Felix Mitelman

Advances in Brief Power Law Distribution of Chromosome Aberrations in Cancer 1 (2008)

Attila Frigyesi, David Gisselsson, Felix Mitelman, Mattias Höglund

Cancer cells are characterized by having aberrant chromosomes. The number of aberrations and the specific chromosomes affected are correlated with tumor progression. We show that for breast,...

The impact of translocations and gene fusions on cancer causation. (2007)

Mitelman, Felix, Johansson, Bertil, Mertens, Fredrik

Abstract is not available

Statistical behavior of complex cancer karyotypes. (2005)

Höglund, Mattias, Frigyesi, Attila, Säll, Torbjörn, Gisselsson, David, Mitelman, Felix

Abstract is not available

Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity. (2005)

Stewénius, Ylva, Gorunova, Ludmila, Jonson, Tord, Larsson, Nina, Höglund, Mattias, Mandahl, Nils, ...

Abstract is not available

Ewing tumours and synovial sarcomas have critical features of karyotype evolution in common with epithelial tumours. (2005)

Höglund, Mattias, Gisselsson, David, Mandahl, Nils, Mitelman, Felix

Abstract is not available

Prevalence estimates of recurrent balanced cytogenetic aberrations and gene fusions in unselected patients with neoplastic disorders. (2005)

Mitelman, Felix, Mertens, Fredrik, Johansson, Bertil

Abstract is not available

Molecular signatures in childhood acute leukemia and their correlations to expression patterns in normal hematopoietic subpopulations. (2005)

Andersson, Anna, Olofsson, Tor, Lindgren, David, Nilsson, Bjorn, Ritz, Cecilia, Edén, Patrik, ...

Abstract is not available

Dissecting karyotypic patterns in malignant melanomas: Temporal clustering of losses and gains in melanoma karyotypic evolution. (2004)

Höglund, Mattias, Gisselsson, David, Hansen, Gunnar B, White, Valerie A, Säll, Torbjörn, Mitelman, Felix, ...

Abstract is not available

The Breakpoint Region of the Most Common Isochromosome, i(17q), in Human Neoplasia Is Characterized by a Complex Genomic Architecture with Large, Palindromic, Low-Copy Repeats. (2004)

Barbouti, Aikaterini, Stankiewicz, Pawel, Nusbaum, Chad, Cuomo, Christina, Cook, April, Höglund, Mattias, ...

Abstract is not available

Identification of cytogenetic subgroups and karyotypic pathways of clonal evolution in follicular lymphomas. (2004)

Höglund, Mattias, Sehn, Laurie, Connors, Joseph M, Gascoyne, Randy D, Siebert, Reiner, Säll, Torbjörn, ...

Abstract is not available

Wilms tumors develop through two distinct karyotypic pathways. (2004)

Höglund, Mattias, Gisselsson, David, Hansen, Gunnar B, Mitelman, Felix

Abstract is not available

Statistical analyses of karyotypic complexity in head and neck squamous cell carcinoma. (2004)

Höglund, Mattias, Jin, Charlotte, Gisselsson, David, Hansen, Gunnar B, Mitelman, Felix, Mertens, Fredrik

Abstract is not available

Clinical impact of internal tandem duplications and activating point mutations in FLT3 in acute myeloid leukemia in elderly patients. (2004)

Andersson, Anna, Johansson, Bertil, Lassen, Carin, Mitelman, Felix, Billström, Rolf, Fioretos, Thoas

Abstract is not available

Identification of a commonly amplified 4.3 Mb region with overexpression of the C8FW gene, encoding a phosphoprotein regulated by mitogenic pathways, but not of the MYC gene in MYC-containing double minutes in myeloid malignancies. (2004)

Storlazzi, Clelia T., Fioretos, Thoas, Paulsson, Kajsa, Strömbeck, Bodil, Lassen, Carin, Ahlgren, Tomas, ...

