Pankuch, G. A., Jacobs, M. R., Appelbaum, P. C.
Daptomycin mean staphylococcal postantibiotic effects (PAEs) were 1.1 to 6.2 h, with a mean of 2.5 h. The mean pneumococcal PAEs were 1.7 h, ranging between 1.0 and 2.5 h. The staphylococcal and...
Pankuch, G. A., Jacobs, M. R., Appelbaum, P. C.
Conventional in vitro methods were used to determine the postantibiotic effects (PAEs), sub-MIC effects (SMEs), and postantibiotic sub-MIC effects (PA-SMEs) of garenoxacin for a range of organisms....
Postantibiotic effects of gatifloxacin against gram-positive and -negative organisms. (1999)
Pankuch, G. A., Jacobs, M. R., Appelbaum, P. C.
Gatifloxacin pneumococcal, staphylococcal and enterococcal postantibiotic effects (PAEs) were 0.5 to 4.0 h, respectively. For Escherichia coli and Pseudomonas aeruginosa, PAEs were 2.2 to 4.8 h....
Postantibiotic effect of trovafloxacin against gram-positive and -negative organisms. (1998)
Pankuch, G. A., Jacobs, M. R., Appelbaum, P. C.
Trovafloxacin pneumococcal and staphylococcal postantibiotic effects (PAEs) were 0.7 to 1.8 and 0.7 to 2.4 h, respectively. For Escherichia coli and Pseudomonas aeruginosa, PAEs were 2.4 to 4.4 h....
Pankuch, G. A., Visalli, M. A., Jacobs, M. R., Appelbaum, P. C.
Susceptibility of 230 penicillin- and erythromycin-susceptible and -resistant pneumococci to HMR 3647 (RU 66647), a new ketolide, was tested by agar dilution, and results were compared with those of...
Pankuch, G. A., Jacobs, M. R., Appelbaum, P. C.
Agar dilution and E-test MICs of penicillin G, ampicillin, amoxycillin, amoxycillin/ clavulanate and cefotaxime were determined against 189 pneumococci. Addition of clavulanate did not influence...
Characterization of a {beta}-lactamase from Clostridium clostridioforme (1994)
Appelbaum, P. C., Spangler, S. K., Pankuch, G. A., Philippon, A., Jacobs, M. R., Shiman, R., ...
A β-lactamase-producing strain of Clostridium clostridioforme isolated from human peritoneal fluid was examined by MIC testing and enzyme characterization. MICs of penicillins (64–512 mg/L)...
Spangler, S. K., Jacobs, M. R., Pankuch, G. A., Appelbaum, P. C.
MICs of six oral cephalosporins (cefdinir, cefpodoxime, cefaclor, cefuroxime, cefixime and Ro 40-6890), four quinolones (ciprofloxacin, ofloxacin, OPC-171 16 and fleroxacm), desacetylcefotaxime, Ro...
Postantibiotic Effects of Gatifloxacin against Gram-Positive and -Negative Organisms
Pankuch, G. A., Jacobs, M. R., Appelbaum, P. C.
Gatifloxacin pneumococcal, staphylococcal and enterococcal postantibiotic effects (PAEs) were 0.5 to 4.0 h, respectively. For Escherichia coli and Pseudomonas aeruginosa, PAEs were 2.2 to 4.8 h....
Pankuch, G. A., Visalli, M. A., Jacobs, M. R., Appelbaum, P. C.
Susceptibility of 230 penicillin- and erythromycin-susceptible and -resistant pneumococci to HMR 3647 (RU 66647), a new ketolide, was tested by agar dilution, and results were compared with those of...
Postantibiotic Effect of Trovafloxacin against Gram-Positive and -Negative Organisms
Pankuch, G. A., Jacobs, M. R., Appelbaum, P. C.
Trovafloxacin pneumococcal and staphylococcal postantibiotic effects (PAEs) were 0.7 to 1.8 and 0.7 to 2.4 h, respectively. For Escherichia coli and Pseudomonas aeruginosa, PAEs were 2.4 to 4.4 h....
Postantibiotic Effects of Garenoxacin (BMS-284756) against 12 Gram-Positive or -Negative Organisms
Pankuch, G. A., Jacobs, M. R., Appelbaum, P. C.
Conventional in vitro methods were used to determine the postantibiotic effects (PAEs), sub-MIC effects (SMEs), and postantibiotic sub-MIC effects (PA-SMEs) of garenoxacin for a range of organisms....
Activities of oral and parenteral agents against penicillin-susceptible and -resistant pneumococci.
