Hamann, Lutz, Kumpf, Oliver, Schuring, Ron P, Alpsoy, Erkan, Bedu-Addo, George, Bienzle, Ulrich, ...
Abstract Background The Toll-like receptors (TLRs) mediate innate immunity to various pathogens. A mutation (S180L) in the TLR downstream signal transducer TIRAP has recently been reported to be...
Zoller, Thomas, Naucke, Torsten J, May, Jürgen, Hoffmeister, Bodo, Flick, Holger, Williams, Christopher J, ...
Abstract In non-endemic areas, malaria is rare and locally acquired infections, particularly with Plasmodium falciparum , are exceptional events. The diagnosis is, therefore, likely to be delayed or...
Mandi, Germain, Mockenhaupt, Frank P, Coulibaly, Boubacar, Meissner, Peter, Müller, Olaf
Abstract Background Combination therapy has become a new paradigm in malaria treatment. Amodiaquine is a common partner drug in different malaria combination therapies used or investigated in...
Djie-Maletz, Andrea, Reither, Klaus, Danour, Stephen, Anyidoho, Louis, Saad, Eiman, Danikuu, Francis, ...
Objectives Information on antimicrobial susceptibility of bacterial pathogens is scarce in resource-poor settings. We determined the susceptibility of bacterial enteric pathogens and faecal...
Hommerich, Lena, Von Oertzen, Christa, Bedu-Addo, George, Holmberg, Ville, Acquah, Patrick A, Eggelte, Teunis A, ...
Abstract Background Intermittent preventive treatment in pregnancy with sulphadoxine-pyrimethamine (IPTp-SP) has been adopted as policy by many countries in sub-Saharan Africa. However, data on the...
Reither, Klaus, Ignatius, Ralf, Weitzel, Thomas, Seidu-Korkor, Andrew, Anyidoho, Louis, Saad, Eiman, ...
Abstract Background Acute diarrhoea is a major cause of childhood morbidity and mortality in sub-Saharan Africa. Its microbiological causes and clinico-epidemiological aspects were examined during...
Detection and clinical manifestation of placental malaria in southern Ghana (2006)
Mockenhaupt, Frank P, Bedu-Addo, George, Von Gaertner, Christiane, Boyé, Renate, Fricke, Katrin, Hannibal, Iris, ...
Abstract Background Plasmodium falciparum can be detected by microscopy, histidine-rich-protein-2 (HRP2) capture test or PCR but the respective clinical relevance of the thereby diagnosed infections...
Schunk, Mirjam, Kumma, Wondimagegn P, Miranda, Isabel, Osman, Maha E, Roewer, Susanne, Alano, Abraham, ...
Abstract Background In Ethiopia, malaria is caused by both Plasmodium falciparum and Plasmodium vivax . Drug resistance of P. falciparum to sulfadoxine-pyrimethamine (SP) and chloroquine (CQ) is...
Concurrence of Plasmodium falciparum dhfrand crtmutations in northern Ghana (2005)
Mockenhaupt, Frank P, Bousema, J Teun, Eggelte, Teunis A, Ehrhardt, Stephan, Otchwemah, Rowland N, Sauerwein, Robert W, ...
Abstract Background Both chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) are failing drugs in much of sub-Saharan Africa. Previous findings suggest an association between resistance to CQ and to...
Wichmann, Ole, Muehlen, Marion, Gruss, Holger, Mockenhaupt, Frank P, Suttorp, Norbert, Jelinek, Tomas
Abstract Malarone ® (atovaquone-proguanil) is an effective drug for the treatment and prophylaxis of multidrug-resistant falciparum malaria. However, first cases of resistance have been reported,...
Cramer, Jakob P, Mockenhaupt, Frank P, Möhl, Ingo, Dittrich, Sabine, Dietz, Ekkehardt, Otchwemah, Rowland N, ...
Abstract Background The erythrocyte binding antigen-175 (EBA-175) on Plasmodium falciparum merozoites mediates sialic acid dependent binding to glycophorin A on host erythrocytes and, therefore,...
