Gu, Fang, Qi, Fengxia, Anderson, Maxwell H., Shi, Wenyuan
The aim of this study was to compare a recently developed monoclonal antibody (MAb)-based salivary Streptococcus mutans detection method with various selective media using polymerase chain reaction...
Qi, Fengxia, Chen, Ping, Caufield, Page W.
The lantibiotic bacteriocin mutacin II is produced by the group II Streptococcus mutans. The mutacin II biosynthetic locus consists of seven genes, mutR, -A, -M, -T, -F, -E, and -G, organized as two...
Chen, Ping, Qi, FengXia, Novak, Jan, Caufield, Page W.
Mutacin II is a ribosomally synthesized peptide lantibiotic produced by group II Streptococcus mutans. DNA sequencing has revealed that the mutacin II biosynthetic gene cluster consists of seven...
Qi, Fengxia, Chen, Ping, Caufield, Page W.
Previously, we reported isolation and characterization of mutacin III and genetic analysis of mutacin III biosynthesis genes from the group III strain of Streptococcus mutans, UA787 (F. Qi, P. Chen,...
Qi, Fengxia, Chen, Ping, Caufield, Page W.
Strains of Streptococcus mutans produce at least three mutacins, I, II, and III. Mutacin II is a member of subgroup AII in the lantibiotic family of bacteriocins, and mutacins I and III belong to...
Qi, Fengxia, Chen, Ping, Caufield, Page W.
Previously, members of our group reported the isolation and characterization of mutacin II from Streptococcus mutans T8 and the genetic analyses of the mutacin II biosynthesis genes (J. Novak, P. W....
Chen, Ping, Novak, Jan, Kirk, Marion, Barnes, Stephen, Qi, FengXia, Caufield, Page W.
Mutacin II, elaborated by group II Streptococcus mutans, is a ribosomally synthesized and posttranslationally modified polypeptide antibiotic containing unusual thioether and didehydro amino acids....
Chen, Ping, Novak, Jan, Qi, Fengxia, Caufield, Page W.
Genetic characterization of a Tn916 transposon mutant, Streptococcus mutans T8-1, defective in mutacin II production, revealed that the transposon was inserted into the 3′ region of a...
Mutation of luxS Affects Biofilm Formation in Streptococcus mutans
Merritt, Justin, Qi, Fengxia, Goodman, Steven D., Anderson, Maxwell H., Shi, Wenyuan
Quorum sensing is a bacterial mechanism for regulating gene expression in response to changes in population density. Many bacteria are capable of acyl-homoserine lactone-based or peptide-based...
Identification of Streptococcus sanguinis with a PCR-Generated Species-Specific DNA Probe
Li, Yihong, Pan, Yaping, Qi, Fengxia, Caufield, Page W.
The objective of the present study was to design a PCR-generated DNA probe and determine the specificity of the probe for the identification of clinical isolates of Streptococcus sanguinis. To do...
Qi, Fengxia, Merritt, Justin, Lux, Renate, Shi, Wenyuan
Many clinical isolates of Streptococcus mutans produce peptide antibiotics called mutacins. Mutacin production may play an important role in the ecology of S. mutans in dental plaque. In this study,...
Kreth, Jens, Merritt, Justin, Shi, Wenyuan, Qi, Fengxia
It is important to ensure DNA availability when bacterial cells develop competence. Previous studies in Streptococcus pneumoniae demonstrated that the competence-stimulating peptide (CSP) induced...
Kreth, Jens, Merritt, Justin, Shi, Wenyuan, Qi, Fengxia
The human mucosal surface is colonized by the indigenous microflora, which normally maintains an ecological balance among different species. Certain environmental or biological factors, however, may...
Eckert, Randal, Qi, Fengxia, Yarbrough, Daniel K., He, Jian, Anderson, Maxwell H., Shi, Wenyuan
Currently available antimicrobials exhibit broad killing with regard to bacterial genera and species. Indiscriminate killing of microbes by these conventional antibiotics can disrupt the ecological...
Qi, Fengxia, Chen, Ping, Caufield, Page W.
The lantibiotic bacteriocin mutacin II is produced by the group II Streptococcus mutans. The mutacin II biosynthetic locus consists of seven genes, mutR, -A, -M, -T, -F, -E, and -G, organized as two...
Chen, Ping, Qi, FengXia, Novak, Jan, Caufield, Page W.
