Bartuma, Hammurabi, Panagopoulos, Ioannis, Collin, Anna, Trombetta, Domenico, Domanski, Henryk A, Mandahl, Nils, ...
Abstract Background The HMGA2 gene encodes a protein that alters chromatin structure. Deregulation, typically through chromosomal rearrangements, of HMGA2 has an important role in the development of...
Henriksson, Eva, Kjellén, Elisabeth, Baldetorp, Bo, Bendahl, Pär-Ola, Borg, Åke, Brun, Eva, ...
Abstract Background The survival of patients with locally advanced head and neck cancer is still poor, with 5-year survival rates of 24–35%. The identification of prognostic and predictive markers...
Tiling resolution array comparative genomic hybridization analysis of a fibrosarcoma of bone. (2007)
Hallor, Karolin H, Heidenblad, Markus, Brosjo, Otte, Mandahl, Nils, Mertens, Fredrik
Abstract is not available
Cytogenetic findings in pediatric renal cell carcinoma. (2007)
Soller, Maria Johansson, Kullendorff, Carl-Magnus, Békássy, Albert N, Alumets, Jan, Mertens, Fredrik
Abstract is not available
Bartuma, Hammurabi, Hallor, Karolin H, Panagopoulos, Ioannis, Collin, Anna, Rydholm, Anders, Gustafson, Pelle, ...
Abstract is not available
The impact of translocations and gene fusions on cancer causation. (2007)
Mitelman, Felix, Johansson, Bertil, Mertens, Fredrik
Abstract is not available
Unstable translocation (8;22) in a case of giant cell reparative granuloma. (2007)
Johnsson, Anna, Collin, Anna, Rydholm, Anders, Domanski, Henryk A, Mertens, Fredrik, Mandahl, Nils
Abstract is not available
Comparison of the proximal promoter regions of the PAX3 and PAX7 genes. (2007)
Moller, Emely, Isaksson, Margareth, Mandahl, Nils, Mertens, Fredrik, Panagopoulos, Ioannis
Abstract is not available
Molecular identification of COL6A3-CSF1 fusion transcripts in tenosynovial giant cell tumors. (2007)
Moller, Emely, Mandahl, Nils, Mertens, Fredrik, Panagopoulos, Ioannis
Abstract is not available
Concurrent gain of 17q and the MYC oncogene in a medullomyoblastoma. (2007)
Lindberg, Eva, Persson, Annette, Ora, Ingrid, Mertens, Fredrik, Englund, Elisabet, Gisselsson, David
Abstract is not available
Panagopoulos, Ioannis, Mandahl, Nils, Mertens, Fredrik, ...
Subungual exostosis is a benign bone- and cartilage-producing tumor occurring in the hands and feet of children and young adults. The recent identification of a recurrent chromosomal translocation...
Cytogenetic abnormalities in 106 oral squamous cell carcinomas. (2006)
Jin, Charlotte, Jin, Yuesheng, Wennerberg, Johan, Annertz, Karin, Enoksson, Jens, Mertens, Fredrik
Abstract is not available
Successful treatment of a child with t(15;19)-positive tumor. (2006)
Mertens, Fredrik, Wiebe, Thomas, Adlercreutz, Catharina, Mandahl, Nils, French, Christopher A
Abstract is not available
Domanski, Henryk A, Akerman, Mans, Engellau, Jacob, Gustafson, Pelle, Mertens, Fredrik, Rydholm, Anders
Abstract is not available
Jin, Yuesheng, Mertens, Fredrik, Kullendorff, Carl-Magnus, Panagopoulos, Ioannis
Abstract is not available
Characterization of the native CREB3L2 transcription factor and the FUS/CREB3L2 chimera. (2006)
Panagopoulos, Ioannis, Moller, Emely, Dahlén, Anna, Isaksson, Margareth, Mandahl, Nils, Vlamis-Gardikas, Alexios, ...
Abstract is not available
Fusion genes in angiomatoid fibrous histiocytoma. (2006)
Hallor, Karolin H, Micci, Francesca, Meis-Kindblom, Jeanne M, Kindblom, Lars-Gunnar, Bacchini, Patrizia, Mandahl, Nils, ...
Abstract is not available
Winnes, Marta, Gorunova, Ludmila, Mertens, Fredrik, Enlund, Fredrik, ...