Concentrations of Chloroquine and Malaria Parasites in Blood in Nigerian Children
Mockenhaupt, Frank P., May, Jürgen, Bergqvist, Yngve, Ademowo, Olusegun G., Olumese, Peter E., Falusi, Adeyinka G., ...
Consumption of chloroquine (CQ) and subtherapeutic drug levels in blood are considered to be widespread in areas where malaria is endemic. A cross-sectional study was performed with 405 Nigerian...
Diagnosis of Placental Malaria
Mockenhaupt, Frank P., Ulmen, Ulrike, Von Gaertner, Christiane, Bedu-Addo, George, Bienzle, Ulrich
In a group of 596 delivering Ghanaian women, the sensitivities of peripheral blood thick film microscopy, ICT Malaria P.f/P.v test, and PCR in detecting microscopically confirmed placental Plasmodium...
Cramer, Jakob P, Mockenhaupt, Frank P, Möhl, Ingo, Dittrich, Sabine, Dietz, Ekkehardt, Otchwemah, Rowland N, ...
Wichmann, Ole, Muehlen, Marion, Gruss, Holger, Mockenhaupt, Frank P, Suttorp, Norbert, Jelinek, Tomas
Malarone® (atovaquone-proguanil) is an effective drug for the treatment and prophylaxis of multidrug-resistant falciparum malaria. However, first cases of resistance have been reported, which are...
Concurrence of Plasmodium falciparum dhfr and crt mutations in northern Ghana
Mockenhaupt, Frank P, Bousema, J Teun, Eggelte, Teunis A, Ehrhardt, Stephan, Otchwemah, Rowland N, Sauerwein, Robert W, ...
Mockenhaupt, Frank P., Cramer, Jakob P., Hamann, Lutz, Stegemann, Miriam S., Eckert, Jana, Oh, Na-Ri, ...
Genetic host factors play a substantial role in susceptibility to and severity of malaria, which continues to cause at least one million deaths per year. Recently, members of the toll-like receptor...
Schunk, Mirjam, Kumma, Wondimagegn P, Miranda, Isabel Barreto, Osman, Maha E, Roewer, Susanne, Alano, Abraham, ...
Detection and clinical manifestation of placental malaria in southern Ghana
Mockenhaupt, Frank P, Bedu-Addo, George, Von Gaertner, Christiane, Boyé, Renate, Fricke, Katrin, Hannibal, Iris, ...
Concentrations of Chloroquine and Malaria Parasites in Blood in Nigerian Children
Mockenhaupt, Frank P., May, Jürgen, Bergqvist, Yngve, Ademowo, Olusegun G., Olumese, Peter E., Falusi, Adeyinka G., ...
Consumption of chloroquine (CQ) and subtherapeutic drug levels in blood are considered to be widespread in areas where malaria is endemic. A cross-sectional study was performed with 405 Nigerian...
Diagnosis of Placental Malaria
Mockenhaupt, Frank P., Ulmen, Ulrike, Von Gaertner, Christiane, Bedu-Addo, George, Bienzle, Ulrich
In a group of 596 delivering Ghanaian women, the sensitivities of peripheral blood thick film microscopy, ICT Malaria P.f/P.v test, and PCR in detecting microscopically confirmed placental Plasmodium...
Cramer, Jakob P, Mockenhaupt, Frank P, Möhl, Ingo, Dittrich, Sabine, Dietz, Ekkehardt, Otchwemah, Rowland N, ...
Wichmann, Ole, Muehlen, Marion, Gruss, Holger, Mockenhaupt, Frank P, Suttorp, Norbert, Jelinek, Tomas
Malarone® (atovaquone-proguanil) is an effective drug for the treatment and prophylaxis of multidrug-resistant falciparum malaria. However, first cases of resistance have been reported, which are...
Concurrence of Plasmodium falciparum dhfr and crt mutations in northern Ghana
Mockenhaupt, Frank P, Bousema, J Teun, Eggelte, Teunis A, Ehrhardt, Stephan, Otchwemah, Rowland N, Sauerwein, Robert W, ...
