Frédéric Barbut

Epidemiology of Recurrences or Reinfections of Clostridium difficile-Associated Diarrhea

Barbut, Frédéric, Richard, Anne, Hamadi, Kheira, Chomette, Valérie, Burghoffer, Béatrice, Petit, Jean-Claude

Approximately 15 to 35% of patients with a first episode of Clostridium difficile-associated diarrhea relapse within 2 months. Between 1994 and 1997, strains from 93 hospitalized patients with C....

Comparison of PCR-Ribotyping, Arbitrarily Primed PCR, and Pulsed-Field Gel Electrophoresis for Typing Clostridium difficile

Bidet, Philippe, Lalande, Valérie, Salauze, Béatrice, Burghoffer, Béatrice, Avesani, Véronique, Delmée, Michel, ...

Clostridium difficile is now recognized as the major agent responsible for nosocomial diarrhea in adults. Among the genotyping methods available, arbitrarily primed PCR (AP-PCR), PCR-ribotyping, and...

Antimicrobial Susceptibilities and Serogroups of Clinical Strains of Clostridium difficile Isolated in France in 1991 and 1997

Barbut, Frédéric, Decré, Dominique, Burghoffer, Béatrice, Lesage, Danièle, Delisle, Françoise, Lalande, Valérie, ...

Glycopeptides (vancomycin and teicoplanin) and metronidazole are the drugs of choice for the treatment of Clostridium difficile infections, but trends in susceptibility patterns have not been...

gyrA and gyrB Mutations Are Implicated in Cross-Resistance to Ciprofloxacin and Moxifloxacin in Clostridium difficile

Dridi, Larbi, Tankovic, Jacques, Burghoffer, Béatrice, Barbut, Frédéric, Petit, Jean-Claude

A total of 198 nonrepetitive clinical strains of Clostridium difficile isolated from different French hospitals in 1991 (n = 100) and 1997 (n = 98) were screened for decreased susceptibility to...

Prevalence and Genetic Characterization of Toxin A Variant Strains of Clostridium difficile among Adults and Children with Diarrhea in France

Barbut, Frédéric, Lalande, Valérie, Burghoffer, Béatrice, Thien, Huong Vu, Grimprel, Emmanuel, Petit, Jean-Claude

Toxin A variant strains (toxin A-negative, toxin B-positive strains) of Clostridium difficile have been reported to be responsible for diarrhea or pseudomembranous colitis in humans. These strains...

Prevalence and Characterization of a Binary Toxin (Actin-Specific ADP-Ribosyltransferase) from Clostridium difficile

Gonçalves, Carina, Decré, Dominique, Barbut, Frédéric, Burghoffer, Béatrice, Petit, Jean-Claude

In addition to the two large clostridial cytotoxins (TcdA and TcdB), some strains of Clostridium difficile also produce an actin-specific ADP-ribosyltransferase, called binary toxin CDT. We used a...

Epidemiology of Recurrences or Reinfections of Clostridium difficile-Associated Diarrhea

Barbut, Frédéric, Richard, Anne, Hamadi, Kheira, Chomette, Valérie, Burghoffer, Béatrice, Petit, Jean-Claude

Approximately 15 to 35% of patients with a first episode of Clostridium difficile-associated diarrhea relapse within 2 months. Between 1994 and 1997, strains from 93 hospitalized patients with C....

Comparison of PCR-Ribotyping, Arbitrarily Primed PCR, and Pulsed-Field Gel Electrophoresis for Typing Clostridium difficile

Bidet, Philippe, Lalande, Valérie, Salauze, Béatrice, Burghoffer, Béatrice, Avesani, Véronique, Delmée, Michel, ...

Clostridium difficile is now recognized as the major agent responsible for nosocomial diarrhea in adults. Among the genotyping methods available, arbitrarily primed PCR (AP-PCR), PCR-ribotyping, and...

Antimicrobial Susceptibilities and Serogroups of Clinical Strains of Clostridium difficile Isolated in France in 1991 and 1997

Barbut, Frédéric, Decré, Dominique, Burghoffer, Béatrice, Lesage, Danièle, Delisle, Françoise, Lalande, Valérie, ...

Glycopeptides (vancomycin and teicoplanin) and metronidazole are the drugs of choice for the treatment of Clostridium difficile infections, but trends in susceptibility patterns have not been...

gyrA and gyrB Mutations Are Implicated in Cross-Resistance to Ciprofloxacin and Moxifloxacin in Clostridium difficile

Dridi, Larbi, Tankovic, Jacques, Burghoffer, Béatrice, Barbut, Frédéric, Petit, Jean-Claude

A total of 198 nonrepetitive clinical strains of Clostridium difficile isolated from different French hospitals in 1991 (n = 100) and 1997 (n = 98) were screened for decreased susceptibility to...

Prevalence and Genetic Characterization of Toxin A Variant Strains of Clostridium difficile among Adults and Children with Diarrhea in France

Barbut, Frédéric, Lalande, Valérie, Burghoffer, Béatrice, Thien, Huong Vu, Grimprel, Emmanuel, Petit, Jean-Claude

Toxin A variant strains (toxin A-negative, toxin B-positive strains) of Clostridium difficile have been reported to be responsible for diarrhea or pseudomembranous colitis in humans. These strains...

Prevalence and Characterization of a Binary Toxin (Actin-Specific ADP-Ribosyltransferase) from Clostridium difficile

Gonçalves, Carina, Decré, Dominique, Barbut, Frédéric, Burghoffer, Béatrice, Petit, Jean-Claude

In addition to the two large clostridial cytotoxins (TcdA and TcdB), some strains of Clostridium difficile also produce an actin-specific ADP-ribosyltransferase, called binary toxin CDT. We used a...