Ice binding structure and mechanism of an antifreeze protein from winter flounder (1995)
The l.5A x-ray crystal structure of a lone $\alpha$-helical antifreeze protein (AFP) from winter flounder is presented, providing the first detailed look at an AFP and its ice binding features. The...
Thesis (Ph. D.)--McMaster University, 1995.
Binns, Kathleen L., Taylor, Paul P., Sicheri, Frank, Pawson, Tony, Holland, Sacha J.
Members of the Eph family of receptor tyrosine kinases exhibit a striking degree of amino acid homology, particularly notable in the kinase and membrane-proximal regions. A mutagenesis approach was...
Dey, Madhusudan, Trieselmann, Bruce, Locke, Emily G., Lu, Jingfang, Cao, Chune, Dar, Arvin C., ...
Four stress-responsive protein kinases, including GCN2 and PKR, phosphorylate eukaryotic translation initiation factor 2α (eIF2α) on Ser51 to regulate general and gene-specific protein synthesis....
Binns, Kathleen L., Taylor, Paul P., Sicheri, Frank, Pawson, Tony, Holland, Sacha J.
Members of the Eph family of receptor tyrosine kinases exhibit a striking degree of amino acid homology, particularly notable in the kinase and membrane-proximal regions. A mutagenesis approach was...
Dey, Madhusudan, Trieselmann, Bruce, Locke, Emily G., Lu, Jingfang, Cao, Chune, Dar, Arvin C., ...
Four stress-responsive protein kinases, including GCN2 and PKR, phosphorylate eukaryotic translation initiation factor 2α (eIF2α) on Ser51 to regulate general and gene-specific protein synthesis....
A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases
Wiesner, Silke, Wybenga-Groot, Leanne E, Warner, Neil, Lin, Hong, Pawson, Tony, Forman-Kay, Julie D, ...
Eph receptor tyrosine kinases (RTKs) mediate numerous developmental processes. Their activity is regulated by auto-phosphorylation on two tyrosines within the juxtamembrane segment (JMS) immediately...
Murphy, James M., Korzhnev, Dmitry M., Ceccarelli, Derek F., Briant, Douglas J., Zarrine-Afsar, Arash, Sicheri, Frank, ...
The Par-1/MARK protein kinases play a pivotal role in establishing cellular polarity. This family of kinases contains a unique domain architecture, in which a ubiquitin-associated (UBA) domain is...
Ice binding structure and mechanism of an antifreeze protein from winter flounder.
Thesis (Ph.D.)--McMaster University (Canada), 1995.
CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling
Rajakulendran, Thanashan, Sahmi, Malha, Kurinov, Igor, Tyers, Mike, Therrien, Marc, Sicheri, Frank
RAF kinase functions in the mitogen-activated protein kinase (MAPK) pathway to transmit growth signals to the downstream kinases MEK and ERK. Activation of RAF catalytic activity is facilitated by a...
Protein kinase PKR mutants resistant to the poxvirus pseudosubstrate K3L protein
Seo, Eun Joo, Liu, Furong, Kawagishi-Kobayashi, Makiko, Ung, Tekly L., Cao, Chune, Dar, Arvin C., ...
As part of the mammalian cell innate immune response, the double-stranded RNA activated protein kinase PKR phosphorylates the translation initiation factor eIF2α to inhibit protein synthesis and...
Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor
Mittag, Tanja, Orlicky, Stephen, Choy, Wing-Yiu, Tang, Xiaojing, Lin, Hong, Sicheri, Frank, ...
Intrinsically disordered proteins play critical but often poorly understood roles in mediating protein interactions. The interactions of disordered proteins studied to date typically entail...