Fumio Kobune

Genetic characterization of measles viruses isolated in Turkey during 2000 and 2001 (2005)

Korukluoglu, Gulay, Liffick, Stephanie, Guris, Dalya, Kobune, Fumio, Rota, Paul A, Bellini, William J, ...

Abstract Background Molecular epidemiologic studies have made significant contributions to measles surveillance activities by helping to identify source and transmission pathways of the virus. This...

Measles Virus Attenuation Associated with Transcriptional Impediment and a Few Amino Acid Changes in the Polymerase and Accessory Proteins

Takeda, Makoto, Kato, Atsushi, Kobune, Fumio, Sakata, Hiroko, Li, Yan, Shioda, Tatsuo, ...

Measles virus (MV) isolated in B95a cells, a marmoset B-cell line, retains full pathogenicity for cynomolgus monkeys, while its derivative obtained by adaptation to the growth in Vero cells, a monkey...

Recovery of Pathogenic Measles Virus from Cloned cDNA

Takeda, Makoto, Takeuchi, Kaoru, Miyajima, Naoko, Kobune, Fumio, Ami, Yasushi, Nagata, Noriyo, ...

Reverse genetics technology so far established for measles virus (MeV) is based on the Edmonston strain, which was isolated several decades ago, has been passaged in nonlymphoid cell lines, and is no...

Recombinant Wild-Type and Edmonston Strain Measles Viruses Bearing Heterologous H Proteins: Role of H Protein in Cell Fusion and Host Cell Specificity

Takeuchi, Kaoru, Takeda, Makoto, Miyajima, Naoko, Kobune, Fumio, Tanabayashi, Kiyoshi, Tashiro, Masato

Wild-type measles virus (MV) isolated from B95a cells has a restricted host cell specificity and hardly replicates in Vero cells, whereas the laboratory strain Edmonston (Ed) replicates in a variety...

Pathogenesis of Rinderpest Virus Infection in Rabbits I. Clinical Signs, Immune Response, Histological Changes, and Virus Growth Patterns

Yamanouchi, Kazuya, Chino, Fumitoshi, Kobune, Fumio, Fukuda, Akiko, Yoshikawa, Yasuhiro

Rabbits were intravenously inoculated with an attenuated rinderpest virus (L strain), and general patterns of the disease were investigated. The rabbits developed fever with concomitant occurrence of...

Pathogenesis of Rinderpest Virus Infection in Rabbits II. Effect of Rinderpest Virus on the Immune Functions of Rabbits

Yamanouchi, Kazuya, Fukuda, Akiko, Kobune, Fumio, Yoshikawa, Yasuhiro, Chino, Fumitoshi

Rinderpest virus infection was shown to induce marked suppression of both humoral antibody response and cell-mediated immunity in rabbits. The virus exhibited a suppressive effect on primary antibody...

Measles Virus Attenuation Associated with Transcriptional Impediment and a Few Amino Acid Changes in the Polymerase and Accessory Proteins

Takeda, Makoto, Kato, Atsushi, Kobune, Fumio, Sakata, Hiroko, Li, Yan, Shioda, Tatsuo, ...

Measles virus (MV) isolated in B95a cells, a marmoset B-cell line, retains full pathogenicity for cynomolgus monkeys, while its derivative obtained by adaptation to the growth in Vero cells, a monkey...

Recovery of Pathogenic Measles Virus from Cloned cDNA

Takeda, Makoto, Takeuchi, Kaoru, Miyajima, Naoko, Kobune, Fumio, Ami, Yasushi, Nagata, Noriyo, ...

Reverse genetics technology so far established for measles virus (MeV) is based on the Edmonston strain, which was isolated several decades ago, has been passaged in nonlymphoid cell lines, and is no...

Recombinant Wild-Type and Edmonston Strain Measles Viruses Bearing Heterologous H Proteins: Role of H Protein in Cell Fusion and Host Cell Specificity

Takeuchi, Kaoru, Takeda, Makoto, Miyajima, Naoko, Kobune, Fumio, Tanabayashi, Kiyoshi, Tashiro, Masato

Wild-type measles virus (MV) isolated from B95a cells has a restricted host cell specificity and hardly replicates in Vero cells, whereas the laboratory strain Edmonston (Ed) replicates in a variety...

Pathogenesis of Rinderpest Virus Infection in Rabbits I. Clinical Signs, Immune Response, Histological Changes, and Virus Growth Patterns

Yamanouchi, Kazuya, Chino, Fumitoshi, Kobune, Fumio, Fukuda, Akiko, Yoshikawa, Yasuhiro

Rabbits were intravenously inoculated with an attenuated rinderpest virus (L strain), and general patterns of the disease were investigated. The rabbits developed fever with concomitant occurrence of...

Pathogenesis of Rinderpest Virus Infection in Rabbits II. Effect of Rinderpest Virus on the Immune Functions of Rabbits

Yamanouchi, Kazuya, Fukuda, Akiko, Kobune, Fumio, Yoshikawa, Yasuhiro, Chino, Fumitoshi

Rinderpest virus infection was shown to induce marked suppression of both humoral antibody response and cell-mediated immunity in rabbits. The virus exhibited a suppressive effect on primary antibody...