Fabien Bonneau

Human Lsg1 defines a family of essential GTPases that correlates with the evolution of compartmentalization (2005)

Reynaud, Emmanuel G, Andrade, Miguel A, Bonneau, Fabien, Ly, Thi, Knop, Michael, Scheffzek, Klaus, ...

Abstract Background Compartmentalization is a key feature of eukaryotic cells, but its evolution remains poorly understood. GTPases are the oldest enzymes that use nucleotides as substrates and they...

A novel bipartite phospholipid-binding module in the neurofibromatosis type 1 protein

D'angelo, Igor, Welti, Stefan, Bonneau, Fabien, Scheffzek, Klaus

Neurofibromatosis type 1 (NF1) is a common tumour predisposition syndrome associated with numerous clinical complications. Mutations in the tumour suppressor gene NF1 are responsible for disease...

The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction

Pena, Vladimir, Hothorn, Michael, Eberth, Alexander, Kaschau, Nikolai, Parret, Annabel, Gremer, Lothar, ...

The brain-specific synaptic guanosine triphosphatase (GTPase)-activating protein (SynGAP) is important in synaptic plasticity. It shows dual specificity for the small guanine nucleotide-binding...