Fan Zhang

Modulation Codes for Flash Memory Based on Load-Balancing Theory (2009)

Zhang, Fan, Pfister, Henry D.

In this paper, we consider modulation codes for practical multilevel flash memory storage systems with cell levels. Instead of maximizing the lifetime of the device [Ajiang-isit07-01,...

HPD: an online integrated human pathway database enabling systems biology studies (2009)

Chowbina, Sudhir R, Wu, Xiaogang, Zhang, Fan, Li, Peter M, Pandey, Ragini, Kasamsetty, Harini N, ...

Abstract Background Pathway-oriented experimental and computational studies have led to a significant accumulation of biological knowledge concerning three major types of biological pathway events:...

Electron-electron interactions in graphene bilayers (2009)

Zhang, Fan, Min, Hongki, Polini, Marco, MacDonald, A. H.

Electrons most often organize into Fermi-liquid states in which electron-electron interactions play an inessential role. A well known exception is the case of one-dimensional (1D) electron systems...

Probabilistic White Matter Fiber Tracking using Particle Filtering and von Mises-Fisher Sampling (2009)

Fan Zhang, Edwin R. Hancock, Guido Gerig

Standard particle filtering technique have previously been applied to the problem of fiber tracking by Brun et al. (2002) and Bjornemo et al. (2002). However, these previous attempts have not...

On the Iterative Decoding of High-Rate LDPC Codes With Applications in Compressed Sensing (2009)

Zhang, Fan, Pfister, Henry D.

-- This paper considers the performance of (j,k)-regular low-density parity-check (LDPC) codes with message-passing (MP) decoding algorithms in the high-rate regime. From a coding perspective, this...

Flexible acoustic particle manipulation device with integrated optical waveguide for enhanced microbead assays (2009)

Glynne-Jones, Peter, Boltryk, Rosemary J., Hill, Martyn, Zhang, Fan, Dong, Liqin, Wilkinson, James S., ...

Realisation of a device intended for the manipulation and detection of bead-tagged DNA and other bio-molecules is presented. Acoustic radiation forces are used to manipulate polystyrene micro-beads...

Fabrication of ordered magnetite-doped rare earth fluoride nanotube arrays by nanocrystal self-assembly (2009)

Zhang, Fan, Zhao, Dongyuan

We describe a nanocrystal self-assembly method for the preparation of rare earth fluoride nanotube (ReF-NT) arrays and magnetite-doped rare earth fluoride nanotubes (Fe3O4-ReF-NTs) by using porous...

A role for monoubiquitinated FANCD2 at telomeres in ALT cells (2009)

Fan, Qiang, Zhang, Fan, Barrett, Briana, Ren, Keqin, Andreassen, Paul R.

Both Fanconi anemia (FA) and telomere dysfunction are associated with chromosome instability and an increased risk of cancer. Because of these similarities, we have investigated whether there is a...

Regulation of CD11b transcription by decreasing PRC2 and increased acH4 level during ATRA-induced HL-60 differentiation (2009)

Tang, Huarong, Chen, Fangping, Tan, Qian, Tan, Sanqin, Liu, Linxin, Zhang, Fan

Polycomb repressive complex 2 (PRC2), which mediates trimethylation of lysine 27 on histone H3 (K27me3), plays an important role in many types of stem cell differentiation. Here, we try to reveal how...

Chord-based Key Establishment Schemes for Sensor Networks (2008)

Fan Zhang, Zhijie Jerry Shi, Bing Wang

Abstract — Because of limited resources at sensor nodes, sensor networks typically adopt symmetric-key algorithms to provide security functions such as protecting communications between nodes. In...

List-Message Passing Achieves Capacity on the q-ary Symmetric Channel for Large q (2008)

Zhang, Fan, Pfister, Henry D.

We discuss and analyze a list-message-passing decoder with verification for low-density parity-check (LDPC) codes on the q-ary symmetric channel (q-SC). Rather than passing messages consisting of...

Porosity Effect on Surface Plasmon Resonance from Metallic Sculptured Thin Films (2008)

Abdulhalim, Ibrahim, Lakhtakia, Akhlesh, Lahav, Amit, Zhang, Fan, Xu, Jian

When a sculptured thin film (STF), made of a metal and $\leq50$ nm thick, is used in lieu of a dense layer of metal in the Kretschmann configuration, experimental data for an STF comprising parallel...

An integrated multimodal acoustic particle manipulator and optical evanescent field waveguide (2008)

Glynne-Jones, Peter, Hill, Martyn, Townsend, Rosemary J., Harris, Nicholas R., Wilkinson, James S., Zhang, Fan, ...

A new acoustic-optical-microfluidic system is presented for the manipulation of bead-tagged DNA molecules. Acoustic radiation forces are used to manipulate microspheres into and away from the...

ABSTRACT High-quality Shadow Rendering with Parallel-Split Shadow Maps (2008)

Fan Zhang, Hanqiu Sun, Leilei Xu, Lee Kit Lun

Shadows play a key role in realistic 3D graphics rendering, which dramatically enhance our perception of a 3D scene by providing useful visual cues. Even tremendous advances in computer graphics and...

Spread-Spectrum Watermark by Synthesizing Texture (2008)

Wenyu Liu, Fan Zhang, Chunxiao Liu

Abstract. Image watermarking is a mapping from watermark message to a set of image counterparts, where every version conveys the same meaning with the original image. Since textures that present...

Replication-Based Partial Dynamic Scheduling on Heterogeneous Network Processors (2008)

Zhiyong Yu, Zhiyi Yang, Fan Zhang, Tuanqing Zhang

Abstract. It is a great challenge to map network processing tasks to processing resources of advanced network processors, which are heterogeneous and multi-threading multiprocessor System-on-Chip....

Adaptive resource allocation for delay differentiated traffic in multiuser OFDM (2008)

Meixia Tao, Ying-chang Liang, Fan Zhang

Most existing work on adaptive allocation of subcarriers and power in multiuser orthogonal frequency division multiplexing (OFDM) systems has focused on homogeneous traffic consisting solely of...

Tensor MRI Regularization via Graph Diffusion (2008)

Fan Zhang, Edwin R. Hancock

A new method for diffusion tensor (DT) image regularization is presented that relies on heat diffusion on discrete structures. We represent a DT image using a weighted undirected graph, where the...

