Kolling, A., Ernst, H., Rittinghausen, S., Heinrich, U., Pott, F.
The data presented in this paper have been derived from a carcinogenicity experiment with rats as part of a comprehensive research project focused on experimental studies on the toxicity and...
Pulmonary tumor types induced in Wistar rats of the so-called "19-dust study" (2006)
Mohr, U., Ernst, H., Roller, M., Pott, F.
The incidences of primary lung tumor types histologically diagnosed in 28 groups of Wistar rats of the so-called "19-dust study" are described, the total study having been already presented by Pott...
The postural reduction in middle cerebral artery blood velocity is not explained by PaCO2 (2006)
Immink, R.V., Secher, N.H., Roos, C.M., Pott, F., Madsen, P.L., Lieshout, J.J. Van
In the normocapnic range, middle cerebral artery mean velocity (MCA V-mean) changes similar to 3.5% per mmHg carbon-dioxide tension in arterial blood (PaCO2) and a decrease in PaCO2 will reduce the...
Ernst, H., Kolling, A., Bellmann, B., Rittinghausen, S., Heinrich, U., Pott, F.
The carcinogenicity experiment with rats, as the last part of a series of investigations, was to provide information on dust carcinogenicity. Quartz and ultrafine amorphous SiO2 as specifically toxic...
Human cerebral venous outflow pathway depends on posture and central venous pressure (2004)
Gisolf, J, Lieshout, J.J. Van, Heusden, K. Van, Pott, F., Stok, W.J., Karemaker, J.M.
Reconstruction of brachial pressure from finger arterial pressure during orthostasis (2004)
Bogert, L.W.J., Harms, M.P.M., Pott, F., Secher, N.H., Wesseling, K.H., Lieshout, J.J. Van
Postural effects on cardiac output and mixed venous oxygen saturation in humans (2003)
Harms, M.P.M., Lieshout, J.J. Van, Jenstrup, M., Pott, F., Secher, N.H.
Ernst, H., Rittinghausen, S., Bartsch, W., Creutzenberg, O., Dasenbrock, C., ...
Effects of poly-2-vinylpyridine-N-oxide (PVNO) were investigated in numerous in vivo and in vitro studies published in the nineteen sixties and seventies. These studies showed that PVNO inhibited...
Middle cerebral artery blood velocity during a Valsalva maneuver in the standing position (2000)
Pott, F., Lieshout, J.J. Van, Ide, K., Madsen, P., Secher, N.H.
Lung tumors in rats after repeated intratracheal instillation of coal dust (2000)
Rittinghausen, S., Pott, F., Roller, M., Ernst, H., Mohr, U.
Five coal-containing dusts from materials of the Ruhr coal mining area were applied to female Wistar rats by intratracheal instillation of a suspension of 6mg dust 10 or 20 times weekly. The content...
Asbestos as reference material for fibre-induced cancer (2000)
The objective of this paper is to review published data on the carcinogenicity of asbestos fibres with regard to the elucidation of a potential risk originating from exposure to man-made vitreous...
Middle cerebral artery blood velocity during exercise in patients with atrial fibrillation (1999)
Ide, K., Gullov, A.L., Pott, F., Lieshout, J.J. Van, Koefoed, B.G., Petersen, P., ...
Hyperbaric oxygen treatment and pulmonary function (1999)
F. Pott, P. Westergaard, J. Mortensen, E. C. Jansen
Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
Results of current intraperitoneal carcinogenicity studies with mineral and vitreous fibres (1996)
Roller, M., Pott, F., Kamino, K., Bellmann, B.
The study includes some 50 groups of male or female Wistar rats tested in three series. Except for one untreated group and 3 vehicle control groups, the animals were injected intraperitoneally (i.p.)...
Biopersistence of man-made vitreous fibres (1995)
Muhle, H., Bellmann, B., Pott, F.
Methods for the determination of biodurability of man-made vitreous fibres are reviewed. For mineral wools the first step was the preparation of respirable fibre fractions. Fibres were administered...
Comparative studies with natural and man-made mineral fibres in vitro and in vivo (1994)
Riebe-Imre, M., Aufderheide, M., Emura, M., Straub, M., Roller, M., Mohr, U., ...
