G. Abruzzo

Discovery of Novel Antifungal (1,3)-β-d-Glucan Synthase Inhibitors

Onishi, J., Meinz, M., Thompson, J., Curotto, J., Dreikorn, S., Rosenbach, M., ...

The increasing incidence of life-threatening fungal infections has driven the search for new, broad-spectrum fungicidal agents that can be used for treatment and prophylaxis in immunocompromised...

Characterization of echinocandin-resistant mutants of Candida albicans: genetic, biochemical, and virulence studies.

Kurtz, M B, Abruzzo, G, Flattery, A, Bartizal, K, Marrinan, J A, Li, W, ...

The pneumocandins are potent antifungal agents of the echinocandin class which are under development for use as broad-spectrum antimycotic therapy. One important consideration for any new therapeutic...

In vitro antifungal activities and in vivo efficacies of 1,3-beta-D-glucan synthesis inhibitors L-671,329, L-646,991, tetrahydroechinocandin B, and L-687,781, a papulacandin.

Bartizal, K, Abruzzo, G, Trainor, C, Krupa, D, Nollstadt, K, Schmatz, D, ...

The in vivo anti-Candida activities of 1,3-beta-D-glucan synthesis inhibitors L-671,329, L-646,991 (cilofungin), L-687,901 (tetrahydroechinocandin B), and L-687,781 (a papulacandin analog) were...

Dissociation of mitogenesis and late-stage promotion of tumor cell phenotype by phorbol esters: mitogen-resistant variants are sensitive to promotion.

Colburn, N H, Wendel, E J, Abruzzo, G

The JB-6 mouse epidermal cell line has been used as a model system for studying the mechanism of late-stage promoter-dependent preneoplastic progression. The studies reported here are concerned with...

Specific Substitutions in the Echinocandin Target Fks1p Account for Reduced Susceptibility of Rare Laboratory and Clinical Candida sp. Isolates

Park, S., Kelly, R., Kahn, J. Nielsen, Robles, J., Hsu, M.-J., Register, E., ...

An association between reduced susceptibility to echinocandins and changes in the 1,3-β-d-glucan synthase (GS) subunit Fks1p was investigated. Specific mutations in fks1 genes from Saccharomyces...

Identification and purification of the reconstitutively active glutamine carrier from rat kidney mitochondria.

Indiveri, C, Abruzzo, G, Stipani, I, Palmieri, F

The glutamine carrier from rat kidney mitochondria, solubilized in dodecyl octaoxyethylene ether (C12E8) and partly purified on hydroxyapatite, was identified and completely purified by Celite...

Discovery of Novel Antifungal (1,3)-β-d-Glucan Synthase Inhibitors

Onishi, J., Meinz, M., Thompson, J., Curotto, J., Dreikorn, S., Rosenbach, M., ...

The increasing incidence of life-threatening fungal infections has driven the search for new, broad-spectrum fungicidal agents that can be used for treatment and prophylaxis in immunocompromised...

Characterization of echinocandin-resistant mutants of Candida albicans: genetic, biochemical, and virulence studies.

Kurtz, M B, Abruzzo, G, Flattery, A, Bartizal, K, Marrinan, J A, Li, W, ...

The pneumocandins are potent antifungal agents of the echinocandin class which are under development for use as broad-spectrum antimycotic therapy. One important consideration for any new therapeutic...

In vitro antifungal activities and in vivo efficacies of 1,3-beta-D-glucan synthesis inhibitors L-671,329, L-646,991, tetrahydroechinocandin B, and L-687,781, a papulacandin.

Bartizal, K, Abruzzo, G, Trainor, C, Krupa, D, Nollstadt, K, Schmatz, D, ...

The in vivo anti-Candida activities of 1,3-beta-D-glucan synthesis inhibitors L-671,329, L-646,991 (cilofungin), L-687,901 (tetrahydroechinocandin B), and L-687,781 (a papulacandin analog) were...

Dissociation of mitogenesis and late-stage promotion of tumor cell phenotype by phorbol esters: mitogen-resistant variants are sensitive to promotion.

Colburn, N H, Wendel, E J, Abruzzo, G

The JB-6 mouse epidermal cell line has been used as a model system for studying the mechanism of late-stage promoter-dependent preneoplastic progression. The studies reported here are concerned with...

Specific Substitutions in the Echinocandin Target Fks1p Account for Reduced Susceptibility of Rare Laboratory and Clinical Candida sp. Isolates

Park, S., Kelly, R., Kahn, J. Nielsen, Robles, J., Hsu, M.-J., Register, E., ...

An association between reduced susceptibility to echinocandins and changes in the 1,3-β-d-glucan synthase (GS) subunit Fks1p was investigated. Specific mutations in fks1 genes from Saccharomyces...

Identification and purification of the reconstitutively active glutamine carrier from rat kidney mitochondria.

Indiveri, C, Abruzzo, G, Stipani, I, Palmieri, F

The glutamine carrier from rat kidney mitochondria, solubilized in dodecyl octaoxyethylene ether (C12E8) and partly purified on hydroxyapatite, was identified and completely purified by Celite...