CIRCULARLY-POLARIZED LIGHT EMISSION BY MICROCAVITY LIGHT-EMITTING DIODES AND VERTICAL-CAVITY SURFACE-EMITTING LASERS (2008)

Zhang, Fan

Compact circularly polarized (CP) light sources have recently attracted wide attention for direct chip-level integration due to potential applications in the fields of optical information processing...

Framework for Building Design Recyclability (2008)

Zhang, Fan

Recycling of building materials is an important aspect of sustainable construction, while sustainable construction is a critical issue to fulfill overall sustainable development. Researchers have...

Familial aggregation analysis of gene expressions (2007)

Rao, Shao-Qi, Xu, Liang-De, Zhang, Guang-Mei, Li, Xia, Li, Lin, Shen, Gong-Qing, ...

Abstract Traditional studies of familial aggregation are aimed at defining the genetic (and non-genetic) causes of a disease from physiological or clinical traits. However, there has been little...

Single-nucleotide polymorphism-gene intermixed networking reveals co-linkers connected to multiple gene expression phenotypes (2007)

Gong, Bin-Sheng, Zhang, Qing-Pu, Zhang, Guang-Mei, Zhang, Shao-Jun, Zhang, Wei, Lv, Hong-Chao, ...

Abstract Gene expression profiles and single-nucleotide polymorphism (SNP) profiles are modern data for genetic analysis. It is possible to use the two types of information to analyze the...

Bright and color-saturated emission from blue light-emitting diodes based on solution-processed colloidal nanocrystal quantum dots (2007)

Tan, Zhanao, Zhang, Fan, Zhu, Ting, Xu, Jian, Wang, Andrew Y., Dixon, D., ...

We report a multilayer solution-processed blue light-emitting diode based on colloidal core/shell CdS/ZnS nanocrystal quantum dots (QDs). At a low-operating voltage of 5.5 V, the device emits...

Diagnosing Explainable Heterogeneity of Variance in Random Eects Models (2007)

Fan Zhang, Robert E. Weiss

Data analytic tools for models other than the normal linear regression model are relatively rare. Here we develop plots and diagnostic statistics for non-constant variance for the random e#ects model...

Diagnosing Explainable Heterogeneity of Variance in Random Effects Models (2007)

Fan Zhang, Robert E. Weiss

Random effects models (REMs) for longitudinal data include both within- and between-subject variances. Standard REMs assume that these two variance terms are constant across subjects. However, we...

In Proceedings of RTSS'02 Processor Voltage Scheduling for Real-Time Tasks with Non-Preemptible Sections (2007)

Fan Zhang, Samuel T. Chanson

As mobile computing is getting popular, there is an increasing interest in techniques that can minimize energy consumption and prolong the battery life on mobile devices. Processor voltage scheduling...

A new amplification strategy for ultrasensitive electrochemical aptasensor with network-like thiocyanuric acid/gold nanoparticles (2007)

Zheng, Jing, Feng, Wanjuan, Lin, Li, Zhang, Fan, Cheng, Guifang, He, Pingang, ...

An ultrasensitive and highly specific electrochemical aptasensor for detection of thrombin based on gold nanoparticles and thiocyanuric acid is presented. For this proposed aptasensor, aptamerI was...

Nodal position in planar resonators for ultrasonic manipulation (2007)

Hill, Martyn, Glynne-Jones, Peter, Townsend, Rosemary J., Harris, Nicholas R., Cranny, Andrew W., Melvin, Tracy, ...

Ultrasonic manipulation of particles has significant potential, particularly in microfluidic devices for controlling and trapping biological cells. One approach to particle manipulation employs...

Resource Allocation for Delay Differentiated Traffic in Multiuser OFDM Systems (2007)

Tao, Meixia, Liang, Ying-Chang, Zhang, Fan

Most existing work on adaptive allocation of subcarriers and power in multiuser orthogonal frequency division multiplexing (OFDM) systems has focused on homogeneous traffic consisting solely of...

Symmetric identities on Bernoulli polynomials (2007)

Fu, Amy M., Pan, Hao, Zhang, Fan

In this paper, we obtain a generalization of an identity due to Carlitz on Bernoulli polynomials. Then we use this generalized formula to derive two symmetric identities which reduce to some known...

Vorticity and Magnetic Field Generation from Initial Anisotropy in Ultrarelativistic Gamma-Ray Burst Blastwaves (2007)

Milosavljevic, Milos, Nakar, Ehud, Zhang, Fan

Because conical segments of quasispherical ultrarelativistic blastwaves are causally disconnected on angular scales larger than the blastwave inverse Lorentz factor, astrophysical blastwaves can...

Time-dependent Density Functional calculation of e-H scattering (2007)

Van Faassen, Meta, Wasserman, Adam, Engel, Eberhard, Zhang, Fan, Burke, Kieron

Phase shifts for single-channel elastic electron-atom scattering are derived from time-dependent density functional theory. The H$^-$ ion is placed in a spherical box, its discrete spectrum found,...

Protein Attributes Microtuning System (PAMS): an effective tool to increase protein structure prediction by data purification (2007)

Zhang, Fan, Povey, David, Krause, Paul J.

Given the expense of more direct determinations, using machine-learning schemes to predict a protein secondary structure from the sequence alone remains an important methodology. To achieve...

X-ray Spectral and timing properties of the black hole x-ray transient Swift J1753.5-0127 (2007)

Zhang, Guobao, Qu, Jinlu, Zhang, Shu, Zhang, Chengmin, Zhang, Fan, Chen, Wei, ...

We have carried out detailed analysis on the black hole candidate (BHC) X- ray transient Swift J1753.5-0127 observed by the Rossi X-Ray Timing Explorer (RXTE) during its outburst in 2005 {2006. The...

High capacity watermarking in nonedge texture under statistical distortion constraint (2007)

Fan Zhang, Wenyu Liu, Chunxiao Liu

Abstract. High-capacity image watermarking scheme aims at maximize bit rate of hiding information, neither eliciting perceptible image distortion nor facilitating special watermark attack. Texture,...

MicroRNA-206 colocalizes with ribosome-rich regions in both the nucleolus and cytoplasm of rat myogenic cells (2006)

Politz, Joan C. Ritland, Zhang, Fan, Pederson, Thoru

MicroRNAs are small, approximately 21- to 24-nt RNAs that have been found to regulate gene expression. miR-206 is a microRNA that is expressed at high levels in Drosophila, zebrafish, and mouse...