Pankuch, G A, Visalli, M A, Jacobs, M R, Appelbaum, P C
This study examined bacteriostatic and bactericidal activities of oral and parenteral antibiotics for penicillin-susceptible and intermediately and fully penicillin-resistant pneumococci....
Pankuch, G A, Lichtenberger, C, Jacobs, M R, Appelbaum, P C
Previous time-kill studies have shown that RP 59500 is rapidly bactericidal against pneumococci. To extend these findings, the activities of RP 59500, its two components RP 57669 RP 54476, penicillin...
Pankuch, G A, Jacobs, M R, Appelbaum, P C
Broth MICs and time-kill studies were used to test the activity of RP 59500 (quinupristin-dalfopristin), RPR 106972, pyostacine (RP 7293), erythromycin, clarithromycin, and cefotaxime for four...
Postantibiotic Effects of Daptomycin against 14 Staphylococcal and Pneumococcal Clinical Isolates
Pankuch, G. A., Jacobs, M. R., Appelbaum, P. C.
Daptomycin mean staphylococcal postantibiotic effects (PAEs) were 1.1 to 6.2 h, with a mean of 2.5 h. The mean pneumococcal PAEs were 1.7 h, ranging between 1.0 and 2.5 h. The staphylococcal and...
Pankuch, G A, Jacobs, M R, Appelbaum, P C
The susceptibilities of 428 gram-negative and gram-positive anaerobes (including selected cefoxitin-resistant strains) to Bay y3118 (a new fluoroquinolone), ciprofloxacin, clindamycin, metronidazole,...
Pankuch, G A, Jacobs, M R, Appelbaum, P C
MICs of eight beta-lactams (piperacillin, piperacillin-tazobactam, ticarcillin, ticarcillin-clavulanate, ampicillin, ampicillin-sulbactam, ceftazidime, and ceftriaxone) were determined by agar...
Pankuch, G A, Jacobs, M R, Appelbaum, P C
The susceptibilities of 123 clinically isolated strains of Xanthomonas maltophilia to six fluoroquinolones (clinafloxacin, PD 131628, PD 138312, PD 140248, ciprofloxacin, and ofloxacin) were examined...
Pankuch, G A, Jacobs, M R, Appelbaum, P C
Time-kill studies were used to examine the in vitro activities of penicillin G, RP 59500, erythromycin, ciprofloxacin, sparfloxacin, and vancomycin against 10 pneumococci expressing various degrees...
Pankuch, G A, Jacobs, M R, Rittenhouse, S F, Appelbaum, P C
This study evaluated the susceptibility of 123 Xanthomonas maltophilia strains to ticarcillin, ticarcillin-clavulanate, ampicillin, amoxicillin-clavulanate, ampicillin-sulbactam, piperacillin,...
Postantibiotic Effect of DX-619 against 16 Gram-Positive Organisms
Pankuch, G. A., Appelbaum, P. C.
The in vitro postantibiotic effects (PAEs), the postantibiotic sub-MIC effects (PA-SMEs), and the sub-MIC effects (SMEs) of DX-619 were determined for 16 gram-positive organisms. DX-619 pneumococcal,...
Postantibiotic Effects of Gatifloxacin against Gram-Positive and -Negative Organisms
Pankuch, G. A., Jacobs, M. R., Appelbaum, P. C.
Gatifloxacin pneumococcal, staphylococcal and enterococcal postantibiotic effects (PAEs) were 0.5 to 4.0 h, respectively. For Escherichia coli and Pseudomonas aeruginosa, PAEs were 2.2 to 4.8 h....
Pankuch, G. A., Visalli, M. A., Jacobs, M. R., Appelbaum, P. C.
Susceptibility of 230 penicillin- and erythromycin-susceptible and -resistant pneumococci to HMR 3647 (RU 66647), a new ketolide, was tested by agar dilution, and results were compared with those of...
Postantibiotic Effect of Trovafloxacin against Gram-Positive and -Negative Organisms
Pankuch, G. A., Jacobs, M. R., Appelbaum, P. C.
Trovafloxacin pneumococcal and staphylococcal postantibiotic effects (PAEs) were 0.7 to 1.8 and 0.7 to 2.4 h, respectively. For Escherichia coli and Pseudomonas aeruginosa, PAEs were 2.4 to 4.4 h....
Postantibiotic Effects of Garenoxacin (BMS-284756) against 12 Gram-Positive or -Negative Organisms
Pankuch, G. A., Jacobs, M. R., Appelbaum, P. C.
