G. Calothy

Transcription of a quail gene expressed in embryonic retinal cells is shut off sharply at hatching.

Guermah, M, Crisanti, P, Laugier, D, Dezelee, P, Bidou, L, Pessac, B, ...

The avian neuroretina (NR) is part of the central nervous system and is composed of photoreceptors, neuronal cells, and Müller (glial) cells. These cells are derived from proliferating...

Transcriptional stimulation of the retina-specific QR1 gene upon growth arrest involves a Maf-related protein.

Pouponnot, C, Nishizawa, M, Calothy, G, Pierani, A

The avian neural retina (NR) is derived from proliferating neuroectodermal precursors which differentiate after terminal mitosis and become organized in cell strata. Proliferation of postmitotic NR...

Developmental control of transcription of a retina-specific gene, QR1, during differentiation: involvement of factors from the POU family.

Pierani, A, Pouponnot, C, Calothy, G

Developmental control of gene expression often results from the coupling of growth arrest with the establishment of differentiation programs. QR1 is a gene specifically expressed in retinas during...

Identification of drm, a novel gene whose expression is suppressed in transformed cells and which can inhibit growth of normal but not transformed cells in culture.

Topol, L Z, Marx, M, Laugier, D, Bogdanova, N N, Boubnov, N V, Clausen, P A, ...

Using differential display analysis, we compared the expression of RNA in v-mos-transformed cells and their flat revertant and isolated a novel gene, drm (down-regulated in mos-transformed cells),...

Functional and biological properties of an avian variant long terminal repeat containing multiple A to G conversions in the U3 sequence.

Felder, M P, Laugier, D, Yatsula, B, Dezélée, P, Calothy, G, Marx, M

We previously reported that infection of chicken embryonic neuroretina cells with Rous-associated virus type 1 leads to the frequent occurrence of spliced readthrough transcripts containing viral and...

Occurrence of alternatively spliced leader-delta onc-poly(A) transcripts in chicken neuroretina cells infected with Rous-associated virus type 1: implication in transduction of the c-mil/c-raf and c-Rmil/B-raf oncogenes.

Felder, M P, Laugier, D, Eychene, A, Calothy, G, Marx, M

We previously reported that serial passaging of Rous-associated virus type 1 in nondividing chicken embryo neuroretina cells leads to reproducible generation of acutely mitogenic retroviruses that...

Common mechanism of retrovirus activation and transduction of c-mil and c-Rmil in chicken neuroretina cells infected with Rous-associated virus type 1.

Felder, M P, Eychène, A, Barnier, J V, Calogeraki, I, Calothy, G, Marx, M

We previously described the isolation of the IC10 retrovirus which transduced the v-Rmil oncogene, a new member of the mil/raf gene family. This virus was generated during serial passaging of...

Transduction of the cellular src gene and 3' adjacent sequences in avian sarcoma virus PR2257.

Geryk, J, Dezélée, P, Barnier, J V, Svoboda, J, Nehyba, J, Karakoz, I, ...

When injected into chickens, a transformation-defective mutant of the Prague C strain of Rous sarcoma virus induced tumors at low incidence and after a long latency. One such tumor released a...

Molecular and biological properties of c-mil transducing retroviruses generated during passage of Rous-associated virus type 1 in chicken neuroretina cells.

Eychène, A, Béchade, C, Marx, M, Laugier, D, Dezélée, P, Calothy, G

IC1, IC2, and IC3 are novel c-mil transducing retroviruses generated during serial passaging of Rous-associated virus type 1 (RAV-1) in chicken embryo neuroretina cells. They were isolated by their...

Transformed and tumorigenic phenotypes induced by avian retroviruses containing the v-mil oncogene.

Béchade, C, Dambrine, G, David-Pfeuty, T, Esnault, E, Calothy, G

Avian retrovirus MH2 contains two oncogenes, v-mil and v-myc. We have previously shown that a spontaneous mutant of MH2 (PA200-MH2), expressing only the v-mil oncogene, is able to induce...

Genetic analysis of p60v-src domains involved in the induction of different cell transformation parameters.

Jove, R, Mayer, B J, Iba, H, Laugier, D, Poirier, F, Calothy, G, ...

The expression of p60v-src in chicken cells infected with Rous sarcoma virus causes stimulation of cell proliferation, morphological alteration, and anchorage independence. PA101 and PA104 are...

Genetic lesions involved in temperature sensitivity of the src gene products of four Rous sarcoma virus mutants.

Mayer, B J, Jove, R, Krane, J F, Poirier, F, Calothy, G, Hanafusa, H

The src genes of four Rous sarcoma virus (RSV) mutants temperature-sensitive (ts) for cell transformation were analyzed. The mutant src genes were cloned into a replication-competent RSV expression...