Recent studies have shown that the t(11;19)(q21;p13) translocation in mucoepidermoid carcinomas and benign Warthin's tumors results in a fusion of the N-terminal CREB-binding domain of the cAMP...
Panagopoulos, Ioannis, Mertens, Fredrik, Isaksson, Margareth, Mandahl, Nils
Abstract is not available
Karyotypic evolution and tumor progression in head and neck squamous cell carcinomas. (2005)
Jin, Yuesheng, Jin, Charlotte, Lv, Mei, Tsao, Sai-Wah, Zhu, Jingke, Wennerberg, Johan, ...
Abstract is not available
Mertens, Fredrik, Fletcher, Christopher D M, Antonescu, Cristina R, Coindre, Jean-Michel, Colecchia, Maurizio, Domanski, Henryk A, ...
Abstract is not available
Atypical lipomatous tumor with rare structural rearrangements involving chromosomes 8 and 12. (2005)
Nilsson, Malin, Domanski, Henryk, Mertens, Fredrik, Mandahl, Nils
Abstract is not available
Stewénius, Ylva, Gorunova, Ludmila, Jonson, Tord, Larsson, Nina, Höglund, Mattias, Mandahl, Nils, ...
Abstract is not available
Core-needle biopsy performed by the cytopathologist. (2005)
Domanski, Henryk A, Akerman, Måns, Carlén, Birgitta, Engellau, Jacob, Gustafson, Pelle, Jonsson, Kjell, ...
Abstract is not available
Hallor, Karolin Hansén, Mertens, Fredrik, Jin, Yuesheng, Meis-Kindblom, Jeanne M, Kindblom, Lars-Gunnar, Behrendtz, Mikael, ...
Abstract is not available
Mitelman, Felix, Mertens, Fredrik, Johansson, Bertil
Abstract is not available
Fusion of the SEC31L1 and ALK genes in an inflammatory myofibroblastic tumor. (2005)
Panagopoulos, Ioannis, Nilsson, Therese, Domanski, Henryk A, Isaksson, Margareth, Lindblom, Pia, Mertens, Fredrik, ...
Abstract is not available
Gene expression profiles relate to SS18/SSX fusion type in synovial sarcoma. (2005)
Fernebro, Josefin, Francis, Princy, Edén, Patrik, Borg, Ake, Panagopoulos, Ioannis, Mertens, Fredrik, ...
Abstract is not available
Surace, Cecilia, Storlazzi, Clelia, Engellau, Jacob, Domanski, Henryk, Gustafson, Pelle, Panagopoulos, Ioannis, ...
Abstract is not available
Prognostic Significance of Chromosome Aberrations in High-Grade Soft Tissue Sarcomas. (2005)
Mertens, Fredrik, Stromberg, Ulf, Rydholm, Anders, Gustafson, Pelle, Bauer, Henrik C F, Brosjo, Otte, ...
Abstract is not available
Fletcher, Christopher D M, Mertens, Fredrik, Fletcher, Jonathan A, Perez-Atayde, Antonio R, Hicks, M John, ...
Activation of the GLI oncogene is an important step in the sonic hedgehog signaling pathway, and leads to, eg, tissue-specific cell proliferation during embryogenesis. GLI activity in adult tissues...
Amplification of chromosome 1 sequences in lipomatous tumors and other sarcomas. (2004)
Nilsson, Malin, Meza-Zepeda, Leonardo A, Mertens, Fredrik, Forus, Anne, Myklebost, Ola, Mandahl, Nils
Abstract is not available
Statistical analyses of karyotypic complexity in head and neck squamous cell carcinoma. (2004)
Höglund, Mattias, Jin, Charlotte, Gisselsson, David, Hansen, Gunnar B, Mitelman, Felix, Mertens, Fredrik
Abstract is not available
Mitotic instability associated with late genomic changes in bone and soft tissue tumours. (2004)
Gisselsson, David, Pålsson, Eva, Yu, Christina, Mertens, Fredrik, Mandahl, Nils
Abstract is not available
Dahlén, Anna, Fletcher, Christopher D M, Mertens, Fredrik, Fletcher, Jonathan A, Perez-Atayde, Antonio R, Hicks, M John, ...
Abstract is not available
The chimeric FUS/CREB3l2 gene is specific for low-grade fibromyxoid sarcoma. (2004)
Panagopoulos, Ioannis, Tiziana Storlazzi, Clelia, Fletcher, Christopher D M, Fletcher, Jonathan A, Nascimento, Antonio, Domanski, Henryk A, ...
