developmental control of integrin expression regulates Th2 effector homing (2008)
Lee, Seung-hyo, Prince, Joseph E., Rais, Muhammad, Kheradmand, Farrah, Ballantyne, Christie M., Weitz-Schmidt, Gabriele, ...
Integrin CD18, a component of the LFA-1 complex that also includes CD11a, is essential for Th2, but not Th1, cell homing, but the explanation for this phenomenon remains obscure. In this study, we...
Antielastin autoimmunity in tobacco smoking-induced emphysema (2007)
Lee, Seung-hyo, Goswami, Sangeeta, Grudo, Ariel, Song, Li-zhen, Bandi, Venkata, Goodnight-White, Sheila, ...
Chronic obstructive pulmonary disease and emphysema are common destructive inflammatory diseases that are leading causes of death worldwide. Here we show that emphysema is an autoimmune disease...
Sandra Grumelli, David B. Corry, Li-Zhen Song, Ling Song, Linda Green, Joseph Huh, ...
The underlying changes that cause smoking-related damage are unclear. This paper suggests that there is a skew towards increased T helper 1 lymphocytes, which may drive progression of this damage.
Sandra Grumelli, David B. Corry, Li-Zhen Song, Ling Song, Linda Green, Joseph Huh, ...
Background Chronic obstructive pulmonary disease and emphysema are a frequent result of long-term smoking, but the exact mechanisms, specifically which types of cells are associated with the lung...
Lee, Seung-hyo, Corry, David B, Kiss, Attila, Song, Li-zhen, Song, Ling, Xu, Jie, ...
The mechanisms that initiate allergic lung inflammation are relevant to expression of diseases such as asthma, but the factors underlying resolution of inflammation are equally important. Previously,...
Lee, Seung-hyo, Kiss, Attila, Xu, Jie, Qian, Yuping, Bashoura, Lara, Kheradmand, Farrah, ...
Background Airway obstruction, perhaps the most relevant clinical feature of asthma, is typically assessed in allergic asthma models as airway hyperresponsiveness. Excess secretion of airway...
Yang, Tao, Liang, Dongcai, Koch, Peter J., Hohl, Daniel, Kheradmand, Farrah, Overbeek, Paul A.
Netherton syndrome (NS) is a human autosomal recessive skin disease caused by mutations in the SPINK5 gene, which encodes the putative proteinase inhibitor LEKTI. We have generated a transgenic mouse...
Differential requirement for CD18 in T-helper effector homing (2003)
Lee, Seung-hyo, Prince, Joseph E, Rais, Muhammad, Kheradmand, Farrah, Shardonofsky, Felix, Lu, Huifang, ...
To understand the integrin requirements of T-helper (TH) effector subsets, we investigated the contribution of CD18 (2 integrin) to TH1 and TH2 function in vitro and in relevant disease models....
Typescript.
Yang, Tao, Liang, Dongcai, Koch, Peter J., Hohl, Daniel, Kheradmand, Farrah, Overbeek, Paul A.
Netherton syndrome (NS) is a human autosomal recessive skin disease caused by mutations in the SPINK5 gene, which encodes the putative proteinase inhibitor LEKTI. We have generated a transgenic mouse...
Grumelli, Sandra, Corry, David B, Song, Li-Zhen, Song, Ling, Green, Linda, Huh, Joseph, ...
The underlying changes that cause smoking-related damage are unclear. This paper suggests that there is a skew towards increased T helper 1 lymphocytes, which may drive progression of this damage
Environmental contributions to the allergic asthma epidemic.
Kheradmand, Farrah, Rishi, Kirtee, Corry, David B
Current data overwhelmingly document the existence of a worldwide asthma epidemic, although individual studies remain controversial. The epidemic is thought to involve primarily persons with allergic...
Yang, Tao, Liang, Dongcai, Koch, Peter J., Hohl, Daniel, Kheradmand, Farrah, Overbeek, Paul A.
Netherton syndrome (NS) is a human autosomal recessive skin disease caused by mutations in the SPINK5 gene, which encodes the putative proteinase inhibitor LEKTI. We have generated a transgenic mouse...
Grumelli, Sandra, Corry, David B, Song, Li-Zhen, Song, Ling, Green, Linda, Huh, Joseph, ...
The underlying changes that cause smoking-related damage are unclear. This paper suggests that there is a skew towards increased T helper 1 lymphocytes, which may drive progression of this damage
Environmental contributions to the allergic asthma epidemic.
Kheradmand, Farrah, Rishi, Kirtee, Corry, David B
Current data overwhelmingly document the existence of a worldwide asthma epidemic, although individual studies remain controversial. The epidemic is thought to involve primarily persons with allergic...
Identification of P311 as a Potential Gene Regulating Alveolar Generation
Zhao, Liqing, Leung, James K., Yamamoto, Hiroaki, Goswami, Sangeeta, Kheradmand, Farrah, Vu, Thiennu H.
Smoking-related destructive lung diseases such as chronic obstructive pulmonary disease (COPD) and emphysema are a major cause of morbidity and mortality worldwide. The immediate cause of emphysema...
Toward a Comprehensive Understanding of Allergic Lung Disease
Corry, David B., Kheradmand, Farrah
Allergic asthma is a respiratory disease induced by exposure to environmental agents that elicit allergic inflammation and transient airway obstruction and which produce the characteristic symptoms...