Inhibition of Fatty Acid Synthase (FAS): A New Drug for Breast Cancer Chemoprevention (2006)
Fatty acid synthase (FAS) has shown promise as a new target for breast cancer therapy. FAS is the primary enzyme responsible for the de novo synthesis of fatty acid and is highly expressed in most...
Xenograft Studies of Fatty Acid Synthesis Inhibition as Novel Therapy for Breast Cancer (2002)
This grant proposes to study the effect of fatty acid synthesis inhibition in human breast cancer xenografts using C75, a novel inhibitor of fatty acid synthesis. C75 has now been shown to have...
Xenograft Studies of Fatty Acid Synthesis Inhibition as Novel Therapy for Breast Cancer (2002)
This grant proposed to study the effect of fatty acid synthesis inhibition in human breast cancer xenografts using C75, a novel inhibitor of fatty acid synthesis. We also proposed to study the...
Antimycobacterial activity of cerulenin and its effects on lipid biosynthesis (1999)
Parrish, Nikki M., Kuhajda, Francis P., Heine, Henry S., Bishai, William R., Dick, James D.
Cerulenin is a potent inhibitor of fatty acid synthase (FAS) in a variety of prokaryotic and eukaryotic cells. Using a standardized mycobacterial susceptibility test, we have observed that cerulenin...
Xenograft Studies of Fatty Acid Synthesis Inhibition as Novel Therapy for Breast Cancer. (1998)
Many common human cancers express high levels of fatty acid synthase (FAS), the primary enzyme responsible for the synthesis of fatty acids. Compared to cancer, fatty acid synthesis is highly down-...
Fatty Acid Synthase Inhibitor Cytotoxicity: Depletion of the Coenzyme-A Pool (1998)
Inhibition of fatty acid synthase (FAS) in human cancer cells leads to cytotoxicity without evidence of DNA damage. Based on this and other biochemical observations, attention was focused on the...
Synthesis and antitumor activity of an inhibitor of fatty acid synthase
Kuhajda, Francis P., Pizer, Ellen S., Li, Ji Nong, Mani, Neelakandha S., Frehywot, Gojeb L., Townsend, Craig A.
Compared to normal human tissues, many common human cancers, including carcinoma of the colon, prostate, ovary, breast, and endometrium, express high levels of fatty acid synthase (FAS, EC 2.3.1.85),...
Mandrup, Susanne, Loftus, Thomas M., MacDougald, Ormond A., Kuhajda, Francis P., Lane, M. Daniel
3T3-F442A preadipocytes implanted s.c. into athymic mice develop into fat pads that are indistinguishable from normal adipose tissue. Implanted preadipocytes harboring a β-galactosidase transgene...
Insulin depletion leads to adipose-specific cell death in obese but not lean mice
Loftus, Thomas M., Kuhajda, Francis P., Lane, M. Daniel
Mutation of the obese gene produces obesity, hyperinsulinemia, and compensatory “overexpression” of the defective gene. As insulin activates obese gene expression, it seemed possible that...
C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity
Thupari, Jagan N., Landree, Leslie E., Ronnett, Gabriele V., Kuhajda, Francis P.
C75, a known inhibitor of fatty acid synthase is postulated to cause significant weight loss through decreased hypothalamic neuropeptide Y (NPY) production. Peripherally, C75, an...
Synthesis and antitumor activity of an inhibitor of fatty acid synthase
Kuhajda, Francis P., Pizer, Ellen S., Li, Ji Nong, Mani, Neelakandha S., Frehywot, Gojeb L., Townsend, Craig A.
Compared to normal human tissues, many common human cancers, including carcinoma of the colon, prostate, ovary, breast, and endometrium, express high levels of fatty acid synthase (FAS, EC 2.3.1.85),...
Mandrup, Susanne, Loftus, Thomas M., MacDougald, Ormond A., Kuhajda, Francis P., Lane, M. Daniel
3T3-F442A preadipocytes implanted s.c. into athymic mice develop into fat pads that are indistinguishable from normal adipose tissue. Implanted preadipocytes harboring a β-galactosidase transgene...
Insulin depletion leads to adipose-specific cell death in obese but not lean mice
Loftus, Thomas M., Kuhajda, Francis P., Lane, M. Daniel
Mutation of the obese gene produces obesity, hyperinsulinemia, and compensatory “overexpression” of the defective gene. As insulin activates obese gene expression, it seemed possible that...
C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity
Thupari, Jagan N., Landree, Leslie E., Ronnett, Gabriele V., Kuhajda, Francis P.
C75, a known inhibitor of fatty acid synthase is postulated to cause significant weight loss through decreased hypothalamic neuropeptide Y (NPY) production. Peripherally, C75, an...
Mansouri, Abdelhak, Aja, Susan, Moran, Timothy H., Ronnett, Gabriele, Kuhajda, Francis P., Arnold, Myrtha, ...
Central and intraperitoneal C75, an inhibitor of fatty acid synthase and stimulator of carnitine palmitoyl-transferase-1, inhibits eating in mice and rats. Mechanisms involved in feeding inhibition...