Impaired memory for scenes but not faces in developmental hippocampal amnesia: a case study (2008)
Bird, C.M., Vargha-Khadem, F., Burgess, N.
Item recognition for unfamiliar faces and scenes was tested in Jon, who has developmental amnesia resulting from bilateral hippocampal pathology. Performance and confidence judgements in healthy...
The hippocampus is required for short-term topographical memory in humans (2007)
Hartley, T., Bird, C.M., Chan, D., Cipolotti, L., Husain, M., Vargha-Khadem, F., ...
The hippocampus plays a crucial role within the neural systems for long-term memory, but little if any role in the short-term retention of some types of stimuli. Nonetheless, the hippocampus may be...
The hippocampus is required for short-term topographical memory in humans (2006)
Hartley, T., Bird, C.M., Chan, D., Cipolotti, L., Husain, M., Vargha-Khadem, F., ...
The hippocampus plays a crucial role within the neural systems for long-term memory, but little if any role in the short-term retention of some types of stimuli. Nonetheless, the hippocampus may be...
Hogan, A.M., Vargha-Khadem, F., Saunders, D.E., Kirkham, F.J., Baldeweg, T.
We examined the impact of discrete white matter lesions in the frontal lobes on event-related potential (ERP) correlates of performance monitoring. We tested the hypothesis that abnormal performance...
Detecting white matter injury in sickle cell disease using voxel-based morphometry (2006)
Baldeweg, T., Hogan, A.M., Saunders, D.E., Telfer, P., Gadian, D.G., Vargha-Khadem, F., ...
Objective: Sickle cell disease (SCD) is associated with cerebrovascular disease, cerebral infarction, and cognitive dysfunction. This study aimed to detect the presence and extent of white matter...
Baddeley, A., Vargha-Khadem, F., Mishkin, M.
We report the performance on recognition memory tests of Jon, who, despite amnesia from early childhood, has developed normal levels of performance on tests of intelligence, language, and general...
Hogan, A.M., Kirkham, F.J., Prengler, M., Telfer, P., Lane, R., Vargha-Khadem, F., ...
This study aimed to investigate whether infants with sickle cell anaemia (SCA) are at risk of neurodevelopmental delay, and whether any delay is associated with SCA pathology. Twenty-eight infants...
Baldeweg, T., Hogan, A.M., Saunders, D., Telfer, P., Gadian, D., Vargha-Khadem, F., ...
Objective: Sickle cell disease (SCD) is associated with cerebrovascular disease, cerebral infarction, and cognitive dysfunction. This study aimed to detect the presence and extent of white matter...
Hogan, A., Vargha-Khadem, F., Prengler, M., Kirkham, F.
Lowered intelligence relative to controls is evident by mid-childhood in children with sickle cell disease. There is consensus that brain infarct contributes to this deficit, but the subtle lowering...
Intellectual decline in children with moyamoya and sickle cell anaemia (2005)
Hogan, A.M., Kirkham, F.J., Isaacs, E.B., Wade, A.M., Vargha-Khadem, F.
Intelligence is reported to decline after onset of moyamoya in Japanese populations, but there is less evidence for this in Western populations where the condition may be secondary to stroke and...
Maturation of action monitoring from adolescence to adulthood: an ERP study (2005)
Hogan, A.M., Vargha-Khadem, F., Kirkham, F.J., Baldeweg, T.
This study investigated the development of the frontal lobe action-monitoring system from late childhood and adolescence to early adulthood using ERP markers of error processing. Error negativity...
Cormack, F., Gadian, D.G., Vargha-Khadem, F., Cross, J.H., Connelly, A., Baldeweg, T.
The aim of this study was to identify grey matter density abnormalities in children with temporal lobe epilepsy and mesial temporal sclerosis. Magnetic resonance T1 weighted 3D datasets were obtained...
Cormack, F., Gadian, D.G., Vargha-Khadem, F., Cross, J.H., Connelly, A., Baldeweg, T.
The aim of this study was to identify grey matter density abnormalities in children with temporal lobe epilepsy and mesial temporal sclerosis. Magnetic resonance T1 weighted 3D datasets were obtained...
FOXP2 and the neuroanatomy of speech and language (2005)
Vargha-Khadem, F., Gadian, D.G., Copp, A., Mishkin, M.
That speech and language are innate capacities of the human brain has long been widely accepted, but only recently has an entry point into the genetic basis of these remarkable faculties been found....
Deferred imitation of action sequences in developmental amnesia (2005)
Adlam, A.L., Vargha-Khadem, F., Mishkin, M., De Haan, M.