Abstract is not available

A model for karyotypic evolution in testicular germ cell tumors. (2004)

Frigyesi, Attila, Gisselsson, David, Hansen, Gunnar B, Soller, Maria, Mitelman, Felix, Höglund, Mattias

Abstract is not available

Dissecting karyotypic patterns in renal cell carcinoma: an analysis of the accumulated cytogenetic data. (2004)

Höglund, Mattias, Gisselsson, David, Soller, Maria, Hansen, Gunnar B, Elfving, Peter, Mitelman, Felix

Abstract is not available

High frequencies of chromosomal aberrations in multiple myeloma and monoclonal gammopathy of undetermined significance in direct chromosome preparation. (2004)

Nilsson, Therese, Lenhoff, Stig, Rylander, Lars, Höglund, Mattias, Turesson, Ingemar, Mitelman, Felix, ...

Abstract is not available

MLL/GRAF fusion in an infant acute monocytic leukemia (AML M5b) with a cytogenetically cryptic ins(5;11)(q31;q23q23). (2004)

Panagopoulos, Ioannis, Kitagawa, Ashly, Isaksson, Margareth, Mörse, Helena, Mitelman, Felix, Johansson, Bertil

Abstract is not available

MDS/AML-associated cytogenetic abnormalities in multiple myeloma and monoclonal gammopathy of undetermined significance: Evidence for frequent de novo occurrence and multipotent stem cell involvement of del(20q). (2004)

Nilsson, Therese, Nilsson, Lars, Lenhoff, Stig, Rylander, Lars, Astrand-Grundström, Ingbritt, Strömbeck, Bodil, ...

Abstract is not available

Statistical dissection of cytogenetic patterns in lung cancer reveals multiple modes of karyotypic evolution independent of histological classification. (2004)

Höglund, Mattias, Gisselsson, David, Hansen, Gunnar B, Mitelman, Felix

Abstract is not available

Formation of der(19)t(1;19)(q23;p13) in acute lymphoblastic leukemia. (2004)

Paulsson, Kajsa, Horvat, Andrea, Fioretos, Thoas, Mitelman, Felix, Johansson, Bertil

Abstract is not available

Clinical and biological importance of cytogenetic abnormalities in childhood and adult acute lymphoblastic leukemia. (2004)

Johansson, Bertil, Mertens, Fredrik, Mitelman, Felix

Abstract is not available

Identification of a commonly amplified 4.3 Mb region with overexpression of the C8FW gene, encoding a phosphoprotein regulated by mitogenic pathways, but not of the MYC gene in MYC-containing double minutes in myeloid malignancies (2004)

Storlazzi, Clelia T., Fioretos, Thoas, Paulsson, Kajsa, Strömbeck, Bodil, Lassen, Carin, Ahlgren, Tomas, ...

Double minutes (dmin), the cytogenetic hallmark of genomic amplification, are found in approximately 1% of karyotypically abnormal acute myeloid leukemias (AML) and myelodysplastic syndromes (MDS)....

Identification of a commonly amplified 4.3 Mb region with overexpression of C8FW, but not MYC in MYC-containing double minutes in myeloid malignancies (2004)

Storlazzi, Clelia T., Fioretos, Thoas, Paulsson, Kajsa, Strömbeck, Bodil, Lassen, Carin, Ahlgren, Tomas, ...

Double minutes (dmin), the cytogenetic hallmark of genomic amplification, are found in ∼1% of karyotypically abnormal acute myeloid leukemias (AML) and myelodysplastic syndromes (MDS). The...

Identification of a commonly amplified 4.3 Mb region with overexpression of the C8FW gene, encoding a phosphoprotein regulated by mitogenic pathways, but not of the MYC gene in MYC-containing double minutes in myeloid malignancies (2004)

Storlazzi, Clelia T., Fioretos, Thoas, Paulsson, Kajsa, Strömbeck, Bodil, Lassen, Carin, Ahlgren, Tomas, ...

Double minutes (dmin), the cytogenetic hallmark of genomic amplification, are found in approximately 1% of karyotypically abnormal acute myeloid leukemias (AML) and myelodysplastic syndromes (MDS)....

