Franclim R. Ribeiro

Both SEPT2and MLLare down-regulated in MLL-SEPT2therapy-related myeloid neoplasia (2009)

Cerveira, Nuno, Santos, Joana, Bizarro, Susana, Costa, Vera, Ribeiro, Franclim R, Lisboa, Susana, ...

Abstract Background A relevant role of septins in leukemogenesis has been uncovered by their involvement as fusion partners in MLL -related leukemia. Recently, we have established the MLL-SEPT2 gene...

A universal assay for detection of oncogenic fusion transcripts by oligo microarray analysis (2009)

Skotheim, Rolf I, Thomassen, Gard OS, Eken, Marthe, Lind, Guro E, Micci, Francesca, Ribeiro, Franclim R, ...

Abstract Background The ability to detect neoplasia-specific fusion genes is important not only in cancer research, but also increasingly in clinical settings to ensure that correct diagnosis is made...

A universal assay for detection of oncogenic fusion transcripts by oligo microarray analysis. (2009)

Skotheim, Rolf I, Thomassen, Gard O S, Eken, Marthe, Lind, Guro E, Micci, Francesca, Ribeiro, Franclim R, ...

BACKGROUND: The ability to detect neoplasia-specific fusion genes is important not only in cancer research, but also increasingly in clinical settings to ensure that correct diagnosis is made and the...

Quantitative promoter methylation analysis of multiple cancer-related genes in renal cell tumors (2007)

Costa, Vera L, Henrique, Rui, Ribeiro, Franclim R, Pinto, Mafalda, Oliveira, Jorge, Lobo, Francisco, ...

Abstract Background Aberrant promoter hypermethylation of cancer-associated genes occurs frequently during carcinogenesis and may serve as a cancer biomarker. In this study we aimed at defining a...

Comparison of chromosomal and array-based comparative genomic hybridization for the detection of genomic imbalances in primary prostate carcinomas (2006)

Ribeiro, Franclim R, Henrique, Rui, Hektoen, Merete, Berg, Marianne, Jerónimo, Carmen, Teixeira, Manuel R, ...

Abstract Background In order to gain new insights into the molecular mechanisms involved in prostate cancer, we performed array-based comparative genomic hybridization (aCGH) on a series of 46...

TMPRSS2-ERG Gene Fusion Causing ERG Overexpression Precedes Chromosome Copy Number Changes in Prostate Carcinomas and Paired HGPIN Lesions1

Cerveira, Nuno, Ribeiro, Franclim R, Peixoto, Ana, Costa, Vera, Henrique, Rui, Jerónimo, Carmen, ...

TMPRSS2-ETS gene fusions have been found recurrently in prostate carcinomas, but not in the presumed precursor lesion, high-grade prostatic intraepithelial neoplasia (HGPIN). However, HGPIN lesions...