BEST3D: a numerical hydrodynamics and water quality model: part 2 - water quality (2006)

Yeh, Gour-Tsyh (George), Shan, Hua, Zhang, Fan, Wu, Tien-Shuenn, Hu, Gordon

Paper presented at The Seventh International Conference on HydroScience and Engineering (ICHE)hosted by the College of Engineering at Drexel Univeristy on September 10-13, 2006 in Philadelphia,...

Cosmological Evolution of the Duty Cycle of Quasars (2006)

Wang, Jian-Min, Chen, Yan-Mei, Zhang, Fan

Quasars are powered by accretion onto supermassive black holes, but the problem of the duty cycle related to the episodic activity of the black holes remains open as one of the major questions of...

Timing Features of the Accretion--driven Millisecond X-Ray Pulsar XTE J1807--294 in 2003 March Outburst (2006)

Zhang, Fan, Qu, J. L., Zhang, C. M., Chen, W., Li, T. P.

In order to probe the activity of the inner disk flow and its effect on the neutron star surface emissions, we carried out the timing analysis of the Rossi X-Ray Timing Explorer (RXTE) observations...

BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ (2005)

Litman, Rachel, Peng, Min, Jin, Zhe, Zhang, Fan, Zhang, Junran, Powell, Simon N., ...

We showed in this study that cells deficient of the BRCA1-associated BACH1 helicase, also known as BRIP1, failed to elicit homologous recombination (HR) after DNA double-stranded breaks (DSBs)....

Selection of some technical issues for rural road construction in Jiangsu Province (2005)

Zhang, Fan, Chen, Shengwu, Yuan, Guolin, Bian, Fenglan

This paper was transferred from the original CD ROM created for this conference. The material on the CD ROM was published using Adobe Acrobat technology. The original CD ROM was produced by Document...

Selection of some technical issues for rural road construction in Jiangsu Province (2005)

Zhang, Fan, Chen, Shengwu, Yuan, Guolin, Bian, Fenglan

This paper was transferred from the original CD ROM created for this conference. The material on the CD ROM was published using Adobe Acrobat technology. The original CD ROM was produced by Document...

An x-ray scattering study of liquid crystalline elastomers (2005)

Zhang, Fan

Liquid crystalline elastomers are a class of new materials which combine the elasticity of elastomers and the orientational alignments of liquid crystals. They have the ability to undergo spontaneous...

Power-aware scheduling in computing and communications with QoS requirements (2005)

Zhang, Fan

Thesis (Ph.D.)--Hong Kong University of Science and Technology, 2005

Power-aware scheduling in computing and communications with QoS requirements / (2005)

Zhang, Fan.

Thesis (Ph.D.)--Hong Kong University of Science and Technology, 2005.

Signal (2005)

Scott T. Avecilla, Andrea T. Hooper, Sergey V. Shmelkov, Carlos A. Ramos, Shahin Rafii, Transduction Articles, ...

doi:10.1182/blood-2004-11-4269 Tie2 activation contributes to hemangiogenic regeneration after myelosuppression

Di-n-Butyl Phthalate Activates Constitutive Androstane Receptor and Pregnane X Receptor and Enhances the Expression of Steroid-Metabolizing Enzymes in the Liver of Rat Fetuses (2005)

Wyde, Michael E., Kirwan, Shaun E., Zhang, Fan, Laughter, Ashley, Hoffman, Holly B., Bartolucci-Page, Erika, ...

The plasticizer di-n-butyl phthalate (DBP) is a reproductive toxicant in rodents. Exposure to DBP in utero at high doses alters early reproductive development in male rats. DBP also affects hepatic...

Di-n-Butyl Phthalate Activates Constitutive Androstane Receptor and Pregnane X Receptor and Enhances the Expression of Steroid-Metabolizing Enzymes in the Liver of Rat Fetuses (2005)

Wyde, Michael E., Kirwan, Shaun E., Zhang, Fan, Laughter, Ashley, Hoffman, Holly B., Bartolucci-Page, Erika, ...

The plasticizer di-n-butyl phthalate (DBP) is a reproductive toxicant in rodents. Exposure to DBP in utero at high doses alters early reproductive development in male rats. Di-n-butyl phthalate also...

Power-aware processor scheduling under average delay constraints (2004)

Zhang, Fan, Chanson, Samuel T.

In this paper, voltage scaling strategies for scheduling aperiodic tasks under average delay constraints are studied. Dynamic voltage scaling in single processor systems is formulated as a...

Necessary and sufficient conditions for localization of multiple robot platforms (2004)

Zhang, Fan, Kumar, R. Vijay, Pereira, Guilherme A. S.

In this paper, we consider the problem of cooperatively localizing a formation of networked robots/vehicles in SE(2). First, we propose necessary and sufficient conditions to establish when a team of...

Angiogenesis Induced by Photodynamic Therapy in Normal Rat Brain¶ (2004)

Feng Jiang, Zheng Gang Zhang, Mark Katakowski, Adam M Robin, Michelle Faber, Fan Zhang, ...

Angiogenesis promotes tumor growth and invasiveness in brain. Because brain injury often induces expression of angiogenic-promoting molecules, we hypothesize that oxidative insult induced by...

Formations of Localization of Robot Networks (2004)

Zhang, Fan, Grocholsky, Ben, Kumar, R. Vijay

In this paper, we consider the problem of cooperatively localizing a formation of networked mobile robots/vehicles in SE(2), and adapting the formation to reduce localization errors. First, we...

The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations (2004)

Cantor, Sharon B., Drapkin, Ronny, Zhang, Fan, Lin, Yafang, Han, Juliana, Pamidi, Sushmita, ...

BACH1 is a nuclear protein that directly interacts with the highly conserved, C-terminal BRCT repeats of the tumor suppressor, BRCA1. Mutations within the BRCT repeats disrupt the interaction between...

Blocking-aware processor voltage scheduling for real-time tasks (2004)

Zhang, Fan, Chanson, Samuel T.

As mobile computing is getting popular, there is a growing need for techniques that minimize energy consumption on battery-powered mobile devices. Processor voltage scheduling can effectively reduce...

June 5, 2004 16:35 (2004)

Asme Design Engineering, Fan Zhang

In this paper, we consider the problem of cooperatively localizing a formation of networked robots/vehicles in SE(2). First, we propose necessary and sufficient conditions to establish when a team of...