Fusion of the NUP98 gene and the homeobox gene HOXC13 in acute myeloid leukemia with t(11;12)(p15;q13). (2003)

Panagopoulos, Ioannis, Isaksson, Margareth, Billström, Rolf, Strömbeck, Bodil, Mitelman, Felix, Johansson, Bertil

Abstract is not available

Genomic characterization of MOZ/CBP and CBP/MOZ chimeras in acute myeloid leukemia suggests the involvement of a damage-repair mechanism in the origin of the t(8;16)(p11;p13). (2003)

Panagopoulos, Ioannis, Isaksson, Margareth, Lindvall, Charlotta, Hagemeijer, Anna, Mitelman, Felix, Johansson, Bertil

Abstract is not available

A Novel Gene, MSI2, Encoding a Putative RNA-binding Protein Is Recurrently Rearranged at Disease Progression of Chronic Myeloid Leukemia and Forms a Fusion Gene with HOXA9 as a Result of the Cryptic t(7;17)(p15;q23). (2003)

Barmpouti, Aikaterini, Höglund, Mattias, Johansson, Bertil, Lassen, Carin, Nilsson, Per-Gunnar, Hagemeijer, Anne, ...

Abstract is not available

A pooled analysis of karyotypic patterns, breakpoints and imbalances in 783 cytogenetically abnormal multiple myelomas reveals frequently involved chromosome segments as well as significant age- and sex-related differences. (2003)

Nilsson, Thérèse, Höglund, Mattias, Lenhoff, Stig, Rylander, Lars, Turesson, Ingemar, Westin, Jan, ...

The cytogenetic features (ploidy, complexity, breakpoints, imbalances) were ascertained in 783 abnormal multiple myeloma (MM) cases to identify frequently involved chromosomal regions as well as a...

The formation of trisomies and their parental origin in hyperdiploid childhood acute lymphoblastic leukemia. (2003)

Paulsson, Kajsa, Panagopoulos, Ioannis, Knuutila, Sakari, Jee, Kowan J, Garwicz, Stanislaw, Fioretos, Thoas, ...

Abstract is not available

Clinical and genetic studies of ETV6/ABL1-positive chronic myeloid leukaemia in blast crisis treated with imatinib mesylate. (2003)

Barbouti, Aikaterini, Ahlgren, Tomas, Johansson, Bertil, Höglund, Mattias, Lassen, Carin, Turesson, Ingemar, ...

Most chronic myeloid leukaemia (CML) patients are genetically characterized by the t(9;22)(q34;q11), generating the BCR/ABL1 fusion gene. However, a few CML patients with rearrangements of 9q34 and...

Ovarian Carcinoma Develops through Multiple Modes of Chromosomal Evolution. (2003)

Höglund, Mattias, Gisselsson, David, Hansen, Gunnar B, Säll, Torbjörn, Mitelman, Felix

Abstract is not available

Cytogenetic and morphologic subgroups of myelodysplastic syndromes in relation to occupational and hobby exposures. (2003)

Albin, Maria, Björk, Jonas, Welinder, Hans, Tinnerberg, Håkan, Mauritzson, Nils, Billström, Rolf, ...

OBJECTIVES: This study investigated the association between occupational and hobby exposure and the risk of myelodysplastic syndromes (MDS) while focusing on differential patterns of clonal...

Formation of trisomies and their parental origin in hyperdiploid childhood acute lymphoblastic leukemia. (2003)

Paulsson, Kajsa, Panagopoulos, Ioannis, Knuutila, Sakari, Jee, Kowan Ja, Garwicz, Stanislaw, Fioretos, Thoas, ...

Abstract is not available

Power law distribution of chromosome aberrations in cancer. (2003)

Frigyesi, Attila, Gisselsson, David, Mitelman, Felix, Höglund, Mattias

Abstract is not available

Prognostically important chromosomal aberrations in soft tissue sarcomas: a report of the Chromosomes and Morphology (CHAMP) Study Group (2002)

Strömberg, Ulf, Mandahl, Nils, Fletcher, Christopher D M, ...

Cytogenetic analysis has not only provided important information on the pathogenesis of soft tissue tumors but, by disclosing distinct chromosomal rearrangements in different histopathological...

Correlation between clinicopathological features and karyotype in 100 cartilaginous and chordoid tumours. A report from the Chromosomes and Morphology (CHAMP) Collaborative Study Group (2002)

Dorfman, Howard, Brys, Peter, Fletcher, Christopher D M, ...

The evaluation of chondroid lesions requires full integration of clinical, radiographic, and pathological data; tumour typing is often a challenge for the diagnostic pathologist. Although a variety...

