Anti-proliferative action of vitamin D in MCF7 is still active after siRNA-VDR knock-down (2009)
Costa, José L, Eijk, Paul P, Van De Wiel, Mark A, Ten Berge, Derk, Schmitt, Fernando, Narvaez, Carmen J, ...
Abstract Background The active form of Vitamin D, 1,25-dihydroxyvitamin D 3 (1,25D), has strong anti-proliferative effects, yet the molecular mechanisms underneath this effect remain unclear. In...
A comparative study of recombinant and native frutalin binding to human prostate tissues (2009)
Oliveira, Carla, Teixeira, José A, Schmitt, Fernando, Domingues, Lucília
Abstract Background Numerous studies indicate that cancer cells present an aberrant glycosylation pattern that can be detected by lectin histochemistry. Lectins have shown the ability to recognise...
Albergaria, André, Paredes, Joana, Sousa, Bárbara, Milanezi, Fernanda, Carneiro, Vítor, Bastos, Joana, ...
Abstract Introduction The expression of additional genes, other than oestrogen receptor (ER), may be important to the hormone-responsive phenotype of breast cancer. Microarray analyses have revealed...
Velho, Sérgia, Moutinho, Cátia, Cirnes, Luís, Albuquerque, Cristina, Hamelin, Richard, Schmitt, Fernando, ...
Abstract Background BRAF , KRAS and PIK3CA mutations are frequently found in sporadic colorectal cancer (CRC). In contrast to KRAS and PIK3CA mutations, BRAF mutations are associated with tumours...
Costa, Sandra, Pinto, Daniela, Pereira, Deolinda, Rodrigues, Helena, Cameselle-Teijeiro, Jorge, Medeiros, Rui, ...
Abstract Background TP53 is one of major tumour suppressor genes being essential in preservation of genome integrity. Two very common polymorphisms have been demonstrated to contribute to cancer...
Martins, Patrícia, Schmitt, Fernando, Almeida, Henrique, Frazão, João M.
Background. Secondary hyperparathyroidism (SHPT) is a common complication of chronic kidney disease. Increased parathyroid hormone (PTH) synthesis and secretion is associated with parathyroid cell...
Tissue microarrays for testing basal biomarkers in familial breast cancer cases (2007)
Dufloth,Rozany Mucha, Matos,Irina, Schmitt,Fernando, Zeferino,Luiz Carlos
CONTEXT AND OBJECTIVE: The proteins p63, p-cadherin and CK5 are consistently expressed by the basal and myoepithelial cells of the breast, although their expression in sporadic and familial breast...
Ferreira,Jane Eyre Alves, Mello,Paulo Andrade De, Magalhães,Albino Verçosa De, Botelho,Carlos Henrique Aguiar, Naves,Luciana Ansaneli, Nosé,Vania, ...
Adenomas clinicamente não-funcionantes de hipófise, não produzem clínica de hipersecreção hormonal. Por esse motivo, seus sinais e sintomas dependem de seu efeito de massa no sistema nervoso...
Carvalho, Inês, Milanezi, Fernanda, Martins, Albino, Reis, Rui M, Schmitt, Fernando
Abstract Introduction Receptor tyrosine kinases have been extensively studied owing to their frequently abnormal activation in the development and progression of human cancers. Platelet-derived...
Dufloth,Rozany Mucha, Carvalho,Sílvia, Heinrich,Juliana Karina, Shinzato,Júlia Yoriko, Santos,César Cabello Dos, Zeferino,Luiz Carlos, ...
CONTEXT AND OBJECTIVE: BRCA1 and BRCA2 are the two principal hereditary breast cancer susceptibility genes, and the prevalence of their mutations among Brazilian women is unknown. The objective was...
Costa, Sandra, Pinto, Daniela, Pereira, Deolinda, Rodrigues, Helena, Cameselle-Teijeiro, Jorge, Medeiros, Rui, ...
Velho, Sérgia, Moutinho, Cátia, Cirnes, Luís, Albuquerque, Cristina, Hamelin, Richard, Schmitt, Fernando, ...
Albergaria, André, Paredes, Joana, Sousa, Bárbara, Milanezi, Fernanda, Carneiro, Vítor, Bastos, Joana, ...