Nan, Fajun, Liu, Lijun, Xiong, Zhaoming, Chen, Yonggang, Li, Tongshuang, Li, Yulin
The first stereoselective synthesis of 2α,3α-epoxy-9β-benzoyloxy-β-agarofuran (3) and 2,3-dehydro-4β,12-epoxy-9β-benzoyloxy-β-dihydroagarofuran (4) from (-)-carvone in 13 steps, respectively,...
Synthesis and Allylic Oxidation of 2,3-Dehydro-9β-benzoyloxy-β-agarofuran (1995)
Chen, Xin, Nan, Fajun, Xiong, Zhaoming, Shao, Sichang, Li, Tongshuang, Li, Yulin
2,3-Dehydro-9β-benzoyloxy-β-agarofuran (VI), possible precursor of (+/-)-triptogelin G-2 (I), has been synthesized through a twelve-step procedure, allylic oxidation of which with various oxidative...
A nonpeptidic agonist of glucagon-like peptide 1 receptors with efficacy in diabetic db/db mice
Chen, Desu, Liao, Jiayu, Li, Na, Zhou, Caihong, Liu, Qing, Wang, Guangxing, ...
Peptidic mimics of the gut hormone glucagon-like peptide (GLP) 1, exemplified by the recently approved drug exenatide, show promise as therapies for type 2 diabetes. Such “incretin mimetics”...
Combinatorial augmentation of voltage-gated KCNQ potassium channels by chemical openers
Xiong, Qiaojie, Sun, Haiyan, Zhang, Yangming, Nan, Fajun, Li, Min
Noninactivating potassium current formed by KCNQ2 (Kv7.2) and KCNQ3 (Kv7.3) subunits resembles neuronal M-currents which are activated by voltage and play a critical role in controlling membrane...