Fernando P. Polack

Successful DNA immunization against measles: neutralizing antibody against either the hemagglutinin or fusion glycoprotein protects rhesus macaques without evidence of atypical measles (2000)

Polack, Fernando P., Lee, Sok H., Permar, Sallie R., Manyara, Elizabeth, Nousari, Hossein G., Jeng, Yaikah, ...

Measles remains a principal cause of worldwide mortality, in part because young infants cannot be immunized effectively. Development of new vaccines has been hindered by previous experience with a...

Role of CD8+ Lymphocytes in Control and Clearance of Measles Virus Infection of Rhesus Monkeys

Permar, Sallie R., Klumpp, Sherry A., Mansfield, Keith G., Kim, Woong-Ki, Gorgone, Darci A., Lifton, Michelle A., ...

The creation of an improved vaccine for global measles control will require an understanding of the immune mechanisms of measles virus containment. To assess the role of CD8+ cytotoxic T lymphocytes...

The cysteine-rich region of respiratory syncytial virus attachment protein inhibits innate immunity elicited by the virus and endotoxin

Polack, Fernando P., Irusta, Pablo M., Hoffman, Scott J., Schiatti, M. Paula, Melendi, Guillermina A., Delgado, M. Florencia, ...

The attachment protein (glycoprotein) of respiratory syncytial virus (RSV) has long been associated with disease potentiation and respiratory symptoms. The glycoprotein has a conserved cysteine-rich...

Modulation of disease, T cell responses, and measles virus clearance in monkeys vaccinated with H-encoding alphavirus replicon particles

Pan, Chien-Hsiung, Valsamakis, Alexandra, Colella, Teresa, Nair, Nitya, Adams, Robert J., Polack, Fernando P., ...

Measles remains a major worldwide problem partly because of difficulties with vaccination of young infants. New vaccine strategies need to be safe and to provide sustained protective immunity. We...

The Cysteine-Rich Region and Secreted Form of the Attachment G Glycoprotein of Respiratory Syncytial Virus Enhance the Cytotoxic T-Lymphocyte Response despite Lacking Major Histocompatibility Complex Class I-Restricted Epitopes

Bukreyev, Alexander, Serra, Maria Elina, Laham, Federico R., Melendi, Guillermina A., Kleeberger, Steven R., Collins, Peter L., ...

The cytotoxic T-lymphocyte (CTL) response is important for the control of viral replication during respiratory syncytial virus (RSV) infection. The attachment glycoprotein (G) of RSV does not encode...

Role of CD8+ Lymphocytes in Control and Clearance of Measles Virus Infection of Rhesus Monkeys

Permar, Sallie R., Klumpp, Sherry A., Mansfield, Keith G., Kim, Woong-Ki, Gorgone, Darci A., Lifton, Michelle A., ...

The creation of an improved vaccine for global measles control will require an understanding of the immune mechanisms of measles virus containment. To assess the role of CD8+ cytotoxic T lymphocytes...

The cysteine-rich region of respiratory syncytial virus attachment protein inhibits innate immunity elicited by the virus and endotoxin

Polack, Fernando P., Irusta, Pablo M., Hoffman, Scott J., Schiatti, M. Paula, Melendi, Guillermina A., Delgado, M. Florencia, ...

The attachment protein (glycoprotein) of respiratory syncytial virus (RSV) has long been associated with disease potentiation and respiratory symptoms. The glycoprotein has a conserved cysteine-rich...

Modulation of disease, T cell responses, and measles virus clearance in monkeys vaccinated with H-encoding alphavirus replicon particles

Pan, Chien-Hsiung, Valsamakis, Alexandra, Colella, Teresa, Nair, Nitya, Adams, Robert J., Polack, Fernando P., ...

Measles remains a major worldwide problem partly because of difficulties with vaccination of young infants. New vaccine strategies need to be safe and to provide sustained protective immunity. We...

The Cysteine-Rich Region and Secreted Form of the Attachment G Glycoprotein of Respiratory Syncytial Virus Enhance the Cytotoxic T-Lymphocyte Response despite Lacking Major Histocompatibility Complex Class I-Restricted Epitopes

Bukreyev, Alexander, Serra, Maria Elina, Laham, Federico R., Melendi, Guillermina A., Kleeberger, Steven R., Collins, Peter L., ...

The cytotoxic T-lymphocyte (CTL) response is important for the control of viral replication during respiratory syncytial virus (RSV) infection. The attachment glycoprotein (G) of RSV does not encode...

C5 Modulates Airway Hyperreactivity and Pulmonary Eosinophilia during Enhanced Respiratory Syncytial Virus Disease by Decreasing C3a Receptor Expression▿

Melendi, Guillermina A., Hoffman, Scott J., Karron, Ruth A., Irusta, Pablo M., Laham, Federico R., Humbles, Alison, ...

Enhanced respiratory syncytial virus disease, a serious pulmonary disorder that affected recipients of an inactivated vaccine against respiratory syncytial virus in the 1960s, has delayed the...

Mapping and Characterization of the Primary and Anamnestic H-2d-Restricted Cytotoxic T-Lymphocyte Response in Mice against Human Metapneumovirus▿

Melendi, Guillermina A., Zavala, Fidel, Buchholz, Ursula J., Boivin, Guy, Collins, Peter L., Kleeberger, Steven R., ...

Cytotoxic T lymphocytes (CTLs) are important for the control of virus replication during respiratory infections. For human metapneumovirus (hMPV), an H-2d-restricted CTL epitope in the M2-2 protein...

A Role for Immune Complexes in Enhanced Respiratory Syncytial Virus Disease

Polack, Fernando P., Teng, Michael N., L.Collins, Peter, Prince, Gregory A., Exner, Marcus, Regele, Heinz, ...

Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and viral pneumonia in infants and young children. Administration of a formalin inactivated vaccine against RSV to children in...

Dose-Dependent Protection against or Exacerbation of Disease by a Polylactide Glycolide Microparticle-Adsorbed, Alphavirus-Based Measles Virus DNA Vaccine in Rhesus Macaques▿

Pan, Chien-Hsiung, Nair, Nitya, Adams, Robert J., Zink, M. Christine, Lee, Eun-Young, Polack, Fernando P., ...

Measles remains an important cause of vaccine-preventable child mortality. Development of a low-cost, heat-stable vaccine for infants under the age of 6 months could improve measles control by...

Use of Vaxfectin Adjuvant with DNA Vaccine Encoding the Measles Virus Hemagglutinin and Fusion Proteins Protects Juvenile and Infant Rhesus Macaques against Measles Virus▿

Pan, Chien-Hsiung, Jimenez, Gretchen S., Nair, Nitya, Wei, Qun, Adams, Robert J., Polack, Fernando P., ...

A measles virus vaccine for infants under 6 months of age would help control measles. DNA vaccines hold promise, but none has provided full protection from challenge. Codon-optimized plasmid DNAs...