Interleukin-18: a therapeutic target in rheumatoid arthritis? (2004)
McInnes, Iain B, Liew, Foo Y, Gracie, J Alastair
Abstract Interleukin 18 (IL-18), a member of the IL-1 superfamily of cytokines has been demonstrated to be an important mediator of both innate and adaptive immune responses. Several reports have...
Khan, Imtiaz A., Moretto, Magali, Wei, Xiao-Qing, Williams, Martha, Schwartzman, Joseph D., Liew, Foo Y.
Khan, Imtiaz A., Moretto, Magali, Wei, Xiao-Qing, Williams, Martha, Schwartzman, Joseph D., Liew, Foo Y.
Sweet, Matthew J., Campbell, Carol C., Sester, David P., Xu, Damo, McDonald, Rebecca C., Stacey, Katryn J., ...
During bacterial infections, the balance between resolution of infection and development of sepsis is dependent upon the macrophage response to bacterial products. We show that priming of murine bone...
Sweet, Matthew J., Campbell, Carol C., Sester, David P., Xu, Damo, McDonald, Rebecca C., Stacey, Katryn J., ...
During bacterial infections, the balance between resolution of infection and development of sepsis is dependent upon the macrophage response to bacterial products. We show that priming of murine bone...
Hume, David A, Underhill, David M, Sweet, Matthew J, Ozinsky, Adrian O, Liew, Foo Y, Aderem, Alan
Abstract Background Macrophages sense microorganisms through activation of members of the Toll-like receptor family, which initiate signals linked to transcription of many inflammation associated...
Cell-cell interactions in synovitis: Interactions between T lymphocytes and synovial cells (2000)
McInnes, Iain B, Leung, Bernard P, Liew, Foo Y
Abstract Mechanisms whereby T lymphocytes contribute to synovial inflammation in rheumatoid arthritis are poorly understood. Here we review data that indicate an important role for cell contact...
CD4+ but not CD8+T cells are required for the induction of oral tolerance (1995)
Garside, Paul, Steel, Margaret, Liew, Foo Y., Mowat, Allan Mcl., Askonas, B. A.
It has been suggested that oral tolerance is mediated by CD8+ T lymphocytes, but the functional properties of these cells are unclear. Here we show that the induction of tolerance by feeding...
The role of inducible nitric oxide synthase in the host response to Coxsackievirus myocarditis
Zaragoza, Carlos, Ocampo, Christopher, Saura, Marta, Leppo, Michelle, Wei, Xiao-Qing, Quick, Richard, ...
The host response to Coxsackievirus infection is complex, including T lymphocytes, B lymphocytes, natural killer cells, and macrophages. Although Coxsackievirus infection induces expression of...
Impaired liver regeneration in inducible nitric oxide synthasedeficient mice
Rai, Rudra M., Lee, Fung Yee J., Rosen, Anthony, Yang, Shi Qi, Lin, Hui Zhi, Koteish, Ayman, ...
The mechanisms that permit adult tissues to regenerate when injured are not well understood. Initiation of liver regeneration requires the injury-related cytokines, tumor necrosis factor (TNF) α and...
Cell-cell interactions in synovitis: Interactions between T lymphocytes and synovial cells
McInnes, Iain B, Leung, Bernard P, Liew, Foo Y
Mechanisms whereby T lymphocytes contribute to synovial inflammation in rheumatoid arthritis are poorly understood. Here we review data that indicate an important role for cell contact between...
Niedbala, Wanda, Wei, Xiao-qing, Campbell, Carol, Thomson, Duncan, Komai-Koma, Mousa, Liew, Foo Y.
Nitric oxide plays an important role in immune regulation. We have shown that although high concentrations of NO generally were immune-suppressive, low concentrations of NO selectively enhanced the...
Shinozaki, Michiya, Hirahashi, Junichi, Lebedeva, Tatiana, Liew, Foo Y., Salant, David J., Maron, Ruth, ...
IL-15, a T cell growth factor, has been linked to exacerbating autoimmune diseases and allograft rejection. To test the hypothesis that IL-15–deficient (IL-15–/–) mice would be protected from T...
TLR2 is expressed on activated T cells as a costimulatory receptor
Komai-Koma, Mousa, Jones, Louise, Ogg, Graham S., Xu, Damo, Liew, Foo Y.
Toll is the founder of a group of pattern recognition receptors that play a critical role in the innate immunity in Drosophila. At least 10 distinct Toll-like receptors (TLRs), recognizing...
A proinflammatory role for IL-18 in rheumatoid arthritis
Gracie, J. Alastair, Forsey, Rosalyn J., Chan, Woon Ling, Gilmour, Ashley, Leung, Bernard P., Greer, Morag R., ...
