Bet-hedging and epigenetic inheritance in bacterial cell development (2008)
Veening, Jan-Willem, Stewart, Eric J., Berngruber, Thomas W., Taddei, François, Kuipers, Oscar P., Hamoen, Leendert W.
Upon nutritional limitation, the bacterium Bacillus subtilis has the capability to enter the irreversible process of sporulation. This developmental process is bistable, and only a subpopulation of...
Dissecting the Genetic Components of Adaptation of Escherichia coli to the Mouse Gut (2008)
Antoine Giraud, Safia Arous, Marianne De Paepe, Valérie Gaboriau-Routhiau, Jean-Christophe Bambou, Sabine Rakotobe, ...
While pleiotropic adaptive mutations are thought to be central for evolution, little is known on the downstream molecular effects allowing adaptation to complex ecologically relevant environments....
Dissecting the genetic components of adaptation of E. coli to the mouse gut (2007)
Antoine Giraud, Safia Arous, Valérie Gaboriau-Routhiau, Marianne De Paepe, Jean-Christophe Bambou, Sabine Rakotobe, ...
Experimental microbial populations have been largely used to gain insight into the mechanisms of evolution. These models have pointed to the possible central role for evolution of pleiotropic...
Tracking of Cells in a Sequence of Images Using a Low-Dimension Image Representation (2007)
Primet, Maël, Demarez, Alice, Taddei, François, Lindner, Ariel, Moisan, Lionel
We propose a new image analysis method to segment and track cells in a growing colony. By using an intermediate low-dimension image representation yielded by a reliable over-segmentation process, we...
Tracking of Cells in a Sequence of Images Using a Low-Dimension Image Representation (2007)
Primet, Maël, Demarez, Alice, Taddei, François, Lindner, Ariel, Moisan, Lionel
We propose a new image analysis method to segment and track cells in a growing colony. By using an intermediate low-dimension image representation yielded by a reliable over-segmentation process, we...
François Taddei, Marianne De Paepe
A comparison of life-history traits of 16 phages infecting E. coli reveals that although these viruses don't age, there is a trade-off between mortality and growth rate, which parallels that observed...
Marianne De Paepe, François Taddei
A comparison of life-history traits of 16 phages infecting E. coli reveals that although these viruses don't age, there is a trade-off between mortality and growth rate, which parallels that observed...
Marianne De Paepe, François Taddei
Life history theory accounts for variations in many traits involved in the reproduction and survival of living organisms, by determining the constraints leading to trade-offs among these different...
De Paepe, Marianne, Taddei, François
Life history theory accounts for variations in many traits involved in the reproduction and survival of living organisms, by determining the constraints leading to trade-offs among these different...
De Paepe, Marianne, Taddei, François
Life history theory accounts for variations in many traits involved in the reproduction and survival of living organisms, by determining the constraints leading to trade-offs among these different...
De Paepe, Marianne, Taddei, François
Life history theory accounts for variations in many traits involved in the reproduction and survival of living organisms, by determining the constraints leading to trade-offs among these different...
De Paepe, Marianne, Taddei, François
Life history theory accounts for variations in many traits involved in the reproduction and survival of living organisms, by determining the constraints leading to trade-offs among these different...
Aging and Death in an Organism That Reproduces by Morphologically Symmetric Division (2005)
Eric J. Stewart, Richard Madden, Gregory Paul, François Taddei
Detailed time lapse photography reveals that organisms that divide symmetrically, such as the bacterium E. coli, can indeed age and consequently that no organism is immune to mortality.
Aging and Death in an Organism That Reproduces by Morphologically Symmetric Division (2005)
Eric J. Stewart, Richard Madden, Gregory Paul, François Taddei
In macroscopic organisms, aging is often obvious; in single-celled organisms, where there is the greatest potential to identify the molecular mechanisms involved, identifying and quantifying aging is...
Aging and death in an organism that reproduces by morphologically symmetric division. (2005)
Stewart, Eric J, Madden, Richard, Paul, Gregory, Taddei, François
In macroscopic organisms, aging is often obvious; in single-celled organisms, where there is the greatest potential to identify the molecular mechanisms involved, identifying and quantifying aging is...