Abstract is not available
A novel FISH assay for SS18-SSX fusion type in synovial sarcoma. (2004)
Surace, Cecilia, Panagopoulos, Ioannis, Pålsson, Eva, Rocchi, Mariano, Mandahl, Nils, Mertens, Fredrik
Abstract is not available
Panagopoulos, Ioannis, Mertens, Fredrik, Isaksson, Margareth, Mandahl, Nils
Abstract is not available
Combined binary ratio labeling fluorescence in situ hybridization analysis of chordoma. (2004)
Kuźniacka, Alina, Mertens, Fredrik, Strömbeck, Bodil, Wiegant, Joop, Mandahl, Nils
Abstract is not available
Nilsson, Malin, Domanski, Henryk A, Mertens, Fredrik, Mandahl, Nils
Abstract is not available
Molecular genetic characterization of the genomic ACTB-GLI fusion in pericytoma with t(7;12). (2004)
Dahlén, Anna, Mertens, Fredrik, Mandahl, Nils, Panagopoulos, Ioannis
Abstract is not available
Johansson, Bertil, Mertens, Fredrik, Mitelman, Felix
Abstract is not available
Clustering of deletions on chromosome 13 in benign and low-malignant lipomatous tumors (2003)
Pedeutour, Florence, Domanski, Henryk A, Höglund, Mattias, Bauer, Henrik C F, ...
Deletions and structural rearrangements of the long arm of chromosome 13 are frequently observed in benign and low-malignant lipomatous tumors, but nothing is known about their molecular genetic...
Cytogenetic findings and clinical course in a consecutive series of Wilms tumors. (2003)
Kullendorff, Carl Magnus, Soller, Maria, Wiebe, Thomas, Mertens, Fredrik
Abstract is not available
Clustering of deletions on chromosome 13 in benign and low-malignant lipomatous tumors. (2003)
Dahlén, Anna, Debiec-Rychter, Maria, Pedeutour, Florence, Domanski, Henryk A, Höglund, Mattias, Bauer, Henrik C F, ...
Abstract is not available
A novel fusion gene, SS18L1/SSX1, in synovial sarcoma. (2003)
Storlazzi, Clelia Tiziana, Mertens, Fredrik, Mandahl, Nils, Gisselsson, David, Isaksson, Margareth, Gustafson, Pelle, ...
Abstract is not available
Fusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma. (2003)
Storlazzi, Clelia Tiziana, Mertens, Fredrik, Nascimento, Antonio, Isaksson, Margareth, Wejde, Johan, Brosjo, Otte, ...
Abstract is not available
Fusion, disruption, and expression of HMGA2 in bone and soft tissue chondromas. (2003)
Dahlén, Anna, Mertens, Fredrik, Rydholm, Anders, Brosjö, Otte, Wejde, Johan, Mandahl, Nils, ...
Abstract is not available
Domanski, Henryk A, Carlén, Birgitta, Mertens, Fredrik, Akerman, Måns
Abstract is not available
Fusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma (2003)
Storlazzi, Clelia Tiziana, Mertens, Fredrik, Nascimento, Antonio, Isaksson, Margareth, Wejde, Johan, Brosjö, Otte, ...
The FUSgene at 16p11 fuses with DDIT3and ATF1 as the result of translocations with chromosome band 12q13 in myxoid liposarcoma and angiomatoid fibrous histiocytoma, respectively, and with ERG as the...
Fusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma (2003)
Storlazzi, Clelia Tiziana, Mertens, Fredrik, Nascimento, Antonio, Isaksson, Margareth, Wejde, Johan, Brosjö, Otte, ...
The FUS gene at 16p11 fuses with DDIT3 and ATF1 as the result of translocations with chromosome band 12q13 in myxoid liposarcoma and angiomatoid fibrous histiocytoma, respectively, and with ERG as...
Fusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma (2003)
Storlazzi, Clelia Tiziana, Mertens, Fredrik, Nascimento, Antonio, Isaksson, Margareth, Wejde, Johan, Brosjö, Otte, ...
The FUSgene at 16p11 fuses with DDIT3and ATF1 as the result of translocations with chromosome band 12q13 in myxoid liposarcoma and angiomatoid fibrous histiocytoma, respectively, and with ERG as the...
Mertens, Fredrik, Isaksson, Margareth, Domanski, Henryk A, Brosjö, Otte, Heim, Sverre, ...