Several types of fibrous dusts have caused lung tumours and mesotheliomas in humans and/or in laboratory animals. In order to study the effects of the fibrous dusts, cell toxicity and transformation...
Pott, F., Roller, M., Kamino, K., Bellmann, B.
At the same time that carcinogenicity of very thin glass fibers after interpleural and intraperitoneal (ip) administration was demonstrated (1,2) researchers found that gypsum fibers and HCI-leached...
Lung tumours in rats after intratracheal instillation of dusts (1994)
Pott, F., Dungworth, D.L., Heinrich, U., Muhle, H., Kamino, K., ...
Intratracheal instillation of several non-fibrous dusts induced tumour rates of between 3 and 65 per cent in female Wistar rats. Diesel soot showed a relatively high tumourigenic potency. However,...
Investigation of the biodurability and carcinogenicity of different man-made mineral fibres (1994)
Bellmann, B., Muhle, H., Pott, F.
The carcinogenicity of mineral fibres depends on length and diameter, however, the exact relationships are not yet known. Additionally the biopersistence is an important factor: the carcinogenic...
Heinrich, U., Roller, M., Pott, F.
Female Wistar rats were exposed to coal tar/pitch condensation (CTP) aerosol containing either 20 or 46 microgrammes/cbm benzo(a)pyrene (BaP) among other polycyclic aromatic hydrocarbons (PAH)...
Comparative investigations of the biodurability of mineral fibers in the rat lung (1994)
Muhle, H., Bellmann, B., Pott, F.
The biodurability of various glass fibers, rockwool, and ceramic fibers was examined in rat lungs and compared with natural mineral fibers. Experiments were based on studies that have shown that the...
Heinrich, U., Dungworth, D.L., Pott, F., Peters, L., Dasenbrock, C., Levsen, K., ...
Carbon black (CB) particles almost completely devoid of organic compounds (Printex 90, Degussa), PAH-rich hard coal tar-pitch condensation aerosol (T-P aerosol) and mixtures of CB and T-P aerosol as...
Heinrich, U., Peters, L., Dasenbrock, C., Kamino, K., Pott, F.
Newborn and 7-month-old NMRI and C57BL/6N mice were exposed in whole body horizontal air flow exposure chambers 17h/day for 5 days or for 4 weeks (newborn mice) and for 17 weeks (7 month old mice) to...
Chronic effects of intratracheally instilled nickel-containing particles in hamsters (1992)
Pott, F., Bellmann, B., Fuhst, R., Mohr, U., Muhle, H., Takenaka, S.
Only limited information is available concerning whether a potential carcinogenic risk is associated with exposure to particles of nickel alloys. In a chronic study, Syrian golden hamsters were...
Faserige Stäube - tierexperimentelle Ergebnisse (1991)
The paper reviews experimental studies which investigate critical properties for the toxicity of mineral fibres. Long, thin mineral fibres show a carcinogenic potency if their durability in...
Durability of various mineral fibres in rat lungs (1991)
Muhle, H., Bellmann, B., Pott, F.
The durability of crocidolite, glass fibres, and wollastonite in rat lungs was examined after intratracheal instillation. Experiments were based on the assumption that thin (< 2µm), long (> 5µm)...
Jacob, J., Brune, H., Grimmer, G., Heinrich, U., Mohtashamipur, E., Norpoth, K., ...
Summarizing the data it may be concluded that high percentages (with up to 70 %) of the PAH material administered can be found in the excretion pruducts in case of oral and intratracheal...
Untersuchung zur Beständigkeit chemisch unterschiedlicher Glasfasern in Rattenlungen (1990)
Bellmann, B., Muhle, H., Pott, F.
The half-times of glass fibre samples of different chemical composition and size was analysed in the rat lung. Up to two years after intratracheal instillation the number of fibres in the ashed lungs...
Animal experiments have shown that the carcinogenic activity of organic extracts of exhaust condensates is caused predominantly by PAHs containing 4-6 rings. The carcinogenic potency not only of...
