmussen, B, Noller, H F, Daubresse, G, Oliva, B, Misulovin, Z, Rothstein, D M, ...
Tetracycline analogs fell into two classes on the basis of their mode of action. Tetracycline, chlortetracycline, minocycline, doxycycline, and 6-demethyl-6-deoxytetracycline inhibited cell-free...
Cooper, S W, Pfeiffer, D G, Tally, F P
The reliability of xylan fermentation in distinguishing Bacteroides ovatus from Bacteroides thetaiotaomicron was examined with strains previously identified by DNA homology studies or bacteriophage...
Differentiation of Bacteroides ovatus and Bacteroides thetaiotaomicron by means of bacteriophage.
Cooper, S W, Szymczak, E G, Jacobus, N V, Tally, F P
Two members of the Bacteroides fragilis group, B. ovatus and B. thetaiotaomicron, are difficult to distinguish by biochemical methods. They are currently identified on the basis of their variable...
Oxygen tolerance of fresh clinical anaerobic bacteria.
Tally, F P, Stewart, P R, Sutter, V L, Rosenblatt, J E
The oxygen tolerance and sensitivity of 57 freshly isolated anaerobic bacteria from clinical specimens was studied. All the organisms tolerated 8 h or more of exposure to oxygen in room air. Growth...
Sullivan, N M, Mayhew, J, DiTullio, D, Tally, F P
Two detection systems for gas-liquid chromatography were compared for the identification of metabolic end products (short-chain organic acids) from anaerobic bacteria. Argon and flame ionization...
Prospective, randomized trial of netilmicin and amikacin, with emphasis on eighth-nerve toxicity.
Barza, M, Lauermann, M W, Tally, F P, Gorbach, S L
The toxicity of netilmicin was compared with that of amikacin in a randomized, prospective trial in 90 adults with a variety of serious gram-negative infections. There was no instance of...
Clinical trial of piperacillin with acquisition of resistance by Pseudomonas and clinical relapse.
Simon, G L, Snydman, D R, Tally, F P, Gorbach, S L
A total of 20 serious infections were treated with piperacillin. These infections included bacteremias (5), pneumonias (5), urinary tract infections (5), soft tissue infections (3), septic arthritis...
In vitro activity of N-formimidoyl thienamycin (MK0787).
Tally, F P, Jacobus, N V, Gorbach, S L
The in vitro activity of N-formimidoyl thienamycin (MK0787), a stable congener of thienamycin, was determined against 200 species of aerobic and 84 species of anaerobic bacteria. The compound was...
Cuchural, G J, Tally, F P, Jacobus, N V, Gorbach, S L, Aldridge, K, Cleary, T, ...
A susceptibility survey of 537 strains of the Bacteroides fragilis group from eight centers in the United States was continued at the Tufts New England Medical Center in 1982. The results were...
Transfer of beta-lactamase-associated cefoxitin resistance in Bacteroides fragilis.
Cuchural, G J, Tally, F P, Storey, J R, Malamy, M H
A cefoxitin-resistant Bacteroides fragilis isolate, TAL 4170, which inactivates cefoxitin, was able to transfer beta-lactamase-mediated cefoxitin resistance to a susceptible B. fragilis recipient....
Rasmussen, B A, Gluzman, Y, Tally, F P
One of the two major mechanisms of tetracycline resistance is ribosomal protection. Of this resistance type, tet(M) is the best characterized. Although the mechanism of tet(M) resistance has not yet...
Antimicrobial activity of metronidazole in anaerobic bacteria.
Tally, F P, Goldin, B R, Sullivan, N, Johnston, J, Gorbach, S L
The antimicrobial activity of metronidazole was investigated in anaerobic bacteria by use of time-viability studies. This antimicrobial agent has a rapid onset of bactericidal activity under proper...
In vitro activity of LY127935.
Barza, M, Tally, F P, Jacobus, N V, Gorbach, S L
The activity of LY127935, a beta-lactam antibiotic of novel structure, was studied in vitro against facultative gram-negative bacilli, Staphylococcus aureus, and Bacteroides fragilis. The strains...
Bacteriophage-associated spherical bodies in Bacteroides fragilis.
Silver, R P, Chase, D G, Tally, F P, Gorbach, S L
Unique spherical bodies with multilayered walls were observed by electron microscopy in cells of a single strain of Bacteroides fragilis subsp. fragilis. Phage-like particles were present in the same...