IL-18 is a novel cytokine with pleiotropic activities critical to the development of T-helper 1 (Th1) responses. We detected IL-18 mRNA and protein within rheumatoid arthritis (RA) synovial tissues...
Interleukin-18: a therapeutic target in rheumatoid arthritis?
McInnes, Iain B, Liew, Foo Y, Gracie, J Alastair
Interleukin 18 (IL-18), a member of the IL-1 superfamily of cytokines has been demonstrated to be an important mediator of both innate and adaptive immune responses. Several reports have implicated...
Regulation of phagosomal iron release from murine macrophages by nitric oxide.
Mulero, Victoriano, Wei, Xiao-qing, Liew, Foo Y, Brock, Jeremy H
The role of NO in macrophage iron turnover was studied in macrophages from inducible nitric oxide synthase (iNOS)-deficient mice. Interferon gamma/lipopolysaccharide (IFNgamma/LPS)-activated bone...
Toll-like receptor 2 signaling modulates the functions of CD4+CD25+ regulatory T cells
Liu, Haiying, Komai-Koma, Mousa, Xu, Damo, Liew, Foo Y.
Toll-like receptors (TLRs) are primary sensors of both innate and adaptive immune systems and play a pivotal role in response against structurally conserved components of pathogens. Synthetic...
Verri, Waldiceu A., Cunha, Thiago M., Parada, Carlos A., Wei, Xiao-qing, Ferreira, Sérgio Henrique, Liew, Foo Y., ...
IL-15 is closely associated with inflammatory diseases. IL-15 targeting is effective in treating experimental and clinical rheumatoid arthritis (RA). Because hyperalgesia accompanies RA, we...
The role of inducible nitric oxide synthase in the host response to Coxsackievirus myocarditis
Zaragoza, Carlos, Ocampo, Christopher, Saura, Marta, Leppo, Michelle, Wei, Xiao-Qing, Quick, Richard, ...
The host response to Coxsackievirus infection is complex, including T lymphocytes, B lymphocytes, natural killer cells, and macrophages. Although Coxsackievirus infection induces expression of...
Impaired liver regeneration in inducible nitric oxide synthasedeficient mice
Rai, Rudra M., Lee, Fung Yee J., Rosen, Anthony, Yang, Shi Qi, Lin, Hui Zhi, Koteish, Ayman, ...
The mechanisms that permit adult tissues to regenerate when injured are not well understood. Initiation of liver regeneration requires the injury-related cytokines, tumor necrosis factor (TNF) α and...
Cell-cell interactions in synovitis: Interactions between T lymphocytes and synovial cells
McInnes, Iain B, Leung, Bernard P, Liew, Foo Y
Mechanisms whereby T lymphocytes contribute to synovial inflammation in rheumatoid arthritis are poorly understood. Here we review data that indicate an important role for cell contact between...
Niedbala, Wanda, Wei, Xiao-qing, Campbell, Carol, Thomson, Duncan, Komai-Koma, Mousa, Liew, Foo Y.
Nitric oxide plays an important role in immune regulation. We have shown that although high concentrations of NO generally were immune-suppressive, low concentrations of NO selectively enhanced the...
Shinozaki, Michiya, Hirahashi, Junichi, Lebedeva, Tatiana, Liew, Foo Y., Salant, David J., Maron, Ruth, ...
IL-15, a T cell growth factor, has been linked to exacerbating autoimmune diseases and allograft rejection. To test the hypothesis that IL-15–deficient (IL-15–/–) mice would be protected from T...
TLR2 is expressed on activated T cells as a costimulatory receptor
Komai-Koma, Mousa, Jones, Louise, Ogg, Graham S., Xu, Damo, Liew, Foo Y.
Toll is the founder of a group of pattern recognition receptors that play a critical role in the innate immunity in Drosophila. At least 10 distinct Toll-like receptors (TLRs), recognizing...
A proinflammatory role for IL-18 in rheumatoid arthritis
Gracie, J. Alastair, Forsey, Rosalyn J., Chan, Woon Ling, Gilmour, Ashley, Leung, Bernard P., Greer, Morag R., ...
IL-18 is a novel cytokine with pleiotropic activities critical to the development of T-helper 1 (Th1) responses. We detected IL-18 mRNA and protein within rheumatoid arthritis (RA) synovial tissues...
Interleukin-18: a therapeutic target in rheumatoid arthritis?
McInnes, Iain B, Liew, Foo Y, Gracie, J Alastair
Interleukin 18 (IL-18), a member of the IL-1 superfamily of cytokines has been demonstrated to be an important mediator of both innate and adaptive immune responses. Several reports have implicated...