Where Are Be/black-hole Binaries? (2003)

Zhang, Fan

We apply the tidal truncation model proposed by Negueruela & Okazaki(2001) to arbitrary Be/compact star binaries to study the truncation efficiency dependance on the binary parameters. We find that...

Cooperative Control for Localization of Mobile Sensor Networks (2003)

Zhang, Fan, Grocholsky, Ben, Kumar, R. Vijay, Mintz, Max L

In this paper, we consider the problem of cooperatively control a formation of networked mobile robots/vehicles to optimize the relative and absolute localization performance in 1D and 2D space. A...

Supernova Remnant Crossing a Density Jump: A Thin Shell Model (2003)

Chen, Yang, Zhang, Fan, Williams, Rosa M., Wang, Q. Daniel

The environments of supernova explosion are often inhomogeneous and there may be jumps in their density structure. We have developed a semi-analytic model under the thin-shell approximation for...

Extension and application of LIBOR market model / (2003)

Zhang, Fan.

Thesis (Ph. D.)--Hong Kong University of Science and Technology, 2003.

Extension and application of LIBOR market model (2003)

Zhang, Fan

Thesis (Ph.D.)--Hong Kong University of Science and Technology, 2003

Throughput and value maximization in wireless packet scheduling under energy and time constraints (2003)

Zhang, Fan, Chanson, Samuel T.

Energy-efficient data transmission is an important issue for mobile communication devices. In this paper, we study throughput and value-based packet scheduling over a wireless link under time and...

Rate-controlled scheduling for networked multimedia applications (2003)

Zhang, Fan, Chanson, Samuel T.

Multimedia applications over the Internet are becoming increasingly popular. The soft real-time constraints of this type of applications have given rise to interesting issues for scheduling in the...

Modulation of capacitative calcium entry by signaling pathways in rabbit corneal epithelial cells / (2003)

Zhang, Fan.

Thesis (M.S.)--State University of New York State College of Optometry, 2003.

Extension and application of LIBOR market model / (2003)

Zhang, Fan.

Thesis (Ph. D.)--Hong Kong University of Science and Technology, 2003.

Extension and application of LIBOR market model / (2003)

Zhang, Fan.

Thesis (Ph. D.)--Hong Kong University of Science and Technology, 2003.

Throughput and Value Maximization in Wireless Packet Scheduling under Energy and Time Constraints (2003)

Fan Zhang, Samuel T. Chanson

Energy-efficient data transmission is an important issue for mobile communication devices. In this paper, we study throughput and value-based packet scheduling over a wireless link under time and...

Streaming media caching algorithms for transcoding proxies (2002)

Tang, Xueyan, Zhang, Fan, Chanson, Samuel T.

Streaming media is expected to become one of the most popular types of web content in the future. Due to increasing variety of client devices and the range of access speeds to the Internet,...

Processor voltage scheduling for real-time tasks with non-preemptible sections (2002)

Zhang, Fan, Chanson, Samuel T.

As mobile computing is getting popular, there is an increasing interest in techniques that can minimize energy consumption and prolong the battery life on mobile devices. Processor voltage scheduling...

Trading agent competition 2002. http://www.sics.se/tac (2002)

Fan Zhang, Samuel T. Chanson

As mobile computing is getting popular, there is a growing need for techniques that minimize energy consumption on battery-powered mobile devices. Processor voltage scheduling can e#ectively reduce...

Streaming Media Caching Algorithms for Transcoding Proxies (2002)

Xueyan Tang, Fan Zhang, Samuel T. Chanson

Streaming media is expected to become one of the most popular types of web content in the future. Due to increasing variety of client devices and the range of access speeds to the Internet,...

Induction of cyclooxygenase-2 by tumor promoters in transformed and cytochrome P450 2E1-expressing hepatocytes (2002)

De Lédinghen, Victor, Liu, Hailing, Zhang, Fan, Lo, Chau R., Subbaramaiah, Kotha, Dannenberg, Andrew J., ...

The induction of cyclooxygenase (COX)-2 expression has been implicated as a mechanism for the formation of non-hepatic tumors. Recent investigations have demonstrated COX-2 expression in human...

Predictive detection in Web server using light and heavy tailed time series (2001)

Zhang, Fan

The exponential growth of network-based services has greatly increased the pressure on network administrators to maintain smooth operation with minimal service interruptions. Abnormal server...

Surfing e-mails (2000)

Fan Zhang, Samuel T. Chanson

Multimedia applications over the Internet are becoming increasingly popular. The soft real-time constraints of this type of applications have given rise to interesting issues for scheduling in the...

Curcumin inhibits cyclooxygenase-2 transcription in bile acid- and phorbol ester-treated human gastrointestinal epithelial cells (1999)

Zhang, Fan, Altorki, Nasser K., Mestre, Juan R., Subbaramaiah, Kotha, Dannenberg, Andrew J.

We investigated whether curcumin, a chemopreventive agent, inhibited chenodeoxycholate (CD)- or phorbol ester (PMA)-mediated induction of cyclooxygenase-2 (COX-2) in several gastrointestinal cell...

Long-term synaptic facilitation of tail sensorimotor connections in Aplysia (1997)

Zhang, Fan

Long-term sensitization in Aplysia is a well studied model for the examination of the cellular and molecules mechanisms of long-term memory. Several lines of evidence suggest long-term sensitization...

Mechanisms of induction of cellular immunity following immunization with cochleate gene vaccines /--by Fan Zhang. (1997)

Zhang, Fan.

Thesis (Ph. D.)--University of Medicine and Dentistry of New Jersey, Graduate School of Biomedical Sciences.

Localization of the two protein-kinase-c-beta mRNA subtypes in cat visual-system (1995)

Zhang, Fan, Mailleux, Pierre, Vanderhaeghen, Jean-Jacques, ...

Protein kinase C (PKC) consists of a family of different subtypes encoded by different PKC genes. We investigated the distribution of PKC beta 1 and PKC beta 2 in the visual system of the adult cat...

A theoretical and empirical study of the effect of product differentiation on collusion (1994)

Zhang, Fan

This dissertation applies the supergame approach to a Salop type product differentiation model with n firms in the market. The theory shows that product differentiation facilitates the formation of...

Phänomene von Wellen in Medien / (1989)

Zhang, Fan.

Thesis (doctoral)--Technische Hochschule Aachen, 1989.

E2F Is Required To Prevent Inappropriate S-Phase Entry of Mammalian Cells

He, Song, Cook, Brian L., Deverman, Benjamin E., Weihe, Ulrich, Zhang, Fan, Prachand, Vivek, ...