Kanzerogenität von Glasfasern mit unterschiedlicher Beständigkeit (1990)
Roller, M., Bellmann, B., Mohr, U., Pott, F., ...
A new type of fibrous glass showing a low durability in the body was injected intraperitoneally into rats. In the range of the doses applied (up to 10 high 9 of a thinner product and up to 0.24 x 10...
Pott, F., Rödelsperger, K., Rippe, R.M., Roller, M., Rosenbruch, M., Bellmann, B., ...
A review of the inhalation studies performed with crocidolite shows that, in the case of mineral fibres, realistic exposure can lead to irrelevant (false negative) results. The intraperitoneal test...
Jacob, J., Brune, H., Gettbarn, G., Mohtashamipur, E., Norpoth, K., Wenzel-Hartung, R., ...
The urinary and faecal excretion of pyrene and 1-hydroxypyrene after oral (53,4 %), intraperitoneal (3,1 %), intratracheal (30-37 %) and intrapulmonary application (0,003 %) to rats has been...
Bellmann, B., Muhle, H., Pott, F., Spurny, K.R.
Rats received nose-only exposure to 11,4 mg/m3 UICC crocidolite and 2,5mg/m3 UICC chrysotile A for 2 hours a week for a period of up to 1 year. One-half of the animals also inhaled cigarette smoke,...
Carcinogenicity studies on natural and man made fibres with the intraperitoneal test in rats. (1989)
Pott, F., Ziem, U., Bellmann, B., Rosenbruch, M., Huth, G., ...
Female Wistar rats were injected intraperitoneally (i.p.) with a suspension of 11 fibrous and 3 granular dusts. A dose of 0.25 mg actinolite or UICC chrysotile induced tumours of the peritoneum in...
Mönig, F.J., König, H., Boose, C., Fuhst, R., Hochrainer, D., Marfels, H., ...
Es wurde ein Verfahren ausgearbeitet und ein Geraet zur Messung von Faseremissionen aus verwitterten und kondierten Asbestzement-Produkten entwickelt. Mit Hilfe dieses Verfahrens werden Emissionen...
Grimmer, G., Brune, H., Dettbarn, G., Jacob, J., Mohtashamipur, E., Norpoth, K., ...
The urinary and faecal excretion of chrysene and its phenolic metabolites after oral, intraperitoneal, intratracheal, and intrapulmonary administration to rats have been studied by means of gas...
Neue Erkenntnisse über die krebserzeugende Wirkung von Dieselmotorabgas (1988)
Die lungenkrebserzeugende Wirkung der Inhalation von Dieselmotorabgas wurde bei Ratten nachgewiesen, und zwar nach Exposition ab einer Höhe, die im Wochenmittel etwa 50 bis 100 mal über...
Animal experiments with chemically treated fibres (1988)
Pott, F., Matscheck, A., Ziem, U., Huth, F., Muhle, H.
After intraperitoneal injection of 25 mg HCI-leached chrysotile into rats acute loxic rats acute toxic effects were observed. Protein might dissolve the amorphous silicic acid ot the leached fibres:...
Persistence of man-made mineral fibres -MMMF- and asbestos in rat lungs (1987)
Klöppel, H., Bellmann, B., König, H., Muhle, H., Pott, F.
In a 2-yr study the persistence of some MMMF, crocidolite and chrysotile in the rat lung was examined after intratracheal instillation. Experiments were based on the assumption that thin, long and...
Inhalation and injection experiments in rats to test the carcinogenicity of MMF (1987)
Pott, F., Ziem, U., Bellmann, B., Muhle, H., Takenaka, S.
In parallel inhalation and intraperitoneal injection (i.p.) experiments with rats, the glass fibre JM 104, Tempstran 475, exemplifying a very thin and durable man-made mineral fibre (MMMF), was...
Carcinogenicity studies on fibres, metal compounds and some other dusts in rats (1987)
Pott, F., Ziem, U., Reiffer, F.J., Huth, F., Ernst, H., Mohr, U.
About 50 dusts were examined on their carcinogenicity in rats mainly after intraperitoneal injection and some after intratracheal instillation. In the i.p. test, very low doses between 0.05 and 0.5...
