Anti-hnRNP and other autoantibodies in systemic sclerosis with joint involvement (2009)
Generini, Sergio, Steiner, Günter, Miniati, Irene, Conforti, Maria L., Guiducci, Serena, Skriner, Karl, ...
Objectives. To investigate joint involvement in SSc and its relationship with autoantibody to the hnRNP and to anti-cyclic citrullinated peptide (anti-CCP). Methods. Sera from 55 SSc patients were...
Smolen, Josef S, Aletaha, Daniel, Grisar, Johannes, Redlich, Kurt, Steiner, Günter, Wagner, Oswald
Abstract Rheumatoid arthritis is a heterogeneous disease with respect to clinical manifestations, serologic abnormalities, joint damage and functional impairment. Predicting outcome in a reliable way...
Fritsch-Stork, Ruth, Müllegger, Daniela, Skriner, Karl, Jahn-Schmid, Beatrice, Smolen, Josef S, Steiner, Günter
Abstract A hallmark of systemic lupus erythematosus (SLE) is the appearance of autoantibodies to nuclear antigens, including autoantibodies directed to the heterogeneous nuclear ribonucleoprotein A2...
JNK1 is not essential for TNF-mediated joint disease (2004)
Köller, Marcus, Hayer, Silvia, Redlich, Kurt, Ricci, Romeo, David, Jean-Pierre, Steiner, Günter, ...
Abstract Tumour necrosis factor (TNF) signalling molecules are considered as promising therapeutic targets of antirheumatic therapy. Among them, mitogen-activated protein kinases are thought to be of...
Köller, Marcus, Zwölfer, Bettina, Steiner, Günter, Smolen, Josef S., Scheinecker, Clemens
Systemic lupus erythematosus (SLE) represents an autoimmune disease for which alterations of T cells, B cells as well as various antigen-presenting cell (APC) populations have been described. In...
Autoantibodies in rheumatoid arthritis and their clinical significance (2002)
Steiner, Günter, Smolen, Josef
Abstract Autoantibodies are proven useful diagnostic tools for a variety of rheumatic and non-rheumatic autoimmune disorders. However, a highly specific marker autoantibody for rheumatoid arthritis...
Schett, Georg, Tohidast-Akrad, Makiyeh, Steiner, Günter, Smolen, Josef
Abstract This review focuses on the mechanisms of stress response in the synovial tissue of rheumatoid arthritis. The major stress factors, such as heat stress, shear stress, proinflammatory...
Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset (2000)
Goldbach-Mansky, Raphaela, Lee, Jennifer, McCoy, Angela, Hoxworth, Joseph, Yarboro, Cheryl, Smolen, Josef S, ...
Statement of findings An inception cohort of 238 patients having peripheral joint synovitis of less than 12 months duration was evaluated clinically and followed prospectively for 1 year to determine...
Steiner, Günter, Lührmann, Reinhard, Kuechler, Ernst
Wybutinep(Ywye) , situated next to the 3′-side of the anti-codon of tRNAPhe from Saccharomyces cerevisiae, can be photo-crosslinked to mRNA when bound to Escherichia coli ribosomes. Crosslinking...
Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset
Goldbach-Mansky, Raphaela, Lee, Jennifer, McCoy, Angela, Hoxworth, Joseph, Yarboro, Cheryl, Smolen, Josef S, ...
An inception cohort of 238 patients having peripheral joint synovitis of less than 12 months duration was evaluated clinically and followed prospectively for 1 year to determine the clinical...
Schett, Georg, Tohidast-Akrad, Makiyeh, Steiner, Günter, Smolen, Josef
This review focuses on the mechanisms of stress response in the synovial tissue of rheumatoid arthritis. The major stress factors, such as heat stress, shear stress, proinflammatory cytokines and...
Osteoclasts are essential for TNF-α–mediated joint destruction
Redlich, Kurt, Hayer, Silvia, Ricci, Romeo, David, Jean-Pierre, Tohidast-Akrad, Makiyeh, Kollias, George, ...
The detailed cellular and molecular mechanisms leading to joint destruction in rheumatoid arthritis, a disease driven by proinflammatory cytokines, are still unknown. To address the question of...
JNK1 is not essential for TNF-mediated joint disease
Köller, Marcus, Hayer, Silvia, Redlich, Kurt, Ricci, Romeo, David, Jean-Pierre, Steiner, Günter, ...
Tumour necrosis factor (TNF) signalling molecules are considered as promising therapeutic targets of antirheumatic therapy. Among them, mitogen-activated protein kinases are thought to be of central...
Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset
Goldbach-Mansky, Raphaela, Lee, Jennifer, McCoy, Angela, Hoxworth, Joseph, Yarboro, Cheryl, Smolen, Josef S, ...
An inception cohort of 238 patients having peripheral joint synovitis of less than 12 months duration was evaluated clinically and followed prospectively for 1 year to determine the clinical...
Schett, Georg, Tohidast-Akrad, Makiyeh, Steiner, Günter, Smolen, Josef
This review focuses on the mechanisms of stress response in the synovial tissue of rheumatoid arthritis. The major stress factors, such as heat stress, shear stress, proinflammatory cytokines and...
Osteoclasts are essential for TNF-α–mediated joint destruction
Redlich, Kurt, Hayer, Silvia, Ricci, Romeo, David, Jean-Pierre, Tohidast-Akrad, Makiyeh, Kollias, George, ...
The detailed cellular and molecular mechanisms leading to joint destruction in rheumatoid arthritis, a disease driven by proinflammatory cytokines, are still unknown. To address the question of...
JNK1 is not essential for TNF-mediated joint disease
Köller, Marcus, Hayer, Silvia, Redlich, Kurt, Ricci, Romeo, David, Jean-Pierre, Steiner, Günter, ...
Tumour necrosis factor (TNF) signalling molecules are considered as promising therapeutic targets of antirheumatic therapy. Among them, mitogen-activated protein kinases are thought to be of central...
Fritsch-Stork, Ruth, Müllegger, Daniela, Skriner, Karl, Jahn-Schmid, Beatrice, Smolen, Josef S, Steiner, Günter
A hallmark of systemic lupus erythematosus (SLE) is the appearance of autoantibodies to nuclear antigens, including autoantibodies directed to the heterogeneous nuclear ribonucleoprotein A2...
Redlich, Kurt, Görtz, Birgit, Hayer, Silvia, Zwerina, Jochen, Doerr, Nicholas, Kostenuik, Paul, ...
Local bone erosion and systemic bone loss are hallmarks of rheumatoid arthritis and cause progressive disability. Tumor necrosis factor (TNF) is a key mediator of arthritis and acts catabolically on...
CD44 is a determinant of inflammatory bone loss
Hayer, Silvia, Steiner, Günter, Görtz, Birgit, Reiter, Erika, Tohidast-Akrad, Makiyeh, Amling, Michael, ...
Chronic inflammation is a major trigger of local and systemic bone loss. Disintegration of cell–matrix interaction is a prerequisite for the invasion of inflammatory tissue into bone. CD44 is a...
Smolen, Josef S, Aletaha, Daniel, Grisar, Johannes, Redlich, Kurt, Steiner, Günter, Wagner, Oswald
Rheumatoid arthritis is a heterogeneous disease with respect to clinical manifestations, serologic abnormalities, joint damage and functional impairment. Predicting outcome in a reliable way to allow...