Regulation of phagosomal iron release from murine macrophages by nitric oxide.
Mulero, Victoriano, Wei, Xiao-qing, Liew, Foo Y, Brock, Jeremy H
The role of NO in macrophage iron turnover was studied in macrophages from inducible nitric oxide synthase (iNOS)-deficient mice. Interferon gamma/lipopolysaccharide (IFNgamma/LPS)-activated bone...
Toll-like receptor 2 signaling modulates the functions of CD4+CD25+ regulatory T cells
Liu, Haiying, Komai-Koma, Mousa, Xu, Damo, Liew, Foo Y.
Toll-like receptors (TLRs) are primary sensors of both innate and adaptive immune systems and play a pivotal role in response against structurally conserved components of pathogens. Synthetic...
Goodridge, Helen S, Marshall, Fraser A, Wilson, Emma H, Houston, Katrina M, Liew, Foo Y, Harnett, Margaret M, ...
We have previously shown in an in vitro study that the filarial nematode phosphorylcholine (PC)-containing glycoprotein ES-62 promotes a murine dendritic cell (DC) phenotype that induces T helper...
Goodridge, Helen S, Harnett, William, Liew, Foo Y, Harnett, Margaret M
Bioactive interleukin (IL)-12 is a 70 000-molecular weight (MW) heterodimeric cytokine comprising p40 and p35 chains. However, p40 can also form homodimers that antagonize bioactive IL-12 or...
Immunology in the new millennium: building on tradition
Kemeny, Mike, Gordon, John, Hayday, Adrian, Hogg, Nancy, Liew, Foo Y, Peakman, Mark, ...
Niedbala, Wanda, Cai, Beilei, Liu, Haiying, Pitman, Nick, Chang, Lynda, Liew, Foo Y.
The principal aim of the immune system is to establish a balance between defense against pathogens and avoidance of autoimmune disease. This balance is achieved partly through regulatory T cells...
Khan, Imtiaz A., Moretto, Magali, Wei, Xiao-qing, Williams, Martha, Schwartzman, Joseph D., Liew, Foo Y.
Interferon (IFN)-γ–producing CD8+ T cells are important for the successful resolution of the obligate intracellular parasite Toxoplasma gondii by preventing the reactivation or controlling a...
Selective Expression of a Stable Cell Surface Molecule on Type 2 but Not Type 1 Helper T Cells
Xu, Damo, Chan, Woon Ling, Leung, Bernard P., Huang, Fang-ping, Wheeler, Rachel, Piedrafita, David, ...
T helper cell type 1 (Th1) and 2 (Th2) are central to immune regulation. However, no stable cell surface marker capable of distinguishing and separating these two subsets of CD4+ cells has yet been...
Xu, Damo, Chan, Woon Ling, Leung, Bernard P., Hunter, David, Schulz, Kerstin, Carter, Robert W., ...
Interleukin (IL)-18 induces interferon (IFN)-γ synthesis and synergizes with IL-12 in T helper type 1 (Th1) but not Th2 cell development. We report here that IL-18 receptor (IL-18R) is selectively...
IL-33 reduces the development of atherosclerosis
Miller, Ashley M., Xu, Damo, Asquith, Darren L., Denby, Laura, Li, Yubin, Sattar, Naveed, ...
Atherosclerosis is a chronic inflammatory disease of the vasculature commonly leading to myocardial infarction and stroke. We show that IL-33, which is a novel IL-1–like cytokine that signals via...
IL-33 mediates antigen-induced cutaneous and articular hypernociception in mice
Verri, Waldiceu A., Guerrero, Ana T. G., Fukada, Sandra Y., Valerio, Daniel A., Cunha, Thiago M., Xu, Damo, ...
IL-33, a new member of the IL-1 family, signals through its receptor ST2 and induces T helper 2 (Th2) cytokine synthesis and mediates inflammatory response. We have investigated the role of IL-33 in...
IL-33 exacerbates antigen-induced arthritis by activating mast cells
Xu, Damo, Jiang, Hui-Rong, Kewin, Peter, Li, Yubin, Mu, Rong, Fraser, Alasdair R., ...
IL-33, a cytokine of the IL-1 family, is closely associated with type II T cell responses. Here, we report an unexpected proinflammatory role of IL-33 in inflammatory arthritis. IL-33 was expressed...
Lemos, Henrique P., Grespan, Renata, Vieira, Silvio M., Cunha, Thiago M., Verri, Waldiceu A., Fernandes, Karla S. S., ...
IL-23/IL-17-induced neutrophil recruitment plays a pivotal role in rheumatoid arthritis (RA). However, the mechanism of the neutrophil recruitment is obscure. Here we report that prostaglandin...