E2F is a family of transcription factors that regulates the cell cycle. It is widely accepted that E2F-mediated transactivation of a set of genes is the critical activity that governs cellular...

Detection of Human Cytomegalovirus pp67 Late Gene Transcripts in Cerebrospinal Fluid of Human Immunodeficiency Virus Type 1-Infected Patients by Nucleic Acid Sequence-Based Amplification

Zhang, Fan, Tetali, Surya, Wang, Xue Ping, Kaplan, Mark H., Cromme, Frans V., Ginocchio, Christine C.

This study examined the clinical correlation between the presence of human cytomegalovirus (HCMV) pp67 mRNA in cerebrospinal fluid (CSF) and active HCMV central nervous system (CNS) disease in...

Tight Binding of the Phosphorylated α Subunit of Initiation Factor 2 (eIF2α) to the Regulatory Subunits of Guanine Nucleotide Exchange Factor eIF2B Is Required for Inhibition of Translation Initiation

Krishnamoorthy, Thanuja, Pavitt, Graham D., Zhang, Fan, Dever, Thomas E., Hinnebusch, Alan G.

Translation initiation factor 2 (eIF2) is a heterotrimeric protein that transfers methionyl-initiator tRNAMet to the small ribosomal subunit in a ternary complex with GTP. The eIF2 phosphorylated on...

Inhibition of Double-Stranded RNA-Dependent Protein Kinase PKR by Vaccinia Virus E3: Role of Complex Formation and the E3 N-Terminal Domain

Romano, Patrick R., Zhang, Fan, Tan, Seng-Lai, Garcia-Barrio, Minerva T., Katze, Michael G., Dever, Thomas E., ...

The human double-stranded RNA (dsRNA)-dependent protein kinase PKR inhibits protein synthesis by phosphorylating translation initiation factor 2α (eIF2α). Vaccinia virus E3L encodes a dsRNA binding...

Autophosphorylation in the Activation Loop Is Required for Full Kinase Activity In Vivo of Human and Yeast Eukaryotic Initiation Factor 2α Kinases PKR and GCN2

Romano, Patrick R., Garcia-Barrio, Minerva T., Zhang, Xiaolong, Wang, Qizhi, Taylor, Deborah R., Zhang, Fan, ...

The human double-stranded RNA-dependent protein kinase (PKR) is an important component of the interferon response to virus infection. The activation of PKR is accompanied by autophosphorylation at...

A Minimal Chimera of Human Cyclin T1 and Tat Binds TAR and Activates Human Immunodeficiency Virus Transcription in Murine Cells

Fujinaga, Koh, Irwin, Dan, Taube, Ran, Zhang, Fan, Geyer, Matthias, Peterlin, B. Matija

The transcriptional elongation of human immunodeficiency virus type 1 (HIV-1) is mediated by the virally encoded transactivator Tat and its cellular cofactor, positive transcription elongation factor...

Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo

Olsen, DeAnne S., Savner, Erin M., Mathew, Amy, Zhang, Fan, Krishnamoorthy, Thanuja, Phan, Lon, ...

Translation initiation factor 1A (eIF1A) is predicted to bind in the decoding site of the 40S ribosome and has been implicated in recruitment of the eIF2–GTP–Met-tRNAiMet ternary complex (TC) and...

A model of repression: CTD analogs and PIE-1 inhibit transcriptional elongation by P-TEFb

Zhang, Fan, Barboric, Matjaz, Blackwell, T. Keith, Peterlin, B. Matija

The positive transcription elongation factor b (P-TEFb) contains cyclin T1 (CycT1) and cyclin-dependent kinase 9 (Cdk9). For activating the expression of eukaryotic genes, the histidine-rich sequence...

Carbon monoxide of vascular origin attenuates the sensitivity of renal arterial vessels to vasoconstrictors

Kaide, Jun-Ichi, Zhang, Fan, Wei, Yuan, Jiang, Houli, Yu, Changhua, Wang, WenHui, ...

Rat renal interlobar arteries express heme oxygenase 2 (HO-2) and manufacture carbon monoxide (CO), which is released into the headspace gas. CO release falls to 30% and 54% of control, respectively,...

The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations

Cantor, Sharon, Drapkin, Ronny, Zhang, Fan, Lin, Yafang, Han, Juliana, Pamidi, Sushmita, ...

BACH1 is a nuclear protein that directly interacts with the highly conserved, C-terminal BRCT repeats of the tumor suppressor, BRCA1. Mutations within the BRCT repeats disrupt the interaction between...

Constitutive versus regulated SNARE assembly: a structural basis

Chen, Yong, Xu, Yibin, Zhang, Fan, Shin, Yeon-Kyun

SNARE complex formation is essential for intracellular membrane fusion. Vesicle-associated (v-) SNARE intertwines with target membrane (t-) SNARE to form a coiled coil that bridges two membranes and...

A Triad of Subunits from the Gal11/Tail Domain of Srb Mediator Is an In Vivo Target of Transcriptional Activator Gcn4p

Zhang, Fan, Sumibcay, Laarni, Hinnebusch, Alan G., Swanson, Mark J.

The Srb mediator is an important transcriptional coactivator for Gcn4p in the yeast Saccharomyces cerevisiae. We show that three subunits of the Gal11/tail domain of mediator, Gal11p, Pgd1p, and...

Interactions of Eukaryotic Translation Initiation Factor 3 (eIF3) Subunit NIP1/c with eIF1 and eIF5 Promote Preinitiation Complex Assembly and Regulate Start Codon Selection

Valášek, Leoš, Nielsen, Klaus H., Zhang, Fan, Fekete, Christie A., Hinnebusch, Alan G.

The N-terminal domain (NTD) of NIP1/eIF3c interacts directly with eIF1 and eIF5 and indirectly through eIF5 with the eIF2-GTP-Met-\documentclass[12pt]{minimal} \usepackage{amsmath}...

Interdependent Recruitment of SAGA and Srb Mediator by Transcriptional Activator Gcn4p

Qiu, Hongfang, Hu, Cuihua, Zhang, Fan, Hwang, Gwo Jiunn, Swanson, Mark J., Boonchird, Cheunchit, ...

Transcriptional activation by Gcn4p is enhanced by the coactivators SWI/SNF, SAGA, and Srb mediator, which stimulate recruitment of TATA binding protein (TBP) and polymerase II to target promoters....