The aims of this study were to investigate whether patients with developmental amnesia (DA) associated with bilateral hippocampal volume reduction show an impairment in incidental nonverbal recall of...
Deferred imitation of action sequences in developmental amnesia (2005)
Adlam, A.L., Vargha-Khadem, F., Mishkin, M., De Haan, M.
The aims of this study were to investigate whether patients with developmental amnesia (DA) associated with bilateral hippocampal volume reduction show an impairment in incidental nonverbal recall of...
Prengler, M., Kirkham, F.J, Hogan, A.M, Telfer, P., Lane, R., Vargha-Khadem, F., ...
This study aimed to investigate whether infants with sickle cell anaemia (SCA) are at risk of neurodevelopmental delay, and whether any delay is associated with SCA pathology. Twenty-eight infants...
Intellectual decline in children with moyamoya and sickle cell anaemia. (2005)
Hogan, A.M., Kirkham, F.J., Isaacs, E.B., Wade, A.M., Vargha-Khadem, F.
Intelligence is reported to decline after onset of moyamoya in Japanese populations, but there is less evidence for this in Western populations where the condition may be secondary to stroke and...
MacDermot, K.D., Bonora, E., Sykes, N., Coupe, A.M., Lai, C.S., Vernes, S.C., ...
FOXP2, the first gene to have been implicated in a developmental communication disorder, offers a unique entry point into neuromolecular mechanisms influencing human speech and language acquisition....
King, J.A., Trinkler, I., Hartley, T., Vargha-Khadem, F., Burgess, N.
Memory for object locations and for events (comprising the receipt of an object) was tested in a case of developmental amnesia with focal hippocampal damage ("Jon"; F. Vargha-Khadem et al., 1997)....
Liégeois, F., Connelly, A., Cross, J.H., Boyd, S.G., Gadian, D.G., Vargha-Khadem, F., ...
It is widely assumed that following extensive damage to the left hemisphere sustained in early childhood, language functions are likely to reorganize and develop in the right hemisphere, especially...
Liégeois, F., Connelly, A., Cross, J. Helen, Boyd, S. G., Gadian, D. G., Vargha-Khadem, F., ...
It is widely assumed that following extensive damage to the left hemisphere sustained in early childhood, language functions are likely to reorganize and develop in the right hemisphere, especially...
Liégeois, F., Connelly, A., Cross, J. Helen, Boyd, S. G., Gadian, D. G., Vargha-Khadem, F., ...
It is widely assumed that following extensive damage to the left hemisphere sustained in early childhood, language functions are likely to reorganize and develop in the right hemisphere, especially...
Liégeois, F., Connelly, A., Cross, J. Helen, Boyd, S. G., Gadian, D. G., Vargha-Khadem, F., ...
It is widely assumed that following extensive damage to the left hemisphere sustained in early childhood, language functions are likely to reorganize and develop in the right hemisphere, especially...
Language fMRI abnormalities associated with FOXP2 gene mutation (2003)
Liégeois, F., Baldeweg, T., Connelly, A., Gadian, D.G., Mishkin, M., Vargha-Khadem, F.
Half the members of the KE family suffer from a speech and language disorder caused by a mutation in the FOXP2 gene. We examined functional brain abnormalities associated with this mutation using two...
Developmental amnesia and its relationship to degree of hippocampal atrophy (2003)
Isaacs, E.B., Vargha-Khadem, F., Watkins, K.E., Lucas, A., Mishkin, M., Gadian, D.G.
Two groups of adolescents, one born preterm and one with a diagnosis of developmental amnesia, were compared with age-matched normal controls on measures of hippocampal volume and memory function....
Nanduri, V.R., Lillywhite, L., Chapman, C., Parry, L., Pritchard, J., Vargha-Khadem, F.
Purpose: Damage to the CNS, including the cerebellum, and to the hypothalamopituitary axis, is documented in Langerhans cell histiocytosis (LCH). Neuropsychologic deficits have been recognized, but...
Developmental amnesia: effect of age at injury (2003)
Vargha-Khadem, F., Salmond, C.H., Watkins, K.E., Friston, K.J., Gadian, D.G., Mishkin, M.
Hypoxic-ischemic events sustained within the first year of life can result in developmental amnesia, a disorder characterized by markedly impaired episodic memory and relatively preserved semantic...
Clinical outcomes of hemispherectomy for epilepsy in childhood and adolescence (2003)
Devlin, A.M., Cross, J.H., Harkness, W., Chong, W.K., Harding, B., Vargha-Khadem, F., ...
Hemispherectomy has been performed in the treatment of epilepsy in association with hemiplegia for over 50 years. However, the optimal timing of surgery with respect to age at presentation and the...
