Molecular characterization of EGFR, PDGFRA and VEGFR2 in cervical adenosquamous carcinoma (2009)
Longatto-Filho, Adhemar, Pinheiro, Céline, Martinho, Olga, Moreira, Marise AR, Ribeiro, Luiz FJ, Queiroz, Geraldo S, ...
Abstract Background Adenosquamous carcinoma of the uterine cervix is an infrequent but aggressive subtype of cervical cancer. A better understanding of its biological behaviour is warranted to define...
Significance of osteopontin expression in human invasive breast tumour stroma (2009)
Rodrigues, L. R., Lopes, Nair, Sousa, Bárbara, Vieira, Daniella, Milanezi, Fernanda, Paulsson, Marie, ...
Osteopontin has been reported to stimulate cell adhesion, migration and specific signalling functions. Its overexpression has been found in melanoma, breast, lung, colorectal, stomach and ovarian...
Lactoferrin and cancer disease prevention (2009)
Rodrigues, L. R., Teixeira, J. A., Schmitt, Fernando C., Paulsson, Marie, Lindmark-Mässon, Helena
Lactoferrin (LF) is an iron-binding glycoprotein that is composed of the transferrin family and is predominantly found in the products of the exocrine glands located in the gateways of the digestive,...
Pinheiro, C., Longatto Filho, Adhemar, Ferreira, Luísa, Pereira, Sónia Maria Miranda, Etlinger, Daniela, Moreira, M. A. R., ...
Solid tumor cells are known to be highly glycolytic and, to prevent apoptosis by cellular acidosis, cells increase proton efflux through pH regulators, such as monocarboxylate transporters (MCTs)....
Lymphangiogenesis : from the pig embryos to cancer (2008)
Longatto Filho, Adhemar, Schmitt, Fernando C., Duarte, Maria
The discovery and the comprehension of lymphatic vessels suffered several historical delays and setbacks. The inherent anatomical problems slowed down the precise identification of the lymphatic...
Demystifying molecular techniques in cytopathology practice (2008)
Schmitt, Fernando C., Longatto Filho, Adhemar, Valent, Alexander, Vielh, Philippe
The last decade was stimulating with the introduction of new molecular techniques to be applied in pathology laboratories. Accordingly, cytology was also benefited with the innovations emerged from...
How useful is the assessment of lymphatic vascular density in oral carcinoma prognosis? (2007)
Longatto Filho, Adhemar, Oliveira, Tiago, Pinheiro, Céline, De Carvalho, Marcos, Curioni, Otávio, Mercante, Ana, ...
Abstract Background Lymphatic vessels are major routes for metastasis in head and neck squamous cell carcinoma (HNSCC), but lymphatic endothelial cells (LECs) are difficult to recognize in tumor...
How useful is the assessment of lymphatic vascular density in oral carcinoma prognosis? (2007)
Longatto Filho, Adhemar, Oliveira, Tiago Gil, Pinheiro, C., Carvalho, Marcos Brasilino, Curioni, Otávio Alberto, ...
Background: Lymphatic vessels are major routes for metastasis in head and neck squamous cell carcinoma (HNSCC), but lymphatic endothelial cells (LECs) are difficult to recognize in tumor histological...
Angiogenesis, haemostasis and cancer: new paradigms and old concerns (2007)
Duarte,Maria, Longatto Filho,Adhemar, Schmitt,Fernando C.
Neovascularization is a crucial phenomenon for the continuous growing of neoplastic cells and cancer progression. The growth of new blood vessels from pre-existing vessels (angiogenesis) occurs in...
Expression of frutalin in Pichia pastoris and evaluation of its potential as a cancer marker (2007)
Duarte, M. L., Felix, W., Moreira, R. A., Teixeira, J. A., Schmitt, Fernando C., ...
P-cadherin expression in breast cancer: a review (2007)
Paredes, Joana, Correia, Ana, Ribeiro, Ana, Albergaria, André, Milanezi, Fernanda, Schmitt, Fernando C
Abstract P-cadherin is frequently over-expressed in high-grade invasive breast carcinomas and has been reported to be an enhancer of migration and invasion of breast cancer cells, being correlated...