Superoxide dismutase in anaerobic bacteria of clinical significance.
Tally, F P, Goldin, B R, Jacobus, N V, Gorbach, S L
Twenty-two anaerobic bacteria isolated from infected sites and normal fecal flora were assayed for superoxide dismutase (SOD). The organisms were also classified according to their oxygen tolerance...
Tally, F P, McGowan, K, Kellum, J M, Gorbach, S L, O'Donnell, T F
The efficacy of cefoxitin, either alone or in combination (+/-) with an aminoglycoside was compared with clindamycin plus (+), an aminoglycoside for the treatment of mixed aerobic-anaerobic surgical...
Candida infections in surgical patients.
Marsh, P K, Tally, F P, Kellum, J, Callow, A, Gorbach, S L
Serious Candida infections were seen in 55 surgical patients from January 1977 through December 1980. Most of the patients had compromising underlying conditions and many were elderly. Broad-spectrum...
Once-Daily Dosing in Dogs Optimizes Daptomycin Safety
Oleson, F. B., Berman, C. L., Kirkpatrick, J. B., Regan, K. S., Tally, F. P.
Daptomycin is a novel lipopeptide antibiotic with potent bactericidal activity against most clinically important gram-positive bacteria, including resistant strains. Daptomycin has been shown to have...
Imipenem resistance in Bacteroides distasonis mediated by a novel beta-lactamase.
Hurlbut, S, Cuchural, G J, Tally, F P
Imipenem is a highly active drug against the Bacteroides fragilis group of organisms. On the basis of a nationwide survey of over 500 isolates, it was found that the frequency of imipenem resistance...
Cuchural, G J, Tally, F P, Jacobus, N V, Cleary, T, Finegold, S M, Hill, G, ...
A nationwide susceptibility survey of 557 isolates of the Bacteroides fragilis group was continued in 1986. The most active beta-lactam drugs were imipenem and ticarcillin-clavulanic acid, which had...
Cloning and sequencing of the class B beta-lactamase gene (ccrA) from Bacteroides fragilis TAL3636.
Rasmussen, B A, Gluzman, Y, Tally, F P
Bacteroides fragilis TAL3636 produces a class B, Zn2(+)-requiring beta-lactamase. The gene, ccrA, was cloned and expressed in Escherichia coli. The gene was sequenced and shown to share greater than...
Activity of trospectomycin against Bacteroides fragilis and other Bacteroides species.
The in vitro activity of trospectomycin (U-63366; 6'-n-propyl spectinomycin pentahydrate sulfate) was evaluated against 189 clinical isolates of the Bacteroides fragilis group and 65 Bacteroides...
Cuchural, G J, Tally, F P, Jacobus, N V, Aldridge, K, Cleary, T, Finegold, S M, ...
An ongoing survey of the susceptibility of the Bacteroides fragilis group of bacteria was continued at New England Medical Center in 1984 and 1985. A total of 1,229 strains were obtained from eight...
Park, B H, Hendricks, M, Malamy, M H, Tally, F P, Levy, S B
Escherichia coli bearing a cryptic tetracycline resistance determinant from Bacteroides fragilis expressed low-level constitutive resistance to tetracycline under aerobic, but not anaerobic, growth...
Nationwide study of the susceptibility of the Bacteroides fragilis group in the United States.
Tally, F P, Cuchural, G J, Jacobus, N V, Gorbach, S L, Aldridge, K, Cleary, T, ...
A nationwide susceptibility survey of the Bacteroides fragilis group was continued at New England Medical Center in 1983. A total of 555 strains were obtained from eight centers in the United States....
Tally, F P, Kellum, J M, Ho, J L, O'Donnell, T F, Barza, M, Gorbach, S L
The efficacy and toxicity of moxalactam were compared with the efficacy and toxicity of cefoxitin given with or without tobramycin to 109 patients with surgical infections. A total of 66 patients...
Beta-lactamase-mediated imipenem resistance in Bacteroides fragilis.
Cuchural, G J, Malamy, M H, Tally, F P
Imipenem has excellent antimicrobial activity owing in part to beta-lactamase stability. We found that only 2 of over 350 Bacteroides fragilis group clinical isolates were resistant to imipenem, with...