Heinrich, U., Pott, F., Rittinghausen, S., Peters, L.
Rats, hamsters and mice were exposed to gasoline and Diesel engine exhaust (GE and DE) containig low concentration of polycyclicaromatic hydrocarbons (PAH) and to the PAH-rich mixture of pyrolized...
PERSISTENCE OF MAN-MADE MINERAL FIBRES (MMMF) AND ASBESTOS IN RAT LUNGS (1987)
BELLMANN, B., MUHLE, H., POTT, F., KÖNIG, H., KLÖPPEL, H., SPURNY, K.
In a 2-yr study the persistence of some MMMF, crocidolite and chrysotile in the rat lung was examined after intratracheal instillation. Experiments were based on the assumption that thin, long and...
INHALATION AND INJECTION EXPERIMENTS IN RATS TO TEST THE CARCINOGENICITY OF MMMF (1987)
MUHLE, H., POTT, F., BELLMANN, B., TAKENAKA, S., ZIEM, U.
In parallel inhalation and intraperitoneal injection (i.p.) experiments with rats, the glass fibre JM 104, Tempstran 475, exemplifying a very thin and durable man-made mineral fibre (MMMF). was...
Short additional presentation: PROBLEMS IN DEFINING CARCINOGENIC FIBRES (1987)
For health protection, not only asbestos fibres but all carcinogenic fibres should be regulated. Therefore, we need a definition for carcinogenic fibres and criteria for grading their carcinogenic...
Persistence of man-made mineral fibres -MMMF- and asbestos in rat lungs (1986)
Koenig, H., Kloeppel, H., Bellmann, B., Muhle, H., Pott, F.
In a two years' study the persistence of some MMMF, crocidolite and chrysotile in the rat lung was examined after intratracheal instillation. Experiments were based on the assumption that thin, long...
Inhalation and injection experiments in rats for testing carcinogenicity of MMMF (1986)
Ziem, U., Bellmann, B., Muhle, H., Pott, F., Takenaka, S.
Parallel inhalation and intraperitoneal injection (i.p.) experiments with rats, the glass fibre JM 104, Tempstran 475, was used as a prototype of very thin and durable man-made mineral fibres (MMMF)....
Evaluation of environmental carcinogens by carcinogen-specific test systems (1986)
Grimmer, G., Abel, U., Brune, H., Deutsch-Wenzel, R., Emura, M., Heinrich, U., ...
Chemische Bestaendigkeit von Asbest und kuenstlichen Mineralfasern in vivo. (1986)
Koenig, H., Bellmann, B., Muhle, H., Pott, F.
Den Untersuchungen liegt die Hypothese zugrunde, dass das kanzerogene Potential von inhalierten mineralischen Fasern durch die chemische Bestaendigkeit im Organismus beeinflusst wird. Bei relativ gut...
Carcinogenic effect of weathered asbestos cement products in rats (1986)
Fuhst, R., Muhle, H., Pott, F., Spurny, K.R., Takenaka, S.
Eine Saeurebehandlung von Chrysotilasbest fuehrt zu einem Auslaugungsprozess von Magnesium aus der Faser, was gleichzeitig zu einer Verringerung der kanzerogenen Potenz der Faser fuehrt. Es wurde in...
Ahland, E., Borneff, J., Brune, H., Grimmer, G., Habs, M., Hermann, P., ...
Kondensierter Rauch aus kohlebeheizten Zimmeröfen und Abgas von Kraftfahrzeugen (mit Ottomotoren) erzeugen auf der Rückenhaut von CFLP-Mäusen dosisabhängig Karzinome. Durch einen Vergleich der...
Recent results of implantation studies (1982)
Pott, F., Schlipkoeter, H.W., Ziem, U., Spurny, K.R., Huth, F.
Identifizierung und krebserzeugende Wirkung von faserförmigem Aktinolith aus einem Steinbruch (1979)
Dose-response relationship of fibrous dusts in intraperitoneal studies.
Roller, M, Pott, F, Kamino, K, Althoff, G H, Bellmann, B
The relationship between the number of fibers injected intraperitoneally and the occurrence of peritoneal mesotheliomas in rats was investigated using data from a series of carcinogenicity studies...
