F. Wayne Outten

Identification of a Copper-Responsive Two-Component System on the Chromosome of Escherichia coli K-12

Munson, George P., Lam, Deborah L., Outten, F. Wayne, O'Halloran, Thomas V.

Using a genetic screen we have identified two chromosomal genes, cusRS (ylcA ybcZ), from Escherichia coli K-12 that encode a two-component, signal transduction system that is responsive to copper...

Identification of a Copper-Responsive Two-Component System on the Chromosome of Escherichia coli K-12

Munson, George P., Lam, Deborah L., Outten, F. Wayne, O'Halloran, Thomas V.

Using a genetic screen we have identified two chromosomal genes, cusRS (ylcA ybcZ), from Escherichia coli K-12 that encode a two-component, signal transduction system that is responsive to copper...

Mutational Analysis To Define an Activating Region on the Redox-Sensitive Transcriptional Regulator OxyR▿

Wang, Xunde, Mukhopadhyay, Partha, Wood, Matthew J., Outten, F. Wayne, Opdyke, Jason A., Storz, Gisela

The OxyR transcription factor is a key regulator of the Escherichia coli response to oxidative stress. Previous studies showed that OxyR binding to a target promoter enhances RNA polymerase binding...

Fe-S Cluster Assembly Pathways in Bacteria

Ayala-Castro, Carla, Saini, Avneesh, Outten, F. Wayne

Summary: Iron-sulfur (Fe-S) clusters are required for critical biochemical pathways, including respiration, photosynthesis, and nitrogen fixation. Assembly of these iron cofactors is a carefully...

IscR Controls Iron-Dependent Biofilm Formation in Escherichia coli by Regulating Type I Fimbria Expression▿ †

Wu, Yun, Outten, F. Wayne

Biofilm formation is a complex developmental process regulated by multiple environmental signals. In addition to other nutrients, the transition metal iron can also regulate biofilm formation....