The role of osteopontin in tumour progression and metastasis in breast cancer (2007)
Rodrigues, L. R., Teixeira, J. A., Schmitt, Fernando C., Paulsson, Marie, Lindmark-Mässon, Helena
The use of cancer biomarkers to anticipate the outlines of disease has been an emerging issue, especially as cancer treatment has made such positive steps in the last few years. Progress in the...
EGFR amplification and lack of activating mutations in metaplastic breast carcinomas (2006)
Reis Filho, Jorge S., Pinheiro, C., Lambros, M. B. K., Milanezi, Fernanda, Carvalho, S., Savage, K., ...
Metaplastic breast carcinomas are reported to harbour epidermal growth factor receptor (EGFR) overexpression in up to 80% of the cases, but EGFR gene amplification is the underlying genetic mechanism...
Metaplastic breast carcinomas are basal-like tumours (2006)
Reis Filho, Jorge S., Milanezi, Fernanda, Steele, D., Savage, K., Simpson, Pete T., Nesland, J. M., ...
Recently, an immunohistochemical panel comprising antibodies against HER2, estrogen receptor (ER), epidermal growth factor receptor (EGFR) and cytokeratin (CK) 5 ⁄ 6 was reported to identify...
Botelho,Carlos Henrique A., Magalhães,Albino Verçosa De, Mello,Paulo Andrade De, Schmitt,Fernando C., Casulari,Luiz Augusto
The subcellular events implicated on the formation and behavior of pituitary adenomas are not fully understood. In this study we investigated the presence of p53, Ki-67 and c-erb B2 in 38 pituitary...
Moreira, M. A. R., Longatto Filho, Adhemar, Taromaru, Eliane, Queiroz, Geraldo Silva, Jubé, L. F., Pinto, S. A., ...
Hybrid capture is an easy and highly sensitive technique for screening population due to its capacity to detect malignant and premalignant lesions of the cervix. To evaluate its ensitivity, we...
Lambros, Maryou B. K., Simpson, Peter T., Jones, Chris, Natrajan, Rachael, Westbury, Charlotte, Steele, Dawn, ...
Chromogenic (CISH) and fluorescent ( FISH) in situ hybridization have emerged as reliable techniques to identify amplifications and chromosomal translocations. CISH provides a spatial distribution of...
Lambros, Maryou B. K., Simpson, Peter T., Jones, Chris, Natrajan, Rachael, Westbury, Charlotte, Steele, Dawn, ...
Chromogenic (CISH) and fluorescent ( FISH) in situ hybridization have emerged as reliable techniques to identify amplifications and chromosomal translocations. CISH provides a spatial distribution of...
Reis-Filho, Jorge S, Milanezi, Fernanda, Carvalho, Silvia, Simpson, Pete T, Steele, Dawn, Savage, Kay, ...
Abstract Introduction Metaplastic breast carcinomas constitute a heterogeneous group of neoplasms, accounting for less than 1% of all invasive mammary carcinomas. Approximately 70–80% of...
Infection with Mycobacterium ulcerans induces persistent inflammatory responses in mice (2005)
Oliveira, Martinha S., Fraga, Alexandra G., Torrado, Egídio, Castro, António G., Pereira, João P., Longatto Filho, Adhemar, ...
Buruli ulcer (BU) is a devastating, necrotizing, tropical skin disease caused by infections with Mycobacterium ulcerans. In contrast to other mycobacterioses, BU has been associated with minimal or...
Molecular characterization of PDGFR-α/PDGF-A and c-KIT/SCF in gliosarcomas (2005)
Reis, R. M., Martins, Albino, Ribeiro, Susana A., Basto, Diana, Longatto Filho, Adhemar, Schmitt, Fernando C., ...
Gliosarcomas are rare and poorly characterized malignant brain tumors that exhibit a biphasic tissue pattern with areas of gliomatous and sarcomatous differentiation. These tumors are histological...
Carvalho, Inês, Milanezi, Fernanda, Martins, Albino, Reis, R. M., Schmitt, Fernando C.
Introduction Receptor tyrosine kinases have been extensively studied owing to their frequently abnormal activation in the development and progression of human cancers. Plateletderived growth factor...
Paredes, Joana, Albergaria, André, Oliveira, João T., Jerónimo, Carmen, Milanezi, Fernanda, Schmitt, Fernando C.