Activation and transduction of c-mil sequences in chicken neuroretina cells induced to proliferate by infection with avian lymphomatosis virus.

Marx, M, Crisanti, P, Eychène, A, Béchade, C, Laugier, D, Ghysdaël, J, ...

We report that nondividing neuroretina cells from chicken embryos can be induced to proliferate following infection with Rous-associated virus type 1 (RAV-1), an avian lymphomatosis retrovirus...

The membrane-binding domain and myristylation of p60v-src are not essential for stimulation of cell proliferation.

Calothy, G, Laugier, D, Cross, F R, Jove, R, Hanafusa, T, Hanafusa, H

Previous studies showed that the amino-terminal domain of Rous sarcoma virus p60v-src involved in myristylation and membrane association of the protein is required for morphological transformation...

Role of the mitogenic property and kinase activity of p60src in tumor formation by Rous sarcoma virus.

Poirier, F, Jullien, P, Dezelee, P, Dambrine, G, Esnault, E, Benatre, A, ...

Expression of the src gene of Rous sarcoma virus in chicken embryo neuroretinal cells results in morphological transformation and sustained proliferation of this normally resting cell population....

N-terminal deletion in the src gene of Rous sarcoma virus results in synthesis of a 45,000-Mr protein with mitogenic activity.

Laugier, D, Marx, M, Barnier, J V, Poirier, F, Genvrin, P, Dezélée, P, ...

Expression of the v-src gene of Rous sarcoma virus in avian embryo neuroretina cells results in transformation and sustained proliferation of these normally resting cells. Transformed neuroretina...

Rous sarcoma virus mutant dlPA105 induces different transformed phenotypes in quail embryonic fibroblasts and neuroretina cells.

Poirier, F, Laugier, D, Marx, M, Dambrine, G, Garber, E A, Genvrin, P, ...

dlPA105 is a spontaneous variant of Rous sarcoma virus, subgroup E, which carries a deletion in the N-terminal portion of the v-src gene coding sequence. This virus was isolated on the basis of its...

Role of p60src kinase activity in the induction of neuroretinal cell proliferation by rous sarcoma virus.

Poirier, F, Calothy, G, Karess, R E, Erikson, E, Hanafusa, H

Expression of the src gene of Rous sarcoma virus (RSV) in chicken embryo neuroretinal (NR) cells results in morphological transformation and sustained proliferation of a normally resting cell...

Transcriptional downregulation of the retina-specific QR1 gene by pp60v-src and identification of a novel v-src-responsive unit.

Pierani, A, Pouponnot, C, Calothy, G

The embryonic avian neuroretina (NR) is part of the central nervous system and is composed of various cell types: photoreceptors and neuronal and Müller (glial) cells. These cells are derived from...

Down regulation by p60v-src of genes specifically expressed and developmentally regulated in postmitotic quail neuroretina cells.

Guermah, M, Gillet, G, Michel, D, Laugier, D, Brun, G, Calothy, G

The avian neuroretina (NR) is composed of photoreceptors and different neurons that are derived from proliferating precursor cells. Neuronal differentiation takes place after terminal mitosis. We...

Crystallin gene expression and lentoid body formation in quail embryo neuroretina cultures transformed by the oncogenic retrovirus Mill Hill 2 or Rous sarcoma virus.

Simonneau, L, Crisanti, P, Lorinet, A M, Alliot, F, Courtois, Y, Calothy, G, ...

The lens-specific proteins alpha and delta crystallins and lentoid bodies, structures that follow a differentiation pathway similar to that of the lens, regularly appear after 4 to 5 weeks in quail...

Effect of Environmental pH on Rescue of Simian Virus 40

Calothy, G., Croce, C. M., Defendi, V., Koprowski, H., Eagle, H.

Rescue of SV40 virus after Sendai virus-mediated fusion of transformed mouse or hamster cell lines with permissive monkey cells was strikingly dependent on pH in the range 6.4-8.8, with a maximum at...

A novel oncogene related to c-mil is transduced in chicken neuroretina cells induced to proliferate by infection with an avian lymphomatosis virus.

Marx, M, Eychène, A, Laugier, D, Béchade, C, Crisanti, P, Dezélée, P, ...

Non-dividing neuroretina cells from chicken embryos are induced to proliferate after a long latency, following infection with Rous associated virus type 1, an avian retrovirus which does not carry a...

Glutamic acid decarboxylase activity is stimulated in quail retina neuronal cells transformed by Rous sarcoma virus and is regulated by pp60v-src.

Crisanti, P, Lorinet, A M, Calothy, G, Pessac, B

Rous sarcoma virus (RSV) stimulates in quail embryo neuro-retina (NR) cultures the specific activity of glutamic acid decarboxylase (GAD), the enzyme responsible for the synthesis of...

