Barth, S, Nesper, J, Hasgall, P A, Wirthner, R, Nytko, K J, Edlich, F, ...
Copyright © 2007, the American Society for Microbiology. All rights reserved.
Glucose-stimulated insulin production in mice deficient for the PAS kinase PASKIN. (2007)
Borter, E, Niessen, M, Zuellig, R, Spinas, G A, Spielmann, P, Camenisch, G, ...
The Per-ARNT-Sim (PAS) domain serine/threonine kinase PASKIN, or PAS kinase, links energy flux and protein synthesis in yeast and regulates glycogen synthase in mammals. A recent report suggested...
Eckhardt, K, Troger, J, Reissmann, J, Katschinski, D M, Wagner, K F, Stengel, P J, ...
PASKIN links energy flux and protein synthesis in yeast, regulates glycogen synthesis in mammals, and has been implicated in glucose-stimulated insulin production in pancreatic beta-cells. Using...
Regulated Function of the Prolyl-4-Hydroxylase Domain (PHD) Oxygen Sensor Proteins (2007)
Nytko, K J, Spielmann, P, Camenisch, G, Wenger, R H, Stiehl, D P
ABSTRACT Cellular oxygen is sensed by prolyl-4-hydroxylase domain (PHD) proteins that hydroxylate hypoxia-inducible factor (HIF) α subunits. Under normoxic conditions, hydroxylated HIFα is bound by...
Stiehl, D P, Wirthner, R, Köditz, J, Spielmann, P, Camenisch, G, Wenger, R H
Prolyl 4-hydroxylase domain (PHD) proteins are oxygen-dependent enzymes that hydroxylate hypoxia-inducible transcription factor (HIF) alpha-subunits, leading to their subsequent ubiquitination and...
Integration of oxygen signaling at the consensus HRE. (2005)
Wenger, R H, Stiehl, D P, Camenisch, G
"This is the author's version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in SCIENCE,VOL(306),Oct18 2005,...
Martin, F, Linden, T, Katschinski, D M, Oehme, F, Flamme, I, Mukhopadhyay, C K, ...
Cellular oxygen partial pressure is sensed by a family of prolyl-4-hydroxylase domain (PHD) enzymes that modify hypoxia-inducible factor (HIF)alpha subunits. Upon hydroxylation under normoxic...
Integration of oxygen signaling at the consensus HRE. (2005)
Wenger, R H, Stiehl, D P, Camenisch, G
The hypoxia-inducible factor 1 (HIF-1) was initially identified as a transcription factor that regulated erythropoietin gene expression in response to a decrease in oxygen availability in kidney...
Depping, R H, Hägele, S, Wagner, K F, Wiesner, R J, Camenisch, G, Wenger, R H, ...
Spermatogenesis in the seminiferous tubuli of the testis occurs under a high proliferation rate, suggesting considerable oxygen consumption. Because of the lack of blood vessels, the oxygen partial...
Attenuation of HIF-1 DNA-binding activity limits hypoxia-inducible endothelin-1 expression. (2001)
Camenisch, G, Stroka, D M, Gassmann, M, Wenger, R H
The original publication is available at www.springerlink.com
Epolones induce erythropoietin expression via hypoxia-inducible factor-1 alpha activation. (2000)
Wanner, R M, Spielmann, P, Stroka, D M, Camenisch, G, Camenisch, I, Scheid, A, ...
Induction of erythropoietin (Epo) expression under hypoxic conditions is mediated by the heterodimeric hypoxia-inducible factor (HIF)-1. Following binding to the 3' hypoxia-response element (HRE) of...
Görlach, A, Camenisch, G, Kvietikova, I, Vogt, L, Wenger, R H, Gassmann, M
The heterodimeric hypoxia-inducible factor-1 (HIF-1), consisting of the subunits HIF-1alpha and HIF-1beta/ARNT, is a master transcriptional regulator of oxygen homeostasis. Under hypoxic conditions,...
Chilov, D, Camenisch, G, Kvietikova, I, Ziegler, U, Gassmann, M, Wenger, R H
Hypoxia-inducible factor-1 (HIF-1) is a master regulator of mammalian oxygen homeostasis. HIF-1 consists of two subunits, HIF-1alpha and the aryl hydrocarbon receptor nuclear translocator (ARNT)....
Camenisch, G, Tini, M, Chilov, D, Kvietikova, I, Srinivas, V, Caro, J, ...
Avian embryos and neonates acquire passive immunity by transferring maternal immunoglobulins from serum to egg yolk. Despite being a convenient source of antibodies, egg yolk immunoglobulins (IgY)...
Oxygen tension modulates beta-globin switching in embryoid bodies. (1999)
Bichet, S, Wenger, R H, Camenisch, G, Rolfs, A, Ehleben, W, Porwol, T, ...
Little is known about the factors influencing the hemoglobin switch in vertebrates during development. Inasmuch as the mammalian conceptus is exposed to changing oxygen tensions in utero, we examined...
Wenger, R H, Camenisch, G, Desbaillets, I, Chilov, D, Gassmann, M
Oxygen-deprived regions of a solid tumor can induce tumor suppressor p53 expression and hence select for p53-mutant tumor cells with diminished apoptotic potential. It has been proposed that the...
Wenger, R H, Kvietikova, I, Rolfs, A, Camenisch, G, Gassmann, M
The hypoxia-inducible factor-1 (HIF-1) is a transcriptional activator involved in the expression of oxygen-regulated genes such as that for erythropoietin. Following exposure to low oxygen partial...
Camenisch, G, Gruber, M, Donoho, G, Van Sloun, P, Wenger, R H, Gassmann, M
We describe the ability of novel episomally maintained vectors to efficiently promote gene expression in embryonic stem (ES) cells as well as in established mouse cell lines. Extrachromosomal...
A polyoma-based episomal vector efficiently expresses exogenous genes in mouse embryonic stem cells.
Camenisch, G, Gruber, M, Donoho, G, Van Sloun, P, Wenger, R H, Gassmann, M
We describe the ability of novel episomally maintained vectors to efficiently promote gene expression in embryonic stem (ES) cells as well as in established mouse cell lines. Extrachromosomal...
A polyoma-based episomal vector efficiently expresses exogenous genes in mouse embryonic stem cells.
Camenisch, G, Gruber, M, Donoho, G, Van Sloun, P, Wenger, R H, Gassmann, M
We describe the ability of novel episomally maintained vectors to efficiently promote gene expression in embryonic stem (ES) cells as well as in established mouse cell lines. Extrachromosomal...