Frederic Simard

Chromosomal plasticity and evolutionary potential in the malaria vector Anopheles gambiaesensu stricto: insights from three decades of rare paracentric inversions (2008)

Pombi, Marco, Caputo, Beniamino, Simard, Frederic, Di Deco, Maria A, Coluzzi, Mario, Torre, Alessandra, ...

Abstract Background In the Anopheles gambiae complex, paracentric chromosomal inversions are non-randomly distributed along the complement: 18/31 (58%) of common polymorphic inversions are on...

Distribution of knock-down resistancemutations in Anopheles gambiaemolecular forms in west and west-central Africa (2008)

Santolamazza, Federica, Calzetta, Maria, Etang, Josiane, Barrese, Elena, Dia, Ibrahima, Caccone, Adalgisa, ...

Abstract Background Knock-down resistance ( kdr ) to DDT and pyrethroids in the major Afrotropical vector species, Anopheles gambiae sensu stricto, is associated with two alternative point mutations...

The molecular evolution of four anti-malarial immune genes in the Anopheles gambiaespecies complex (2008)

Parmakelis, Aristeidis, Slotman, Michel A, Marshall, Jonathon C, Awono-Ambene, Parfait H, Antonio-Nkondjio, Christophe, Simard, Frederic, ...

Abstract Background If the insect innate immune system is to be used as a potential blocking step in transmission of malaria, then it will require targeting one or a few genes with highest relevance...

Localization of Candidate Regions Maintaining a Common Polymorphic Inversion (2La) in Anopheles gambiae (2007)

Bradley J. White, Matthew W. Hahn, Marco Pombi, Bryan J. Cassone, Neil F. Lobo, Frederic Simard, ...

Chromosomal inversion polymorphisms are thought to play a role in adaptive divergence, but the genes conferring adaptive benefits remain elusive. Here we study 2La, a common polymorphic inversion in...

Genetic population structure of Anopheles gambiaein Equatorial Guinea (2007)

Moreno, Marta, Salgueiro, Patricia, Vicente, José, Cano, Jorge, Berzosa, Pedro J, De Lucio, Aida, ...

Abstract Background Patterns of genetic structure among mosquito vector populations in islands have received particular attention as these are considered potentially suitable sites for experimental...

Localization of Candidate Regions Maintaining a Common Polymorphic Inversion (2La) in Anopheles gambiae (2007)

Bradley J White, Matthew W. Hahn, Marco Pombi, Bryan J Cassone, Neil F. Lobo, Frederic Simard, ...

Chromosomal inversion polymorphisms are thought to play a role in adaptive divergence, but the genes conferring adaptive benefits remain elusive. Here we study 2La, a common polymorphic inversion in...

Population genetic structure of Plasmodium falciparum in the two main African vectors, Anopheles gambiale and Anopheles funestus (2007)

Koella, Jacob C., Annan, Zeinab, Simard, Frederic, Renaud, Francois, Arnathau, Celine, Awono-Ambene, Parfait, ...

We investigated patterns of genetic diversity of Plasmodium falciparum associated with its two main African vectors: Anopheles gambiae and Anopheles funestus. We dissected 10,296 wild-caught...

Larval Development of the Molecular Forms of Anopheles gambiae (Diptera: Culicidae) in Different Habitats: A Transplantation Experiment (2005)

Abdoulaye Diabaté, Roch K. Dabire, Eun H. Kim, Ryan Dalton, Niama Millogo, Thierry Baldet, ...

We compared the development of the molecular forms of Anopheles gambiae s.s. in different larval habitats. First stage larvae (L1s) of wild-caught females were placed into cages in natural habitats...

High Malaria Transmission Intensity Due to Anopheles funestus (Diptera: Culicidae) in a Village of Savannah–Forest Transition Area in Cameroon (2004)

Anna Cohuet, Frederic Simard, Charles S. Wondji, Christophe Antonio-Nkondjio, Parfait Awono-Ambene, Didier Fontenille

An entomological survey was conducted on vectors of malaria in a village of the forest–savannah transition area in Cameroon from February 1999 to October 2000. A total of 2,050 anopheline...

Increased melanizing activity in Anopheles gambiae does not affect development of Plasmodium falciparum

Michel, Kristin, Suwanchaichinda, Chansak, Morlais, Isabelle, Lambrechts, Louis, Cohuet, Anna, Awono-Ambene, Parfait H., ...

Serpins are central to the modulation of various innate immune responses in insects and are suspected to influence the outcome of malaria parasite infection in mosquito vectors. Three Anopheles...

Anopheles and Plasmodium: from laboratory models to natural systems in the field

Cohuet, Anna, Osta, Mike A, Morlais, Isabelle, Awono-Ambene, Parfait H, Michel, Kristin, Simard, Frederic, ...

Parasites that cause malaria must complete a complex life cycle in Anopheles vector mosquitoes in order to be transmitted from human to human. Previous gene-silencing studies have shown the influence...

Localization of Candidate Regions Maintaining a Common Polymorphic Inversion (2La) in Anopheles gambiae

White, Bradley J, Hahn, Matthew W, Pombi, Marco, Cassone, Bryan J, Lobo, Neil F, Simard, Frederic, ...

Chromosomal inversion polymorphisms are thought to play a role in adaptive divergence, but the genes conferring adaptive benefits remain elusive. Here we study 2La, a common polymorphic inversion in...

Exploring Proteins in Anopheles gambiae Male and Female Antennae through MALDI Mass Spectrometry Profiling

Dani, Francesca R., Francese, Simona, Mastrobuoni, Guido, Felicioli, Antonio, Caputo, Beniamino, Simard, Frederic, ...

MALDI profiling and imaging mass spectrometry (IMS) are novel techniques for direct analysis of peptides and small proteins in biological tissues. In this work we applied them to the study of...