Transcription of a quail gene expressed in embryonic retinal cells is shut off sharply at hatching.

Guermah, M, Crisanti, P, Laugier, D, Dezelee, P, Bidou, L, Pessac, B, ...

The avian neuroretina (NR) is part of the central nervous system and is composed of photoreceptors, neuronal cells, and Müller (glial) cells. These cells are derived from proliferating...

Transcriptional stimulation of the retina-specific QR1 gene upon growth arrest involves a Maf-related protein.

Pouponnot, C, Nishizawa, M, Calothy, G, Pierani, A

The avian neural retina (NR) is derived from proliferating neuroectodermal precursors which differentiate after terminal mitosis and become organized in cell strata. Proliferation of postmitotic NR...

Developmental control of transcription of a retina-specific gene, QR1, during differentiation: involvement of factors from the POU family.

Pierani, A, Pouponnot, C, Calothy, G

Developmental control of gene expression often results from the coupling of growth arrest with the establishment of differentiation programs. QR1 is a gene specifically expressed in retinas during...

Identification of drm, a novel gene whose expression is suppressed in transformed cells and which can inhibit growth of normal but not transformed cells in culture.

Topol, L Z, Marx, M, Laugier, D, Bogdanova, N N, Boubnov, N V, Clausen, P A, ...

Using differential display analysis, we compared the expression of RNA in v-mos-transformed cells and their flat revertant and isolated a novel gene, drm (down-regulated in mos-transformed cells),...

Functional and biological properties of an avian variant long terminal repeat containing multiple A to G conversions in the U3 sequence.

Felder, M P, Laugier, D, Yatsula, B, Dezélée, P, Calothy, G, Marx, M

We previously reported that infection of chicken embryonic neuroretina cells with Rous-associated virus type 1 leads to the frequent occurrence of spliced readthrough transcripts containing viral and...

Occurrence of alternatively spliced leader-delta onc-poly(A) transcripts in chicken neuroretina cells infected with Rous-associated virus type 1: implication in transduction of the c-mil/c-raf and c-Rmil/B-raf oncogenes.

Felder, M P, Laugier, D, Eychene, A, Calothy, G, Marx, M

We previously reported that serial passaging of Rous-associated virus type 1 in nondividing chicken embryo neuroretina cells leads to reproducible generation of acutely mitogenic retroviruses that...

Common mechanism of retrovirus activation and transduction of c-mil and c-Rmil in chicken neuroretina cells infected with Rous-associated virus type 1.

Felder, M P, Eychène, A, Barnier, J V, Calogeraki, I, Calothy, G, Marx, M

We previously described the isolation of the IC10 retrovirus which transduced the v-Rmil oncogene, a new member of the mil/raf gene family. This virus was generated during serial passaging of...

Transduction of the cellular src gene and 3' adjacent sequences in avian sarcoma virus PR2257.

Geryk, J, Dezélée, P, Barnier, J V, Svoboda, J, Nehyba, J, Karakoz, I, ...

When injected into chickens, a transformation-defective mutant of the Prague C strain of Rous sarcoma virus induced tumors at low incidence and after a long latency. One such tumor released a...

Molecular and biological properties of c-mil transducing retroviruses generated during passage of Rous-associated virus type 1 in chicken neuroretina cells.

Eychène, A, Béchade, C, Marx, M, Laugier, D, Dezélée, P, Calothy, G

IC1, IC2, and IC3 are novel c-mil transducing retroviruses generated during serial passaging of Rous-associated virus type 1 (RAV-1) in chicken embryo neuroretina cells. They were isolated by their...

Transformed and tumorigenic phenotypes induced by avian retroviruses containing the v-mil oncogene.

Béchade, C, Dambrine, G, David-Pfeuty, T, Esnault, E, Calothy, G

Avian retrovirus MH2 contains two oncogenes, v-mil and v-myc. We have previously shown that a spontaneous mutant of MH2 (PA200-MH2), expressing only the v-mil oncogene, is able to induce...

Genetic analysis of p60v-src domains involved in the induction of different cell transformation parameters.

Jove, R, Mayer, B J, Iba, H, Laugier, D, Poirier, F, Calothy, G, ...

The expression of p60v-src in chicken cells infected with Rous sarcoma virus causes stimulation of cell proliferation, morphological alteration, and anchorage independence. PA101 and PA104 are...

Genetic lesions involved in temperature sensitivity of the src gene products of four Rous sarcoma virus mutants.

Mayer, B J, Jove, R, Krane, J F, Poirier, F, Calothy, G, Hanafusa, H

The src genes of four Rous sarcoma virus (RSV) mutants temperature-sensitive (ts) for cell transformation were analyzed. The mutant src genes were cloned into a replication-competent RSV expression...