Cytogenetic and molecular genetic evolution of chronic myeloid leukemia. (2002)

Johansson, Bertil, Fioretos, Thoas, Mitelman, Felix

Chronic myeloid leukemia (CML) is genetically characterized by the presence of the reciprocal translocation t(9;22)(q34;q11), resulting in a BCR/ABL gene fusion on the derivative chromosome 22 called...

Multivariate analysis of chromosomal imbalances in breast cancer delineates cytogenetic pathways and reveals complex relationships among imbalances. (2002)

Höglund, Mattias, Gisselsson, David, Hansen, Gunnar B, Säll, Torbjörn, Mitelman, Felix

More than 550 breast adenocarcinomas with clonal chromosomal abnormalities have been reported. Although the aberration pattern is clearly nonrandom, no specific primary or secondary karyotypic...

Expression of NUP98/TOP1, but not of TOP1/NUP98, in a treatment-related myelodysplastic syndrome with t(10;20;11)(q24;q11;p15). (2002)

Panagopoulos, Ioannis, Fioretos, Thoas, Isaksson, Margareth, Larsson, Gun, Billström, Rolf, Mitelman, Felix, ...

The t(11;20)(p15;q11) is a rare but recurrent translocation that so far has been described in only four acute myeloid leukemias (AMLs), two treatment-related myelodysplastic syndromes (t-MDSs), and...

Prognostically important chromosomal aberrations in soft tissue sarcomas: a report of the Chromosomes and Morphology (CHAMP) Study Group. (2002)

Mertens, Fredrik, Strömberg, Ulf, Mandahl, Nils, Cin, Paola Dal, De Wever, Ivo, Fletcher, Christopher D M, ...

Cytogenetic analysis has not only provided important information on the pathogenesis of soft tissue tumors but, by disclosing distinct chromosomal rearrangements in different histopathological...

Coping with complexity. multivariate analysis of tumor karyotypes. (2002)

Höglund, Mattias, Gisselsson, David, Säll, Torbjörn, Mitelman, Felix

Human cancers are characterized by chromosomal aberrations, and an increasing number of specific balanced rearrangements have been found among malignant hematologic disorders. Most solid tumors,...

Multicolor COBRA-FISH analysis of chronic myeloid leukemia reveals novel cryptic balanced translocations during disease progression. (2002)

Barbouti, Aikaterini, Johansson, Bertil, Höglund, Mattias, Mauritzson, Nils, Strömbeck, Bodil, Nilsson, Per-Gunnar, ...

During the initial indolent chronic phase of chronic myeloid leukemia (CML), the t(9;22)(q34;q11), resulting in the Philadelphia chromosome (Ph), is usually the sole cytogenetic anomaly, but as the...

Dissecting karyotypic patterns in colorectal tumors: two distinct but overlapping pathways in the adenoma-carcinoma transition. (2002)

Höglund, Mattias, Gisselsson, David, Hansen, Gunnar B, Säll, Torbjörn, Mitelman, Felix, Nilbert, Mef

More than 500 colorectal tumors with clonal chromosomal abnormalities have been reported. Although the pattern of aberrations is nonrandom, no specific primary or secondary karyotypic abnormality has...

RT-PCR analysis of acute myeloid leukemia with t(8;16)(p11;p13): Identification of a novel MOZ/CBP transcript and absence of CBP/MOZ expression. (2002)

Panagopoulos, Ioannis, Fioretos, Thoas, Isaksson, Margareth, Mitelman, Felix, Johansson, Bertil, Theorin, Niklas, ...

Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13) (2001)

Panagopoulos, Ioannis, Fioretos, Thoas, Isaksson, Margareth, Samuelsson, Ulf, Billström, Rolf, Strömbeck, Bodil, ...

The CBP gene at 16p13 fuses to MOZ and MLL as a result of the t(8;16)(p11;p13) in acute (myelo)monocytic leukemias (AML M4/M5) and the t(11;16)(q23;p13) in treatment-related AML, respectively. We...

Cytogenetic, clinical, and morphologic correlations in 78 cases of fibromatosis: a report from the CHAMP Study Group (2000)

Fletcher, Christopher D. M, Mandahl, Nils, Mertens, Fredrik, Mitelman, Felix, ...