Aging and death in an organism that reproduces by morphologically symmetric division. (2005)
Stewart, Eric J, Madden, Richard, Paul, Gregory, Taddei, François
In macroscopic organisms, aging is often obvious; in single-celled organisms, where there is the greatest potential to identify the molecular mechanisms involved, identifying and quantifying aging is...
Aging and death in an organism that reproduces by morphologically symmetric division. (2005)
Stewart, Eric J, Madden, Richard, Paul, Gregory, Taddei, François
In macroscopic organisms, aging is often obvious; in single-celled organisms, where there is the greatest potential to identify the molecular mechanisms involved, identifying and quantifying aging is...
Aging and death in an organism that reproduces by morphologically symmetric division, PLoS (2005)
Eric J. Stewart, Richard Madden, Gregory Paul, François Taddei
In macroscopic organisms, aging is often obvious; in single-celled organisms, where there is the greatest potential to identify the molecular mechanisms involved, identifying and quantifying aging is...
Aging and death in an organism that reproduces by morphologically symmetric division. (2005)
Stewart, Eric J, Madden, Richard, Paul, Gregory, Taddei, François
In macroscopic organisms, aging is often obvious; in single-celled organisms, where there is the greatest potential to identify the molecular mechanisms involved, identifying and quantifying aging is...
Sources of genetic and phenotypic variability (2003)
The availability of hundreds of genomes allows us to learn rapidly about genomic differences between micro-organisms. Comparative genomics shows that horizontal gene transfer, mutations and...
Rocha, Eduardo P. C., Matic, Ivan, Taddei, François
The survival of individual organisms facing stress is enhanced by the induction of a set of changes. As the intensity, duration and nature of stress is highly variable, the optimal response to stress...
Translational misreading: a tRNA modification counteracts a +2 ribosomal frameshift (2001)
Brégeon, Damien, Colot, Vincent, Radman, Miroslav, Taddei, François
Molecular keys to speciation: DNA polymorphism and the control of genetic exchange in enterobacteria
Vulić, Marin, Dionisio, Francisco, Taddei, François, Radman, Miroslav
Speciation involves the establishment of genetic barriers between closely related organisms. The extent of genetic recombination is a key determinant and a measure of genetic isolation. The results...
Mutators and sex in bacteria: Conflict between adaptive strategies
Tenaillon, Olivier, Le Nagard, Hervé, Godelle, Bernard, Taddei, François
Bacterial mutation rates can increase and produce genetic novelty, as shown by in vitro and in silico experiments. Despite the cost due to a heavy deleterious mutation load, mutator alleles, which...
Matic, Ivan, Taddei, François, Radman, Miroslav
Conjugational crosses trigger SOS induction in Escherichia coli F− cells mated with Salmonella enterica serovar Typhimurium Hfr donors. Using an epigenetic indicator of SOS induction, we showed...
Mutator Natural Escherichia coli Isolates Have an Unusual Virulence Phenotype
Picard, Bertrand, Duriez, Patrick, Gouriou, Stéphanie, Matic, Ivan, Denamur, Erick, Taddei, François
A small percentage of natural Escherichia coli isolates (both commensal and pathogenic) have a mutator phenotype related to defects in methyl-directed mismatch repair (MR) genes. We investigated...
Rocha, Eduardo P. C., Matic, Ivan, Taddei, François
The survival of individual organisms facing stress is enhanced by the induction of a set of changes. As the intensity, duration and nature of stress is highly variable, the optimal response to stress...
Mutator Bacteria as a Risk Factor in Treatment of Infectious Diseases†
Giraud, Antoine, Matic, Ivan, Radman, Miroslav, Fons, Michel, Taddei, François
We show in a gnotobiotic mouse model that, in addition to direct selection of antibiotic-resistant bacteria, some antibiotic treatments also select for mutator alleles. Because of these mutator...