Ubiquitylation of Cdk9 by Skp2 Facilitates Optimal Tat Transactivation

Barboric, Matjaz, Zhang, Fan, Besenicar, Mojca, Plemenitas, Ana, Peterlin, B. Matija

By recruiting the positive transcriptional elongation factor b (P-TEFb) to paused RNA polymerase II, the transactivator Tat stimulates transcriptional elongation of the human immunodeficiency virus...

Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling

Vincent, Loïc, Kermani, Pouneh, Young, Lauren M., Cheng, Joseph, Zhang, Fan, Shido, Koji, ...

The molecular and cellular pathways that support the maintenance and stability of tumor neovessels are not well defined. The efficacy of microtubule-disrupting agents, such as combretastatin A4...

Runx1 Binds Positive Transcription Elongation Factor b and Represses Transcriptional Elongation by RNA Polymerase II: Possible Mechanism of CD4 Silencing

Jiang, Huimin, Zhang, Fan, Kurosu, Takeshi, Peterlin, B. Matija

Runx1 binds the silencer and represses CD4 transcription in immature thymocytes. In this study, we found that Runx1 inhibits P-TEFb, which contains CycT1, CycT2, or CycK and Cdk9 and stimulates...

Thrombospondins deployed by thrombopoietic cells determine angiogenic switch and extent of revascularization

Kopp, Hans-Georg, Hooper, Andrea T., Broekman, M. Johan, Avecilla, Scott T., Petit, Isabelle, Luo, Min, ...

Thrombopoietic cells may differentially promote or inhibit tissue vascularization by releasing both pro- and antiangiogenic factors. However, the molecular determinants controlling the angiogenic...

P-TEFb is not an essential elongation factor for the intronless human U2 snRNA and histone H2b genes

Medlin, Joanne, Scurry, Andrew, Taylor, Alice, Zhang, Fan, Peterlin, B Matija, Murphy, Shona

Phosphorylation of Ser2 of the heptapeptide repeat of the CTD of mammalian pol II by P-TEFb is associated with productive elongation of transcription of protein-coding genes. Here, we show that the...

E2F Is Required To Prevent Inappropriate S-Phase Entry of Mammalian Cells

He, Song, Cook, Brian L., Deverman, Benjamin E., Weihe, Ulrich, Zhang, Fan, Prachand, Vivek, ...

E2F is a family of transcription factors that regulates the cell cycle. It is widely accepted that E2F-mediated transactivation of a set of genes is the critical activity that governs cellular...

Detection of Human Cytomegalovirus pp67 Late Gene Transcripts in Cerebrospinal Fluid of Human Immunodeficiency Virus Type 1-Infected Patients by Nucleic Acid Sequence-Based Amplification

Zhang, Fan, Tetali, Surya, Wang, Xue Ping, Kaplan, Mark H., Cromme, Frans V., Ginocchio, Christine C.

This study examined the clinical correlation between the presence of human cytomegalovirus (HCMV) pp67 mRNA in cerebrospinal fluid (CSF) and active HCMV central nervous system (CNS) disease in...

Tight Binding of the Phosphorylated α Subunit of Initiation Factor 2 (eIF2α) to the Regulatory Subunits of Guanine Nucleotide Exchange Factor eIF2B Is Required for Inhibition of Translation Initiation

Krishnamoorthy, Thanuja, Pavitt, Graham D., Zhang, Fan, Dever, Thomas E., Hinnebusch, Alan G.

Translation initiation factor 2 (eIF2) is a heterotrimeric protein that transfers methionyl-initiator tRNAMet to the small ribosomal subunit in a ternary complex with GTP. The eIF2 phosphorylated on...

Inhibition of Double-Stranded RNA-Dependent Protein Kinase PKR by Vaccinia Virus E3: Role of Complex Formation and the E3 N-Terminal Domain

Romano, Patrick R., Zhang, Fan, Tan, Seng-Lai, Garcia-Barrio, Minerva T., Katze, Michael G., Dever, Thomas E., ...

The human double-stranded RNA (dsRNA)-dependent protein kinase PKR inhibits protein synthesis by phosphorylating translation initiation factor 2α (eIF2α). Vaccinia virus E3L encodes a dsRNA binding...

Autophosphorylation in the Activation Loop Is Required for Full Kinase Activity In Vivo of Human and Yeast Eukaryotic Initiation Factor 2α Kinases PKR and GCN2

Romano, Patrick R., Garcia-Barrio, Minerva T., Zhang, Xiaolong, Wang, Qizhi, Taylor, Deborah R., Zhang, Fan, ...

The human double-stranded RNA-dependent protein kinase (PKR) is an important component of the interferon response to virus infection. The activation of PKR is accompanied by autophosphorylation at...

A Minimal Chimera of Human Cyclin T1 and Tat Binds TAR and Activates Human Immunodeficiency Virus Transcription in Murine Cells

Fujinaga, Koh, Irwin, Dan, Taube, Ran, Zhang, Fan, Geyer, Matthias, Peterlin, B. Matija

The transcriptional elongation of human immunodeficiency virus type 1 (HIV-1) is mediated by the virally encoded transactivator Tat and its cellular cofactor, positive transcription elongation factor...

Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo

Olsen, DeAnne S., Savner, Erin M., Mathew, Amy, Zhang, Fan, Krishnamoorthy, Thanuja, Phan, Lon, ...

Translation initiation factor 1A (eIF1A) is predicted to bind in the decoding site of the 40S ribosome and has been implicated in recruitment of the eIF2–GTP–Met-tRNAiMet ternary complex (TC) and...

A model of repression: CTD analogs and PIE-1 inhibit transcriptional elongation by P-TEFb

Zhang, Fan, Barboric, Matjaz, Blackwell, T. Keith, Peterlin, B. Matija

The positive transcription elongation factor b (P-TEFb) contains cyclin T1 (CycT1) and cyclin-dependent kinase 9 (Cdk9). For activating the expression of eukaryotic genes, the histidine-rich sequence...

Carbon monoxide of vascular origin attenuates the sensitivity of renal arterial vessels to vasoconstrictors

Kaide, Jun-Ichi, Zhang, Fan, Wei, Yuan, Jiang, Houli, Yu, Changhua, Wang, WenHui, ...

Rat renal interlobar arteries express heme oxygenase 2 (HO-2) and manufacture carbon monoxide (CO), which is released into the headspace gas. CO release falls to 30% and 54% of control, respectively,...