Conventional in vitro methods were used to determine the postantibiotic effects (PAEs), sub-MIC effects (SMEs), and postantibiotic sub-MIC effects (PA-SMEs) of garenoxacin for a range of organisms....
Activities of oral and parenteral agents against penicillin-susceptible and -resistant pneumococci.
Pankuch, G A, Visalli, M A, Jacobs, M R, Appelbaum, P C
This study examined bacteriostatic and bactericidal activities of oral and parenteral antibiotics for penicillin-susceptible and intermediately and fully penicillin-resistant pneumococci....
Pankuch, G A, Lichtenberger, C, Jacobs, M R, Appelbaum, P C
Previous time-kill studies have shown that RP 59500 is rapidly bactericidal against pneumococci. To extend these findings, the activities of RP 59500, its two components RP 57669 RP 54476, penicillin...
Pankuch, G A, Jacobs, M R, Appelbaum, P C
Broth MICs and time-kill studies were used to test the activity of RP 59500 (quinupristin-dalfopristin), RPR 106972, pyostacine (RP 7293), erythromycin, clarithromycin, and cefotaxime for four...
Postantibiotic Effects of Daptomycin against 14 Staphylococcal and Pneumococcal Clinical Isolates
Pankuch, G. A., Jacobs, M. R., Appelbaum, P. C.
Daptomycin mean staphylococcal postantibiotic effects (PAEs) were 1.1 to 6.2 h, with a mean of 2.5 h. The mean pneumococcal PAEs were 1.7 h, ranging between 1.0 and 2.5 h. The staphylococcal and...
Pankuch, G A, Jacobs, M R, Appelbaum, P C
The susceptibilities of 428 gram-negative and gram-positive anaerobes (including selected cefoxitin-resistant strains) to Bay y3118 (a new fluoroquinolone), ciprofloxacin, clindamycin, metronidazole,...
Pankuch, G A, Jacobs, M R, Appelbaum, P C
MICs of eight beta-lactams (piperacillin, piperacillin-tazobactam, ticarcillin, ticarcillin-clavulanate, ampicillin, ampicillin-sulbactam, ceftazidime, and ceftriaxone) were determined by agar...
Pankuch, G A, Jacobs, M R, Appelbaum, P C
The susceptibilities of 123 clinically isolated strains of Xanthomonas maltophilia to six fluoroquinolones (clinafloxacin, PD 131628, PD 138312, PD 140248, ciprofloxacin, and ofloxacin) were examined...
Pankuch, G A, Jacobs, M R, Appelbaum, P C
Time-kill studies were used to examine the in vitro activities of penicillin G, RP 59500, erythromycin, ciprofloxacin, sparfloxacin, and vancomycin against 10 pneumococci expressing various degrees...
Pankuch, G A, Jacobs, M R, Rittenhouse, S F, Appelbaum, P C
This study evaluated the susceptibility of 123 Xanthomonas maltophilia strains to ticarcillin, ticarcillin-clavulanate, ampicillin, amoxicillin-clavulanate, ampicillin-sulbactam, piperacillin,...
Postantibiotic Effect of DX-619 against 16 Gram-Positive Organisms
Pankuch, G. A., Appelbaum, P. C.
The in vitro postantibiotic effects (PAEs), the postantibiotic sub-MIC effects (PA-SMEs), and the sub-MIC effects (SMEs) of DX-619 were determined for 16 gram-positive organisms. DX-619 pneumococcal,...
Postantibiotic Effect of Ceftobiprole against 12 Gram-Positive Organisms
Pankuch, G. A., Appelbaum, P. C.
The in vitro postantibiotic effects (PAEs), postantibiotic sub-MIC effects (PA-SMEs), and sub-MIC effects of ceftobiprole were determined for 12 gram-positive organisms. Pneumococcal, staphylococcal,...
Postantibiotic Effect of Tigecycline against 14 Gram-Positive Organisms▿
Pankuch, G. A., Appelbaum, P. C.
The in vitro postantibiotic effects (PAEs), postantibiotic sub-MIC effects (PA-SMEs), and sub-MIC effects of tigecycline were determined for 14 gram-positive and gram-negative organisms. The...
Postantibiotic Effects of Telavancin against 16 Gram-Positive Organisms▿
Pankuch, G. A., Appelbaum, P. C.
The in vitro postantibiotic effects (PAEs), postantibiotic sub-MIC effects (PA-SMEs), and sub-MIC effects of telavancin were determined for 16 gram-positive organisms. Telavancin staphylococcal,...