Fangwen Rao

Adrenergic beta-1 receptor genetic variation predicts longitudinal rate of GFR decline in hypertensive nephrosclerosis (2009)

Fung, Maple M., Chen, Yuqing, Lipkowitz, Michael S., Salem, Rany M., Bhatnagar, Vibha, Mahata, Manjula, ...

Background. End-stage renal disease (ESRD) due to hypertension is common and displays familial aggregation in African Americans, suggesting genetic risk factors, including adrenergic activity...

An ancestral variant of Secretogranin II confers regulation by PHOX2 transcription factors and association with hypertension (2007)

Wen, Gen, Wessel, Jennifer, Zhou, Weidong, Ehret, Georg B., Rao, Fangwen, Stridsberg, Mats, ...

Granins regulate secretory vesicle formation in neuroendocrine cells and granin-derived peptides are co-released with neurotransmitters as modulatory signals at sympathetic sites. We report evidence...

Both Rare and Common Polymorphisms Contribute Functional Variation at CHGA, a Regulator of Catecholamine Physiology

Wen, Gen, Mahata, Sushil K., Cadman, Peter, Mahata, Manjula, Ghosh, Sajalendu, Mahapatra, Nitish R., ...

The chromogranin/secretogranin proteins are costored and coreleased with catecholamines from secretory vesicles in chromaffin cells and noradrenergic neurons. Chromogranin A (CHGA) regulates...

Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk

Zhang, Lian, Rao, Fangwen, Zhang, Kuixing, Khandrika, Srikrishna, Das, Madhusudan, Vaingankar, Sucheta M., ...

GTP cyclohydrolase 1 (GCH1) is rate limiting in the provision of the cofactor tetrahydrobiopterin for biosynthesis of catecholamines and NO. We asked whether common genetic variation at GCH1 alters...

Chromogranin A Polymorphisms Are Associated With Hypertensive Renal Disease

Salem, Rany M., Cadman, Peter E., Chen, Yuqing, Rao, Fangwen, Wen, Gen, Hamilton, Bruce A., ...

Chromogranin A is released together with epinephrine and norepinephrine from catecholaminergic cells. Specific endopeptidases cleave chromogranin A into biologically active peptide fragments,...