Afdeling Oncologische heelkunde. Departement Menselijke erfelijkheid.

The chromosomes of rous rat sarcomas / (1972)

Mitelman, Felix.

Proefschrift Lund.

Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity

Gisselsson, David, Pettersson, Louise, Höglund, Mattias, Heidenblad, Markus, Gorunova, Ludmila, Wiegant, Joop, ...

It has long been known that rearrangements of chromosomes through breakage-fusion-bridge (BFB) cycles may cause variability of phenotypic and genetic traits within a cell population. Because...

Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors

Gisselsson, David, Jonson, Tord, Petersén, Åsa, Strömbeck, Bodil, Dal Cin, Paola, Höglund, Mattias, ...

Although mechanisms for chromosomal instability in tumors have been described in animal and in vitro models, little is known about these processes in man. To explore cytogenetic evolution in human...

Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity

Stewénius, Ylva, Gorunova, Ludmila, Jonson, Tord, Larsson, Nina, Höglund, Mattias, Mandahl, Nils, ...

Telomere dysfunction has been associated with chromosomal instability in colorectal carcinoma, but the consequences of telomere-dependent instability for chromosome integrity and clonal evolution...

Molecular signatures in childhood acute leukemia and their correlations to expression patterns in normal hematopoietic subpopulations

Andersson, Anna, Olofsson, Tor, Lindgren, David, Nilsson, Björn, Ritz, Cecilia, Edén, Patrik, ...

Global expression profiles of a consecutive series of 121 childhood acute leukemias (87 B lineage acute lymphoblastic leukemias, 11 T cell acute lymphoblastic leukemias, and 23 acute myeloid...

Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity

Gisselsson, David, Pettersson, Louise, Höglund, Mattias, Heidenblad, Markus, Gorunova, Ludmila, Wiegant, Joop, ...

It has long been known that rearrangements of chromosomes through breakage-fusion-bridge (BFB) cycles may cause variability of phenotypic and genetic traits within a cell population. Because...

Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors

Gisselsson, David, Jonson, Tord, Petersén, Åsa, Strömbeck, Bodil, Dal Cin, Paola, Höglund, Mattias, ...

Although mechanisms for chromosomal instability in tumors have been described in animal and in vitro models, little is known about these processes in man. To explore cytogenetic evolution in human...

Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity

Stewénius, Ylva, Gorunova, Ludmila, Jonson, Tord, Larsson, Nina, Höglund, Mattias, Mandahl, Nils, ...

Telomere dysfunction has been associated with chromosomal instability in colorectal carcinoma, but the consequences of telomere-dependent instability for chromosome integrity and clonal evolution...

The Breakpoint Region of the Most Common Isochromosome, i(17q), in Human Neoplasia Is Characterized by a Complex Genomic Architecture with Large, Palindromic, Low-Copy Repeats

Barbouti, Aikaterini, Stankiewicz, Pawel, Nusbaum, Chad, Cuomo, Christina, Cook, April, Höglund, Mattias, ...

Although a great deal of information has accumulated regarding the mechanisms underlying constitutional DNA rearrangements associated with inherited disorders, virtually nothing is known about the...

Molecular signatures in childhood acute leukemia and their correlations to expression patterns in normal hematopoietic subpopulations

Andersson, Anna, Olofsson, Tor, Lindgren, David, Nilsson, Björn, Ritz, Cecilia, Edén, Patrik, ...

Global expression profiles of a consecutive series of 121 childhood acute leukemias (87 B lineage acute lymphoblastic leukemias, 11 T cell acute lymphoblastic leukemias, and 23 acute myeloid...

Correlation between Clinicopathological Features and Karyotype in Spindle Cell Sarcomas : A Report of 130 Cases from the CHAMP Study Group

Fletcher, Christopher D. M., Dal Cin, Paola, De Wever, Ivo, Mandahl, Nils, Mertens, Fredrik, Mitelman, Felix, ...

Soft-tissue tumors have proved to be a fruitful area for the identification of reproducible cytogenetic aberrations, especially among pediatric round-cell sarcomas and lipomatous tumors. Thus far,...