Extraskeletal myxoid chondrosarcoma (EMC) is a soft-tissue neoplasm cytogenetically characterized by the translocations t(9;22)(q22;q11-12) or t(9;17)(q22;q11), generating EWS/CHN or RBP56/CHN fusion...
Mertens, Fredrik, Isaksson, Margareth, Limon, Janusz, Kardas, Iwona, ...
Clear cell sarcoma (CCS) is a rare malignant soft tissue tumor particularly associated with tendons and aponeuroses. The cytogenetic hallmark is the translocation t(12;22)(q13;q12) resulting in a...
Differentially amplified chromosome 12 sequences in low- and high-grade osteosarcoma (2002)
Pålsson, Eva, Höglund, Mattias, Domanski, Henryk, Mertens, Fredrik, Pandis, Nikos, ...
Most osteosarcomas are highly aggressive malignancies characterized by a complex pattern of chromosome abnormalities. However, a subgroup of low-grade, parosteal tumors exhibits a relatively simple...
Dorfman, Howard, Brys, Peter, Fletcher, Christopher D M, ...
The evaluation of chondroid lesions requires full integration of clinical, radiographic, and pathological data; tumour typing is often a challenge for the diagnostic pathologist. Although a variety...
Jin, Charlotte, Jin, Yuesheng, Wennerberg, Johan, Akervall, Jan, Dictor, Michael, Mertens, Fredrik
Head and neck squamous cell carcinomas (HNSCC) are often characterized by complex karyotypic changes, and a substantial proportion of the reported tumors have shown intratumor heterogeneity in the...
Cytogenetic aberrations and their prognostic impact in chondrosarcoma. (2002)
Mandahl, Nils, Gustafson, Pelle, Mertens, Fredrik, Akerman, Måns, Baldetorp, Bo, Gisselsson, David, ...
Chondrosarcoma is the second most common primary malignancy of bone. Cytogenetic data are available from close to 100 cases, including all subtypes of chondrosarcoma. Specific chromosomal...
Differentially amplified chromosome 12 sequences in low- and high-grade osteosarcoma. (2002)
Gisselsson, David, Pålsson, Eva, Höglund, Mattias, Domanski, Henryk, Mertens, Fredrik, Pandis, Nikos, ...
Most osteosarcomas are highly aggressive malignancies characterized by a complex pattern of chromosome abnormalities. However, a subgroup of low-grade, parosteal tumors exhibits a relatively simple...
Akervall, Jan, Borg, Ake, Dictor, Michael, Jin, Charlotte, Jin, Yuesheng, Tanner, Minna, ...
CCND1 amplification results in cyclin D1 overexpression. However, other unidentified genetic mechanisms contribute to enhanced gene expression. In the present study, 32 squamous cell carcinoma of the...
Jin, Yuesheng, Jin, Charlotte, Wennerberg, Johan, Höglund, Mattias, Mertens, Fredrik
Eight cytogenetically characterized head and neck squamous cell carcinomas (HNSCCs) with CCND1 amplification in the form of a homogeneously staining region (hsr) in 11q13 were studied by COBRA FISH...
Panagopoulos, Ioannis, Mertens, Fredrik, Dêbiec-Rychter, Maria, Isaksson, Margareth, Limon, Janusz, Kardas, Iwona, ...
Clear cell sarcoma (CCS) is a rare malignant soft tissue tumor particularly associated with tendons and aponeuroses. The cytogenetic hallmark is the translocation t(12;22)(q13;q12) resulting in a...
Broberg, Karin, Zhang, Miao, Strombeck, Bodil, Isaksson, Margareth, Nilsson, Malin, Mertens, Fredrik, ...
Rearrangements of chromosome bands 12q13-15 are frequent in various benign mesenchymal and epithelial tumors, and the gene HMGA2 seems to be the most common target within this chromosome region. In...
Mertens, Fredrik, Strömberg, Ulf, Mandahl, Nils, Cin, Paola Dal, De Wever, Ivo, Fletcher, Christopher D M, ...
Cytogenetic analysis has not only provided important information on the pathogenesis of soft tissue tumors but, by disclosing distinct chromosomal rearrangements in different histopathological...
Panagopoulos, Ioannis, Mertens, Fredrik, Isaksson, Margareth, Domanski, Henryk A, Brosjö, Otte, Heim, Sverre, ...
