Francesca Walker

Activation of the Ras/Mitogen-Activated Protein Kinase Pathway by Kinase-Defective Epidermal Growth Factor Receptors Results in Cell Survival but Not Proliferation

Walker, Francesca, Kato, Akiko, Gonez, L. Jorge, Hibbs, Margaret L., Pouliot, Normand, Levitzki, Alexander, ...

Signalling by the epidermal growth factor (EGF) receptor (EGFR) has been studied intensively, but for most cell types the analysis is complicated by the fact that EGFR not only homodimerizes but can...

Antitumor efficacy of cytotoxic drugs and the monoclonal antibody 806 is enhanced by the EGF receptor inhibitor AG1478

Johns, Terrance G., Luwor, Rodney B., Murone, Carmel, Walker, Francesca, Weinstock, Janet, Vitali, Angela A., ...

Blockade of epidermal growth factor receptor (EGFR) signaling with specific inhibitors of the EGFR tyrosine kinase retards cellular proliferation and arrests the growth of tumor xenografts. AG1478,...

Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling

Nicholson, Sandra E., Metcalf, Donald, Sprigg, Naomi S., Columbus, Ruth, Walker, Francesca, Silva, Anabel, ...

The suppressors of cytokine signaling (SOCS) proteins are a family of SH2 domain-containing intracellular inhibitors of cytokine signal transduction that act by several different mechanisms. Recent...

Activation of the Ras/Mitogen-Activated Protein Kinase Pathway by Kinase-Defective Epidermal Growth Factor Receptors Results in Cell Survival but Not Proliferation

Walker, Francesca, Kato, Akiko, Gonez, L. Jorge, Hibbs, Margaret L., Pouliot, Normand, Levitzki, Alexander, ...

Signalling by the epidermal growth factor (EGF) receptor (EGFR) has been studied intensively, but for most cell types the analysis is complicated by the fact that EGFR not only homodimerizes but can...

Antitumor efficacy of cytotoxic drugs and the monoclonal antibody 806 is enhanced by the EGF receptor inhibitor AG1478

Johns, Terrance G., Luwor, Rodney B., Murone, Carmel, Walker, Francesca, Weinstock, Janet, Vitali, Angela A., ...

Blockade of epidermal growth factor receptor (EGFR) signaling with specific inhibitors of the EGFR tyrosine kinase retards cellular proliferation and arrests the growth of tumor xenografts. AG1478,...

Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling

Nicholson, Sandra E., Metcalf, Donald, Sprigg, Naomi S., Columbus, Ruth, Walker, Francesca, Silva, Anabel, ...

The suppressors of cytokine signaling (SOCS) proteins are a family of SH2 domain-containing intracellular inhibitors of cytokine signal transduction that act by several different mechanisms. Recent...

Antibodies specifically targeting a locally misfolded region of tumor associated EGFR

Garrett, Thomas P. J., Burgess, Antony W., Gan, Hui K., Luwor, Rod B., Cartwright, Glenn, Walker, Francesca, ...

Epidermal Growth Factor Receptor (EGFR) is involved in stimulating the growth of many human tumors, but the success of therapeutic agents has been limited in part by interference from the EGFR on...