Hiroki Shimura, Hideyo Suzuki, Asako Miyazaki, Fumihiko Furuya, Kazuyasu Ohta, Kazutaka Haraguchi, ...
Gene therapy with thyroglobulin (TG) promoter and a prodrug/suicide gene combination may prove useful as a treatment for thyroid carcinoma. However, most poorly differentiated and anaplastic thyroid...
Furuya, Fumihiko, Lu, Changxue, Willingham, Mark C., Cheng, Sheue-yann
Aberrant activation of the phosphatidylinositol 3-kinase (PI3K)–AKT/protein kinase B-signaling pathway has been associated with multiple human cancers, including thyroid cancer. Recently, we showed...
Ying, Hao, Furuya, Fumihiko, Willingham, Mark C., Xu, Jianming, O'Malley, Bert W., Cheng, Sheue-yann
Mutations of the thyroid hormone receptor β (TRβ) gene cause resistance to thyroid hormone (RTH). RTH is characterized by increased serum thyroid hormone associated with nonsuppressible...
Araki, Osamu, Ying, Hao, Furuya, Fumihiko, Zhu, Xuguang, Cheng, Sheue-yann
Thyroid hormone (T3) and peroxisome proliferators have overlapping metabolic effects in the maintenance of lipid homeostasis. Their actions are mediated by their respective receptors: thyroid hormone...
Activation of phosphatidylinositol 3-kinase signaling by a mutant thyroid hormone β receptor
Furuya, Fumihiko, Hanover, John A., Cheng, Sheue-yann
Activation of the phosphatidylinositol 3-kinase (PI3K)–AKT/protein kinase B signaling pathway has been associated with multiple human cancers. Recently we showed that AKT is activated in both the...
Ying, Hao, Furuya, Fumihiko, Zhao, Li, Araki, Osamu, West, Brian L., Hanover, John A., ...
Overexpression of pituitary tumor–transforming 1 (PTTG1) is associated with thyroid cancer. We found elevated PTTG1 levels in the thyroid tumors of a mouse model of follicular thyroid carcinoma...
Ying, Hao, Furuya, Fumihiko, Willingham, Mark C., Xu, Jianming, O'Malley, Bert W., Cheng, Sheue-yann
Mutations of the thyroid hormone receptor β (TRβ) gene cause resistance to thyroid hormone (RTH). RTH is characterized by increased serum thyroid hormone associated with nonsuppressible...
Araki, Osamu, Ying, Hao, Furuya, Fumihiko, Zhu, Xuguang, Cheng, Sheue-yann
Thyroid hormone (T3) and peroxisome proliferators have overlapping metabolic effects in the maintenance of lipid homeostasis. Their actions are mediated by their respective receptors: thyroid hormone...
Activation of phosphatidylinositol 3-kinase signaling by a mutant thyroid hormone β receptor
Furuya, Fumihiko, Hanover, John A., Cheng, Sheue-yann
Activation of the phosphatidylinositol 3-kinase (PI3K)–AKT/protein kinase B signaling pathway has been associated with multiple human cancers. Recently we showed that AKT is activated in both the...
Ying, Hao, Furuya, Fumihiko, Zhao, Li, Araki, Osamu, West, Brian L., Hanover, John A., ...
Overexpression of pituitary tumor–transforming 1 (PTTG1) is associated with thyroid cancer. We found elevated PTTG1 levels in the thyroid tumors of a mouse model of follicular thyroid carcinoma...
Rapid nongenomic actions of thyroid hormone
Hiroi, Yukio, Kim, Hyung-Hwan, Ying, Hao, Furuya, Fumihiko, Huang, Zhihong, Simoncini, Tommaso, ...
The binding of thyroid hormone to the thyroid hormone receptor (TR) mediates important physiological effects. However, the transcriptional effects of TR mediated by the thyroid response element (TRE)...
Impaired Adipogenesis Caused by a Mutated Thyroid Hormone α1 Receptor▿
Ying, Hao, Araki, Osamu, Furuya, Fumihiko, Kato, Yasuhito, Cheng, Sheue-Yann
Thyroid hormone (T3) is critical for growth, differentiation, and maintenance of metabolic homeostasis. Mice with a knock-in mutation in the thyroid hormone receptor α gene (TRα1PV) were created...
Nuclear Receptor Corepressor Is a Novel Regulator of Phosphatidylinositol 3-Kinase Signaling▿
Furuya, Fumihiko, Guigon, Celine J., Zhao, Li, Lu, Changxue, Hanover, John A., Cheng, Sheue-yann
The nuclear receptor corepressor (NCoR) regulates the activities of DNA-binding transcription factors. Recent observations of its distribution in the extranuclear compartment raised the possibility...
Lu, Changxue, Willingham, Mark C., Furuya, Fumihiko, Cheng, Sheue-yann
TSH-secreting pituitary tumors (TSHomas) are pituitary tumors that constitutively secrete TSH. Molecular mechanisms underlying this abnormality are largely undefined. We recently created a knock-in...