Functional MRI abnormalities during covert speech associated with FOXP2 gene mutation (2003)
Liegeois, F., Baldeweg, T., Connelly, A., Gadian, D.G., Mishkin, M., Vargha-Khadem, F.
Half the members of the KE family suffer from a speech and language disorder caused by a mutation in the FOXP2 gene. We examined functional brain abnormalities associated with this mutation using two...
Clinical outcomes of hemispherectomy for epilepsy in childhood and adolescence (2003)
Devlin, A. M., Cross, J. H., Harkness, W., Chong, W. K., Harding, B., Vargha-Khadem, F., ...
Hemispherectomy has been performed in the treatment of epilepsy in association with hemiplegia for over 50 years. However, the optimal timing of surgery with respect to age at presentation and the...
Liegeois, F., Connelly, A., Salmond, C.H., Gadian, D.G., Vargha-Khadem, F., Baldeweg, T.
This study introduces a direct method of assessing cerebral lateralization for language based on fMRI activation. The method, derived from a voxel-based morphometry study by C. H. Salmond et al....
MRI analysis of an inherited speech and language disorder: structural brain abnormalities (2002)
Watkins, K.E., Vargha-Khadem, F., Ashburner, J., Passingham, R.E., Connelly, A., Friston, K.J., ...
Analyses of brain structure in genetic speech and language disorders provide an opportunity to identify neurobiological phenotypes and further elucidate the neural bases of language and its...
Watkins, K.E., Dronkers, N.F., Vargha-Khadem, F.
Genetic speech and language disorders provide the opportunity to investigate the biological bases of language and its development. Critical to these investigations are the definition of behavioural...
Human hippocampus and viewpoint dependence in spatial memory (2002)
King, J.A., Burgess, N., Hartley, T., Vargha-Khadem, F., O'Keefe, J.
Virtual reality was used to sequentially present objects within a town square and to test recognition of object locations from the same viewpoint as presentation, or from a shifted viewpoint. A...
Watkins, K. E., Dronkers, N. F., Vargha-Khadem, F.
Genetic speech and language disorders provide the opportunity to investigate the biological bases of language and its development. Critical to these investigations are the definition of behavioural...
MRI analysis of an inherited speech and language disorder: structural brain abnormalities (2002)
Watkins, K. E., Vargha-Khadem, F., Ashburner, J., Passingham, R. E., Connelly, A., Friston, K. J., ...
Analyses of brain structure in genetic speech and language disorders provide an opportunity to identify neurobiological phenotypes and further elucidate the neural bases of language and its...
A novel forkhead-domain gene is mutated in a severe speech and language disorder (2001)
Lai, C.S.L., Fisher, S.E., Hurst, J.A., Vargha-Khadem, F., Monaco, A.P.
Individuals affected with developmental disorders of speech and language have substantial difficulty acquiring expressive and/or receptive language in the absence of any profound sensory or...
Reading and spelling performance was analysed for a sample of 45 children with unilateral brain damage. Boys showed impairments only when the lesion was on the left, while girls showed no significant...
Spiers, H., Burgess, N., Hartley, T., Vargha-Khadem, F., O'Keefe, J.
A virtual reality environment was used to test memory performance for simulated real-world spatial and episodic information in a 22-year-old male, Jon, who has selective bilateral hippocampal...
Neural basis of an inherited speech and language disorder. (1998)
Vargha-Khadem, F., Watkins, K.E., Price, C.J., Ashburner, J., Alcock, K. J., Connelly, A., ...
Isaacs, E., Christie, D., Vargha-Khadem, F., Mishkin, M.
Dichotic listening, manual functions, and IQ were measured in a large group of hemiplegic children with unilateral hemispheric damage. In the children without a history of seizure disorder, only...
Onset of speech after left hemispherectomy in a nine-year-old boy (1997)
Vargha-Khadem, F., Carr, L.J., Isaacs, E.B., Brett, E., Adams, C., Mishkin, M.
Case Alex, with Sturge-Weber Syndrome affecting the left hemisphere, failed to develop speech throughout early boyhood, and his comprehension of single words and simple commands remained stagnant at...
Onset of speech after left hemispherectomy in a nine-year-old boy (1997)
Vargha-Khadem, F, Carr, LJ, Isaacs, E, Brett, E, Adams, C, Mishkin, M
Vargha-Khadem, F., Watkins, K., Alcock, K. J., Fletcher, P., Passingham, R.
A pronounced speech and language disorder affecting half of the 30 members of the four-generational KE family has been attributed by some researchers to a specific defect in the generation of...