Purpose: P-cadherin overexpressionhas been reported in breast carcinomas,where itwas associated with proliferative high-grade histological tumors. This study aimed to analyze P-cadherin expression in...
Longatto Filho, Adhemar, Albergaria, André, Paredes, Joana, Moreira, M. A. R., Milanezi, Fernanda, Schmitt, Fernando C.
Objective: To study P-cadherin aberrant expression as a possible marker for cervical adenocarcinomas in cytological samples. Methods: We studied P-cadherin immunoexpression in liquid-based cervical...
Desmoplastic small round cell tumour : cytological and immunocytochemical features (2005)
Granja, Nara M., Begnami, Maria D., Bortolan, Jeni, Longatto Filho, Adhemar, Schmitt, Fernando C.
Background: Desmoplastic small round cell tumor (DSRCT) is a rare and highly aggressive neoplasm. The cytological diagnosis of these tumors can be difficult because they show morphological features...
Desmoplastic small round cell tumour: Cytological and immunocytochemical features (2005)
Granja, Nara M, Begnami, Maria D, Bortolan, Jeni, Filho, Adhemar, Schmitt, Fernando C
Abstract Background Desmoplastic small round cell tumor (DSRCT) is a rare and highly aggressive neoplasm. The cytological diagnosis of these tumors can be difficult because they show morphological...
VEGFR-3 expression in breast cancer tissue is not restricted to lymphatic vessels (2005)
Longatto Filho, Adhemar, Martins, Albino, Schmitt, Fernando C.
We examined the immunohistochemical reactivity for vascular endothelial growth factor receptor 3 (VEGFR-3), a protein playing an important role in lymphangiogenesis, in breast cancer. A retrospective...
Pathologic quiz case : a 62-year-old woman with a 4.5-cm nodule in the rigth breast (2003)
Reis Filho, Jorge S., Fulford, Laura G., Lakhani, Sunil R., Schmitt, Fernando C.
World Pathology Foundations - Gordon Signy Foreign Fellowship.
Schmitt, Fernando C, Reis-Filho, Jorge S
Abstract The predictive and prognostic implication of oncogene amplification in breast cancer has received great attention in the past two decades. her -2/ neu and c- myc are two oncogenes that are...
Schmitt, Fernando C., Reis Filho, Jorge S.
The predictive and prognostic implication of oncogene amplification in breast cancer has received great attention in the past two decades. her-2/neu and c-myc are two oncogenes that are frequently...
Novel and classic myoepithelial/stem cell markers in metaplastic carcinomas of the breast (2003)
Reis Filho, Jorge S., Milanezi, Fernanda, Paredes, Joana, Silva, Paula, Pereira, Emílio M., Maeda, Sueli A., ...
Metaplastic carcinomas of the breast (MCBs) are unusual neoplasms characterized by an admixture of glandular epithelial components, which frequently exhibit features of squamous differentiation, and...
Reis Filho, Jorge S., Milanezi, Fernanda, Amendoeira, Isabel, Albergaria, André, Schmitt, Fernando C.
BACKGROUND. The presence of myoepithelial cells (MECs) in fine-needle aspiration biopsies (FNAB) of the breast constitute an important criterion used to diagnose benign breast lesions. However, MECs...
Reis Filho, Jorge S., Simpson, Pete T., Martins, Albino, Gartner, Fátima, Schmitt, Fernando C.
p63, cytokeratin (CK) 5/6 and CK 14 have been employed in diagnostic pathology as markers of basal, squamous and myoepithelial differentiation in several types of human neoplasms; however, there is...
Lipoma-like hibernoma: an atypical lipoma/well-differentiated liposarcoma mimicker (2002)
Reis-Filho,Jorge S., Cruz,João, Valbueva,Carmen Ruiz De, Schmitt,Fernando C.
Hibernomas are benign lipomatous tumors which show differentiation toward brown fat. Recently, unusual variants have been described, including myxoid, spindle cell, and lipoma-like variants....
Naked nuclei revisited : p63 immunoexpression (2002)
Reis Filho, Jorge S., Albergaria, André, Milanezi, Fernanda, Amendoeira, Isabel, Schmitt, Fernando C.
The presence of naked nuclei (NN) in cytological preparations of fibroadenomas is a well-known finding. Regardless of their importance on the differential diagnosis of fibroadenoma and other benign...
p63 expression in normal skin and usual cutaneous carcinomas (2002)
Reis Filho, Jorge S., Torlo, Beatriz, Albergaria, André, Schmitt, Fernando C.
