Filippo Castiglione

Immune control of HIV-1 infection after therapy interruption: immediate versus deferred antiretroviral therapy (2009)

Paci, Paola, Carello, Rossella, Bernaschi, Massimo, D'Offizi, Gianpiero, Castiglione, Filippo

Abstract Background The optimal stage for initiating antiretroviral therapies in HIV-1 bearing patients is still a matter of debate. Methods We present computer simulations of HIV-1 infection aimed...

ImmunoGrid, an integrative environment for large-scale simulation of the immune system for vaccine discovery, design and optimization (2009)

Pappalardo, Francesco, Halling-Brown, Mark D., Rapin, Nicolas, Zhang, Ping, Alemani, Davide, Emerson, Andrew, ...

Vaccine research is a combinatorial science requiring computational analysis of vaccine components, formulations and optimization. We have developed a framework that combines computational tools for...

Implementation of a regulatory gene network to simulate the TH1/2 differentiation in an agent-based model of hypersensitivity reactions (2008)

Santoni, Daniele, Pedicini, Marco, Castiglione, Filippo

Motivation: An unbalanced differentiation of T helper cells from precursor type TH0 to the TH1 or TH2 phenotype in immune responses often leads to a pathological condition. In general, immune...

World Scientific Publishing Company DIFFUSION AND AGGREGATION IN AN AGENT BASED MODEL OF STOCK MARKET FLUCTUATIONS (2007)

Filippo Castiglione

We describe a new model to simulate the dynamic interactions between market price and the decisions of two di#erent kind of traders. They possess spatial mobility allowing to group together to form...

Simulating Epstein-Barr virus infection with C-ImmSim (2007)

Castiglione, Filippo, Duca, Karen, Jarrah, Abdul, Laubenbacher, Reinhard, Hochberg, Donna, Thorley-Lawson, David

Motivation: Epstein-Barr virus (EBV) infects greater than 90% of humans benignly for life but can be associated with tumors. It is a uniquely human pathogen that is amenable to quantitative analysis;...

ProtNet: a tool for stochastic simulations of protein interaction networks dynamics (2007)

Bernaschi, Massimo, Castiglione, Filippo, Ferranti, Alessandra, Gavrila, Caius, Tinti, Michele, Cesareni, Gianni

Abstract Background Protein interactions support cell organization and mediate its response to any specific stimulus. Recent technological advances have produced large data-sets that aim at...

Modelling vaccination schedules for a cancer immunoprevention vaccine (2005)

Motta, Santo, Castiglione, Filippo, Lollini, Pierluigi, Pappalardo, Francesco

Abstract We present a systematic approach to search for an effective vaccination schedule using mathematical computerized models. Our study is based on our previous model that simulates the cancer vs...

Microsimulation of Complex System Dynamics: Automata Models in Biology and Finance (2001)

Castiglione, Filippo

The main question addressed in this dissertation is how to derive ``the collective'' (i.e. macroscopic) properties of a system starting from the knowledge of the laws ruling the individual (i.e....

Forecasting price increments using an artificial Neural Network (2000)

Castiglione, Filippo

Financial forecasting is a difficult task due to the intrinsic complexity of the financial system. In the present paper we relate our experience using neural nets as financial time series forecast...

Diffusion and Aggregation in an Agent Based Model of Stock Market Fluctuations (2000)

Castiglione, Filippo

We describe a new model to simulate the dynamic interactions between market price and the decisions of two different kind of traders. They possess spatial mobility allowing to group together to form...

Forecasting price increments using an artificial Neural Network (2000)

Filippo Castiglione

. Financial forecasting is a difficult task due to the intrinsic complexity of the financial system. A simplified approach in forecasting is given by "black box" methods like neural...

Estimating the Keratoconus Index from ultrasound images of the human cornea (1999)

Filippo Castiglione, Francesco Castiglione

The keratoconus index (KI) is a valuable measure to make diagnosis of the keratoconus in human eyes. Using images from an ultrasound biomicroscope, we show a method to automatically compute the KI...

Modelling vaccination schedules for a cancer immunoprevention vaccine

Motta, Santo, Castiglione, Filippo, Lollini, Pierluigi, Pappalardo, Francesco

We present a systematic approach to search for an effective vaccination schedule using mathematical computerized models. Our study is based on our previous model that simulates the cancer vs immune...

Modelling vaccination schedules for a cancer immunoprevention vaccine

Motta, Santo, Castiglione, Filippo, Lollini, Pierluigi, Pappalardo, Francesco

We present a systematic approach to search for an effective vaccination schedule using mathematical computerized models. Our study is based on our previous model that simulates the cancer vs immune...

FORECASTING PRICE INCREMENTS USING AN ARTIFICIAL NEURAL NETWORK

FILIPPO CASTIGLIONE

Financial forecasting is a difficult task due to the intrinsic complexity of the financial system. A simplified approach in forecasting is given by "black box" methods like neural networks that...

A Model of Ischemia-Induced Neuroblast Activation in the Adult Subventricular Zone

Vergni, Davide, Castiglione, Filippo, Briani, Maya, Middei, Silvia, Alberdi, Elena, Reymann, Klaus G., ...

We have developed a rat brain organotypic culture model, in which tissue slices contain cortex-subventricular zone-striatum regions, to model neuroblast activity in response to in vitro ischemia....

Diffusion and Aggregation in an Agent Based Model of Stock Market Fluctuations

Filippo Castiglione

We describe a new model to simulate the dynamic interactions between market price and the decisions of two different kind of traders. They possess spatial mobility allowing to group together to form...