Etude des conséquences physiologiques de l'utilisation de la thymidylate synthase ThyX. (2008)
La conversion par les thymidylate synthases du désoxyuridine 5-monophosphate (dUMP) en désoxythymidine 5-monophosphate (dTMP) est une des étapes clés de la biosynthèse des...
Wilde, Caroline, Escartin, Frédéric, Kokeguchi, Susumu, Latour-Lambert, Patricia, Lectard, Aude, Clément, Jean-Marie
Insertion sequences (IS)1397 and ISKpn1, found in Escherichia coli and Klebsiella pneumoniae, respectively, are IS3 family members that insert specifically into short palindromic repeated sequences...
Wilde, Caroline, Escartin, Frédéric, Kokeguchi, Susumu, Latour-Lambert, Patricia, Lectard, Aude, Clément, Jean-Marie
Insertion sequences (IS)1397 and ISKpn1, found in Escherichia coli and Klebsiella pneumoniae, respectively, are IS3 family members that insert specifically into short palindromic repeated sequences...
Wilde, Caroline, Escartin, Frédéric, Kokeguchi, Susumu, Latour-Lambert, Patricia, Lectard, Aude, Clément, Jean-Marie
Insertion sequences (IS)1397 and ISKpn1, found in Escherichia coli and Klebsiella pneumoniae, respectively, are IS3 family members that insert specifically into short palindromic repeated sequences...
Leduc, Damien, Escartin, Frédéric, Nijhout, H. Frederik, Reed, Michael C., Liebl, Ursula, Skouloubris, Stéphane, ...
Although flavin-dependent ThyX proteins show thymidylate synthase activity in vitro and functionally complement thyA defects in heterologous systems, direct proof of their cellular functions is...
Flavin-dependent thymidylate synthase X limits chromosomal DNA replication
Escartin, Frédéric, Skouloubris, Stéphane, Liebl, Ursula, Myllykallio, Hannu
We have investigated the hitherto unexplored possibility that differences in the catalytic efficiencies of thymidylate synthases ThyX and ThyA, enzymes that produce the essential DNA precursor dTMP,...