The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations

Cantor, Sharon, Drapkin, Ronny, Zhang, Fan, Lin, Yafang, Han, Juliana, Pamidi, Sushmita, ...

BACH1 is a nuclear protein that directly interacts with the highly conserved, C-terminal BRCT repeats of the tumor suppressor, BRCA1. Mutations within the BRCT repeats disrupt the interaction between...

Constitutive versus regulated SNARE assembly: a structural basis

Chen, Yong, Xu, Yibin, Zhang, Fan, Shin, Yeon-Kyun

SNARE complex formation is essential for intracellular membrane fusion. Vesicle-associated (v-) SNARE intertwines with target membrane (t-) SNARE to form a coiled coil that bridges two membranes and...

A Triad of Subunits from the Gal11/Tail Domain of Srb Mediator Is an In Vivo Target of Transcriptional Activator Gcn4p

Zhang, Fan, Sumibcay, Laarni, Hinnebusch, Alan G., Swanson, Mark J.

The Srb mediator is an important transcriptional coactivator for Gcn4p in the yeast Saccharomyces cerevisiae. We show that three subunits of the Gal11/tail domain of mediator, Gal11p, Pgd1p, and...

Interactions of Eukaryotic Translation Initiation Factor 3 (eIF3) Subunit NIP1/c with eIF1 and eIF5 Promote Preinitiation Complex Assembly and Regulate Start Codon Selection

Valášek, Leoš, Nielsen, Klaus H., Zhang, Fan, Fekete, Christie A., Hinnebusch, Alan G.

The N-terminal domain (NTD) of NIP1/eIF3c interacts directly with eIF1 and eIF5 and indirectly through eIF5 with the eIF2-GTP-Met-\documentclass[12pt]{minimal} \usepackage{amsmath}...

Interdependent Recruitment of SAGA and Srb Mediator by Transcriptional Activator Gcn4p

Qiu, Hongfang, Hu, Cuihua, Zhang, Fan, Hwang, Gwo Jiunn, Swanson, Mark J., Boonchird, Cheunchit, ...

Transcriptional activation by Gcn4p is enhanced by the coactivators SWI/SNF, SAGA, and Srb mediator, which stimulate recruitment of TATA binding protein (TBP) and polymerase II to target promoters....

Ubiquitylation of Cdk9 by Skp2 Facilitates Optimal Tat Transactivation

Barboric, Matjaz, Zhang, Fan, Besenicar, Mojca, Plemenitas, Ana, Peterlin, B. Matija

By recruiting the positive transcriptional elongation factor b (P-TEFb) to paused RNA polymerase II, the transactivator Tat stimulates transcriptional elongation of the human immunodeficiency virus...

Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling

Vincent, Loïc, Kermani, Pouneh, Young, Lauren M., Cheng, Joseph, Zhang, Fan, Shido, Koji, ...

The molecular and cellular pathways that support the maintenance and stability of tumor neovessels are not well defined. The efficacy of microtubule-disrupting agents, such as combretastatin A4...

Runx1 Binds Positive Transcription Elongation Factor b and Represses Transcriptional Elongation by RNA Polymerase II: Possible Mechanism of CD4 Silencing

Jiang, Huimin, Zhang, Fan, Kurosu, Takeshi, Peterlin, B. Matija

Runx1 binds the silencer and represses CD4 transcription in immature thymocytes. In this study, we found that Runx1 inhibits P-TEFb, which contains CycT1, CycT2, or CycK and Cdk9 and stimulates...

P-TEFb is not an essential elongation factor for the intronless human U2 snRNA and histone H2b genes

Medlin, Joanne, Scurry, Andrew, Taylor, Alice, Zhang, Fan, Peterlin, B Matija, Murphy, Shona

Phosphorylation of Ser2 of the heptapeptide repeat of the CTD of mammalian pol II by P-TEFb is associated with productive elongation of transcription of protein-coding genes. Here, we show that the...

Thrombospondins deployed by thrombopoietic cells determine angiogenic switch and extent of revascularization

Kopp, Hans-Georg, Hooper, Andrea T., Broekman, M. Johan, Avecilla, Scott T., Petit, Isabelle, Luo, Min, ...

Thrombopoietic cells may differentially promote or inhibit tissue vascularization by releasing both pro- and antiangiogenic factors. However, the molecular determinants controlling the angiogenic...

Does uncertainty matter ? A stochastic dynamic analysis of bankable emission permit trading for global climate change policy

Zhang, Fan

Emission permit trading is a centerpiece of the Kyoto Protocol which allows participating nations to trade and bank greenhouse gas permits under the Framework Convention on Climate Change. When...

MicroRNA-206 colocalizes with ribosome-rich regions in both the nucleolus and cytoplasm of rat myogenic cells

Ritland Politz, Joan C., Zhang, Fan, Pederson, Thoru

MicroRNAs are small, ≈21- to 24-nt RNAs that have been found to regulate gene expression. miR-206 is a microRNA that is expressed at high levels in Drosophila, zebrafish, and mouse skeletal muscle...

Multiple intermediates in SNARE-induced membrane fusion

Yoon, Tae-Young, Okumus, Burak, Zhang, Fan, Shin, Yeon-Kyun, Ha, Taekjip

Membrane fusion in eukaryotic cells is thought to be mediated by a highly conserved family of proteins called SNAREs (soluble N-ethyl maleimide sensitive-factor attachment protein receptors). The...

Tie2 activation contributes to hemangiogenic regeneration after myelosuppression

Kopp, Hans-Georg, Avecilla, Scott T., Hooper, Andrea T., Shmelkov, Sergey V., Ramos, Carlos A., Zhang, Fan, ...

Chemotherapy- or radiation-induced myelosuppression results in apoptosis of cycling hematopoietic cells and induces regression of bone marrow (BM) sinusoidal vessels. Moreover, timely regeneration of...

Active tissue-specific DNA demethylation conferred by somatic cell nuclei in stable heterokaryons

Zhang, Fan, Pomerantz, Jason H., Sen, George, Palermo, Adam T., Blau, Helen M.

DNA methylation is among the most stable epigenetic marks, ensuring tissue-specific gene expression in a heritable manner throughout development. Here we report that differentiated mesodermal somatic...

