Guo, Zhuyan, Dose, Marei, Kovalovsky, Damian, Chang, Rui, O'Neil, Jennifer Elinor, Look, A. Thomas, ...
Activation of beta-catenin has been causatively linked to the etiology of colon cancer. Conditional stabilization of this molecule in pro-T cells promotes thymocyte development without the...
Cancer Immunology in an Inducible Model of Breast Cancer (1998)
Khazaie, Khashayarsha, Klein, Ludger, Gounari, Fotini, Chen, Mei L., Siermann, Anja
In the first year we have demonstrated rapid initiation of mammary metaplasia upon tissue specific stabilization of Beta-catenin, made fundamental observations on the role of the thymus and antigen...
Khazaie, Khashayarsha, Gounari, Fotini, Antoniou, Michael, DeBoer, Ernie, Grosveld, Frank
The above paper was submitted by one of the authors (KK) without the knowledge of three of the other authors (MA, EdB and FG). We would like to add the following, after consultation with the other...
Khazaie, Khashayarsha, Gounari, Fotini, Antoniou, Michael, DeBoer, Ernie, Grosveld, Frank
We report here the localisation of sequences responsible for the faulty expression of human β-globin gene in Putko and K562 cells. Complete β-globin gene introduced into these cells produces...
Miyoshi, Keiko, Shillingford, Jonathan M., Le Provost, Fabienne, Gounari, Fotini, Bronson, Roderick, Von Boehmer, Harald, ...
Mammary anlagen are formed in the embryo as a derivative of the epidermis, a process that is controlled by Lef-1 and therefore possibly by β-catenin. To investigate the role of β-catenin signaling...
Miyoshi, Keiko, Shillingford, Jonathan M., Le Provost, Fabienne, Gounari, Fotini, Bronson, Roderick, Von Boehmer, Harald, ...
Mammary anlagen are formed in the embryo as a derivative of the epidermis, a process that is controlled by Lef-1 and therefore possibly by β-catenin. To investigate the role of β-catenin signaling...
c-Myc mediates pre-TCR-induced proliferation but not developmental progression
Dose, Marei, Khan, Irum, Guo, Zhuyan, Kovalovsky, Damian, Krueger, Andreas, Von Boehmer, Harald, ...
Constitutive and cell-autonomous signals emanating from the pre-T-cell receptor (pre-TCR) promote proliferation, survival and differentiation of immature thymocytes. We show here that induction of...
Differential synergy of Notch and T cell receptor signaling determines αβ versus γδ lineage fate
Garbe, Annette I., Krueger, Andreas, Gounari, Fotini, Zúñiga-Pflücker, Juan Carlos, Von Boehmer, Harald
Thymic precursors expressing the pre–T cell receptor (TCR), the γδTCR, or the αβTCR can all enter the CD4+8+ αβ lineage, albeit with different efficacy. Here it is shown that proliferation...
Pre-TCRα and TCRα Are Not Interchangeable Partners of TCRβ during T Lymphocyte Development
Borowski, Christine, Li, Xiaoyan, Aifantis, Iannis, Gounari, Fotini, Von Boehmer, Harald
In contrast with the αβ T cell receptor (TCR), the pre-TCR spontaneously segregates to membrane rafts from where it signals in a cell-autonomous fashion. The disparate behaviors of these two...
Guo, Zhuyan, Dose, Marei, Kovalovsky, Damian, Chang, Rui, O'Neil, Jennifer, Look, A. Thomas, ...
Activation of β-catenin has been causatively linked to the etiology of colon cancer. Conditional stabilization of this molecule in pro-T cells promotes thymocyte development without the requirement...
Mast cells are an essential hematopoietic component for polyp development
Gounaris, Elias, Erdman, Susan E., Restaino, Clifford, Gurish, Michael F., Friend, Daniel S., Gounari, Fotini, ...
It is generally agreed that most colon cancers develop from adenomatous polyps, and it is this fact on which screening strategies are based. Although there is overwhelming evidence to link intrinsic...
Lef-1: NOTCHed up in T-cell lymphomas
In this issue of Blood, Spaulding and colleagues show that Lef-1, one of the transcription factors mediating Wnt signaling, is a transcriptional target of Notch in T-cell lymphomas. Notch-activating...
Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1
Li, Xiaoyu, Gounari, Fotini, Protopopov, Alexei, Khazaie, Khashayarsha, Von Boehmer, Harald
Mutations resulting in overexpression of intracellular Notch1 (ICN1) are frequently observed in human T cell acute lymphoblastic leukemia (T-ALL). We have determined the consequences of ICN1...
The fireworks from the spectacular emergence of Notch as the protagonist in the etiology of T-ALL are not likely to end any time soon. Indeed, in this issue of Blood, Sulis and colleagues describe...