Activation and transduction of c-mil sequences in chicken neuroretina cells induced to proliferate by infection with avian lymphomatosis virus.

Marx, M, Crisanti, P, Eychène, A, Béchade, C, Laugier, D, Ghysdaël, J, ...

We report that nondividing neuroretina cells from chicken embryos can be induced to proliferate following infection with Rous-associated virus type 1 (RAV-1), an avian lymphomatosis retrovirus...

The membrane-binding domain and myristylation of p60v-src are not essential for stimulation of cell proliferation.

Calothy, G, Laugier, D, Cross, F R, Jove, R, Hanafusa, T, Hanafusa, H

Previous studies showed that the amino-terminal domain of Rous sarcoma virus p60v-src involved in myristylation and membrane association of the protein is required for morphological transformation...

Role of the mitogenic property and kinase activity of p60src in tumor formation by Rous sarcoma virus.

Poirier, F, Jullien, P, Dezelee, P, Dambrine, G, Esnault, E, Benatre, A, ...

Expression of the src gene of Rous sarcoma virus in chicken embryo neuroretinal cells results in morphological transformation and sustained proliferation of this normally resting cell population....

N-terminal deletion in the src gene of Rous sarcoma virus results in synthesis of a 45,000-Mr protein with mitogenic activity.

Laugier, D, Marx, M, Barnier, J V, Poirier, F, Genvrin, P, Dezélée, P, ...

Expression of the v-src gene of Rous sarcoma virus in avian embryo neuroretina cells results in transformation and sustained proliferation of these normally resting cells. Transformed neuroretina...

Rous sarcoma virus mutant dlPA105 induces different transformed phenotypes in quail embryonic fibroblasts and neuroretina cells.

Poirier, F, Laugier, D, Marx, M, Dambrine, G, Garber, E A, Genvrin, P, ...

dlPA105 is a spontaneous variant of Rous sarcoma virus, subgroup E, which carries a deletion in the N-terminal portion of the v-src gene coding sequence. This virus was isolated on the basis of its...

Role of p60src kinase activity in the induction of neuroretinal cell proliferation by rous sarcoma virus.

Poirier, F, Calothy, G, Karess, R E, Erikson, E, Hanafusa, H

Expression of the src gene of Rous sarcoma virus (RSV) in chicken embryo neuroretinal (NR) cells results in morphological transformation and sustained proliferation of a normally resting cell...

Transcriptional downregulation of the retina-specific QR1 gene by pp60v-src and identification of a novel v-src-responsive unit.

Pierani, A, Pouponnot, C, Calothy, G

The embryonic avian neuroretina (NR) is part of the central nervous system and is composed of various cell types: photoreceptors and neuronal and Müller (glial) cells. These cells are derived from...

Down regulation by p60v-src of genes specifically expressed and developmentally regulated in postmitotic quail neuroretina cells.

Guermah, M, Gillet, G, Michel, D, Laugier, D, Brun, G, Calothy, G

The avian neuroretina (NR) is composed of photoreceptors and different neurons that are derived from proliferating precursor cells. Neuronal differentiation takes place after terminal mitosis. We...

Crystallin gene expression and lentoid body formation in quail embryo neuroretina cultures transformed by the oncogenic retrovirus Mill Hill 2 or Rous sarcoma virus.

Simonneau, L, Crisanti, P, Lorinet, A M, Alliot, F, Courtois, Y, Calothy, G, ...

The lens-specific proteins alpha and delta crystallins and lentoid bodies, structures that follow a differentiation pathway similar to that of the lens, regularly appear after 4 to 5 weeks in quail...

Effect of Environmental pH on Rescue of Simian Virus 40

Calothy, G., Croce, C. M., Defendi, V., Koprowski, H., Eagle, H.

Rescue of SV40 virus after Sendai virus-mediated fusion of transformed mouse or hamster cell lines with permissive monkey cells was strikingly dependent on pH in the range 6.4-8.8, with a maximum at...

A novel oncogene related to c-mil is transduced in chicken neuroretina cells induced to proliferate by infection with an avian lymphomatosis virus.

Marx, M, Eychène, A, Laugier, D, Béchade, C, Crisanti, P, Dezélée, P, ...

Non-dividing neuroretina cells from chicken embryos are induced to proliferate after a long latency, following infection with Rous associated virus type 1, an avian retrovirus which does not carry a...

Glutamic acid decarboxylase activity is stimulated in quail retina neuronal cells transformed by Rous sarcoma virus and is regulated by pp60v-src.

Crisanti, P, Lorinet, A M, Calothy, G, Pessac, B

Rous sarcoma virus (RSV) stimulates in quail embryo neuro-retina (NR) cultures the specific activity of glutamic acid decarboxylase (GAD), the enzyme responsible for the synthesis of...