Fiber-specific molecular features of tumors induced in rat peritoneum.
Unfried, K, Roller, M, Pott, F, Friemann, J, Dehnen, W
Molecular markers such as mutational spectra or mRNA expression patterns may give some indication of the mechanisms of carcinogenesis induced by fibers and other carcinogens. In our study, tumors...
Tumorigenic effect of fibrous dust in experimental animals
Pott, F., Huth, F., Friedrichs, K. H.
Fibrous dusts (chrysotile, glass fibers, nemalite, palygorscite, and gypsum) and granular dusts (actinolite, biotite, hematite, pectolite, sanidine, and talcum) were injected intraperitoneally into...
Comparative investigations of the biodurability of mineral fibers in the rat lung.
Muhle, H, Bellmann, B, Pott, F
The biodurability of various glass fibers, rockwool, and ceramic fibers was examined in rat lungs and compared with natural mineral fibers. Experiments were based on studies that have shown that the...
Pott, F, Roller, M, Kamino, K, Bellmann, B
At the same time that carcinogenicity of very thin glass fibers after intrapleural and intraperitoneal (ip) administration was demonstrated (1,2) researchers found that gypsum fibers and HCI-leached...
Most air pollution in West Germany is caused by combustion products. Particulate organic matter released by incomplete combustion is suspected to contribute to the "urban factor" of lung cancer...
Human cerebral venous outflow pathway depends on posture and central venous pressure
Gisolf, J, Van Lieshout, J J, Van Heusden, K, Pott, F, Stok, W J, Karemaker, J M
Internal jugular veins are the major cerebral venous outflow pathway in supine humans. In upright humans the positioning of these veins above heart level causes them to collapse. An alternative...
Dose-response relationship of fibrous dusts in intraperitoneal studies.
Roller, M, Pott, F, Kamino, K, Althoff, G H, Bellmann, B
The relationship between the number of fibers injected intraperitoneally and the occurrence of peritoneal mesotheliomas in rats was investigated using data from a series of carcinogenicity studies...
Fiber-specific molecular features of tumors induced in rat peritoneum.
Unfried, K, Roller, M, Pott, F, Friemann, J, Dehnen, W
Molecular markers such as mutational spectra or mRNA expression patterns may give some indication of the mechanisms of carcinogenesis induced by fibers and other carcinogens. In our study, tumors...
Tumorigenic effect of fibrous dust in experimental animals
Pott, F., Huth, F., Friedrichs, K. H.
Fibrous dusts (chrysotile, glass fibers, nemalite, palygorscite, and gypsum) and granular dusts (actinolite, biotite, hematite, pectolite, sanidine, and talcum) were injected intraperitoneally into...
Comparative investigations of the biodurability of mineral fibers in the rat lung.
Muhle, H, Bellmann, B, Pott, F
The biodurability of various glass fibers, rockwool, and ceramic fibers was examined in rat lungs and compared with natural mineral fibers. Experiments were based on studies that have shown that the...
Pott, F, Roller, M, Kamino, K, Bellmann, B
At the same time that carcinogenicity of very thin glass fibers after intrapleural and intraperitoneal (ip) administration was demonstrated (1,2) researchers found that gypsum fibers and HCI-leached...
Most air pollution in West Germany is caused by combustion products. Particulate organic matter released by incomplete combustion is suspected to contribute to the "urban factor" of lung cancer...
Human cerebral venous outflow pathway depends on posture and central venous pressure
Gisolf, J, Van Lieshout, J J, Van Heusden, K, Pott, F, Stok, W J, Karemaker, J M
Internal jugular veins are the major cerebral venous outflow pathway in supine humans. In upright humans the positioning of these veins above heart level causes them to collapse. An alternative...
Potential health risks from the use of fibrous mineral absorption granulates.
Rödelsperger, K, Brückel, B, Manke, J, Woitowitz, H J, Pott, F
Attapulgite (palygorskite) and sepiolite are fibrous clay minerals used commercially as components in a wide variety of products including oil and grease adsorbents, carriers for pharmaceuticals,...