Background: p63 is a p53 homologue that is mapped to chromosome 3q27. This gene encodes six different isoforms, which have either transactivating or dominant negative effects on p53-reporter genes....
Invasive medullary thymoma associated with myasthenia gravis: an unusual case (2000)
REIS FILHO,JORGE S., MILANEZI,MARIA FERNANDA, MOREIRA,CHRISTIANO G., WERNECK,LINEU C., BOSCARDIN,PAULO, IOSHII,SERGIO OSSAMU, ...
Thymomas are tumors characterized by a remarkable morphological heterogeneity and variable clinical behavior. This tumor has unique clinical associations, most notably with hematological...
Schmitt, Fernando C, Reis-Filho, Jorge S
The predictive and prognostic implication of oncogene amplification in breast cancer has received great attention in the past two decades. her-2/neu and c-myc are two oncogenes that are frequently...
Desmoplastic small round cell tumour: Cytological and immunocytochemical features
Granja, Nara M, Begnami, Maria D, Bortolan, Jeni, Filho, Adhemar Longatto, Schmitt, Fernando C
Infection with Mycobacterium ulcerans Induces Persistent Inflammatory Responses in Mice
Oliveira, Martinha S., Fraga, Alexandra G., Torrado, Egídio, Castro, António G., Pereira, João P., Filho, Adhemar Longatto, ...
Buruli ulcer (BU) is a devastating, necrotizing, tropical skin disease caused by infections with Mycobacterium ulcerans. In contrast to other mycobacterioses, BU has been associated with minimal or...
Reis-Filho, Jorge S, Milanezi, Fernanda, Carvalho, Silvia, Simpson, Pete T, Steele, Dawn, Savage, Kay, ...
Schmitt, Fernando C, Reis-Filho, Jorge S
The predictive and prognostic implication of oncogene amplification in breast cancer has received great attention in the past two decades. her-2/neu and c-myc are two oncogenes that are frequently...
Desmoplastic small round cell tumour: Cytological and immunocytochemical features
Granja, Nara M, Begnami, Maria D, Bortolan, Jeni, Filho, Adhemar Longatto, Schmitt, Fernando C
Infection with Mycobacterium ulcerans Induces Persistent Inflammatory Responses in Mice
Oliveira, Martinha S., Fraga, Alexandra G., Torrado, Egídio, Castro, António G., Pereira, João P., Filho, Adhemar Longatto, ...
Buruli ulcer (BU) is a devastating, necrotizing, tropical skin disease caused by infections with Mycobacterium ulcerans. In contrast to other mycobacterioses, BU has been associated with minimal or...
Reis-Filho, Jorge S, Milanezi, Fernanda, Carvalho, Silvia, Simpson, Pete T, Steele, Dawn, Savage, Kay, ...
Immunohistochemical expression and distribution of VEGFR-3 in malignant mesothelioma
Filho, Adhemar Longatto, Baltazar, FÁtima, Bedrossian, Carlos, Michael, Claire, Schmitt, Fernando C.
Homogeneity of mesothelial and lymphatic endothelial cells, express some markers that are presumed to be exclusive of the endothelium was recently reported. This similarity is important to improve...
How useful is the assessment of lymphatic vascular density in oral carcinoma prognosis?
Longatto Filho, Adhemar, Oliveira, Tiago Gil, Pinheiro, Céline, De Carvalho, Marcos Brasilino, Curioni, Otávio Alberto, ...
P-cadherin expression in breast cancer: a review
Paredes, Joana, Correia, Ana Luísa, Ribeiro, Ana Sofia, Albergaria, André, Milanezi, Fernanda, Schmitt, Fernando C
P-cadherin is frequently over-expressed in high-grade invasive breast carcinomas and has been reported to be an enhancer of migration and invasion of breast cancer cells, being correlated with tumour...
Molecular characterization of EGFR, PDGFRA and VEGFR2 in cervical adenosquamous carcinoma
Longatto-Filho, Adhemar, Pinheiro, Céline, Martinho, Olga, Moreira, Marise AR, Ribeiro, Luiz FJ, Queiroz, Geraldo S, ...