Mockenhaupt, Frank P., Cramer, Jakob P., Hamann, Lutz, Stegemann, Miriam S., Eckert, Jana, Oh, Na-Ri, ...
Genetic host factors play a substantial role in susceptibility to and severity of malaria, which continues to cause at least one million deaths per year. Recently, members of the toll-like receptor...
Schunk, Mirjam, Kumma, Wondimagegn P, Miranda, Isabel Barreto, Osman, Maha E, Roewer, Susanne, Alano, Abraham, ...
Mockenhaupt, Frank P., Bedu-Addo, George, Junge, Claudia, Hommerich, Lena, Eggelte, Teunis A., Bienzle, Ulrich
Placental sequestration of Plasmodium falciparum in pregnancy may impair the usefulness of molecular markers of sulfadoxine-pyrimethamine resistance. In 300 infected, delivering women, the...
Reither, Klaus, Ignatius, Ralf, Weitzel, Thomas, Seidu-Korkor, Andrew, Anyidoho, Louis, Saad, Eiman, ...
Weitzel, Thomas, Reither, Klaus, Mockenhaupt, Frank P., Stark, Klaus, Ignatius, Ralf, Saad, Eiman, ...
We evaluated the Rida Quick rotavirus/adenovirus Combi rapid immunochromatographic test (ICT) under field conditions with Ghanaian children with acute diarrhea. Compared to PCR results, sensitivities...
Mockenhaupt, Frank P., Reither, Klaus, Zanger, Philipp, Roepcke, Felix, Danquah, Ina, Saad, Eiman, ...
Morbidity and mortality from malaria remain unacceptably high among young children in sub-Saharan Africa. Intermittent preventive treatment in infancy (IPTi) involves the administration of...
Large-Scale Surveillance of Plasmodium falciparum crt(K76T) in Northern Ghana▿
Ehrhardt, Stephan, Eggelte, Teunis A., Kaiser, Sarah, Adjei, Lydia, Burchard, Gerd D., Anemana, Sylvester D., ...
Surveillance of Plasmodium falciparum crt(K76T) [Pfcrt(K76T)], a resistance marker of chloroquine and, limitedly, amodiaquine, in >4,000 children in northern Ghana revealed a prevalence of 79%....
Hommerich, Lena, Von Oertzen, Christa, Bedu-Addo, George, Holmberg, Ville, Acquah, Patrick A, Eggelte, Teunis A, ...
Zoungrana, Augustin, Coulibaly, Boubacar, Sié, Ali, Walter-Sack, Ingeborg, Mockenhaupt, Frank P., Kouyaté, Bocar, ...
Zoller, Thomas, Naucke, Torsten J, May, Jürgen, Hoffmeister, Bodo, Flick, Holger, Williams, Christopher J, ...
In non-endemic areas, malaria is rare and locally acquired infections, particularly with Plasmodium falciparum, are exceptional events. The diagnosis is, therefore, likely to be delayed or missed in...
Coulibaly, Boubacar, Zoungrana, Augustin, Mockenhaupt, Frank P., Schirmer, R. Heiner, Klose, Christina, Mansmann, Ulrich, ...
Hamann, Lutz, Kumpf, Oliver, Schuring, Ron P, Alpsoy, Erkan, Bedu-Addo, George, Bienzle, Ulrich, ...
Zoller, Thomas, Naucke, Torsten J, May, Jürgen, Hoffmeister, Bodo, Flick, Holger, Williams, Christopher J, ...
In non-endemic areas, malaria is rare and locally acquired infections, particularly with Plasmodium falciparum, are exceptional events. The diagnosis is, therefore, likely to be delayed or missed in...
Reduced Efficacy of Intermittent Preventive Treatment of Malaria in Malnourished Children▿
Danquah, Ina, Dietz, Ekkehart, Zanger, Philipp, Reither, Klaus, Ziniel, Peter, Bienzle, Ulrich, ...
Intermittent preventive treatment in infants with sulfadoxine-pyrimethamine (IPTi-SP) reduces malaria episodes by 20 to 59% across Africa. This protective efficacy, however, may be affected by the...