Antimicrobial spectrum of Win 49375.
Jacobus, N V, Tally, F P, Barza, M
Win 49375 had excellent activity against members of the family Enterobacteriaceae and staphylococcal species. Its activity against Pseudomonas aeruginosa was equal to that of gentamicin. Win 49375...
In vitro activity of cefbuperazone against Bacteroides spp.
Dias, M B, Jacobus, N V, Gorbach, S L, Tally, F P
The activity of cefbuperazone was tested in vitro against 287 clinical isolates of Bacteroides spp. Cefbuperazone showed good activity against B. fragilis, B. vulgatus, and other Bacteroides species,...
Susceptibility of the Bacteroides fragilis group in the United States in 1981.
Tally, F P, Cuchural, G J, Jacobus, N V, Gorbach, S L, Aldridge, K E, Cleary, T J, ...
The minimal inhibitory concentrations of nine antimicrobial agents was determined for over 750 clinical isolates of the Bacteroides fragilis group of anaerobic bacteria collected from nine centers in...
Sequence homology of clindamycin resistance determinants in clinical isolates of Bacteroides spp.
Marsh, P K, Malamy, M H, Shimell, M J, Tally, F P
The sequence homology of clindamycin resistance (Clnr) determinants was studied in 16 Clnr Bacteroides strains. The isolates were surveyed for plasmid content, homology with the Clnr determinant of...
Cefoxitin inactivation by Bacteroides fragilis.
Cuchural, G J, Tally, F P, Jacobus, N V, Marsh, P K, Mayhew, J W
We have surveyed the susceptibility of 1,575 clinical isolates of the Bacteroides fragilis group of organisms to cefoxitin and eight other antimicrobial agents. Eleven isolates, 0.7% of the total,...
Bacteroides fragilis resistance to clindamycin in vitro.
Sosa, A, Tally, F P, Jacobus, N V, Gorbach, S L
Clindamycin resistance in Bacteroides fragilis was examined in 507 strains isolated from 1973 to 1981. Three groups were recognized: highly susceptible (minimum inhibitory concentration [MIC] less...
Testa, R T, Petersen, P J, Jacobus, N V, Sum, P E, Lee, V J, Tally, F P
N,N-Dimethylglycylamido (DMG) derivatives of minocycline and 6-demethyl-6-deoxytetracycline are new semisynthetic tetracyclines referred to as the glycylcyclines. The in vitro activities of the...
Tn4400, a compound transposon isolated from Bacteroides fragilis, functions in Escherichia coli.
Robillard, N J, Tally, F P, Malamy, M H
Transfer factor pBFTM10, isolated from the obligate anaerobic bacterium Bacteroides fragilis, carries a clindamycin resistance determinant which we have suggested is part of a transposable element....
Tally, F P, Snydman, D R, Shimell, M J, Malamy, M H
Bacteroides fragilis TMP10, which is clindamycin-erythromycin resistant (Clnr) and tetracycline resistant (Tetr), contains several plasmids and is capable of transferring drug resistance markers to...
Shimell, M J, Smith, C J, Tally, F P, Macrina, F L, Malamy, M H
Two clindamycin-erythromycin resistance transfer factors of Bacteroides fragilis, pBF4 and pBFTM10, were analyzed for regions of DNA homology. Although the plasmids were derived from different...
Rasmussen, B, Noller, H F, Daubresse, G, Oliva, B, Misulovin, Z, Rothstein, D M, ...
Tetracycline analogs fell into two classes on the basis of their mode of action. Tetracycline, chlortetracycline, minocycline, doxycycline, and 6-demethyl-6-deoxytetracycline inhibited cell-free...
Cooper, S W, Pfeiffer, D G, Tally, F P
The reliability of xylan fermentation in distinguishing Bacteroides ovatus from Bacteroides thetaiotaomicron was examined with strains previously identified by DNA homology studies or bacteriophage...
Differentiation of Bacteroides ovatus and Bacteroides thetaiotaomicron by means of bacteriophage.
Cooper, S W, Szymczak, E G, Jacobus, N V, Tally, F P
Two members of the Bacteroides fragilis group, B. ovatus and B. thetaiotaomicron, are difficult to distinguish by biochemical methods. They are currently identified on the basis of their variable...
Oxygen tolerance of fresh clinical anaerobic bacteria.