DOES ELECTRICITY RESTRUCTURING WORK? EVIDENCE FROM THE U.S. NUCLEAR ENERGY INDUSTRY -super-*

FAN ZHANG

This paper examines whether electricity restructuring improves the efficiency of U.S. nuclear power generation. Using a panel dataset consisting of the full sample of 73 investor-owned nuclear plants...

VEGF-B inhibits apoptosis via VEGFR-1–mediated suppression of the expression of BH3-only protein genes in mice and rats

Li, Yang, Zhang, Fan, Nagai, Nobuo, Tang, Zhongshu, Zhang, Shuihua, Scotney, Pierre, ...

Despite its early discovery and high sequence homology to the other VEGF family members, the biological functions of VEGF-B remain poorly understood. We revealed here a novel function for VEGF-B as a...

Fast swaption pricing under the market model with a square-root volatility process

Lixin Wu, Fan Zhang

In this paper we study a correlation-based LIBOR market model with a square-root volatility process. This model captures downward volatility skews through taking negative correlations between forward...

Single-nucleotide polymorphism-gene intermixed networking reveals co-linkers connected to multiple gene expression phenotypes

Gong, Bin-Sheng, Zhang, Qing-Pu, Zhang, Guang-Mei, Zhang, Shao-Jun, Zhang, Wei, Lv, Hong-Chao, ...

Gene expression profiles and single-nucleotide polymorphism (SNP) profiles are modern data for genetic analysis. It is possible to use the two types of information to analyze the relationships among...

Familial aggregation analysis of gene expressions

Rao, Shao-Qi, Xu, Liang-De, Zhang, Guang-Mei, Li, Xia, Li, Lin, Shen, Gong-Qing, ...

Traditional studies of familial aggregation are aimed at defining the genetic (and non-genetic) causes of a disease from physiological or clinical traits. However, there has been little attempt to...

Clinical Evaluation of NucliSENS Magnetic Extraction and NucliSENS Analyte-Specific Reagents for Real-Time Detection of Human Metapneumovirus in Pediatric Respiratory Specimens▿ †

Ginocchio, Christine C., Manji, Ryhana, Lotlikar, Madhavi, Zhang, Fan

In this study, we evaluated the NucliSENS miniMAG (MM) and easyMAG (EM) nucleic acid extraction platforms (bioMérieux, Durham, NC) in combination with the NucliSENS EasyQ basic kit and...

Mitochondrial DNA Evidence for a Diversified Origin of Workers Building Mausoleum for First Emperor of China

Xu, Zhi, Zhang, Fan, Xu, Bosong, Tan, Jingze, Li, Shilin, Li, Chunxiang, ...

Variant studies on ancient DNA have attempted to reveal individual origin. Here, based on cloning sequencing and polymerase chain reaction-restriction fragment length polymorphisms, we analyzed...

Banning Foie Gras in California

Baker, Gregory A., Zhang, Fan

Sonoma Foie Gras is one of three producers of foie gras in the U.S. and the sole producer in California. The company employs the practice of force-feeding ducks and geese to produce this culinary...

A role for monoubiquitinated FANCD2 at telomeres in ALT cells

Fan, Qiang, Zhang, Fan, Barrett, Briana, Ren, Keqin, Andreassen, Paul R.

Both Fanconi anemia (FA) and telomere dysfunction are associated with chromosome instability and an increased risk of cancer. Because of these similarities, we have investigated whether there is a...

Disrupting Vesicular Trafficking at the Endosome Attenuates Transcriptional Activation by Gcn4▿

Zhang, Fan, Gaur, Naseem A., Hasek, Jiri, Kim, Soon-ja, Qiu, Hongfang, Swanson, Mark J., ...

The late endosome (MVB) plays a key role in coordinating vesicular transport of proteins between the Golgi complex, vacuole/lysosome, and plasma membrane. We found that deleting multiple genes...

Generation of a functional and durable vascular niche by the adenoviral E4ORF1 gene

Seandel, Marco, Butler, Jason M., Kobayashi, Hideki, Hooper, Andrea T., White, Ian A., Zhang, Fan, ...

Vascular cells contribute to organogenesis and tumorigenesis by producing unknown factors. Primary endothelial cells (PECs) provide an instructive platform for identifying factors that support stem...

Liposomal honokiol, a potent anti-angiogenesis agent, in combination with radiotherapy produces a synergistic antitumor efficacy without increasing toxicity

Hu, Jia, Chen, Li-juan, Liu, Li, Chen, Xiang, Chen, Ping, Yang, Guang-li, ...

Honokiol is an active compound purified from magnolia that has been shown to induce cell differentiation, apoptosis, and anti-angiogenesis effects, as well as an enhancement in tumor growth delay in...

Marginal Opportunity Cost Pricing for Wastewater Disposal: A Case Study of Wuxi China

Fan Zhang

Industrialization has given birth to a new environmental problem in both developed and developing countries -- wastewater collection, disposal, and treatment. Inappropriate wastewater disposal is one...

Pricing Wastewater Treatment In China

Fan Zhang

One of the most pressing environmental problems facing Asia's cities is a lack of effective wastewater treatment. In particular, urban areas in China, which have experienced very rapid...

Formation and function of ceramide-enriched membrane platforms with CD38 during M1-receptor stimulation in bovine coronary arterial myocytes

Jia, Su-Jie, Jin, Si, Zhang, Fan, Yi, Fan, Dewey, William L., Li, Pin-Lan

CD38 contains an ADP ribosylcyclase domain that mediates intracellular Ca2+ signaling by the production of cyclic ADP-ribose (cADPR), but the mechanisms by which the agonists activate this enzyme...

VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis

Zhang, Fan, Tang, Zhongshu, Hou, Xu, Lennartsson, Johan, Li, Yang, Koch, Alexander W., ...

VEGF-B, a homolog of VEGF discovered a long time ago, has not been considered an important target in antiangiogenic therapy. Instead, it has received little attention from the field. In this study,...

SubpathwayMiner: a software package for flexible identification of pathways

Li, Chunquan, Li, Xia, Miao, Yingbo, Wang, Qianghu, Jiang, Wei, Xu, Chun, ...

With the development of high-throughput experimental techniques such as microarray, mass spectrometry and large-scale mutagenesis, there is an increasing need to automatically annotate gene sets and...

The Effects of China’s Rural Policies on the Sustainability of Agriculture in China

Justin Yifu Lin, Fan Zhang

Major rural policies in China before the reform include the state-monopolized procurement and marketing system (SMPMS), collectivization and grain self-sufficiency policy. All these three policies...