Fumihiko Takeshita

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes (2008)

Spanel-Borowski, Katharina, Smith, Mark A., Simone, Cristiano, Simonsen, Anne, Simon, Hans-Uwe, ...

Research in autophagy continues to accelerate, and as a result many new scientists are entering the field. Accordingly, it is important to establish a standard set of criteria for monitoring...

Toll-Like Receptor Adaptor Molecules Enhance DNA-Raised Adaptive Immune Responses against Influenza and Tumors through Activation of Innate Immunity

Takeshita, Fumihiko, Tanaka, Toshiyuki, Matsuda, Tomoko, Tozuka, Miyuki, Kobiyama, Kouji, Saha, Sukumar, ...

Toll-like receptors (TLRs) recognize microbial components and trigger the signaling cascade that activates the innate and adaptive immunity. TLR adaptor molecules play a central role in this cascade;...

Toll-Like Receptor Adaptor Molecules Enhance DNA-Raised Adaptive Immune Responses against Influenza and Tumors through Activation of Innate Immunity

Takeshita, Fumihiko, Tanaka, Toshiyuki, Matsuda, Tomoko, Tozuka, Miyuki, Kobiyama, Kouji, Saha, Sukumar, ...

Toll-like receptors (TLRs) recognize microbial components and trigger the signaling cascade that activates the innate and adaptive immunity. TLR adaptor molecules play a central role in this cascade;...

Localization of CORO1A in the Macrophages Containing Mycobacterium leprae

Suzuki, Koichi, Takeshita, Fumihiko, Nakata, Noboru, Ishii, Norihisa, Makino, Masahiko

Mycobacteria have acquired an intracellular lifestyle within the macrophage, which is best exemplified by the enlarged infected histiocytes seen in lepromatous leprosy. To survive within the cell,...

The Atg5–Atg12 conjugate associates with innate antiviral immune responses

Jounai, Nao, Takeshita, Fumihiko, Kobiyama, Kouji, Sawano, Asako, Miyawaki, Atsushi, Xin, Ke-Qin, ...

Autophagy is an essential process for physiological homeostasis, but its role in viral infection is only beginning to be elucidated. We show here that the Atg5–Atg12 conjugate, a key regulator of...

Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction

Uematsu, Satoshi, Sato, Shintaro, Yamamoto, Masahiro, Hirotani, Tomonori, Kato, Hiroki, Takeshita, Fumihiko, ...

Toll-like receptors (TLRs) recognize microbial pathogens and trigger innate immune responses. Among TLR family members, TLR7, TLR8, and TLR9 induce interferon (IFN)-α in plasmacytoid dendritic cells...

Potential Role of Phosphatidylinositol 3 Kinase, rather than DNA-dependent Protein Kinase, in CpG DNA–induced Immune Activation

Ishii, Ken J., Takeshita, Fumihiko, Gursel, Ihsan, Gursel, Mayda, Conover, Jacqueline, Nussenzweig, Andre, ...

Unmethylated CpG motifs present in bacterial DNA stimulate a strong innate immune response. There is evidence that DNA-dependent protein kinase (DNA-PK) mediates CpG signaling. Specifically,...