Neural basis of an inherited speech and language disorder
Vargha-Khadem, F., Watkins, K. E., Price, C. J., Ashburner, J., Alcock, K. J., Connelly, A., ...
Investigation of the three-generation KE family, half of whose members are affected by a pronounced verbal dyspraxia, has led to identification of their core deficit as one involving sequential...
Brain activity evidence for recognition without recollection after early hippocampal damage
Düzel, E., Vargha-Khadem, F., Heinze, H. J., Mishkin, M.
Amnesic patients with early and seemingly isolated hippocampal injury show relatively normal recognition memory scores. The cognitive profile of these patients raises the possibility that this...
Vargha-Khadem, F, Watkins, K, Alcock, K, Fletcher, P, Passingham, R
A pronounced speech and language disorder affecting half of the 30 members of the four-generational KE family has been attributed by some researchers to a specific defect in the generation of...
Developmental amnesia: Effect of age at injury
Vargha-Khadem, F., Salmond, C. H., Watkins, K. E., Friston, K. J., Gadian, D. G., Mishkin, M.
Hypoxic–ischemic events sustained within the first year of life can result in developmental amnesia, a disorder characterized by markedly impaired episodic memory and relatively preserved semantic...
Developmental amnesia and its relationship to degree of hippocampal atrophy
Isaacs, E. B., Vargha-Khadem, F., Watkins, K. E., Lucas, A., Mishkin, M., Gadian, D. G.
Two groups of adolescents, one born preterm and one with a diagnosis of developmental amnesia, were compared with age-matched normal controls on measures of hippocampal volume and memory function....
Neural basis of an inherited speech and language disorder
Vargha-Khadem, F., Watkins, K. E., Price, C. J., Ashburner, J., Alcock, K. J., Connelly, A., ...
Investigation of the three-generation KE family, half of whose members are affected by a pronounced verbal dyspraxia, has led to identification of their core deficit as one involving sequential...
Brain activity evidence for recognition without recollection after early hippocampal damage
Düzel, E., Vargha-Khadem, F., Heinze, H. J., Mishkin, M.
Amnesic patients with early and seemingly isolated hippocampal injury show relatively normal recognition memory scores. The cognitive profile of these patients raises the possibility that this...
Vargha-Khadem, F, Watkins, K, Alcock, K, Fletcher, P, Passingham, R
A pronounced speech and language disorder affecting half of the 30 members of the four-generational KE family has been attributed by some researchers to a specific defect in the generation of...
Developmental amnesia: Effect of age at injury
Vargha-Khadem, F., Salmond, C. H., Watkins, K. E., Friston, K. J., Gadian, D. G., Mishkin, M.
Hypoxic–ischemic events sustained within the first year of life can result in developmental amnesia, a disorder characterized by markedly impaired episodic memory and relatively preserved semantic...
Developmental amnesia and its relationship to degree of hippocampal atrophy
Isaacs, E. B., Vargha-Khadem, F., Watkins, K. E., Lucas, A., Mishkin, M., Gadian, D. G.
Two groups of adolescents, one born preterm and one with a diagnosis of developmental amnesia, were compared with age-matched normal controls on measures of hippocampal volume and memory function....
Dissociations in cognitive memory: the syndrome of developmental amnesia.
Vargha-Khadem, F, Gadian, D G, Mishkin, M
The dearth of studies on amnesia in children has led to the assumption that when damage to the medial temporal lobe system occurs early in life, the compensatory capacity of the immature brain...
Hierarchical organization of cognitive memory.
Mishkin, M, Suzuki, W A, Gadian, D G, Vargha-Khadem, F
This paper addresses the question of the organization of memory processes within the medial temporal lobe. Evidence obtained in patients with late-onset amnesia resulting from medial temporal...
Investigating individual differences in brain abnormalities in autism.
Salmond, C H, De Haan, M, Friston, K J, Gadian, D G, Vargha-Khadem, F
Autism is a psychiatric syndrome characterized by impairments in three domains: social interaction, communication, and restricted and repetitive behaviours and interests. Recent findings implicate...
Neuropsychological and neurological outcome after relapse of lymphoblastic leukaemia.
Christie, D, Battin, M, Leiper, A D, Chessells, J, Vargha-Khadem, F, Neville, B G
Fourteen children who relapsed after initial remission of leukaemia were studied. Six received a second course of cranial radiotherapy, while the remaining eight children were given total body...
Christie, D, Leiper, A D, Chessells, J M, Vargha-Khadem, F
Cognitive outcome, as measured by verbal and performance IQs, was compared in 35 girls and 47 boys who were in first remission for acute lymphoblastic leukaemia. All children had received...