Abedi-Valugerdi, Manuchehr, Hu, Hui, Möller, Göran
Treatment with HgCl2 induces a systemic autoimmune disease in certain mice and rats. The major characteristic of this disease in mice with H-2s genotype is the production of anti-nucleolar...
Antigen-induced suppression of the in vitro lymphocyte response to different antigens and mitogens
Möller, Göran, Kashiwagi, Noboru
Certain concentrations of antigen stimulated DNA synthesis in sensitized human lymphocytes cultivated in vitro, higher and lower concentrations being less stimulatory. The simultaneous addition of...
Survival of H-2 incompatible mouse erythrocytes in untreated and isoimmune recipients
51Cr labelled strain A erythrocytes transfused into various H-2 incompatible mouse strains (A.CA, A.BY, A.SW, C3H and DBA/2) were not eliminated more rapidly than after transfusion into compatible...
Fractionation of immunocompetent spleen cells by albumin density gradient centrifugation
Fractionation of spleen cells was performed on albumin density gradients. Larger cells localized in the low density fractions. 19S and 7S antibody producing cells against SRBC and Esch. coli...
Human blood lymphocytes stimulated in vitro with non-specific mitogens, such as PHA, ALS and streptolysin, responded with DNA synthesis only to certain optimal doses of the mitogens, higher and lower...
Mice immunized with a high dose of sheep red blood cells and 24–48 hours later given specific antiserum produced on the average only 1 per cent of the direct and indirect number of plaque-forming...
Suppressive effect of graft versus host reactions on the immune response to heterologous red cells
Graft versus host (GVH) reactions induced by the inoculation of parental spleen cells into adult untreated F1 recipients caused a marked suppression of the cellular and humoral immune response to...
Experiments were performed to study the mechanisms of the sensitivity of normal and neoplastic mouse cells to the cytotoxic action of humoral isoantibodies. A quantitative in vitro absorption...
The suppressing activity of passively transferred antibodies on antibody synthesis against sheep red cells was investigated at the cellular level by the agar-plaque technique developed by Jerne....
Transfer of spleen cells from mice immunized against sheep red blood cells (SRBC) into irradiated (600 R) nonimmune, syngeneic mice in the presence of antigen resulted in excessive cellular 7S...
Generation of cytotoxic effector cells by a unidirectional mixed lymphocyte reaction (MLR) in the mouse H-2 system was studied using labeled YAC (H-2a) leukemia cells as targets. The responding...
Coutinho, Antonio, Gronowicz, Eva, Bullock, Wesley W., Möller, Göran
The present experiments were performed in order to analyze the mechanism by which thymus-independent antigens (nonspecific B-cell mitogens) can induce specific immune responses to antigenic...
EFFECT OF B-CELL MITOGENS ON LYMPHOCYTE SUBPOPULATIONS POSSESSING C'3 AND Fc RECEPTORS
By the use of a rosette method allowing the detection at the cellular level of lymphocytes simultaneously binding Fc- and C'3-sensitized red cells it was found that about 70% of the rosette-forming...
DEMONSTRATION OF MOUSE ISOANTIGENS AT THE CELLULAR LEVEL BY THE FLUORESCENT ANTIBODY TECHNIQUE
The fluorescent antibody technique has been applied for the demonstration of mouse isoantigens at the cellular level. Specific reactions were obtained by the indirect or "sandwich" technique with a...