High Frequency of Mutator Strains among Human Uropathogenic Escherichia coli Isolates
Denamur, Erick, Bonacorsi, Stéphane, Giraud, Antoine, Duriez, Patrick, Hilali, Farida, Amorin, Christine, ...
By using a panel of 603 commensal and pathogenic Escherichia coli and Shigella isolates, we showed that mutation rates of strains vary considerably among different ecotypes. Uropathogenic strains had...
Aging and Death in an Organism That Reproduces by Morphologically Symmetric Division
Stewart, Eric J, Madden, Richard, Paul, Gregory, Taddei, François
In macroscopic organisms, aging is often obvious; in single-celled organisms, where there is the greatest potential to identify the molecular mechanisms involved, identifying and quantifying aging is...
Translational misreading: a tRNA modification counteracts a +2 ribosomal frameshift
Brégeon, Damien, Colot, Vincent, Radman, Miroslav, Taddei, François
Errors during gene expression from DNA to proteins via transcription and translation may be deleterious for the functional maintenance of cells. In this paper, extensive genetic studies of the...
De Paepe, Marianne, Taddei, François
Life history theory accounts for variations in many traits involved in the reproduction and survival of living organisms, by determining the constraints leading to trade-offs among these different...
Taddei, François, De Paepe, Marianne
A comparison of life-history traits of 16 phages infecting E. coli reveals that although these viruses don't age, there is a trade-off between mortality and growth rate, which parallels that observed...
Stress and Survival of Aging Escherichia coli rpoS Colonies
Saint-Ruf, Claude, Taddei, François, Matic, Ivan
In Escherichia coli, the expression of the RpoS regulon is known to be crucial for survival in liquid cultures during stationary phase. By measuring cell viability and by transcriptome analysis, here...
Plasmids spread very fast in heterogeneous bacterial communities.
Dionisio, Francisco, Matic, Ivan, Radman, Miroslav, Rodrigues, Olivia R, Taddei, François
Conjugative plasmids can mediate gene transfer between bacterial taxa in diverse environments. The ability to donate the F-type conjugative plasmid R1 greatly varies among enteric bacteria due to the...
Molecular keys to speciation: DNA polymorphism and the control of genetic exchange in enterobacteria
Vulić, Marin, Dionisio, Francisco, Taddei, François, Radman, Miroslav
Speciation involves the establishment of genetic barriers between closely related organisms. The extent of genetic recombination is a key determinant and a measure of genetic isolation. The results...
Mutators and sex in bacteria: Conflict between adaptive strategies
Tenaillon, Olivier, Le Nagard, Hervé, Godelle, Bernard, Taddei, François
Bacterial mutation rates can increase and produce genetic novelty, as shown by in vitro and in silico experiments. Despite the cost due to a heavy deleterious mutation load, mutator alleles, which...
Matic, Ivan, Taddei, François, Radman, Miroslav
Conjugational crosses trigger SOS induction in Escherichia coli F− cells mated with Salmonella enterica serovar Typhimurium Hfr donors. Using an epigenetic indicator of SOS induction, we showed...
Mutator Natural Escherichia coli Isolates Have an Unusual Virulence Phenotype
Picard, Bertrand, Duriez, Patrick, Gouriou, Stéphanie, Matic, Ivan, Denamur, Erick, Taddei, François
A small percentage of natural Escherichia coli isolates (both commensal and pathogenic) have a mutator phenotype related to defects in methyl-directed mismatch repair (MR) genes. We investigated...
Rocha, Eduardo P. C., Matic, Ivan, Taddei, François
The survival of individual organisms facing stress is enhanced by the induction of a set of changes. As the intensity, duration and nature of stress is highly variable, the optimal response to stress...
Mutator Bacteria as a Risk Factor in Treatment of Infectious Diseases†
Giraud, Antoine, Matic, Ivan, Radman, Miroslav, Fons, Michel, Taddei, François
We show in a gnotobiotic mouse model that, in addition to direct selection of antibiotic-resistant bacteria, some antibiotic treatments also select for mutator alleles. Because of these mutator...
