Review TRENDS in Microbiology Vol.15 No.1 The nature of systems biology (2008)
Frank J. Bruggeman, Hans V. Westerhoff
The advent of functional genomics has enabled the molecular biosciences to come a long way towards characterizing the molecular constituents of life. Yet, the challenge for biology overall is to...
Jorrit J. Hornberg, Frank J. Bruggeman, Bernd Binder, Christian R. Geest, Jan Lankelma, Reinhart Heinrich, ...
Principles behind the multifarious control of signal transduction
Untangling the wires: A strategy to trace functional interactions in signaling and gene networks
Kholodenko, Boris N., Kiyatkin, Anatoly, Bruggeman, Frank J., Sontag, Eduardo, Westerhoff, Hans V., Hoek, Jan B.
Emerging technologies have enabled the acquisition of large genomics and proteomics data sets. However, current methodologies for analysis do not permit interpretation of the data in ways that...
Untangling the wires: A strategy to trace functional interactions in signaling and gene networks
Kholodenko, Boris N., Kiyatkin, Anatoly, Bruggeman, Frank J., Sontag, Eduardo, Westerhoff, Hans V., Hoek, Jan B.
Emerging technologies have enabled the acquisition of large genomics and proteomics data sets. However, current methodologies for analysis do not permit interpretation of the data in ways that...
Elongation dynamics shape bursty transcription and translation
Dobrzyński, Maciej, Bruggeman, Frank J.
Cells in isogenic populations may differ substantially in their molecular make up because of the stochastic nature of molecular processes. Stochastic bursts in process activity have a great potential...
Noise Management by Molecular Networks
Bruggeman, Frank J., Blüthgen, Nils, Westerhoff, Hans V.
Fluctuations in the copy number of key regulatory macromolecules (“noise”) may cause physiological heterogeneity in populations of (isogenic) cells. The kinetics of processes and their wiring in...