Base sequence determinants of amonafide stimulation of topoisomerase II DNA cleavage.
De Isabella, P, Zunino, F, Capranico, G
A number of antitumor drugs including naphthalimides, a new class of intercalating agents, interfere with the DNA breakage-reunion activity of mammalian DNA topoisomerase II resulting in DNA cleavage...
Pommier, Y, Capranico, G, Orr, A, Kohn, K W
Several classes of antitumor drugs are known to stabilize topoisomerase complexes in which the enzyme is covalently bound to a terminus of a DNA strand break. The DNA cleavage sites generally are...
Capranico, G, Jaxel, C, Roberge, M, Kohn, K W, Pommier, Y
We have assessed the ability of nucleosomes to influence the formation of mammalian topoisomerase II-DNA complexes by mapping the sites of cleavage induced by four unrelated topoisomerase II...
Capranico, G, Kohn, K W, Pommier, Y
Doxorubicin, a DNA-intercalator, is one of several anti-cancer drugs that have been found to stabilizes topoisomerase II cleavage complexes at drug-specific DNA sites. The distribution and DNA...
Bigioni, M, Zunino, F, Capranico, G
Antitumor drugs, such as anthracyclines, interfere with mammalian DNA topoisomerase II by forming a ternary complex, DNA-drug-enzyme, in which DNA strands are cleaved and covalently linked to the...
Base sequence determinants of amonafide stimulation of topoisomerase II DNA cleavage.
De Isabella, P, Zunino, F, Capranico, G
A number of antitumor drugs including naphthalimides, a new class of intercalating agents, interfere with the DNA breakage-reunion activity of mammalian DNA topoisomerase II resulting in DNA cleavage...
Pommier, Y, Capranico, G, Orr, A, Kohn, K W
Several classes of antitumor drugs are known to stabilize topoisomerase complexes in which the enzyme is covalently bound to a terminus of a DNA strand break. The DNA cleavage sites generally are...
Capranico, G, Jaxel, C, Roberge, M, Kohn, K W, Pommier, Y
We have assessed the ability of nucleosomes to influence the formation of mammalian topoisomerase II-DNA complexes by mapping the sites of cleavage induced by four unrelated topoisomerase II...
Capranico, G, Kohn, K W, Pommier, Y
Doxorubicin, a DNA-intercalator, is one of several anti-cancer drugs that have been found to stabilizes topoisomerase II cleavage complexes at drug-specific DNA sites. The distribution and DNA...
Bigioni, M, Zunino, F, Capranico, G
Antitumor drugs, such as anthracyclines, interfere with mammalian DNA topoisomerase II by forming a ternary complex, DNA-drug-enzyme, in which DNA strands are cleaved and covalently linked to the...