Tally, F P, Stewart, P R, Sutter, V L, Rosenblatt, J E
The oxygen tolerance and sensitivity of 57 freshly isolated anaerobic bacteria from clinical specimens was studied. All the organisms tolerated 8 h or more of exposure to oxygen in room air. Growth...
Sullivan, N M, Mayhew, J, DiTullio, D, Tally, F P
Two detection systems for gas-liquid chromatography were compared for the identification of metabolic end products (short-chain organic acids) from anaerobic bacteria. Argon and flame ionization...
Prospective, randomized trial of netilmicin and amikacin, with emphasis on eighth-nerve toxicity.
Barza, M, Lauermann, M W, Tally, F P, Gorbach, S L
The toxicity of netilmicin was compared with that of amikacin in a randomized, prospective trial in 90 adults with a variety of serious gram-negative infections. There was no instance of...
Clinical trial of piperacillin with acquisition of resistance by Pseudomonas and clinical relapse.
Simon, G L, Snydman, D R, Tally, F P, Gorbach, S L
A total of 20 serious infections were treated with piperacillin. These infections included bacteremias (5), pneumonias (5), urinary tract infections (5), soft tissue infections (3), septic arthritis...
In vitro activity of N-formimidoyl thienamycin (MK0787).
Tally, F P, Jacobus, N V, Gorbach, S L
The in vitro activity of N-formimidoyl thienamycin (MK0787), a stable congener of thienamycin, was determined against 200 species of aerobic and 84 species of anaerobic bacteria. The compound was...
Cuchural, G J, Tally, F P, Jacobus, N V, Gorbach, S L, Aldridge, K, Cleary, T, ...
A susceptibility survey of 537 strains of the Bacteroides fragilis group from eight centers in the United States was continued at the Tufts New England Medical Center in 1982. The results were...
Transfer of beta-lactamase-associated cefoxitin resistance in Bacteroides fragilis.
Cuchural, G J, Tally, F P, Storey, J R, Malamy, M H
A cefoxitin-resistant Bacteroides fragilis isolate, TAL 4170, which inactivates cefoxitin, was able to transfer beta-lactamase-mediated cefoxitin resistance to a susceptible B. fragilis recipient....
Rasmussen, B A, Gluzman, Y, Tally, F P
One of the two major mechanisms of tetracycline resistance is ribosomal protection. Of this resistance type, tet(M) is the best characterized. Although the mechanism of tet(M) resistance has not yet...
Antimicrobial activity of metronidazole in anaerobic bacteria.
Tally, F P, Goldin, B R, Sullivan, N, Johnston, J, Gorbach, S L
The antimicrobial activity of metronidazole was investigated in anaerobic bacteria by use of time-viability studies. This antimicrobial agent has a rapid onset of bactericidal activity under proper...
In vitro activity of LY127935.
Barza, M, Tally, F P, Jacobus, N V, Gorbach, S L
The activity of LY127935, a beta-lactam antibiotic of novel structure, was studied in vitro against facultative gram-negative bacilli, Staphylococcus aureus, and Bacteroides fragilis. The strains...
Bacteriophage-associated spherical bodies in Bacteroides fragilis.
Silver, R P, Chase, D G, Tally, F P, Gorbach, S L
Unique spherical bodies with multilayered walls were observed by electron microscopy in cells of a single strain of Bacteroides fragilis subsp. fragilis. Phage-like particles were present in the same...
Superoxide dismutase in anaerobic bacteria of clinical significance.
Tally, F P, Goldin, B R, Jacobus, N V, Gorbach, S L
Twenty-two anaerobic bacteria isolated from infected sites and normal fecal flora were assayed for superoxide dismutase (SOD). The organisms were also classified according to their oxygen tolerance...
Tally, F P, McGowan, K, Kellum, J M, Gorbach, S L, O'Donnell, T F
The efficacy of cefoxitin, either alone or in combination (+/-) with an aminoglycoside was compared with clindamycin plus (+), an aminoglycoside for the treatment of mixed aerobic-anaerobic surgical...
Candida infections in surgical patients.
Marsh, P K, Tally, F P, Kellum, J, Callow, A, Gorbach, S L
Serious Candida infections were seen in 55 surgical patients from January 1977 through December 1980. Most of the patients had compromising underlying conditions and many were elderly. Broad-spectrum...