Extraskeletal myxoid chondrosarcoma (EMC) is a soft-tissue neoplasm cytogenetically characterized by the translocations t(9;22)(q22;q11-12) or t(9;17)(q22;q11), generating EWS/CHN or RBP56/CHN fusion...
Fletcher, Christopher D. M, Mandahl, Nils, Mertens, Fredrik, Mitelman, Felix, ...
Afdeling Oncologische heelkunde. Departement Menselijke erfelijkheid.
Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity
Gisselsson, David, Pettersson, Louise, Höglund, Mattias, Heidenblad, Markus, Gorunova, Ludmila, Wiegant, Joop, ...
It has long been known that rearrangements of chromosomes through breakage-fusion-bridge (BFB) cycles may cause variability of phenotypic and genetic traits within a cell population. Because...
Gisselsson, David, Jonson, Tord, Petersén, Åsa, Strömbeck, Bodil, Dal Cin, Paola, Höglund, Mattias, ...
Although mechanisms for chromosomal instability in tumors have been described in animal and in vitro models, little is known about these processes in man. To explore cytogenetic evolution in human...
Stewénius, Ylva, Gorunova, Ludmila, Jonson, Tord, Larsson, Nina, Höglund, Mattias, Mandahl, Nils, ...
Telomere dysfunction has been associated with chromosomal instability in colorectal carcinoma, but the consequences of telomere-dependent instability for chromosome integrity and clonal evolution...
Jin, Yuesheng, Mertens, Fredrik, Kullendorff, Carl-Magnus, Panagopoulos, Ioannis
We characterized the molecular genetic consequences of a balanced chromosome translocation t(8;22)(p21;q12) which occurred as the sole cytogenetic aberration in short-term cultured cells from an...
Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity
Gisselsson, David, Pettersson, Louise, Höglund, Mattias, Heidenblad, Markus, Gorunova, Ludmila, Wiegant, Joop, ...
It has long been known that rearrangements of chromosomes through breakage-fusion-bridge (BFB) cycles may cause variability of phenotypic and genetic traits within a cell population. Because...
Gisselsson, David, Jonson, Tord, Petersén, Åsa, Strömbeck, Bodil, Dal Cin, Paola, Höglund, Mattias, ...
Although mechanisms for chromosomal instability in tumors have been described in animal and in vitro models, little is known about these processes in man. To explore cytogenetic evolution in human...
Stewénius, Ylva, Gorunova, Ludmila, Jonson, Tord, Larsson, Nina, Höglund, Mattias, Mandahl, Nils, ...
Telomere dysfunction has been associated with chromosomal instability in colorectal carcinoma, but the consequences of telomere-dependent instability for chromosome integrity and clonal evolution...
Jin, Yuesheng, Mertens, Fredrik, Kullendorff, Carl-Magnus, Panagopoulos, Ioannis
We characterized the molecular genetic consequences of a balanced chromosome translocation t(8;22)(p21;q12) which occurred as the sole cytogenetic aberration in short-term cultured cells from an...
Dahlén, Anna, Fletcher, Christopher D. M., Mertens, Fredrik, Fletcher, Jonathan A., Perez-Atayde, Antonio R., Hicks, M. John, ...
Activation of the GLI oncogene is an important step in the sonic hedgehog signaling pathway, and leads to, eg, tissue-specific cell proliferation during embryogenesis. GLI activity in adult tissues...
Fletcher, Christopher D. M., Dal Cin, Paola, De Wever, Ivo, Mandahl, Nils, Mertens, Fredrik, Mitelman, Felix, ...
Soft-tissue tumors have proved to be a fruitful area for the identification of reproducible cytogenetic aberrations, especially among pediatric round-cell sarcomas and lipomatous tumors. Thus far,...
Gisselsson, David, Höglund, Mattias, Mertens, Fredrik, Dal Cin, Paola, Mandahl, Nils
Hibernomas are benign tumors of brown fat, frequently characterized by aberrations of chromosome band 11q13. In this study, the chromosome 11 changes in five hibernomas were analyzed in detail by...
Abnormal Nuclear Shape in Solid Tumors Reflects Mitotic Instability
Gisselsson, David, Björk, Jonas, Höglund, Mattias, Mertens, Fredrik, Dal Cin, Paola, Åkerman, Måns, ...
Abnormalities in nuclear morphology are frequently observed in malignant tissues but the mechanisms behind these phenomena are still poorly understood. In this study, the relation between abnormal...