Gao, Honghai, Huang, Jianmin, Barany, Francis, Cao, Weiguo
Endonuclease V (endo V) recognizes a broad range of aberrations in DNA such as deaminated bases or mismatches. It nicks DNA at the second phosphodiester bond 3′ to a deaminated base or a mismatch....
Dafna Tsafrir, Manny Bacolod, Zachariah Selvanayagam, Ilan Tsafrir, Jinru Shia, Zhaoshi Zeng, ...
Several studies have verified the existence of multiple chromosomal abnormalities in colon cancer. However, the relationships between DNA copy number and gene expression have not been adequately...
Cheng, Yu-Wei, Shawber, Carrie, Notterman, Dan, Paty, Philip, Barany, Francis
DNA methylation in CpG islands is associated with transcriptional silencing. Accurate determination of cytosine methylation status in promoter CpG dinucleotides may provide diagnostic and prognostic...
High sensitivity EndoV mutation scanning through real-time ligase proofreading (2004)
Pincas, Hanna, Pingle, Maneesh R., Huang, Jianmin, Lao, Kaiqin, Paty, Philip B., Friedman, Alan M., ...
The ability to associate mutations in cancer genes with the disease and its subtypes is critical for understanding oncogenesis and identifying biomarkers for clinical diagnosis. A two-step mutation...
Overholtzer, Michael, Rao, Pulivarthi H., Favis, Reyna, Lu, Xin-Yan, Elowitz, Michael B., Barany, Francis, ...
The p53 gene is a critical tumor suppressor that is inactivated in a majority of cancers. The central role of p53 in response to stresses such as DNA damage, hypoxia, and oncogene activation...
Single nucleotide polymorphism seeking long term association with complex disease (2002)
Kirk, Brian W., Feinsod, Matthew, Favis, Reyna, Kliman, Richard M., Barany, Francis
Successful investigation of common diseases requires advances in our understanding of the organization of the genome. Linkage disequilibrium provides a theoretical basis for performing candidate gene...
Detecting Colorectal Cancer in Stool With the Use of Multiple Genetic Targets (2001)
Dong, Seung Myung, Traverso, Giovanni, Johnson, Constance, Geng, Li, Favis, Reyna, Boynton, Kevin, ...
Background: Colorectal cancer cells are shed into the stool, providing a potential means for the early detection of the disease using noninvasive approaches. Our goal was to develop reliable,...
Tong, Jie, Barany, Francis, Cao, Weiguo
An NAD+-dependent DNA ligase from the hyperthermophilic bacterium Aquifex aeolicus was cloned, expressed in Escherichia coli and purified to homogeneity. The enzyme is most active in slightly...
Universal DNA microarray method for multiplex detection of low abundance point mutations (1999)
Norman P. Gerry, Nancy E. Witowski, Joseph Day, Robert P. Hammer, George Barany, Francis Barany
Cancers arise from the accumulation of mutations in genes controling the cell cycle, apoptosis, and genome integrity. These mutations may be inherited or somatic, arising from exposure to
Plasmid transformation in Streptococcus pneumoniae. (1981)
Thesis (Ph. D.)--Rockefeller University.
Tong, Jie, Barany, Francis, Cao, Weiguo
An NAD+-dependent DNA ligase from the hyperthermophilic bacterium Aquifex aeolicus was cloned, expressed in Escherichia coli and purified to homogeneity. The enzyme is most active in slightly...
Kirk, Brian W., Feinsod, Matthew, Favis, Reyna, Kliman, Richard M., Barany, Francis
Successful investigation of common diseases requires advances in our understanding of the organization of the genome. Linkage disequilibrium provides a theoretical basis for performing candidate gene...
Overholtzer, Michael, Rao, Pulivarthi H., Favis, Reyna, Lu, Xin-Yan, Elowitz, Michael B., Barany, Francis, ...
The p53 gene is a critical tumor suppressor that is inactivated in a majority of cancers. The central role of p53 in response to stresses such as DNA damage, hypoxia, and oncogene activation...
High sensitivity EndoV mutation scanning through real-time ligase proofreading
Pincas, Hanna, Pingle, Maneesh R., Huang, Jianmin, Lao, Kaiqin, Paty, Philip B., Friedman, Alan M., ...
The ability to associate mutations in cancer genes with the disease and its subtypes is critical for understanding oncogenesis and identifying biomarkers for clinical diagnosis. A two-step mutation...
Cheng, Yu-Wei, Shawber, Carrie, Notterman, Dan, Paty, Philip, Barany, Francis
DNA methylation in CpG islands is associated with transcriptional silencing. Accurate determination of cytosine methylation status in promoter CpG dinucleotides may provide diagnostic and prognostic...
Tong, Jie, Barany, Francis, Cao, Weiguo
An NAD+-dependent DNA ligase from the hyperthermophilic bacterium Aquifex aeolicus was cloned, expressed in Escherichia coli and purified to homogeneity. The enzyme is most active in slightly...
Kirk, Brian W., Feinsod, Matthew, Favis, Reyna, Kliman, Richard M., Barany, Francis
Successful investigation of common diseases requires advances in our understanding of the organization of the genome. Linkage disequilibrium provides a theoretical basis for performing candidate gene...
Overholtzer, Michael, Rao, Pulivarthi H., Favis, Reyna, Lu, Xin-Yan, Elowitz, Michael B., Barany, Francis, ...
The p53 gene is a critical tumor suppressor that is inactivated in a majority of cancers. The central role of p53 in response to stresses such as DNA damage, hypoxia, and oncogene activation...
High sensitivity EndoV mutation scanning through real-time ligase proofreading
Pincas, Hanna, Pingle, Maneesh R., Huang, Jianmin, Lao, Kaiqin, Paty, Philip B., Friedman, Alan M., ...
The ability to associate mutations in cancer genes with the disease and its subtypes is critical for understanding oncogenesis and identifying biomarkers for clinical diagnosis. A two-step mutation...
Cheng, Yu-Wei, Shawber, Carrie, Notterman, Dan, Paty, Philip, Barany, Francis
DNA methylation in CpG islands is associated with transcriptional silencing. Accurate determination of cytosine methylation status in promoter CpG dinucleotides may provide diagnostic and prognostic...
Gao, Honghai, Huang, Jianmin, Barany, Francis, Cao, Weiguo
Endonuclease V (endo V) recognizes a broad range of aberrations in DNA such as deaminated bases or mismatches. It nicks DNA at the second phosphodiester bond 3′ to a deaminated base or a mismatch....
Pingle, Maneesh R., Granger, Kathleen, Feinberg, Philip, Shatsky, Rebecca, Sterling, Bram, Rundell, Mark, ...
We have developed a novel high-throughput PCR-ligase detection reaction-capillary electrophoresis (PCR-LDR-CE) assay for the multiplexed identification of 20 blood-borne pathogens (Staphylococcus...
Sheffer, Michal, Bacolod, Manny D., Zuk, Or, Giardina, Sarah F., Pincas, Hanna, Barany, Francis, ...
During disease progression the cells that comprise solid malignancies undergo significant changes in gene copy number and chromosome structure. Colorectal cancer provides an excellent model to study...