Mutacin II is a ribosomally synthesized peptide lantibiotic produced by group II Streptococcus mutans. DNA sequencing has revealed that the mutacin II biosynthetic gene cluster consists of seven...
Qi, Fengxia, Chen, Ping, Caufield, Page W.
Previously, we reported isolation and characterization of mutacin III and genetic analysis of mutacin III biosynthesis genes from the group III strain of Streptococcus mutans, UA787 (F. Qi, P. Chen,...
Qi, Fengxia, Chen, Ping, Caufield, Page W.
Strains of Streptococcus mutans produce at least three mutacins, I, II, and III. Mutacin II is a member of subgroup AII in the lantibiotic family of bacteriocins, and mutacins I and III belong to...
Qi, Fengxia, Chen, Ping, Caufield, Page W.
Previously, members of our group reported the isolation and characterization of mutacin II from Streptococcus mutans T8 and the genetic analyses of the mutacin II biosynthesis genes (J. Novak, P. W....
Chen, Ping, Novak, Jan, Kirk, Marion, Barnes, Stephen, Qi, FengXia, Caufield, Page W.
Mutacin II, elaborated by group II Streptococcus mutans, is a ribosomally synthesized and posttranslationally modified polypeptide antibiotic containing unusual thioether and didehydro amino acids....
Chen, Ping, Novak, Jan, Qi, Fengxia, Caufield, Page W.
Genetic characterization of a Tn916 transposon mutant, Streptococcus mutans T8-1, defective in mutacin II production, revealed that the transposon was inserted into the 3′ region of a...
Mutation of luxS Affects Biofilm Formation in Streptococcus mutans
Merritt, Justin, Qi, Fengxia, Goodman, Steven D., Anderson, Maxwell H., Shi, Wenyuan
Quorum sensing is a bacterial mechanism for regulating gene expression in response to changes in population density. Many bacteria are capable of acyl-homoserine lactone-based or peptide-based...
Identification of Streptococcus sanguinis with a PCR-Generated Species-Specific DNA Probe
Li, Yihong, Pan, Yaping, Qi, Fengxia, Caufield, Page W.
The objective of the present study was to design a PCR-generated DNA probe and determine the specificity of the probe for the identification of clinical isolates of Streptococcus sanguinis. To do...
Qi, Fengxia, Merritt, Justin, Lux, Renate, Shi, Wenyuan
Many clinical isolates of Streptococcus mutans produce peptide antibiotics called mutacins. Mutacin production may play an important role in the ecology of S. mutans in dental plaque. In this study,...
Kreth, Jens, Merritt, Justin, Shi, Wenyuan, Qi, Fengxia
The human mucosal surface is colonized by the indigenous microflora, which normally maintains an ecological balance among different species. Certain environmental or biological factors, however, may...
Eckert, Randal, Qi, Fengxia, Yarbrough, Daniel K., He, Jian, Anderson, Maxwell H., Shi, Wenyuan
Currently available antimicrobials exhibit broad killing with regard to bacterial genera and species. Indiscriminate killing of microbes by these conventional antibiotics can disrupt the ecological...
Targeted Killing of Streptococcus mutans by a Pheromone-Guided “Smart” Antimicrobial Peptide
Eckert, Randal , He, Jian, Yarbrough, Daniel K., Qi, Fengxia, Anderson, Maxwell H., Shi, Wenyuan
Within the repertoire of antibiotics available to a prescribing clinician, the majority affect a broad range of microorganisms, including the normal flora. The ecological disruption resulting from...
Eckert, Randal, Brady, Keith M., Greenberg, E. Peter, Qi, Fengxia, Yarbrough, Daniel K., He, Jian, ...
Pseudomonas aeruginosa is a common opportunistic human pathogen that is associated with life-threatening acute infections and chronic airway colonization during cystic fibrosis. Previously, we...
Novel Synthetic Antimicrobial Peptides against Streptococcus mutans▿
He, Jian, Eckert, Randal, Pharm, Thanh, Simanian, Maurice D., Hu, Chuhong, Yarbrough, Daniel K., ...
Streptococcus mutans, a common oral pathogen and the causative agent of dental caries, has persisted and even thrived on the tooth surface despite constant removal and eradication efforts. In this...
Tong, Huichun, Chen, Wei, Shi, Wenyuan, Qi, Fengxia, Dong, Xiuzhu
We previously demonstrated that Streptococcus oligofermentans suppressed the growth of Streptococcus mutans, the primary cariogenic pathogen, by producing hydrogen peroxide (H2O2) through lactate...