RECENT ATTENTION HAS BEEN FOCUSED ON Signal transduction (2008)
Kinji Fuchikami, Hiroko Togame, Atsuko Sagara, Tomoko Satoh, Florian Gantner, ...
The family of phosphoinositide 3-kinases (PI3K) regulates fundamental cellular responses such as proliferation, apoptosis, motility, and adhesion. In particular, the PI3K � isoform plays a critical...
Hermann, Corinna, Aulock, Sonja Von, Dehus, Oliver, Keller, Moritz, Okigami, Hiromi, Gantner, Florian, ...
To investigate the circadian rhythm of inducible cytokine release and a potential pacemaker role of endogenous cortisol, cortisol levels as well as cytokine release from ex vivo LPS-stimulated blood...
Takeshita, Keisuke, Yamasaki, Tsugiko, Akira, Shizuo, Gantner, Florian, Bacon, Kevin B.
Contact hypersensitivity (CHS) induced by a hapten is thought to be mediated by T helper type 1 (Th1) cells. However, FITC can induce contact allergy in vivo, and in vitro studies suggest that this...
CRTH2 is a prominent effector in contact hypersensitivity-induced neutrophil inflammation (2004)
Takeshita, Keisuke, Yamasaki, Tsugiko, Nagao, Koichi, Sugimoto, Hiromi, Shichijo, Michitaka, Gantner, Florian, ...
Chemoattractant receptor‐homologous molecule expressed on Th2 lymphocytes, CRTH2, is a cognate receptor for prostaglandin (PG) D2 and, in humans, is suggested to play a functional role in...
Phagocytosis of Nonapoptotic Cells Dying by Caspase-Independent Mechanisms (2000)
Hirt, Ulrich, Gantner, Florian, Leist, Marcel
Caspase activation, exposure of phosphatidylserine (PS) on the outer surface of the plasma membrane, and rapid phagocytic removal of dying cells are key features of apoptosis. Nonapoptotic/necrotic...
Cytokine-Mediated Hepatic Apoptosis (1998)
Leist, Marcel, Gantner, Florian, Künstle, Gerald, Wendel, Albrecht
Thirty years ago liver pathology defined apoptosis as a novel mode of cell death. Recently, experimental models of liver injury have been made available for examining the signaling molecules and...
Tumor necrosis factor-induced apoptosis during the poisoning of mice with hepatotoxins (1997)
Leist, Marcel, Gantner, Florian, Naumann, Heike, Bluethmann, Horst, Vogt, Kathrin, Brigelius-Flohe, Regina, ...
BACKGROUND & AIMS: Treatment with tumor necrosis factor (TNF) induces murine hepatocyte apoptosis in vitro and in vivo when sensitizing concentrations of toxins are present. The aim of this study was...
DNA Fragmentation In Mouse Organs during Endotoxic Shock (1996)
Bohlinger, Ines, Leist, Marcel, Gantner, Florian, Angermüller, Sabine, Tiegs, Gisa, Wendel, Albrecht
The systemic inflammatory response syndrome has still an unpredictable outcome, and patients often die of multiple organ failure despite circulatory stabilization therapy. The still incompletely...
Gantner, Florian, Leist, Marcel, Küsters, Sabine, Vogt, Katrin, Volk, Hans-Dieter, Tiegs, Gisa
Polyclonal T cell stimulation in humans leads to a cytokine burst syndrome that may result in organ failure or lethality. Mechanisms of such cytokine-dependent morbidity can be studied in mice...
Leist, Marcel, Gantner, Florian, Künstle, Gerald, Bohlinger, Ines, Tiegs, Gisa, Bluethmann, Horst, ...
BACKGROUND: Activation of either the 55-kD tumor necrosis factor receptor (TNF-R1) or CD95 (Fas/Apo-1) causes apoptosis of cells and liver failure in mice, and has been associated with human liver...
Gantner, Florian, Leist, Marcel, Lohse, Ansgar Wilhelm, Germann, Paul Georg, Tiegs, Gisa
Concanavalin A activates T lymphocytes in vitro and causes T-cell-dependent hepatic injury in mice. T lymphocytes were previously identified as effector cells of concanavalin A-induced liver injury....
Leist, Marcel, Gantner, Florian, Bohlinger, Ines, Tiegs, Gisa, Germann, Paul Georg, Wendel, Albrecht
We investigated the role of hepatocyte apoptosis in four different murine models of acute inflammatory liver failure. Liver damage induced in D-galactosamine-sensitized mice by endotoxin infection...
Leist, Marcel, Gantner, Florian, Jilg, Sabine, Wendel, Albrecht
The systemic inflammatory response is characterized by release of circulating TNF which may cause multiorgan failure including septic liver failure. We studied TNF signaling in an appropriate in...
T cell-dependent inflammatory liver injury in mice / (1994)
Konstanz, Univ., Diss., 1994.
Leist, Marcel, Gantner, Florian, Bohlinger, Ines, Germann, Paul G., Tiegs, Gisa, Wendel, Albrecht
Freshly isolated mouse hepatocytes were essentially insensitive to TNF- alpha cytotoxicity. However, TNF-alpha induced a concentration- dependent cell death in hepatocytes that had been pretreated...
Hentze, Hannes, Gantner, Florian, Kolb, Stefan A., Wendel, Albrecht
The activation of the death receptors, tumor necrosis factor-receptor-1 (TNF-R1) or CD95, is a hallmark of inflammatory or viral liver disease. In different murine in vivo models, we found that...
Gantner, Florian, Kupferschmidt, Rochus, Schudt, Christian, Wendel, Albrecht, Hatzelmann, Armin
During in vitro culture in 10% human AB serum, human peripheral blood monocytes acquire a macrophage-like phenotype. The underlying differentiation was characterized by increased activities of the...
Gantner, Florian, Götz, Christine, Gekeler, Volker, Schudt, Christian, Wendel, Albrecht, Hatzelmann, Armin
CD19+ B lymphocytes were purified from the peripheral blood of normal and atopic subjects to analyse and compare the phosphodiesterase (PDE) activity profile, PDE mRNA expression and the importance...
Ziegelbauer, Karl, Gantner, Florian, Lukacs, Nicholas W, Berlin, Aaron, Fuchikami, Kinji, Niki, Toshiro, ...
Pulmonary inflammatory diseases such as asthma are characterized by chronic, cell-mediated inflammation of the bronchial mucosa.Recruitment and activation of inflammatory cells is orchestrated by a...