Franklin Renty

Differential expression of metallothioneins (MTs) 1, 2, and 3 in response to zinc treatment in human prostate normal and malignant cells and tissues (2008)

Wei Hua, Desouki Mohamed, Lin Shufei, Xiao Dakai, Franklin Renty, Feng Pei

Abstract Background The disturbance of zinc homeostasis featured with a significant decrease of cellular zinc level was well documented to associate with the development and progression of human...

The Involvement of Bax in Zinc-Induced Mitochondrial Apoptogenesis in Malignant Prostate Cells (2008)

Feng Pei, Li Tieluo, Guan Zhixin, Franklin Renty, Costello Leslie

Abstract Background The development and progression of prostate cancer requires the transformation of normal zinc-accumulating epithelial cells to malignant cells that have lost the ability to...

hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands (2007)

Desouki Mohamed, Geradts Joseph, Milon Beatrice, Franklin Renty, Costello Leslie

Abstract Background The normal human prostate glandular epithelium has the unique function of accumulating high levels of zinc. In prostate cancer this capability is lost as an early event in the...

EAAC1 is expressed in rat and human prostate epithelial cells; functions as a high-affinity L-aspartate transporter; and is regulated by prolactin and testosterone (2006)

Franklin Renty, Zou Jing, Yu Ziqiang, Costello Les

Abstract Background Prostate epithelial cells accumulate a high level of aspartate that is utilized as a substrate for their unique function of production and secretion of enormously high levels of...

Mitochondrial aconitase and citrate metabolism in malignant and nonmalignant human prostate tissues (2006)

Singh Keshav, Desouki Mohamed, Franklin Renty, Costello Leslie

Abstract Background In prostate cancer, normal citrate-producing glandular secretory epithelial cells undergo a metabolic transformation to malignant citrate-oxidizing cells. m-Aconitase is the...

The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots (2006)

Costello Leslie, Franklin Renty

Abstract Background The genetic and molecular mechanisms responsible for and associated specifically with the development and progression of malignant prostate cells are largely unidentified. In...

Tumor cell metabolism: the marriage of molecular genetics and proteomics with cellular intermediary metabolism; proceed with caution! (2006)

Costello Leslie, Franklin Renty

Abstract Metabolic transformations of malignant cells are essential to the development and progression of all cancers. The understanding of the pathogenesis and progression of cancer requires the...

hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer (2005)

Franklin Renty, Feng Pei, Milon B, Desouki Mohamed, Singh Keshav, Kajdacsy-Balla André, ...

Abstract Background The genetic and molecular mechanisms responsible for and associated with the development and progression of prostate malignancy are largely unidentified. The peripheral zone is...