G. Balboni

Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders (2001)

Balboni, G, Pavani, M G, Spalluto, G, Tabrizi, M A, Clercq, E D, ...

We have synthesized and evaluated a series of hybrids, denoted 22--27, for in vitro cytotoxic activity against a variety of cancer cell lines. These hybrids represent a molecular combination of...

Delta opioidmimetic antagonists: prototypes for designing a new generation of ultraselective opioid peptides.

Salvadori, S., Attila, M., Balboni, G., Bianchi, C., Bryant, S. D., Crescenzi, O., ...

BACKGROUND: Tyr-Tic (1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid) and Tyr-Tic-Ala were the first peptides with delta opioid antagonist activity lacking Phe, considered essential for opioid...

In vitro and in vivo pharmacological profile of UFP-512, a novel selective δ-opioid receptor agonist; correlations between desensitization and tolerance

Aguila, B, Coulbault, L, Boulouard, M, Lιveillι, F, Davis, A, Tσth, G, ...

In vitro and in vivo pharmacological profile of UFP-512, a novel selective δ-opioid receptor agonist; correlations between desensitization and tolerance

Aguila, B, Coulbault, L, Boulouard, M, Léveillé, F, Davis, A, Tóth, G, ...