High Frequency of Mutator Strains among Human Uropathogenic Escherichia coli Isolates
Denamur, Erick, Bonacorsi, Stéphane, Giraud, Antoine, Duriez, Patrick, Hilali, Farida, Amorin, Christine, ...
By using a panel of 603 commensal and pathogenic Escherichia coli and Shigella isolates, we showed that mutation rates of strains vary considerably among different ecotypes. Uropathogenic strains had...
Translational misreading: a tRNA modification counteracts a +2 ribosomal frameshift
Brégeon, Damien, Colot, Vincent, Radman, Miroslav, Taddei, François
Errors during gene expression from DNA to proteins via transcription and translation may be deleterious for the functional maintenance of cells. In this paper, extensive genetic studies of the...
Aging and Death in an Organism That Reproduces by Morphologically Symmetric Division
Stewart, Eric J, Madden, Richard, Paul, Gregory, Taddei, François
In macroscopic organisms, aging is often obvious; in single-celled organisms, where there is the greatest potential to identify the molecular mechanisms involved, identifying and quantifying aging is...
Stress and Survival of Aging Escherichia coli rpoS Colonies
Saint-Ruf, Claude, Taddei, François, Matic, Ivan
In Escherichia coli, the expression of the RpoS regulon is known to be crucial for survival in liquid cultures during stationary phase. By measuring cell viability and by transcriptome analysis, here...
Plasmids spread very fast in heterogeneous bacterial communities.
Dionisio, Francisco, Matic, Ivan, Radman, Miroslav, Rodrigues, Olivia R, Taddei, François
Conjugative plasmids can mediate gene transfer between bacterial taxa in diverse environments. The ability to donate the F-type conjugative plasmid R1 greatly varies among enteric bacteria due to the...
De Paepe, Marianne, Taddei, François
Life history theory accounts for variations in many traits involved in the reproduction and survival of living organisms, by determining the constraints leading to trade-offs among these different...
Taddei, François, De Paepe, Marianne
A comparison of life-history traits of 16 phages infecting E. coli reveals that although these viruses don't age, there is a trade-off between mortality and growth rate, which parallels that observed...
The Durability of Public Goods Changes the Dynamics and Nature of Social Dilemmas
Brown, Sam P., Taddei, François
An implicit assumption underpins basic models of the evolution of cooperation, mutualism and altruism: The benefits (or pay-offs) of cooperation and defection are defined by the current frequency or...
Dissecting the Genetic Components of Adaptation of Escherichia coli to the Mouse Gut
Giraud, Antoine, Arous, Safia, Paepe, Marianne De, Gaboriau-Routhiau, Valérie, Bambou, Jean-Christophe, Rakotobe, Sabine, ...
While pleiotropic adaptive mutations are thought to be central for evolution, little is known on the downstream molecular effects allowing adaptation to complex ecologically relevant environments....
Brown, Sam P, Le Chat, Ludovic, Taddei, François
Virulence is generally considered to benefit parasites by enhancing resource-transfer from host to pathogen. Here, we offer an alternative framework where virulent immune-provoking behaviours and...
Mutations in two global regulators lower individual mortality in Escherichia coli
Fontaine, Fanette, Stewart, Eric J, Lindner, Ariel B, Taddei, François
There has been considerable investigation into the survival of bacterial cells under stress conditions, but little is known about the causes of mortality in the absence of exogenous stress. That...
Asymmetric segregation of protein aggregates is associated with cellular aging and rejuvenation
Lindner, Ariel B., Madden, Richard, Demarez, Alice, Stewart, Eric J., Taddei, François
Aging, defined as a decrease in reproduction rate with age, is a fundamental characteristic of all living organisms down to bacteria. Yet we know little about the causal molecular mechanisms of aging...
Bet-hedging and epigenetic inheritance in bacterial cell development
Veening, Jan-Willem, Stewart, Eric J., Berngruber, Thomas W., Taddei, François, Kuipers, Oscar P., Hamoen, Leendert W.
Upon nutritional limitation, the bacterium Bacillus subtilis has the capability to enter the irreversible process of sporulation. This developmental process is bistable, and only a subpopulation of...